
Places to stay near Mission San Luis Obispo de Tolosa
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Top-rated vacation rentals near Mission San Luis Obispo de Tolosa
Guests agree: these stays are highly rated for location, cleanliness, and more.

SLO Guesthouse - quiet - near downtown - #115545
Private studio with it's own entrance located in lovely SLO. Includes a queen size Murphy bed (people rave about the comfort of this bed), 3 piece bathroom, table & two chairs, desk, closet, TV, WiFi & kitchenette. Coffee, tea with fixings are provided. 4 blocks from the downtown cultural-hub, hip restaurants, Farmer's Market, the Historic Mission and more. The Edna Valley wine country is 5 minutes away and the Beach is 10 minutes away. The Perfect Location to come experience the "SLO Life"!
4.97 out of 5 average rating, 699 reviews
San Luis Obispo Oasis near DT SLO w/ Hot Tub + EV
Newly renovated SLOasis bungalow 10 mins walk from downtown SLO shops/restaurants/nightlife. New 4-6 person Hot Tub in private yard. Beautiful spacious kitchen, cozy bedrooms and nice porch. Located in the residential High St Neighborhood (SoHi) with easy access to coffee shops, local wineries, wedding venues and local attractions. Enjoy the entire place with relaxing in the hot tub, cooking in the kitchen or taking a short walk to a popular trailhead or downtown shops, bars and restaurants.
4.95 out of 5 average rating, 315 reviews
Eclectic apartment in the heart of downtown SLO.
This charming, newly updated, 1 BR apartment is part of an 1883 Folk Victorian in the heart of SLO's downtown historic district and was recently added to the California Master List of Historic Resources as 'The D.M. & Carrie Proper Meredith House'. This cozy apartment offers convenience, style, safety, and privacy - all while being just a two-minute walk to all your favorite bars, restaurants, cafes, movie theatres, and shops. Your hosts aim to provide you with an amazing 5-star experience!
4.97 out of 5 average rating, 351 reviews
Downtown Historic District Sunset Studio
Enjoy a hotel quality stay, professionally cleaned prior to each guest, located in the beautiful downtown historic district. Studio is equipped to provide you with everything you need for an enjoyable stay; including washer/dryer, AC/ Heat. From the deck enjoy magnificent sunset views framed by San Luis Mountain and Bishop's Peak while enjoying dining al fresco. We are 4 walkable blocks to downtown and a mile to Cal Poly. The beach is about a 10 min drive away. You can't beat the location!
4.97 out of 5 average rating, 633 reviews
Cozy Studio Close to Downtown SLO
Cozy Studio is located in a quiet residential neighbor with secure off street parking. Whether you choose to relax in my comfortably furnished studio or enjoy the private outdoor patio, my home will provide a serene retreat. From the house, it is a ten minute walk to downtown. Home features smart tv with Netflix, Hulu, and Sling. It also features high-speed wifi and air conditioning. Please note that the bedroom is upstairs and the bathroom is downstairs . Home Stay Permit # 0235-2020
4.87 out of 5 average rating, 223 reviews
Upscale. Pet friendly. Great location! 6-10 guests
Welcome! This 4/2 fully upgraded, Spanish Med. in D/T SLO is filled with ambiance! Hotel-grade queen beds and furnishings suit up to 10 perfectly. Formal or gazebo dining, fire pit/BBQ, and games area. 2 car driveway parking. Easy self-entry. Complimentary drink on arrival! Clean quiet house trained pets Ok! 20 mins to beaches/wineries. Includes a detached bungalow/master suite with 1/2 bath. A quality spot for entertaining, or to relax in. You’ll LOVE it here~
4.95 out of 5 average rating, 258 reviews
Cozy, Clean and Close to downtown SLO!
Relax in my comfortably furnished, air conditioned (a rare amenity in SLO), 3 bedroom home. Located in a quiet, residential neighborhood with secure, off-street parking. Multiple indoor and outdoor living spaces will provide a quiet retreat for everyone! My home features Air-conditioning, soft water, reverse osmosis drinking water, a record player with vinyl collection and games. WiFi, Sling TV, Netflix & Hulu! Business Lic # 113276. Home Stay Permit # 0235-2020
4.9 out of 5 average rating, 569 reviews
Serenity On Serrano
Serenity on Serrano is a Frank Lloyd Wright-inspired peaceful haven set in one of SLO's most prestigious neighborhoods right on the edge of a creek. This midcentury modern home is just steps to hiking, the downtown, shopping, and restaurants. Be prepared for nature as it's common to be greeted by wild turkeys, birds, and more. Enjoy the tranquility of minimalist design. Note: There is $25 per night for each extra guest over 4. Permit # H-0408-2023
4.86 out of 5 average rating, 143 reviews
Cozy Retreat Walking Distance to Downtown
This historic home has been recently remodeled. It sits in a quiet, friendly neighborhood which is walking distance to downtown. The second bedroom overlooks a large, beautiful garden and you can hear the gentle song of frogs at night and church bells in the morning. All beds feature luxury linens and the Wifi is fantastic! Forget your worries in this spacious and serene space. Walking distance to High Street Deli and Village Host Pizza.
4.76 out of 5 average rating, 233 reviews
The Downtown House SLO with Private Parking
Charming 1920s bungalow in the heart of downtown San Luis Obispo! Walk to top restaurants, coffee shops, parks, and the famous Farmers Market. Perfect for SLO Marathon runners—just a mile from the starting line. Original details + modern upgrades, A/C, full kitchen, laundry, and parking. Ideal for guests who love vibrant, walkable neighborhoods. We’re locals and happy to share our favorite hikes, wineries, and spots to explore!
4.96 out of 5 average rating, 477 reviews
Mid Century Modern Loft Downtown SLO
This unique place has a style all it's own. Mid century modern loft located just a few blocks from downtown SLO. 10 min walk and 3 min drive to all the great shops and restaurants SLO has to offer. Thick glass walls in the bedroom allow for an open loft like experience. Many fun details throughout the place create a truly unique vibe. This 800sf loft located upstairs above a salon is private and has designed parking.
4.99 out of 5 average rating, 338 reviews
Close to Downtown SLO
Enjoy this clean 420 sqft space in a great SLO location. Close distance to town, restaurants, bike paths & hiking. Private entrance. Open concept style, queen bed and twin sofa option. Large walk-closet with extra bedding and towels. Fully equipped kitchen: refrigerator, oven, microwave, dishwasher, reverse osmosis for drinking water & garbage disposal. Beautifully done bathroom with large shower & vanity
4.99 out of 5 average rating, 185 reviewsPopular amenities for vacation rentals near Mission San Luis Obispo de Tolosa
Condo rentals with wifi

