Seneca vacation rentals

Book unique vacation rentals, houses, and more on Airbnb

Top-rated vacation rentals in Seneca

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Shipping container in Walhalla

4.98 out of 5 average rating, 406 reviews

The Southern Cross at Hi Saw Gap

The quintessential Tiny Home experience at beautiful Hi Saw Gap! The Southern Cross is located cliff's edge with endless views over untouched natural beauty. Fabulous outdoor amenities compel you to be outside, including a glass enclosed shelter, propane fire pit, charcoal BBQ grill, and covered bistro deck with outdoor kitchen and prep station. Located just a half-mile from Stumphouse Tunnel, Issaqueena Falls, Yellow Branch Falls hiking trail, and the World class Stumphouse Mountain Bike Park.

Feb 13 – 20

ﺩ.ﺇ520 per night

Guest favorite

Condo in Clemson

4.93 out of 5 average rating, 120 reviews

Clemson Cedarwood Condo with a Deck

This Cedarwood condo is in a quiet neighborhood located 5 minutes from Clemson University. It is an excellent place to stay if visiting campus, and it is also perfect for those just looking for a getaway in close proximity to lakes, waterfalls, and hiking trails. The condo is two bedrooms and two baths, with an open area living room, dining room, kitchen area and a deck off of the living room. New washer, dryer, dishwasher, flooring, and carpeting! Stay for a week to receive a 35% discount!

Mar 7 – 14

ﺩ.ﺇ291 per night

Guest favorite

Home in Seneca

4.95 out of 5 average rating, 143 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

May 18 – 25

ﺩ.ﺇ466 per night

Guest favorite

Cottage in Central

5.0 out of 5 average rating, 160 reviews

Cozy Cottage on Oak Grove

The Cozy Cottage is just 9 miles from Clemson’s Memorial Stadium (Death Valley). This peaceful retreat has plenty of comfortable interior space and has an expansive exterior country setting. Close enough to enjoy all of the game day excitement and local restaurants, yet far enough away to escape for a restful vacation. The best of both worlds! Close to hiking, waterfalls, and lakes. 4 miles to Southern Wesleyan University. 25 miles to downtown Greenville. *No pets allowed. No Smoking

Oct 10 – 17

ﺩ.ﺇ495 per night

Guest favorite

Tiny home in West Union

4.96 out of 5 average rating, 211 reviews

Holliday's Inn Tiny Tree-house

Tiny Treehouse is a ‘container’ house set in a private wooded locale at the foothills of the mountains. Find yourself hiking at Oconee State park or Caesar's Head mountain along with a multitude of waterfalls within our county. 5 minutes from downtown historic Walhalla, 10 minutes to city of Seneca, and 20 minutes from Clemson University where tailgaters unite before the big football game! Explore the artistic venues and cultural scenes of Greenville just an hour away!

Feb 15 – 22

ﺩ.ﺇ377 per night

Guest favorite

Cottage in Westminster

4.98 out of 5 average rating, 413 reviews

Tiny house

BRAND NEW 490 sq ft tiny house/cottage nestled in the woods in a country setting. Complete with a queen bedroom, a twin/day bed and then a queen bed in loft ( comfortably sleeps 4 adults and one child). We are conveniently located 10 miles from I-85 exit 1 on S Hwy 11. 20 minutes from Clemson, 8 minutes from Seneca, and just a short drive to many hiking trails, lakes and parks in the beautiful foothills of the Blue Ridge mountains.

Feb 17 – 24

ﺩ.ﺇ390 per night

Guest favorite

Guest suite in Seneca

4.99 out of 5 average rating, 111 reviews

Haven on the Lake-Entire downstairs, near Clemson

Beautiful setting on Lake Hartwell. Guests will have the entire downstairs which includes 2 bedrooms, bar area and entertainment area. Guests may bring their boat and dock it. There is plenty of room for trailer parking on premise and the boat ramp is less than 1/4 mile from house. Stay includes 2 hand thrown coffee mugs made by Purple Unicorn Pottery. Please note upstairs is private residence, hosts live there.

Jul 28 – Aug 4

ﺩ.ﺇ393 per night

Guest favorite

Cottage in Townville

4.96 out of 5 average rating, 203 reviews

The Little Cottage on Pine/20 minutes to Clemson

The Cottage was created for the purpose of having a beautiful place to host our out-of-town family and friends. We chose to make it available for guests like you as well. It is tucked away in the quiet countryside of Upstate SC. Enjoy the peaceful farmland, your morning cup of coffee on the front porch, the nearby lakes and a short drive to downtown Clemson. Perfect for a relaxing weekend getaway.

