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Hotel vacation rentals in Mississippi River

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Mississippi River

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A spacious room features large windows overlooking Beaver Lake, allowing natural light to fill the space. A cozy sitting area includes a beige sofa and a rustic coffee table, while a queen pillow-top bed is positioned nearby. Accent walls of natural stone add texture to the room.

Hotel room in Eureka Springs

4.95 out of 5 average rating, 263 reviews

Romantic Lakeview Jacuzzi Suite

Jacuzzi Suites are the size of a hotel room with the privacy of a woodsy cabin. Our suites the perfect way to spend a romantic getaway. Each suite has a queen pillow-top bed, a sitting area, a Jacuzzi for two and a small deck with a stunning view of Beaver Lake. No kitchens; however, each one has a coffee bar w/ mini fridge, microwave and Keurig. Each suite has its own private boardwalk entrance to ensure privacy. We have 3 suites attached to the office building. No pets allowed in the suites.

Top guest favorite

A spacious room features antique stone walls and hardwood flooring. A large wooden bed is flanked by two lamps, with decorative pillows adding color. A seated area includes a soft chair, and a dresser complements the warm, inviting decor.

Hotel room in Eureka Springs

4.99 out of 5 average rating, 295 reviews

Downtown luxury suite, privacy and convenience!

Relax in a spacious, private suite that allows you to stretch. The Anderson Suite at Twilight Terrace offers 800 gorgeous square feet. Feel right at home with the great Arts and Crafts décor, a kitchenette with fridge and microwave, Wifi and a flat screen TV with cable. The bath boasts a jet tub for 2 and a tiled shower for 2. Antique accents with modern amenities give you a comfortable, luxurious base to enjoy Eureka Springs! Add in OFF-STREET PARKING and you’re set for a fabulous stay!

The elegant Grand Manor is set against a vibrant sunset, surrounded by tall palm trees. The two-story structure showcases a classic southern architectural style with a grand entrance, adorned with decorative lighting along the pathway and lush greenery enhancing the inviting exterior.

Hotel room in Galveston

4.87 out of 5 average rating, 547 reviews

Garden Lace Suite- Grand Manor Boutique Hotel

The elegant Grand Manor (3.5 blks to cruise) Built 1905, a true southern tropical mansion. Luxury amenities seamlessly blended with Victorian grace (6 other rooms avail) Located in Galveston's East End Historic District , considered one of the top architectural structures on the Island Guest rooms are richly appointed, with king size beds. Private baths are soaker or claw-footed tubs. Best walking location to Island Funky bars & rooftop patios,harbor minutes to WORLD FAMOUS STRAND

Top guest favorite

The room features a queen size bed adorned with a decorative red and gold coverlet. Two windows are dressed with plush maroon curtains. A dresser with a mirror and a TV are positioned against one wall, while a faux fireplace adds warmth to the inviting space.

Hotel room in Osceola

4.92 out of 5 average rating, 104 reviews

Historic Commercial Hotel(1868),Sally Rand Suite

The Historic Commercial Hotel (Est.1868) on the Downtown square in beautiful Osceola,Missouri. Old world feel with modernized accommodations. The Historic Commercial Hotel has numerous themed rooms which are designed and named after past historical guests. This specific room is "The Sally Rand Suite". Named after past historical guest Sally Rand ( 1904 – 1979) who was an American burlesque dancer and Silver Screen star, most noted for her ostrich feather fan dance and balloon bubble dance.

A bright bedroom is adorned with a light blue wall, creating a serene atmosphere. The spacious bed is covered with a decorative blanket, flanked by crisp white linens. A bedside table and a dresser provide practical storage, while a large window allows natural light to fill the room.

Hotel room in St. Louis

4.87 out of 5 average rating, 734 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

A Lovely room in a historical St. Louis home! The Blue Spruce Room is on the 2nd floor, and has a recently renovated and beautiful bathroom complete with a walk-in rain shower right next to it. The room has a desk, chair, lamp, table, Amazon Fire TV with basically every major streaming App, newly installed hardwood floors, and a Queen sized-bed. The room has two large windows for plenty of natural light with heavy blinds for sleeping in! Full use of the kitchen upstairs is available!

The room features exposed brick walls and a wooden ceiling, enhancing the rustic charm. A spacious bed sits beside a cozy seating area with an orange armchair and a guitar. Natural light floods in through multiple large windows, with decorative elements like a cowhide rug and artwork adding character.

