Vacation rentals in Mississippi River

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Top-rated vacation rentals in Mississippi River

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Cabin in Elizabeth
4.99 out of 5 average rating, 117 reviews

Secluded Lakefront Estate | Couples Retreat

Welcome to Sunset Cove on Norfork Lake, a secluded 60-acre gated lakefront estate where modern luxury meets untouched Ozark wilderness. Wake up to sweeping lake views, spend the day at the luxury pool overlooking Norfork Lake, kayak from lakeside decks in a quiet cove, and unwind in the private hot tub beneath the stars. With only two other rentals spread across the property and 500+ acres of surrounding wilderness, this is a rare escape designed for connection and unforgettable moments together

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Top guest favorite
A rustic home built of natural wood is framed by blooming pink trees and lush green grass. The structure features a spacious porch with seating, while large windows allow views into the inviting interior.
Farm stay in Steelville
4.98 out of 5 average rating, 173 reviews

Yeary Farms Milt's Place with Private Beach!

An Ozark Oasis in the middle of a working cattle ranch, this custom designed home offers deluxe comfort. With multiple decks, porches and views out every window, this home is the perfect getaway for romantic retreats, family and friends to relax and make memories, artists and writers to host workshops or retreats, or even the single person to just get away from it all. Good dogs welcome, $35 per dog per week, fee collected separately at time of check in. Look for Yeary Farms site for more info.

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Top guest favorite
A charming cottage sits beside a tranquil spring-fed pond, featuring a large deck accessible from the rear. A fire pit resides in the grassy area, with lush green trees surrounding the property, enhancing the peaceful outdoor setting.
Cottage in New Eucha
4.99 out of 5 average rating, 168 reviews

Private Spring Fed Reservoir w/paddle boat

Off the beaten path, approximately 1 mile down a bumpy dirty road you will find a hidden gem. At the edge of the Ozarks in the heart of green country is a small cottage located on a beautiful one acre spring feed pond. You can see the spring gushing out of the hillside. Our cottage is small, cozy, and very relaxing. Whether you are kicking back watching the tube or paddling around the pond you will feel right at home and may not want to leave. Paddle boat, 4 paddle boards and 2 kayaks included

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Guest favorite
Cottage in Carthage
4.96 out of 5 average rating, 491 reviews

Private Lakefront Romantic Cottage w/Swimspa&sauna

This cozy cottage is for couples looking to escape from it all and regenerate on many levels. You'll have your very own steam shower ....check out the company description.... . "Featuring 10 acupuncture jets, sunken tub and a high efficiency steam engine, the 608P steam bath is designed to greatly increase your spa experience. Indulge yourself in a state of complete relaxation". You'll also enjoy the comfy bed, fully stocked kitchen, private deck and access to a Swimspa and sauna 100 ft away.

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Top guest favorite
The treehouse sits elevated among trees, showcasing a spacious deck with circular windows. Leaves and twigs cover the ground, while a gentle stream flows nearby. A hammock is visible, inviting relaxation within the serene natural landscape.
Home in Fayetteville
5.0 out of 5 average rating, 335 reviews

A Luxury Treehouse Experience | Wood-Fired Cedar Hot Tub

Welcome to Whitetail & Pine, a Luxury Treehouse Experience. Nestled in the branches of two centuries old red oak trees and suspended 25 feet above Goose Creek, this arboreal abode offers a unique twist on traditional lodging. If you are seeking a rejuvenating getaway accented with the sights and sounds of nature, yet desire to be close to Fayetteville’s best restaurants and attractions, look no further than the Treehouse @ Whitetail & Pine. If you are on the fence, check out our reviews!

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Top guest favorite
The treehouse, elevated 35 feet in the air, features a natural wooden structure with a thatched roof. Surrounding greenery includes tall trees and lush plants. A wooden sign reading 'Tropical Treehouse' is positioned in the foreground, complemented by a small, nearby covered seating area.
Treehouse in Arkadelphia
5.0 out of 5 average rating, 259 reviews

The Treehouse is a quiet and peaceful retreat.

Tropical Treehouse set in a ten acre Jungle Garden with a canal lagoon. Private mature forest park of 250 acres and five miles of nature trails. There are four lakes and the Treehouse overlooks Lake Winnamocka. The house is 35 feet in the air accessible by stairs but with a cargo lift for luggage and groceries. The bath is tile with heated floor and tile shower. There is a bidet, washer/dryer in the full bath. The kitchen is modern. There are 3 porches. Master bed and two loft bunks.

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Top guest favorite
A screened-in porch features two woven armchairs positioned around a small table. The view highlights a serene landscape with a lake and mountains in the distance, bathed in the warm colors of sunrise. A colorful rug adds a cozy touch underfoot.
Home in Mountainburg
4.95 out of 5 average rating, 147 reviews

Locust Mountain View

This unique place has a style all its own. 5 minutes off the interstate and you can wake up to the most beautiful sunrises and views that Arkansas has to offer. This home has all the amenities you are looking for while still making you feel like you are away from the rest of the world. In the master bedroom we have a king size adjustable mattress that you can set to your exact preference. We are a quick drive to Fayetteville if calling the Hogs and great eateries is more your style!