Jun 26 – Jul 3

ﺩ.ﺇ362 per night

Guest favorite

Home in Seneca

4.99 out of 5 average rating, 174 reviews

The Cozy Cottage

Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. Perfect for getaways, football weekends, graduation, and other Clemson University events! *NO SMOKING OR VAPING ALLOWED INSIDE THE HOUSE OR ON THE PROPERTY

Oct 1 – 8

ﺩ.ﺇ747 per night

Superhost

Treehouse in Walhalla

4.96 out of 5 average rating, 735 reviews

The Majestic Treehouse romantic, luxury retreat

LIVE LIKE KINGS & PLAY LIKE KIDS in this extraordinary, award-winning treehouse. This luxury treehouse was designed by Seth Bolt (from the band NEEDTOBREATHE), who grew up on Bolt Farm. Larry Bolt (Seth's dad), proprietor, Eagle Scout, and licensed custom home builder has been building & remodeling homes for over 40 years in upstate SC. We are 32x Superhosts! Named the Most Popular Airbnb in SC!

Mar 12 – 19

ﺩ.ﺇ2,188 per night

Guest favorite

Guesthouse in Westminster

4.99 out of 5 average rating, 148 reviews

Lit'l Bit O' Heaven- Rocky Top Lodge

Rocky Top Lodge is nestled in the Foothills of the Blue Ridge Mountains and was carefully designed and thoughtfully decorated. All of the décor was hand chosen over a 2 year period. Be sure to check out our sister cabin, The Farmhouse, also listed on Airbnb. Cabins are situated next to each other yet very private.

Oct 6 – 13

ﺩ.ﺇ477 per night

Guest favorite

Cottage in Westminster

4.96 out of 5 average rating, 294 reviews

Chauga River Cottage

Freshly updated cottage sitting high above the Chauga River provides an intimate retreat. Come relax in the quiet setting in the woods with porches, open deck, and a river overlook. Numerous waterfalls and hiking trails nearby as well as quaint towns with coffee shops and restaurants. But staying in is highly rated.

Oct 7 – 14

ﺩ.ﺇ595 per night

Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for Seneca vacation rentals

Lake access

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Stay near Seneca's top sights

Ingles Market17 locals recommend

Copper River Grill10 locals recommend

Time Drive In7 locals recommend

Dienners Kitchen6 locals recommend

Premiere Seneca Cinema 814 locals recommend

Seneca Family Restaurant3 locals recommend

Other great vacation rentals in Seneca

Guest favorite

Cottage in Townville

4.88 out of 5 average rating, 100 reviews

Waterfront cottage w/deep dock 17 miles to Clemson

Oct 11 – 18

ﺩ.ﺇ501 per night

Guest favorite

Condo in Salem

4.95 out of 5 average rating, 107 reviews

Beautiful Lake Keowee Condo with great Amenities

May 30 – Jun 6

ﺩ.ﺇ675 per night

Guest favorite

Guesthouse in Toccoa

4.99 out of 5 average rating, 106 reviews

Cozy Rustic Lakefront Cabin

Jun 24 – Jul 1

ﺩ.ﺇ486 per night

Guest favorite

Home in Anderson

4.99 out of 5 average rating, 178 reviews

Lake Escape

Mar 6 – 13

ﺩ.ﺇ497 per night

Guest favorite

Place to stay in Townville

4.95 out of 5 average rating, 99 reviews

Peaceful Living Guest House on quiet cove

Oct 18 – 25

ﺩ.ﺇ447 per night

Guest favorite

Guesthouse in Anderson

5.0 out of 5 average rating, 217 reviews

Game Day Cottage in the Woods

Sep 4 – 11

ﺩ.ﺇ577 per night

Guest favorite

Guest suite in Hartwell

4.97 out of 5 average rating, 208 reviews

Relaxing retreat on Lake Hartwell.

Apr 18 – 25

ﺩ.ﺇ387 per night

Guest favorite

Cabin in Fair Play

4.93 out of 5 average rating, 175 reviews

Hartwell Hideaway - Cozy Cabin on Lake Hartwell!

Aug 18 – 25

ﺩ.ﺇ414 per night

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Seneca house rentals

Guest favorite

Home in Pendleton

4.89 out of 5 average rating, 128 reviews

Comfort & Convenience Close to Campus

Oct 10 – 17

ﺩ.ﺇ440 per night

Guest favorite

Home in Lavonia

4.99 out of 5 average rating, 112 reviews

The Willow Lake House

Jan 10 – 17

ﺩ.ﺇ502 per night

Guest favorite

Home in Six Mile

4.98 out of 5 average rating, 125 reviews

Quaint country home near Clemson

Dec 4 – 11

ﺩ.ﺇ475 per night

Guest favorite

Home in Pendleton

4.99 out of 5 average rating, 130 reviews

3 BR/2BA Cottage in Pendleton - 9 Miles to Clemson

Dec 28 – Jan 4

ﺩ.ﺇ467 per night

Guest favorite

Home in Central

4.96 out of 5 average rating, 222 reviews

The Little House @ Cozy Hollow

Oct 10 – 17

ﺩ.ﺇ396 per night

Guest favorite

Home in Salem

4.85 out of 5 average rating, 110 reviews

Mountains and Lake Area

Nov 27 – Dec 4

ﺩ.ﺇ460 per night

Guest favorite

Home in Hartwell

4.84 out of 5 average rating, 363 reviews

3 little Care Bear bungalow

Aug 6 – 13

ﺩ.ﺇ378 per night

Guest favorite

Home in Anderson

4.93 out of 5 average rating, 149 reviews

Broadway Lake Retreat in Anderson, SC

Mar 28 – Apr 4

ﺩ.ﺇ538 per night

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Seneca fishing house rentals