Hotel room in Hannibal

4.96 out of 5 average rating, 137 reviews

The Woodsman Suite

A third floor suite, facing the river with the train tracks only a couple blocks away. It took 2 months to do the ceiling. Carefully polished and placed the old lath in a specific design, the ceiling is a work of art. Eighty percent of the material used in this room is from re purposed lumber, either from this building or from a childhood barn built in the late 1800's. It will take you a while to notice every detail down to the toilet paper holder which is from an old barn post.

A bright living space is showcased with large windows offering city views. A gray sofa is positioned around a dark wooden coffee table on a patterned area rug. The kitchen area features modern appliances, while stylish curtains frame the windows, enhancing natural light.

Hotel room in Tulsa

4.92 out of 5 average rating, 24 reviews

Modern Escape #506 - Reese Tower

Discover the perfect blend of comfort and convenience at Reese Tower Airbnb in the heart of Tulsa! This stylish and modern space offers stunning city views and is just minutes away from some of Tulsa's best attractions, including the Philbrook Museum of Art, Tulsa Zoo, and the vibrant Blue Dome District. Whether you're here for a weekend getaway or an extended stay, Reese Tower is the ideal home base to explore everything Tulsa has to offer.

Top guest favorite

A spacious guest room is furnished with an antique queen bed and a vintage leather Chesterfield sofa. Natural light filters through the blackout shades, illuminating wooden flooring and a small dresser, while a large window offers a view. A decorative mirror is positioned beside the bed.

Hotel room in Galveston

5 out of 5 average rating, 117 reviews

#1 @ St. Helen's Hideaway + Cruise Port & Strand

Room #1 at Saint Helen's Hideaway -- This is the only downstairs guest room, no stairs to climb (except for the front porch stairs) and it's just steps from the kitchen, coffee bar, and back garden. It features an antique queen bed, blackout shades, a vintage leather Chesterfield sofa, and a flat-screen TV. There’s also an antique vanity and dresser, plus a private ensuite bathroom with classic black-and-white tile and a walk-in shower.

A spacious bedroom features exposed brick walls and wooden beams, creating a rustic atmosphere. A grand wooden bed is complemented by two bedside lamps. A seating bench is positioned at the foot of the bed. Natural light enters through a large window, enhancing the room's open feel.

Hotel room in Natchez

4.94 out of 5 average rating, 245 reviews

The River Walk Inn - Room 801

Spacious upstairs room in a charming 1840's building located on top of the bluff with exquisite views of the MS river. This room has beautiful period furniture, a Keurig, mini fridge, access to a shared balcony, ice machine, washer/dryer, and is within walking distance to all events downtown. Please note that the rooms are above a popular restaurant/bar that frequently offers live entertainment on the weekends.

A vase of fresh tulips in various colors is placed on a round wooden table, contrasting with the white bedding of a spacious bed in the background. Soft natural light filters into the room, enhancing the serene atmosphere.

Hotel room in Jacksonville

4.96 out of 5 average rating, 119 reviews

Charming downtown hotel above wine bar - Room 1

Modern one-bedroom hotel room in a completely renovated historic building in downtown Jacksonville. Old charm with all new amenities. Rainfall shower, king bed, workspace, smart tv, free high-speed WiFi, free parking, & access to lovely downtown. Steps away from The Little Stove, an Italian Market & Wine bar in the front half of the building.

A studio space features a cozy sleeping area with a striped bedspread, complemented by a vibrant orange accent wall. Kitchen amenities include a refrigerator, microwave, and sleek countertop sink. A vintage-style boombox artwork adds character above the bed, while open shelving displays glassware.

Casa particular in Eureka Springs

4.9 out of 5 average rating, 108 reviews

NewYork Studio 8minutes to Dtown

Kick back and relax in this calm, stylish space. This New York themed studio is perfect for a 2 person getaway, tucked in the valley yet just minutes from all the allure of Downtown Eureka. Enjoy a nice fire in the firepit after a night out, relax and watch a show on the SmartTV, or just simply enjoy our take on "New York in Eureka".

A two-person wooden soaker tub is set against a backdrop of warm, natural wood paneling. The tub features a smooth, curved design and is equipped with chrome fixtures. A folded white towel rests on the edge, with a wooden rack holding toiletries nearby.

Hotel room in Washington

4.91 out of 5 average rating, 185 reviews

American Bounty: Upper Patio Access

This large room features patio access, a two person wooden tub and a separate glass shower. It is located on the second floor over our quaint wine bar and overlooks the Missouri River. Just steps from our Historic downtown riverfront community with plenty of bars, restaurants, and charming shops to explore.

