Guesthouse vacation rentals in James Island
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Top-rated guesthouse rentals in James Island
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for James Island guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Charleston
4.91 out of 5 average rating, 648 reviewsIsland Oasis—Near Downtown
Oct 21 – 28
Guesthouse in Charleston
4.99 out of 5 average rating, 264 reviewsSpacious Daniel Island Apartment
Oct 8 – 15
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 214 reviewsBungalow Under The Oaks
Sep 21 – 28
Guesthouse in Charleston
4.93 out of 5 average rating, 317 reviewsCozy Island Cottage
Mar 21 – 28
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
Dec 5 – 12
Guesthouse in Summerville
4.98 out of 5 average rating, 643 reviews★Delightful guest house near historic plantations★
Apr 6 – 13
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 220 reviewsGreen Garden Studio @greengardenstudio2017
Sep 26 – Oct 3
Guesthouse in Johns Island
4.98 out of 5 average rating, 239 reviewsPrivate waterfront apt in the oaks
Jul 18 – 25
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 123 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Sep 26 – Oct 3
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Apr 21 – 28
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
Jul 21 – 28
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
Dec 10 – 17
Guesthouse in Charleston
5.0 out of 5 average rating, 23 reviews1/1 sleeps 3 ADU Modern+Amazing!
Jul 10 – 17
Guesthouse in Charleston
4.95 out of 5 average rating, 41 reviewsGuest suite in Charleston
Oct 13 – 20
Guesthouse in Charleston
5.0 out of 5 average rating, 13 reviewsGas Light Carriage House James Island
Oct 14 – 21
Guesthouse in Charleston
5.0 out of 5 average rating, 32 reviewsCharleston Beach Getaway
Nov 9 – 16
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.98 out of 5 average rating, 108 reviewsCharleston Casita near Folly Beach *Dog Friendly*
Jun 8 – 15
Guesthouse in Charleston
4.99 out of 5 average rating, 143 reviewsLarge Guesthouse with Private Dock & Marsh Views
Jan 28 – Feb 4
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 407 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Apr 28 – May 5
Guesthouse in Charleston
4.98 out of 5 average rating, 245 reviewsDetached Guest Suite
Apr 4 – 11
Guesthouse in Charleston
4.9 out of 5 average rating, 549 reviewsCute, Cozy, Charleston Cottage
Sep 14 – 21
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 222 reviewsCozy Apartment in Mount Pleasant
Apr 28 – May 5
Guesthouse in Charleston
4.99 out of 5 average rating, 207 reviewsRedesigned suite! 12min to city, pet-friendly
Sep 30 – Oct 7
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 436 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Nov 2 – 9
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- Rentals with outdoor seating James Island
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