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Boutique hotel vacation rentals in Panama

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Panama

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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A spacious queen suite features a cozy bed adorned with a warm-toned throw. Two wicker chairs and a small table are arranged on the private patio, with sunlight filtering in through large glass doors that open to a lush outdoor setting.

Hotel room in Panamá

4.75 out of 5 average rating, 8 reviews

Avani Eco Hotel ~ Romantic Nature Getaway ~ Patio!

Step into the comfort of this beautiful queen suite in the high-end, eco-friendly Avani Boutique Hotel, offering easy access to sandy beaches and the many stunning amenities and activities of Contadora Island. Spend the day exploring this breathtaking island and then retreat to the attractive suite whose stylish design and scenic surroundings will mesmerize you. ✔ Comfy Queen Bed ✔ Spa-Like Bathroom ✔ Private Patio ✔ Wi-Fi ✔ Hotel Amenities (Breakfast, Transport, Activities) Learn more below!

A furnished bedroom features a spacious bed with white linens, flanked by bedside tables with lamps. Soft artwork adorns the wall above, while a bench rests at the foot of the bed. A cozy throw drapes over the bench, completing the inviting arrangement.

Hotel room in Boquete

4.89 out of 5 average rating, 113 reviews

Villa Alejandro - Tastefully Furnished Room

Just 5 minutes walk to centre, calmly situated and close to town located in an extraordinary mansion. Lovely furnished bedroom (King-Size/Orthopedic mattress) with private bathroom and walk-in closet . Affectionately decorated living room with spectacular view to the Boquete valley by large windows and large, full equipped kitchen can be shared with other guests. Lot of space for dining/reading in the living room. Lovely garden and terrace can be used. Gated carport. Fast WiFi, CableTV, Netflix

A spacious bedroom features a wooden platform bed with a blue patterned mattress. Large glass doors open to a private patio, surrounded by lush greenery. Two chairs are positioned on the terrace, and a colorful framed artwork adorns the wall near a window.

Hotel room in PA

4.9 out of 5 average rating, 29 reviews

Treetop views of the Pacific in a boutique cabaña

No detail left unnoticed…our boutique cabañas are nestled in jungle gardens with private porches overlooking the Pacific, hammocks for lounging, indoor/outdoor concept bathrooms, stunning hardwood floors, and custom-made furniture. Each of our three cabañas has its own unique charm where comfort meets luxury. We are steps from the beach and minutes from consistent surf breaks and community yoga classes. A shared kitchen is on site, with individual cooking utensils provided for each room.

A light and airy room is shown with large glass doors leading to a lush outdoor area. A wide-brimmed hat rests on a bed, while a figure stands at the door, showcasing a flowy floral skirt and a simple top amid greenery.

Hotel room in PA

4.91 out of 5 average rating, 34 reviews

Villa Coco King Room

Villa Coco is a beautiful boutique hotel in Santa Catalina, only footsteps away of the world known surf break “La Punta” and Unesco world heritage Coiba island. The carefully designed cabañas, provide a space of tranquility and a sense of timelessness. Unwind in the hammocks and canvas chairs on your private terrace, dwell on reading your favorite book or sip on a cool drink from the bar. Our Restaurant “Ai Mamita” offers different kinds of meat, fresh seafood and other tasty delights.

The bungalow features a screened-in porch, framed by lush greenery and colorful plants. Warm sunlight casts shadows across the wooden structure, creating a serene and inviting atmosphere amidst the surrounding foliage.

Hotel room in Bastimentos Island

4.95 out of 5 average rating, 64 reviews

Casa Florecer- bungalow at the edge of the sea

Welcome to Casa Florecer, a bungalow at the edge of the sea. Your space is simple and elegant. A studio apartment with plenty of room to enjoy a quiet & peaceful time on the island. The bungalow boasts a screened in porch, gorgeous views, and pristine coral reef for your front yard. All stays include a locally sourced vegetarian breakfast served in our over the water eatery, Juntos. For fun closer to home: we have snorkel gear, paddle boards, and yoga mats available for your enjoyment.

A bright and airy bedroom features a spacious bed centered against a muted wall. Two bedside lamps provide soft illumination, while three framed marine-themed artworks are displayed above the bed. Large windows allow natural light to fill the room, enhancing the relaxed ambiance.

Hotel room in Playa Venao

4.75 out of 5 average rating, 4 reviews

Deluxe King Ocean View @ Villa Marina Playa Venao

Amamos el océano tanto como tú. Por eso hemos creado el lugar perfecto para que disfrutes de las olas y de todo lo que el Pacífico panameño tiene para ti en las playas de Pedasí. Villa Marina Lodge es un lugar único en su categoría. Ubicado en Playa Venao, un paraíso internacional del surf, ofrece habitaciones cómodas y amenidades de primera para que tu viaje a la playa sea siempre una experiencia especial. Un lodge, a diferencia de un resort, es más relajado, casual y acogedor.