Vacation rentals for every style

Get the amount of space that is right for you

Bungalows

Intimate homes. inviting architecture

Cabins

Kick off your hiking boots at these rustic lodgings

Chalets

Adventure-ready homes with après-ski style

Popular amenities for Mississippi River hotel rentals

Free parking on premises

Air conditioning

Family-friendly hotel rentals

A detailed emergency evacuation map is displayed, outlining the layout of the building. Key areas such as emergency exits, escape routes, and vending locations are marked clearly, providing a comprehensive guide for safe navigation in case of an emergency.

Hotel room in Baxter Springs

5 out of 5 average rating, 7 reviews

Little Brick Inn: Route 66 Single King Suite 24

Top guest favorite

The exterior of the Courtland Hotel showcases red brick architecture, featuring large windows with green trim. A sidewalk runs alongside, complemented by planters and benches, enhancing the inviting atmosphere of the surrounding downtown area.

Hotel room in Fort Scott

4.9 out of 5 average rating, 73 reviews

Charming Historic Hotel lodging

A well-appointed guestroom features two spacious queen beds with soft white bedding. A large window offers a view of the city skyline. A green chair and a flat-screen TV are positioned in the room, while a modern desk and seating area add to the functionality.

Hotel room in New Orleans

4.88 out of 5 average rating, 16 reviews

No Cleaning Fee l Amazing Traditional Room at NOLA

The hotel building features a modern architectural design with a welcoming entrance. A spacious canopy provides shade at the entrance, supported by stone columns. Large windows reflect natural light, showcasing the contemporary facade accented with blue and beige tones.

Hotel room in Gladstone

4.89 out of 5 average rating, 18 reviews

Your Home Away from Home | Free Breakfast

A cozy bedroom features a spacious bed dressed in soft linens and a warm blanket. A double closet is visible along with a comfortable armchair and a side table with a lamp. Natural light filters through golden curtains, creating a serene atmosphere.

Hotel room in Brunswick

5 out of 5 average rating, 11 reviews

Cozy Private Bed and Bath

Top guest favorite

The Governor's Suite features a four-poster bed elegantly framed against blue floral wallpaper. A light-colored blanket is neatly arranged atop the bed. A decorative mirror and a wooden side table complement the room, while a fireplace adds a cozy touch.

Hotel room in Ste. Genevieve

4.97 out of 5 average rating, 37 reviews

Dr. Hertich’s House - The Governor's Suite

A modern bedroom features a plush, spacious bed with a tufted teal headboard. Decorative pillows add a subtle pop of color, while a sleek bedside lamp sits on a wooden nightstand. Neutral walls enhance the serene ambiance of the room.

Hotel room in Chicago

4.78 out of 5 average rating, 330 reviews

A polished, modern affair on iconic Michigan Ave.

Top guest favorite

A well-lit room features two queen beds, complemented by bedside lamps. A mirrored accent and a flat-screen TV are mounted on the wall. A work desk and chair are positioned next to a small vanity area, with a landscape artwork adding a touch of decor.

Hotel room in Branson

4.95 out of 5 average rating, 74 reviews

Double Queen room in Branson

Hotel rentals with a pool

Top guest favorite

A comfortable sitting area is anchored by a plush sofa adorned with decorative pillows. A small coffee table is centered in front, while a cozy armchair sits to the side. Large windows provide natural light and a view of the outdoors, framed by floor-length curtains.

Hotel room in Le Claire

5 out of 5 average rating, 11 reviews

River View Lodge - King Suite 202

A well-lit indoor pool area features a rectangular swimming pool with steps on one end. Brightly colored walls complement sleek lounge chairs and vibrant red chairs. A drinking fountain is located nearby, while ceiling lights emit a tranquil, soft glow throughout the space.

Hotel room in Naperville

4.85 out of 5 average rating, 34 reviews

Modern Naperville Room | Pool. Free Breakfast

The spacious lobby area features a mix of comfortable seating arrangements, including circular ottomans and sleek lounge chairs. A long, curved sofa complements the modern design. The adjoining bar area is illuminated with blue lighting, enhancing the contemporary ambiance.

Hotel room in Itasca

4.81 out of 5 average rating, 396 reviews

King Bed at Chicago Northwest + PET Friendly

A warm living area features a dark wood piano positioned against a red accent wall. Sunlight filters through the window blinds, creating a soft glow on the hardwood floor. A comfortable sofa is complemented by decorative cushions and a modern chandelier hangs above.

