Guesthouse vacation rentals in Charleston County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Charleston County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A vibrant sleeping area features a spacious bed with crisp white bedding. A neon sign reading "the Folly Beach swell and a Charleston belle" adds a modern touch to the wooden headboard. Tropical-themed wallpaper and decorative lamps create a lively atmosphere.

Guesthouse in Charleston

4.99 out of 5 average rating, 166 reviews

The James: “Tiny” Home b/w Downtown & Folly

The James is a unique NEW 530 sq ft retro coastal tiny home located in a gorgeous neighborhood on James Island ◡̈ 10 mins to downtown Charleston 12 minutes to Folly Beach Walking distance to restaurants The James sleeps up to 6 people and 2 dogs (NO PET FEE) & boasts a private fenced yard & patio with an outdoor shower and Clawfoot tub! The James is ideal for solo travelers, couples, families, those traveling w/ their dog(s), those w/ limited mobility and groups of friends. #BNB-2023-02

Guest favorite

A compact laundry area is displayed, featuring a stacked washer and dryer unit in a bright white finish. The door is open, revealing the appliances inside. Natural light flows in from nearby windows, illuminating the clean, minimalist design of the space.

Guesthouse in Mount Pleasant

4.89 out of 5 average rating, 127 reviews

Old Village Guest House - 5 Mins to the Beach!

Discover the ultimate Charleston experience in the heart of Mount Pleasant's charming Old Village! Immerse yourself in the vibrant energy of this renovated, adorable guest house. Nestled close to pristine beaches, restaurants, and the storied streets of historic Charleston, this Airbnb is your gateway to a quintessential Lowcountry adventure. Don't just visit Charleston—live it, love it and make unforgettable memories at this delightful retreat! $3500/mo. MP Permit - ST240210 MP BL – 20123265

Top guest favorite

A wooden boardwalk leads through coastal vegetation toward the beach. Grassy areas and subtle earth tones surround the pathway, while the ocean is visible in the distance under a sky with soft clouds and gentle hues, creating a serene atmosphere.

Guesthouse in Mount Pleasant

4.99 out of 5 average rating, 295 reviews

Upscale Couple's Escape | Beach & Downtown CHS

Perfect getaway for anyone looking to relax and enjoy the beautiful Charleston beaches. We maintain the highest standards for luxury - including curated interior design touches to make you forget reality and enjoy some much needed R&R time. The Pump House is the ideal place to escape to and enjoy the outdoors, local restaurants, breweries, parks, and, of course, beaches! Our reviews speak for themselves - Always 5 stars and many return guests! Permit #ST250099 | Business License #20122954

Guest favorite

An outdoor lounge area is showcased on a wooden deck. It features a dark sectional sofa positioned alongside potted plants. A grill is visible in the background, and a wooden chair adds to the seating options. Lush greenery surrounds the space, enhancing the ambiance.

Guesthouse in Charleston

4.95 out of 5 average rating, 242 reviews

Quaint Cottage Studio in Ashley Forest (Avondale).

Take in the peace, calm, and hospitality of Charleston at this small, quaint, stand-alone cottage. The studio is situated on our property and shares an outdoor lounge and dining area. Located in the neighborhood of Ashley Forest, a small corner of Avondale, you are walking distance to breweries, cafes, wine bars, sushi restaurants and more. Downtown is a 10 minute ride share away, and there is also a bus stop five minutes from the property that will take you to the heart of King Street.

Top guest favorite

A welcoming entryway features a white door with a glass panel, complemented by a wreath. A flat-screen TV is mounted on the wall opposite a white chair adorned with a colorful pillow. A patterned curtain frames the window, adding a touch of color.

Guesthouse in Charleston

4.97 out of 5 average rating, 292 reviews

Guest suite w/ patio, 12min to city, pet-friendly

Enjoy the privacy of a hotel stay! This guest suite features a private entrance, Casper mattress, hotel-worthy shower, outdoor patio, desk space & on-site parking. Head downtown just 12 minutes away, or walk to Avondale's shopping & dining district. With a travel pro as your host, expect a BnB experience focusing on sustainability (solar power and recyclable coffee pods), cleanliness, and thoughtful design. Rollaway twin bed and infant pack n' play on request. STR License #02084

Guest favorite

An outdoor patio area features a square stone layout with a firepit at the center. Two wooden chairs are positioned around the firepit, and string lights provide soft illumination in the trees above. A grill is visible nearby, surrounded by greenery.

Guesthouse in Charleston

4.9 out of 5 average rating, 626 reviews

Cozy Cottage w Games, Firepit, Grill, and More!

Centrally located cottage perfect for exploring the wonders of Charleston! - Amazing location; quick drive to downtown, minutes from Avondale, 12 miles to Folly Beach. - On a beautiful 9 mile bike & walking path - Backyard oasis with games, firepit, grill, and outdoor dining space - Beach chairs, cooler, and umbrella available - Updated interiors with king bed, games, streaming, and fast wifi Enjoy the perfect home base to explore the Lowcountry. We can't wait to host you!