The room features an earthy decor with a queen bed flanked by two mounted shelves. A mini fridge is positioned next to a wooden side table. Natural light filters through the sheer curtains, creating a calming atmosphere.

Hotel room in Playa Venao

5 out of 5 average rating, 8 reviews

Olas Room - Quiet, Second Floor w/ Queen bed

Olas Room is a peaceful, economical, 2 person room located at the stunning El Sitio Hotel. Here you will find a comfortable clean, queen bed, a mini fridge in your room to keep your drinks cool and a bathroom equipped with hot and cold water to wash away the sand and salt after a day in the sun. Your room is steps away from an incredible pool/lounge area with a stunning view of the ocean. *A 10% tax will be collected separately as Airbnb do not collect tax on behalf of host.

A wooden plaque with the name 'Andy 1' is displayed prominently. The name is painted in black cursive lettering on a light wood background. A few elegant cream-colored flowers are attached to the top corner of the plaque, adding a decorative touch.

Hotel room in Punta Chame

4.89 out of 5 average rating, 9 reviews

Andy 1, habitación en casa con acceso a la playa

La habitación Andy 1 está ubicada en un altillo al que se accede por escaleras desde el primer piso de la casa barco. La habitación tiene capacidad para tres personas, cuenta con una cama queen y una sencilla. Dispone de su propio baño privado en la habitación, un escritorio, una televisión, y cuenta con aire acondicionado y acceso a internet. Los huéspedes de esta habitación tienen acceso a una cocina ubicada dentro del lote, a corta distancia de la casa barco.

A close-up view of vibrant purple bougainvillea flowers is presented alongside a well-maintained pathway, leading to a charming building with arched windows and a wooden front door. Green foliage frames the entrance, enhancing the welcoming atmosphere.

Hotel room in Panamá

4.86 out of 5 average rating, 43 reviews

Habitaciones privadas Sofia's B&B Hostal Boutique

Alojamiento tipo hostal boutique, contamos con 7 cómodas habitaciones privadas con baño, para una capacidad total de 18 huéspedes. La tarifa mostrada por Airbnb para tu reserva distribuye 2 huéspedes por habitación, es decir, los huéspedes deberan compartir camas y/o habitaciones. Si requieres una distribución especial de habitaciones para tu grupo, contacta primero con el anfitrión, ya que la tarifa podría variar.

A spacious bed is positioned centrally in the room, adorned with neutral-toned bedding. Two ottoman-like stools are placed at the foot of the bed. A laptop is being used on the bed, with soft lighting emanating from lamps on either side, creating a cozy ambiance.

Hotel room in San Carlos

4.77 out of 5 average rating, 128 reviews

B) Beach, surf and Relax with King size bed

Manglar Lodge is a small beach Hotel located at El Palmar beach on the Pacific coast on the town of San Carlos, If you like nature and comfort, you'll enjoy your stay at Manglar Lodge We are small beach hotel that offers the visitor four cozy and clean rooms, WiFi, restaurant (open form 8.30am until 8pm) with great food and a great selection of craft beer and The Room is on a 1 floor you have to walk up the stairs

The villa is situated amidst lush greenery, showcasing a modern design that blends with the surrounding jungle. Spacious outdoor areas are visible, with seating arrangements under the shade of trees, inviting a relaxed atmosphere for guests to enjoy their surroundings.

Hotel room in Cambutal

4.95 out of 5 average rating, 20 reviews

Boutique Inn_The Hill 2_Private Entry_Tripple_+16

The Hill Panama, our Boutique Inn Adult Only (16+) is proud to be featured on Architectural Digest Magazine, located in the heart of enchanted Cambutal Beach, just a 5 five-minute walk to the beach, surrounded by several surf spots, balance between mountain and sea, hidden amongst the jungle canopy. This listed Room 2 was designed as a boutique hotel room with separated private entry and communal kitchen.

A charming stone structure is surrounded by lush greenery in this tranquil setting. Soft lighting enhances the architectural details, while the inviting garden area features neatly trimmed hedges and flower beds. A patio area can be seen beside the main building, perfect for outdoor relaxation.