Hotel room in Eureka Springs

4.84 out of 5 average rating, 37 reviews

The Grand Suite at Tradewinds

The room features a spacious bed with crisp white linens, flanked by bedside lamps. A minimalist black and white art piece adorns the wall above the headboard, providing a modern touch. A wooden nightstand is positioned alongside the bed.

Hotel room in Rosemont

4.9 out of 5 average rating, 359 reviews

Relaxing Standard Room l Free Airport Shuttle

A spacious room features a large bed dressed in white linens, complemented by navy blue pillows. A modern chair and bedside tables with lamps enhance the decor. A flat-screen television is mounted on the wall, and natural light enters through the window adorned with light shades.

Hotel room in Rogers

5 out of 5 average rating, 27 reviews

Stunning Lake Escape - King Room w/ Pool

The historic warehouse building showcases a brick facade featuring arched windows and bright blue doors. The large entrance is highlighted with a modern sign. Symmetrical staircases lead up to the entrance, enhancing the inviting ambiance of the exterior.

Hotel room in New Orleans

4.93 out of 5 average rating, 15 reviews

Luxury Studio Apt w Balcony in Memoir Building

An outdoor courtyard features woven brick paths surrounding a clear pool. Sun loungers are placed adjacent to the water. Lush greenery adds a touch of nature, with climbing plants and shrubbery illuminating the space. A hot tub is positioned nearby within the courtyard area.

Hotel room in New Orleans

4.93 out of 5 average rating, 881 reviews

Grenoble House Courtyard King Studio + Pool Access

Hotel rentals with a patio

A cozy room is styled with rich red walls and a turquoise ceiling. A spacious bed is framed by decorative wooden panels and plush pillows. Two lamps provide soft lighting, and antique mirrors enhance the historic decor. A small air conditioning unit is mounted on the wall.

Hotel room in New Orleans

4.85 out of 5 average rating, 153 reviews

Grand Suite in Historic Victorian Guest House

Top guest favorite

An inviting entryway features two green Adirondack chairs positioned on a stone patio. A small white table is placed beside one chair. A lantern hangs above the door, illuminating the entrance, which is framed by a light-colored wall and a gravel border.

Casa particular in Houston

4.96 out of 5 average rating, 79 reviews

Pecan Grove

A spacious bathroom features rustic brick walls and a striking freestanding tub. A glass shower enclosure is situated nearby, with natural light filtering through a textured window. Decorative lighting is integrated into a cozy nook, adding a warm touch to the inviting space.

Hotel room in Saint Charles

5 out of 5 average rating, 28 reviews

#4 – Penny Farthing Le Velo Inn

A modern kitchen features stainless steel appliances, including a stove and refrigerator, alongside a spacious breakfast bar with two stools. The living area includes a gray sofa, with artwork displayed on the wall and natural light illuminating the space from a nearby window.

Hotel room in Bryan

4.9 out of 5 average rating, 259 reviews

1 BR w/ Queen Beds, Full Kitchen

Top guest favorite

The room features two spacious beds with wooden frames and a neutral color palette. A large area rug with vibrant colors adds contrast to the stone wall backdrop. Natural light enhances the room's inviting atmosphere, while bedside lamps provide additional illumination.

Hotel room in Pawhuska

4.98 out of 5 average rating, 44 reviews

The Cross Bell Downtown 204

A cozy sleeping area features a queen-sized bed adorned with plaid bear-themed bedding. A bedside lamp casts a warm glow, while decorative items, including a bear silhouette and a small tree, add character. The room is complemented by a ceiling fan and a light-colored wall.

Hotel room in Lead Hill

5 out of 5 average rating, 6 reviews

The Inn@BullShoalsLake|Tucker Hollow|Firepit|Pet

A modern suite is equipped with a practical coffee station and a decorative mirror. Two green sofas are positioned next to a bedside table and lamp, providing a cozy lounging area. The spacious bed is visible in the background, contributing to a comfortable atmosphere.

Hotel room in Laurel

4.88 out of 5 average rating, 140 reviews

Hotel Pinehurst- Jean Theatre, Suite 103

A serene lakeside view captures a sunset reflecting on calm waters. Soft light filters through trees and shrubs, highlighting the natural landscape. The vibrant sky is filled with clouds, creating a peaceful ambiance in this private retreat setting.

Private room in Waterloo

4.83 out of 5 average rating, 18 reviews

Bedroom #1 - main lodge on serene 25 acres w/ lake

Destinations to explore