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Top guest favorite
The treehouse structure is elevated, supported by stilts, with large windows that reflect the surrounding greenery. The exterior features a combination of wood finishes, and warm lighting casts a welcoming glow in the evening. The pathway leads through the natural landscape to the entrance.
Treehouse in Perryville
5.0 out of 5 average rating, 716 reviews

Private Treehouse Retreat | Hot tub

The TreeLoft is the first of two treehouses at BaseCamp—designed for cozy seclusion, romance, and rest. Nestled in a private forest just 1 hour from St. Louis, it blends upscale comfort with immersive nature, while still being 20–35 minutes from hiking, wineries, and dining. ✨Our NEW treehouse, The TreeRise, offers an even more elevated, spacious experience at BaseCamp. Perfect for romantic getaways, anniversaries, personal retreats, and intentional escapes to unplug and reconnect.

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Top guest favorite
The treehouse is illuminated at night, highlighting its modern architecture nestled among trees. Warm lights glow from the windows, contrasting with the dark sky. Surrounding foliage displays vibrant orange hues, adding a serene ambiance to the outdoor setting.
Treehouse in Hermann
4.99 out of 5 average rating, 172 reviews

Out On A Limb Treehouse

A unique Treehouse, 6 miles from Hermann, MO, offers a luxury escape with stunning views and sunsets. Perched on stilts by Daniel Boone Conservation Area, enjoy tranquility, hiking, and wildlife. Relax in a king-size bed beneath skylights, soak in a tub, or unwind in the hot tub and firepit. Just a mile from the Katy Trail, perfect for cycling or relaxing. Explore Hermann’s wineries, shops, and events. Transportation available from Hermann Trolley, Uber & Lyft. Sleeps 2 adults.

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Top guest favorite
A hot tub is positioned on a private deck, surrounded by soft lighting from candles. Steps lead up to the tub, which features a control panel and a cover resting nearby. The serene environment is enhanced by the night sky and distant lights.
Cottage in Joplin
4.99 out of 5 average rating, 496 reviews

The Hideaway

Welcome to your private hot tub & (Seasonal) above ground swimming pool!! ENJOY!! 👙 🌞 NO PARTIES Your family will be close to everything when you stay at this centrally-located cottage. Carthage, Webb City & Joplin. Enjoy our quiet, peaceful, cozy cottage, equipped with a queen size bed & full size Lazy Boy hideabed. Sit on the wrap around porch & watch the deer & turkey stroll thru. We are located about 1 mile off Route 66 and easy access to I-49 & I-44.

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Top guest favorite
A spacious living area showcases wooden beams and walls, creating a warm atmosphere. Large, angled windows provide views of surrounding trees. Comfortable seating arrangements include a white sofa and two armchairs on a textured rug, complemented by a natural stone fireplace offering a rustic touch.
Treehouse in Ozark
4.98 out of 5 average rating, 270 reviews

Treehouse in the Ozarks w/Hot Tub, on 2 Acres

Escape the hustle and bustle and retreat to our cozy treehouse nestled in the Ozark wilderness. Our one-of-a-kind cabin features 4 decks, 2 electric fire places, 1 wood stove, spiral staircase, indoor rock waterfall and hidden reading/painting nook. Enjoy the outdoors while relaxing in the hot tub taking in the serene view. Within 30 minutes of dining, bars, entertainment, Table Rock Lake, amusement parks and more!

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Top guest favorite
A cozy outdoor seating area is highlighted by a gas fire pit, with flames dancing over a bed of stones. The distant horizon showcases a sunset with vibrant colors, while the private hot tub is visible nearby, surrounded by the open landscape.
Home in Carthage
5.0 out of 5 average rating, 197 reviews

The Perfect Retreat: Modern Tiny Home- Hot Tub

A cozy and romantic luxury tiny home with a private hot tub under the stars. Wake up with coffee on the porch swing, watch the sunset from the spa, and unwind by the firelight in the evenings. Designed for slow mornings, peaceful nights, and reconnecting — just outside Carthage and next to I-44, enjoy the countryside and easy access to town. Perfect for couples, solo retreats, or a small, restful escape.

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Popular amenities for Mississippi River vacation rentals

Frequently Asked Questions

  • Where is Mississippi River located?

    The Mississippi River winds through the central United States, passing through states like Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana before reaching the Gulf of Mexico. Its banks host diverse communities and landscapes shaped by the river.

  • When is the best time to visit Mississippi River?

    Late spring and early fall are frequently suggested, as temperatures are milder and local events often take place. Summer provides lush scenery but can feel humid, while winter attracts those interested in quieter river landscapes.

  • What are some things to do near Mississippi River?

    You can explore riverfront parks, nature trails, and historic sites, or join boat tours to learn about local wildlife and history. The area also has museums, cultural events, and opportunities for fishing or paddling.

  • How is the weather near Mississippi River?

    Winters are generally cold, ranging from 22–44°F (-5–7°C), while summers reach 83–88°F (28–31°C) with humid conditions. Spring and fall are often recommended for milder temperatures and changing scenery along the river.

Destinations to explore