Hotel room in El Valle de Antón

4.78 out of 5 average rating, 32 reviews

Suite medievale natura & arte

La Corte del Re é un hotel boutique composto da un insieme di suite con tematica medievale (arte macabra) immerse nel bosco dove arte e natura si fondono nel cuore del Valle di Anton. A pochi passi dal centro sono dotate di tutti i confort e contano con un parco, piscina, lago con carpe Koi e parcheggio. Sono suite e pertanto non dispongono di una cucina.

Vacation rentals for every style

Get the amount of space that is right for you

Apartments

Convenient locations with everyday essentials

Bungalows

Intimate homes. inviting architecture

Cabins

Kick off your hiking boots at these rustic lodgings

Popular amenities for Panama boutique hotel rentals

Free parking on premises

Air conditioning

Family-friendly boutique hotels rentals

A spacious room is highlighted by wooden beams on the ceiling and warm hardwood floors. A queen bed is positioned in the center, complemented by two bedside lamps. Light filters through a window, illuminating a cozy seating area and a bookshelf against the wall.

Hotel room in PA

4.86 out of 5 average rating, 50 reviews

Rancho Cabaña- Private Porch, Loft, 1 min to beach

A spacious bedroom features two beds with vibrant pink bedding and rolled towels. Natural wood walls and a high ceiling made of exposed beams create a cozy atmosphere. Accent pillows add a touch of color, contributing to a welcoming and relaxed setting.

Hotel room in Punta Laurel

Family & Group Bungalow

The entrance of El Bongo Boutique Hotel is framed by lush greenery and vines, leading to a stone pathway that guides visitors to the reception area. The building features a two-story structure with wooden accents and large windows, inviting natural light into the space.

Hotel room in Portobelo

Beachfront Boutique Hotel and Restaurant Portobelo

A vibrant yellow coastal property is set against a lush green backdrop. The structure features multiple levels with a patio area overlooking the beach. A small pool is visible on the upper deck, with lounge seating underneath a shaded dining space.

Hotel room in Las Tablas Abajo

4.72 out of 5 average rating, 18 reviews

Yellow Room for 4 at Casa Lassini - Oceanfront!

A private patio is shown with modern wooden lounge chairs positioned to face the ocean view. Lush greenery surrounds the space, enhancing the serene atmosphere. Sunlight filters through the foliage, casting soft shadows on the wooden deck.

Hotel room in Cambutal

5 out of 5 average rating, 12 reviews

Boutique Inn_The Hill 1_Private Entry_Sea View_16+

A stylish bathroom is highlighted by a dual sink vanity with circular mirrors above. Vibrant striped walls frame the space, while natural stone flooring enhances the earthy feel. Shelves are adorned with neatly stacked towels and decorative plants, providing an inviting ambiance.

Hotel room in Soná District

5 out of 5 average rating, 3 reviews

Deluxe Room

A cozy seating area is displayed, featuring a light-colored sofa positioned against a textured wall. Two circular artworks adorn the wall above, complemented by a soft-glow lamp on a side table. A glass-top table with a cane chair is visible in the foreground.

Hotel room in Cambutal

5 out of 5 average rating, 10 reviews

Boutique Inn_The Hill 4_Private Entry_16+

An outdoor pool with crystal-clear water reflects the evening sky, framed by tall palm trees. Lounge chairs and shaded seating areas surround the pool, offering relaxing spaces. The beach and ocean are visible in the background, providing a serene coastal atmosphere.

Hotel room in Las Escobas del Venado

4.17 out of 5 average rating, 18 reviews

Selina Playa Venao-Private Teepee, Shared Bathroom

Boutique hotels rentals with a patio

A bright sleeping area features a spacious bed dressed in crisp white linens and a decorative blanket with a blue pattern. Natural light enters through glass doors, leading to a private outdoor patio. Warm wooden accents and soft beige curtains add to the inviting ambiance.

Hotel room in Lagartero

4.75 out of 5 average rating, 16 reviews

Charming 1-Bedroom Beachfront Hotel With Pool

An infinity pool extends towards a breathtaking sunset, reflecting vibrant hues of orange and purple. The surrounding landscape features rolling hills and distant bodies of water, enhancing the serene atmosphere. The pool's edge seamlessly blends with the view, creating a sense of tranquility.

Hotel room in PA

Vida Lotus Jungle King Room with Hot Tub, Desk

A spacious room features a true king size bed with striped linens and an orthopedic mattress. Skylights provide natural light, illuminating the warm wooden accents and stone wall. The floor is laid with herringbone-patterned tiles, contributing to the room's tranquil ambiance.

Hotel room in Panamá

4.86 out of 5 average rating, 28 reviews

Beautiful loft #5 - kingsize bed

A calming bedroom features a spacious bed adorned with soft linens. A large wall art piece depicting a serene face adds depth to the navy-blue walls. Natural light filters through draped curtains, and two decorative lamps provide gentle illumination beside the bed.