The Hideaway in SLO
4.86 out of 5 average rating, 488 reviews
Beautiful Walk to Downtown from European Flat.
4.94 out of 5 average rating, 251 reviews
Downtown Loft with Panoramic Rooftop
4.87 out of 5 average rating, 110 reviews
Just Built and Furnished! Luxury Condo 326 Stimson
4.96 out of 5 average rating, 141 reviews
Avila Good Life - A luxury 2 Bdrm condo 3 houses f
4.96 out of 5 average rating, 125 reviews
Coastal Home w/ EV Charger & BBQ near The Village
4.99 out of 5 average rating, 298 reviews
Pismo Beach Condo by Sea, steps to Beach & Pier!
4.79 out of 5 average rating, 126 reviews
Spacious Pismo Beach condo -block to sand and fun!
4.97 out of 5 average rating, 279 reviewsFamily-friendly house rentals

OMG Playground, close to Beach, Family Fun
4.97 out of 5 average rating, 109 reviews
Family Home Close to Downtown
4.92 out of 5 average rating, 412 reviews
Downtown Craftsman with Courtyard
4.99 out of 5 average rating, 162 reviews
SLO Vibes
4.96 out of 5 average rating, 152 reviews
Boutique Bungalow San Luis Obispo
4.88 out of 5 average rating, 310 reviews
Iconic Modern Farmhouse+walkable+views+BBQ
4.89 out of 5 average rating, 239 reviews
1884 Elegant Home: Fire Pit, Tesla Tech, Near DT
5.0 out of 5 average rating, 244 reviews
STENNER CREEK RANCH
4.91 out of 5 average rating, 188 reviewsApartment rentals with air conditioning

Pet Friendly Bright & Airy SLO Apartment
4.99 out of 5 average rating, 303 reviews
Very Spacious Edna Valley Luxury Apartment
5.0 out of 5 average rating, 176 reviews
Downtown View Suite at Pismo Beach Club
4.88 out of 5 average rating, 441 reviews
Spacious 2BD w/rural views
4.98 out of 5 average rating, 292 reviews
Village Oasis
4.87 out of 5 average rating, 300 reviews
Boho Bungalow with Ocean View in Grover Beach
4.89 out of 5 average rating, 428 reviews
URGH Casita (Pequeña Casita en un granero)
4.88 out of 5 average rating, 546 reviews
The Pine House | Dog Friendly Ocean View · Avila
4.77 out of 5 average rating, 222 reviewsOther great vacation rentals near Mission San Luis Obispo de Tolosa

Cottage in SLO / Historic Downtown District
4.98 out of 5 average rating, 701 reviews
Amazing Airstream in private garden
4.86 out of 5 average rating, 346 reviews
Rooftop Patio Downtown Suite- 4-5 Guests
4.98 out of 5 average rating, 593 reviews
Cozy Casita: Private Guest Unit in SLO
4.94 out of 5 average rating, 148 reviews
Private Creekside Cabin • Gated • Near Avila Beach
5.0 out of 5 average rating, 150 reviews
Harris House
4.92 out of 5 average rating, 508 reviews
Ranch Estate: EPIC Views Spa Firepit Game Room
4.93 out of 5 average rating, 113 reviews
Downtown SLO Abode- Walk downtown & close to Poly
5.0 out of 5 average rating, 157 reviewsDestinations to explore
- Cayucos Beach
- Moonstone Beach
- Pismo State Beach
- Hearst Castle
- Montaña de Oro State Park
- Morro Strand State Beach
- Los Padres National Forest
- Cayucos State Beach
- Morro Rock Beach
- California Polytechnic State University
- Dinosaur Caves Park
- Sensorio
- Pismo Preserve
- Charles Paddock Zoo
- Monarch Butterfly Grove
- Vina Robles Amphitheatre
- JUSTIN Vineyards & Winery
- Tablas Creek Vineyard
- Downtown City Park
- Niner Wine Estates
- Talley Vineyards
- Harmony Headlands State Park
- Fess Parker Winery & Vineyard
- Oceano Dunes State Vehicular Recreation Area