Guest favorite

Home in Seneca

4.97 out of 5 average rating, 119 reviews

Lake Hartwell house w/ dock 2 miles from Clemson.

Aug 7 – 14

ﺩ.ﺇ866 per night

Guest favorite

Home in Townville

4.94 out of 5 average rating, 151 reviews

Zoey’s Cottage on Lake Hartwell w/dock- Secluded

Oct 7 – 14

ﺩ.ﺇ951 per night

Superhost

Home in Seneca

4.85 out of 5 average rating, 174 reviews

Cozy Lake House 5 miles from Clemson w Dock

May 29 – Jun 5

ﺩ.ﺇ895 per night

Guest favorite

Home in Pickens

4.97 out of 5 average rating, 132 reviews

Our Slice of Heaven w/Views of Table Rock-Pickens

May 2 – 9

ﺩ.ﺇ478 per night

Guest favorite

Home in Anderson

4.99 out of 5 average rating, 137 reviews

Lake House, close to Clemson Kayaks & Paddleboards

Sep 26 – Oct 3

ﺩ.ﺇ1,239 per night

Guest favorite

Home in Easley

4.9 out of 5 average rating, 276 reviews

“Lake House Paradise” Waterfront Oasis

Jun 16 – 23

ﺩ.ﺇ604 per night

Guest favorite

Home in Anderson

4.88 out of 5 average rating, 168 reviews

Lake Living with Amazing Views of Lake Hartwell

Mar 21 – 28

ﺩ.ﺇ783 per night

Guest favorite

Home in Townville

4.99 out of 5 average rating, 100 reviews

Sweet Serenity - Rest Relax Enjoy

Dec 27 – Jan 3

ﺩ.ﺇ780 per night

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Quick stats about vacation rentals in Seneca

Total rentals
50 properties
Rentals with dedicated workspaces
20 properties have a dedicated workspace
Pet-friendly rentals
10 properties allow pets
Family-friendly rentals
40 properties are a good fit for families
Total number of reviews
1.7K reviews
Nightly prices starting at
ﺩ.ﺇ147 before taxes and fees

Frequently Asked Questions

Are there vacation rentals with a dedicated workspace in Seneca?
Yes! Work meets play with ease at over 20 vacation rentals in Seneca featuring dedicated workspaces. Stay connected and productive in your home away from home.
Are there pet-friendly vacation rentals in Seneca?
Four-legged friends are welcome in Seneca. Choose from more than 10 vacation rentals for guests traveling with pets.
How much does it cost to stay in house rentals in Seneca?
Experience the best of Seneca with our house rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Do house rentals in Seneca have a bbq area?
Absolutely! We offer over 10 house rentals with a bbq area in Seneca. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly house rentals in Seneca?
Seneca has more than 30 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
Do house rentals in Seneca have wireless internet?
Absolutely! We offer over 30 house rentals with wireless internet in Seneca. Enjoy a tailored experience with all the comforts you desire.

Seneca vacation rentals

Top-rated vacation rentals in Seneca

Vacation rentals for every style

Houses

Hotels

Unique stays

Popular amenities for Seneca vacation rentals

Stay near Seneca's top sights

Other great vacation rentals in Seneca

Cottage in Townville

Condo in Salem

Guesthouse in Toccoa

Home in Anderson

Place to stay in Townville

Guesthouse in Anderson

Guest suite in Hartwell

Cabin in Fair Play

Seneca house rentals

Home in Pendleton

Home in Lavonia

Home in Six Mile

Home in Pendleton

Home in Central

Home in Salem

Home in Hartwell

Home in Anderson

Seneca fishing house rentals

Home in Seneca

Home in Townville

Home in Seneca

Home in Pickens

Home in Anderson

Home in Easley

Home in Anderson

Home in Townville

Quick stats about vacation rentals in Seneca

Total rentals

Rentals with dedicated workspaces

Pet-friendly rentals

Family-friendly rentals

Total number of reviews

Nightly prices starting at

Frequently Asked Questions

Are there vacation rentals with a dedicated workspace in Seneca?

Are there pet-friendly vacation rentals in Seneca?

How much does it cost to stay in house rentals in Seneca?

Do house rentals in Seneca have a bbq area?

Are there family-friendly house rentals in Seneca?

Do house rentals in Seneca have wireless internet?

Destinations to explore