Hotel room in Panama City

4.67 out of 5 average rating, 3 reviews

Suite Room in the ORHO Hotel

Top guest favorite

An aerial view displays a lush green landscape bordering turquoise waters. A wooden dock extends into the water, while nearby structures are surrounded by dense tropical foliage. The property offers a harmonious blend of nature and the sea, set against the vibrant backdrop of Isla Solarte.

Hotel room in Bastimentos Island

5 out of 5 average rating, 17 reviews

Agradecer: Surf lover's dream

A stone pathway leads downwards through lush tropical foliage towards a serene ocean view. The tranquil water reflects sunlight under a clear sky, with a wooden structure visible in the distance. The warm tones of the cottage complement the natural surroundings.

Hotel room in Boca Chica

4.89 out of 5 average rating, 9 reviews

Tranquil Ocean View Cottage At Seagull Cove Resort

A modern room features a spacious bed with neutral bedding, complemented by a light-colored accent wall. A small dining table with two chairs is positioned near a floor-to-ceiling window, which is framed by soft curtains. A flat-screen TV is mounted on the opposite wall.

Hotel room in Panamá

5 out of 5 average rating, 3 reviews

Eshel Panama Suites, Atlantic suite 04

Aerial view of the lush surroundings featuring a mix of vibrant green foliage and the tranquil Caribbean Sea. Solar panels are visible among the trees, emphasizing eco-friendliness. Several buildings are scattered throughout the landscape, highlighting the natural integration of the property within its jungle setting.

Hotel room in Bastimentos Island

5 out of 5 average rating, 29 reviews

Amanecer : Delicious Included Breakfast

Other boutique hotel vacation rentals

The room features two spacious beds with modern wooden frames. A wooden bench runs along the foot of one bed. A large area rug adds a pop of color to the floor. Soft lighting complements the earthy tones of the walls.

Hotel room in Playa Venao

5 out of 5 average rating, 14 reviews

Brisa - Ocean Views, Calm Vibes, King/Twin beds

A room with rustic decor features a king bed framed in wood, accompanied by decorative pillows. A small table with two chairs is positioned beside a mini fridge. Natural bamboo accents add warmth to the space, while a patterned area rug enhances the earthy atmosphere.

Hotel room in Playa Venao

5 out of 5 average rating, 10 reviews

Palmas Room - Tranquil Space with King Bed

A modern room is displayed featuring a spacious bed, accompanied by a stylish seating area with a sofa and a small desk. Natural light filters through the sheer curtains, reflecting off a round mirror. A flat-screen TV is mounted on the wall near a light-colored dresser.

Hotel room in Boquete

4.89 out of 5 average rating, 28 reviews

La Residencia - Habitacion Colibri

A serene room features two single beds with crisp white linens, offering comfortable sleeping arrangements. A wooden cabinet provides storage space, and shelves above the beds showcase a natural aesthetic. Soft light filters through a window dressed with sheer curtains.

Hotel room in Playa Venao

4.92 out of 5 average rating, 13 reviews

Luna Room - Peaceful and Economical, two twin beds

A spacious room is furnished with a comfortable king bed, accented by decorative pillows. Natural light filters through large glass doors leading to a private balcony. A nearby wooden table and chairs complement the earthy Moroccan decor, while a ceiling fan circulates the air.

Hotel room in Playa Venao

5 out of 5 average rating, 8 reviews

Sol Suite - Large room, King bed, Ocean Views

A warm-toned room features a wooden nightstand with a decorative lantern and neatly folded blue towels. A spacious bed with white linens is positioned against a textured wall, creating a serene atmosphere. The rustic details offer a touch of Moroccan style.

Hotel room in Playa Venao

5 out of 5 average rating, 5 reviews

Morro Room - Second Floor, Peaceful location

A spacious patio is framed by wooden railing, offering stunning views of the ocean and surrounding lush greenery. Comfortable seating arrangements of wooden chairs invite relaxation, while the sea's glistening surface complements the vibrant foliage in the background.

Hotel room in Cambutal

4.91 out of 5 average rating, 11 reviews

Boutique Inn_The Hill 3_Private Entry_Sea View_16+

The exterior features a warm yellow facade with a large arched window and distinct wooden door, complemented by a neatly landscaped flower bed. Paved pathways lead to the entrance, providing a welcoming approach to the boutique hostel.

Hotel room in Panamá

4.75 out of 5 average rating, 12 reviews

Alojamiento entero Sofia's B&B Hostal Boutique

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