Guesthouse vacation rentals in Charleston County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Charleston County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Charleston County guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Summerville
4.98 out of 5 average rating, 642 reviews★Delightful guest house near historic plantations★
Oct 30 – Nov 6
Guesthouse in Charleston
4.95 out of 5 average rating, 331 reviewsThe White House of Avondale
Oct 13 – 20
Guesthouse in North Charleston
5.0 out of 5 average rating, 110 reviewsThe Park Circle Clerestory Studio Guest House
Jun 20 – 27
Guesthouse in Ridgeville
4.82 out of 5 average rating, 212 reviewsPond House Bungalow at Natural Gathering Grounds
Oct 29 – Nov 5
Guesthouse in Summerville
4.94 out of 5 average rating, 212 reviewsNina's Cottage -Historic Downtown Summerville
Dec 13 – 20
Guesthouse in Charleston
4.91 out of 5 average rating, 647 reviewsIsland Oasis—Near Downtown
Oct 21 – 28
Guesthouse in Summerville
4.87 out of 5 average rating, 748 reviewsNew Loft in Historic Summerville
Oct 21 – 28
Guesthouse in North Charleston
4.86 out of 5 average rating, 441 reviewsPark Circle Jungalow Loft
Aug 7 – 14
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 121 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Jan 13 – 20
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Apr 13 – 20
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
Oct 7 – 14
Guesthouse in Goose Creek
4.96 out of 5 average rating, 49 reviewsThe Blue Secret
Jun 18 – 25
Guesthouse in Hanahan
4.99 out of 5 average rating, 76 reviewsThe Violet Villa w/ no cleaning fee
Aug 6 – 13
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
Apr 16 – 23
Guesthouse in Charleston
4.94 out of 5 average rating, 78 reviewsSpacious 1 bedroom cottage in Avondale
Mar 13 – 20
Guesthouse in Charleston
5.0 out of 5 average rating, 12 reviewsLowcountry Guesthouse
Jul 19 – 26
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Jan 23 – 30
Guesthouse in Charleston
4.9 out of 5 average rating, 548 reviewsCute, Cozy, Charleston Cottage
Aug 12 – 19
Guesthouse in Charleston
5.0 out of 5 average rating, 216 reviewsJames Island "La Casita" Nestled btw Beach & City
Oct 2 – 9
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 435 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Sep 30 – Oct 7
Guesthouse in Charleston
4.99 out of 5 average rating, 141 reviewsLarge Guesthouse with Private Dock & Marsh Views
Sep 2 – 9
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 248 reviewsUpscale Couple's Escape | Beach & Downtown CHS
Jul 5 – 12
Guesthouse in Charleston
4.99 out of 5 average rating, 205 reviewsRedesigned suite! 12min to city, pet-friendly
Nov 14 – 21
Guesthouse in Charleston
5.0 out of 5 average rating, 143 reviewsThe Guesthouse at Old Orchard
Aug 2 – 9
Destinations to explore
- Guesthouse rentals United States
- House rentals United States
- House rentals Myrtle Beach
- Guesthouse rentals Charleston
- House rentals Charleston
- Guesthouse rentals Savannah
- House rentals Savannah
- Guesthouse rentals South Carolina
- House rentals South Carolina
- Rentals with beach access Charleston County
- Townhouse rentals Charleston County
- Rentals with breakfast Charleston County
- Hotel rentals Charleston County
- Villa rentals Charleston County
- Rentals with a hot tub Charleston County
- Rentals with a washer and dryer Charleston County
- Rentals with pools Charleston County
- Kid-friendly rentals Charleston County
- Luxury rentals Charleston County
- Tiny house rentals Charleston County
- House rentals Charleston County
- Apartment rentals Charleston County
- Bed and breakfasts Charleston County
- Pet-friendly rentals Charleston County
- Rentals with a fireplace Charleston County
- Waterfront rentals Charleston County
- Rentals with outdoor seating Charleston County
- Condo rentals Charleston County
- Monthly Rentals Charleston County
- Rentals with an accessible height toilet Charleston County
- Beachfront rentals Charleston County
- Family-friendly rentals Charleston County
- Rentals with a kayak Charleston County
- Rentals with lake access Charleston County
- Rentals with a patio Charleston County
- Rentals with an EV charger Charleston County
- Rentals with a fire pit Charleston County
- Fitness-friendly rentals Charleston County
- Private suite rentals Charleston County
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom