Guesthouse vacation rentals in Charleston County

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Top-rated guesthouse rentals in Charleston County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A spacious sleeping area features a king bed with a simple wooden frame and high-quality linens. Two white dogs sit on the floor, with a neon sign hanging above the bed, stating 'the Folly Beach swell and a Charleston lake.' The room is adorned with tropical-themed decor.

Guesthouse in Charleston

4.99 out of 5 average rating, 181 reviews

The James: “Tiny” Home b/w Downtown & Folly

The James is a unique NEW 530 sq ft retro coastal tiny home located in a gorgeous neighborhood on James Island ◡̈ 10 mins to downtown Charleston 12 minutes to Folly Beach Walking distance to restaurants The James sleeps up to 6 people and 2 dogs (NO PET FEE) & boasts a private fenced yard & patio with an outdoor shower and Clawfoot tub! The James is ideal for solo travelers, couples, families, those traveling w/ their dog(s), those w/ limited mobility and groups of friends. #BNB-2023-02

Top guest favorite

A dining area features a wooden table set for four, complete with tableware and decorative accents. Natural light filters through large windows adorned with elegant curtains, illuminating the room and providing a view of the greenery outside.

Guesthouse in Charleston

5 out of 5 average rating, 182 reviews

The Guesthouse at Old Orchard

Relax in the treetops of our beautiful pecan grove! Guests adore the peaceful surroundings of our new 1260 sq ft guesthouse located on the second floor of a detached garage. This private space has an open floor plan, fully stocked kitchen, 2 queen bedrooms, 2 full baths, wifi, Roku TVs, and new appliances including washer and dryer. Sitting on 1.3 acres, the property is home to gardens, a tidal creek, and happy hens! It is quiet yet centrally located between downtown Charleston and Folly Beach.

Top guest favorite

An outdoor lounge area features a spacious sectional sofa in dark upholstery, surrounding a low wooden coffee table. Potted plants add greenery around the space. A shed with blue siding and double glass doors sits in the background, framed by tall trees and a wooden fence.

Guesthouse in Charleston

4.95 out of 5 average rating, 249 reviews

Quaint Cottage Studio in Ashley Forest (Avondale).

Take in the peace, calm, and hospitality of Charleston at this small, quaint, stand-alone cottage. The studio is situated on our property and shares an outdoor lounge and dining area. Located in the neighborhood of Ashley Forest, a small corner of Avondale, you are walking distance to breweries, cafes, wine bars, sushi restaurants and more. Downtown is a 10 minute ride share away, and there is also a bus stop five minutes from the property that will take you to the heart of King Street.

Top guest favorite

A guest suite is presented with a spacious bed adorned with a decorative pillow. A small green desk and chair are positioned beside the bed, while a wooden bench sits at the foot of the bed. A bamboo shelving unit provides storage, and wall-mounted lights create a soft ambiance.

Guesthouse in Charleston

4.97 out of 5 average rating, 300 reviews

Guest suite w/ patio, 12min to city, pet-friendly

Enjoy the privacy of a hotel stay! This guest suite features a private entrance, Casper mattress, hotel-worthy shower, outdoor patio, desk space & on-site parking. Head downtown just 12 minutes away, or walk to Avondale's shopping & dining district. With a travel pro as your host, expect a BnB experience focusing on sustainability (solar power and recyclable coffee pods), cleanliness, and thoughtful design. Rollaway twin bed and infant pack n' play on request. STR License #02084

Top guest favorite

A spacious bedroom features a black metal bed frame adorned with white bedding. Two stylish chairs are positioned beside large windows offering views of the surrounding landscape. A wooden dresser and a woven area rug add elements of comfort and warmth to the room.

Guesthouse in Charleston

4.99 out of 5 average rating, 208 reviews

Large Guesthouse with Private Dock & Marsh Views

This newly built carriage house is separate from the main house. The cottage is about 1,200 sqft so it very open and spacious and great views of marsh and our tidal creek. We have a separate work area with desk and a massive dinning table if you need more room to work or to gather with friends. Full kitchen, washer and dryer, massive shower, the list goes on. You may not want to leave! Feel free to go sit and have coffee or cocktails on the dock. PERMIT# OP2024-04998

Top guest favorite

A tranquil waterfront view features a dock extending into calm waters, framed by lush greenery and trees. A hammock can be seen suspended from the dock, inviting relaxation. The sunlight glistens on the water's surface, creating a serene atmosphere.

Guesthouse in Charleston

4.99 out of 5 average rating, 310 reviews

Spacious Daniel Island Apartment

Fully furnished 1 bedroom (queen bed) apartment on Daniel Island. We are able to bring a single mattress out to the apartment for guests bringing a child, so the apartment can accommodate up to three (two adults and a child). Full kitchen with glass cook top, dish washer, full-sized refrigerator/freezer, toaster oven, etc. Includes linens, dishes and utensils. Washer/dryer en suite. Has Youtube TV, HBO Max, and wifi. 15 mins from airport, downtown Charleston, and beaches.