Top guest favorite

The exterior of the carriage house is illuminated at night, showcasing its architectural features against the tranquil waters. Surrounding greenery and reflections of the buildings in the water create a serene atmosphere, complemented by the soft glow of outdoor lights.

Guesthouse in Charleston

4.99 out of 5 average rating, 203 reviews

Large Guesthouse with Private Dock & Marsh Views

This newly built carriage house is separate from the main house. The cottage is about 1,200 sqft so it very open and spacious and great views of marsh and our tidal creek. We have a separate work area with desk and a massive dinning table if you need more room to work or to gather with friends. Full kitchen, washer and dryer, massive shower, the list goes on. You may not want to leave! Feel free to go sit and have coffee or cocktails on the dock. PERMIT# OP2024-04998

Top guest favorite

A staircase with white wooden steps leads up surrounded by green foliage and palm trees. The railing is white and features decorative details, enhancing the inviting approach to the entrance.

Guesthouse in Charleston

4.99 out of 5 average rating, 303 reviews

Spacious Daniel Island Apartment

Fully furnished 1 bedroom (queen bed) apartment on Daniel Island. We are able to bring a single mattress out to the apartment for guests bringing a child, so the apartment can accommodate up to three (two adults and a child). Full kitchen with glass cook top, dish washer, full-sized refrigerator/freezer, toaster oven, etc. Includes linens, dishes and utensils. Washer/dryer en suite. Has Youtube TV, HBO Max, and wifi. 15 mins from airport, downtown Charleston, and beaches.

Top guest favorite

A clean kitchen area features white cabinetry and open shelving. A sink is positioned between a microwave and a Keurig coffee maker, with several glassware pieces displayed above. Natural light filters through a nearby window, enhancing the bright and airy feel.

Guesthouse in Charleston

4.97 out of 5 average rating, 378 reviews

Daniel Island Getaway

Welcome to your home away from home near Center Park on Daniel Island, located within 20 minutes from Downtown Charleston, Sullivan’s Island and Isle of Palms. This almost 600sqft above garage guest house has a separate bedroom and full bathroom in addition to a spacious living room with a Queen sofa bed and a kitchen area that will meet all of your basic needs. The kitchen includes a Keurig, microwave and griddle. There is even an outdoor shower for guests to use.

Top guest favorite

A small outdoor balcony is shown with two striped chairs positioned at a round table. A potted plant with bright pink flowers adds a pop of color to the wooden decking. Sunlight filters through greenery in the background.

Guesthouse in Charleston

5 out of 5 average rating, 262 reviews

James Island "La Casita" Nestled btw Beach & City

Wake up to the 2 grand oaks just outside your window. Visit Folly Beach (14 minutes) or Historic Downtown Charleston (9 minutes). Craft your own meal in the complete kitchen or try one of the many renowned Charleston restaurants recognized by foodies worldwide. Visit James Island County Park & Waterpark (1 mile). Take a trip to the local Farmer's Market or the Municipal Golf Club. Then stroll down the (Woodland Shores) road for a spectacular view of the wetlands.

Top guest favorite

A wooden dock features two lounge chairs placed beside a small table, providing a relaxing space to enjoy the surrounding marsh views. Sunlight pours in, highlighting the natural wood grain and the expansive landscape beyond the water.

Guesthouse in Mount Pleasant

4.99 out of 5 average rating, 179 reviews

Stunning Couples Cottage with Creek Dock!

You will fall in love with this stunning, newly-built guest cottage nestled under the canopy of a majestic 400-year-old live oak tree! Providing ultimate comfort, convenience and serenity, this is the perfect place to launch your Charleston adventure – 10 minutes to Shem Creek, & 15 minutes to Sullivan's Island or Downtown Charleston. PLUS, come enjoy our brand new dock on the creek! A picture-perfect spot to relax and enjoy the stunning Lowcountry scenery!

Top guest favorite

A cozy outdoor area features a circular fire pit surrounded by a built-in bench and cushioned seating. Two stylish chairs are positioned nearby, with lush greenery and potted flowers adding a natural touch. Warm string lights are hung along the wooden fence, enhancing the inviting ambiance.

Guesthouse in Charleston

4.98 out of 5 average rating, 181 reviews

Private Backyard With Fire Pit, 15 Min to Downtown

Welcome to this newly renovated guesthouse in the heart of West Ashley. While staying in this adorable 850 sqft. home, you'll fall in love with the newly redone kitchen featuring a cozy breakfast nook. You'll also enjoy: Deck with outdoor table & chairs Free Laundry Smart TVs in all rooms Fully stocked and equipped kitchen Extremely safe neighborhood Free Parking You are only: 10 mins to Avondale 15 mins to Downtown Charleston 30 mins to Folly Beach