Top guest favorite

A bright living room features a comfortable beige sofa adorned with decorative pillows. A circular coffee table sits on a patterned area rug, complemented by a small wooden side table and a stylish lamp. Light streams in through a window dressed with a floral valance.

Guesthouse in Charleston

4.97 out of 5 average rating, 384 reviews

Daniel Island Getaway

Welcome to your home away from home near Center Park on Daniel Island, located within 20 minutes from Downtown Charleston, Sullivan’s Island and Isle of Palms. This almost 600sqft above garage guest house has a separate bedroom and full bathroom in addition to a spacious living room with a Queen sofa bed and a kitchen area that will meet all of your basic needs. The kitchen includes a Keurig, microwave and griddle. There is even an outdoor shower for guests to use.

Top guest favorite

A modern living area features a light gray sectional sofa accented with orange and green cushions. A wooden coffee table sits in front, with a green accent table beside it. A large window provides ample natural light, and a small workspace with a chair is visible.

Guesthouse in Charleston

5 out of 5 average rating, 267 reviews

James Island "La Casita" Nestled btw Beach & City

Wake up to the 2 grand oaks just outside your window. Visit Folly Beach (14 minutes) or Historic Downtown Charleston (9 minutes). Craft your own meal in the complete kitchen or try one of the many renowned Charleston restaurants recognized by foodies worldwide. Visit James Island County Park & Waterpark (1 mile). Take a trip to the local Farmer's Market or the Municipal Golf Club. Then stroll down the (Woodland Shores) road for a spectacular view of the wetlands.

Top guest favorite

A light and airy living space features a comfortable white sofa adorned with decorative pillows. An area rug enhances the room's warmth, while a kitchen area with modern appliances is visible in the background. Natural light enters through a nearby window, illuminating the open layout.

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 166 reviews

Beach, downtown, Alhambra Hall weddings so close!

Quiet location close to everything Charleston has to offer! Located in historic Old Village we are less than 2 blocks from Alhambra hall (with playground) and 10 minutes walking to Pitt street bridge recreational area. Sullivan's Island beach is 3 miles away, with a bike path or sidewalk the entire way! After a day of exploring, relax for a few then go downtown Charleston (10 minutes away) or to the Shem Creek district (minutes away)! Cable/Wi-Fi are provided.

Top guest favorite

A newly-built guest cottage is depicted, elevated on pilings and surrounded by lush greenery. Light-colored siding is complemented by green shutters. Steps lead up to a welcoming porch with a railing, providing access to the spacious entry and large windows that invite natural light.

Guesthouse in Mount Pleasant

4.99 out of 5 average rating, 191 reviews

Stunning Couples Cottage with Creek Dock!

You will fall in love with this stunning, newly-built guest cottage nestled under the canopy of a majestic 400-year-old live oak tree! Providing ultimate comfort, convenience and serenity, this is the perfect place to launch your Charleston adventure – 10 minutes to Shem Creek, & 15 minutes to Sullivan's Island or Downtown Charleston. PLUS, come enjoy our brand new dock on the creek! A picture-perfect spot to relax and enjoy the stunning Lowcountry scenery!

Top guest favorite

A stylish living area features a green velvet sofa paired with a round wooden coffee table. Decorative items are placed atop the table, while a floor lamp provides soft lighting. Large windows allow natural light to illuminate the space, which is accented by framed artwork and a potted plant.

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 103 reviews

Old Village Guesthouse walkable, close to beach/DT

Location. Location. Location! It's trite, but it's true. You’ll be minutes from downtown Charleston and the beach at Sullivan’s Island when you stay with us in the historic Old Village of Mount Pleasant. Walk to some of the town’s best restaurants and waterfront bars or seize the moment to relax in our breezy, modern guest house in one of the oldest, most beautiful neighborhoods in the country. STR permit number: ST250100 Business license number: 20122246

Guest favorite

The kitchen features white cabinetry and a sleek stainless steel refrigerator. Natural light streams through two windows, illuminating the space. A wooden table with a bench provides seating, and open shelves display decorative items above the countertop.

Guesthouse in Charleston

4.98 out of 5 average rating, 190 reviews

Private Backyard With Fire Pit, 15 Min to Downtown

Welcome to this newly renovated guesthouse in the heart of West Ashley. While staying in this adorable 850 sqft. home, you'll fall in love with the newly redone kitchen featuring a cozy breakfast nook. You'll also enjoy: Deck with outdoor table & chairs Free Laundry Smart TVs in all rooms Fully stocked and equipped kitchen Extremely safe neighborhood Free Parking You are only: 10 mins to Avondale 15 mins to Downtown Charleston 30 mins to Folly Beach