House vacation rentals in Cape Girardeau

5 out of 5 average rating, 572 reviews

A charming bungalow is displayed with a covered front porch featuring white railings and hanging flower baskets. The entrance is framed by landscaped greenery, and steps lead up to a decorative door. Natural light brightens the front yard, adding to the welcoming appearance.

Home in Carbondale

Charming 3 bedroom bungalow in Downtown Carbondale

Originally built in 1920, this cute bungalow house has been totally renovated and modernized. You'll enjoy 3 furnished bedrooms, 1 bathroom, covered porch, and back with lighted pergola and firepit. The location is exceptional - just two blocks North of the Carbondale downtown "strip," and EASILY walkable to all the downtown businesses, Memorial Hospital of Carbondale (0.4 miles), restaurants, pubs, Amtrak station (0.5 miles), and SIU (about 1.2 miles). Officially Permitted Airbnb VRU 23-03

4.93 out of 5 average rating, 61 reviews

A private pool area is surrounded by a wooden fence, featuring a circular blue pool and a spacious deck. Two orange umbrellas provide shade over lounge chairs. The natural landscape is visible in the background, with trees and rolling hills under a cloudy sky.

Home in Cobden

Wine trail, views, hot tub, pool…

Escape your worries in this spacious, serene retreat. Whether your exploring the local wineries, embarking on a girl’s trips, hiking scenic trails, enjoying a family vacation, or even casting a line on a fishing trip, our home is the perfect destination. After a day of adventure, unwind in the comfort of our well-appointed space. End your day by the pool, soak in the hot tub, or enjoy a campfire. Located just a short distance from Bald Knob Cross. Cameras actively recording at all times.

A bright living area is highlighted by a comfortable grey sofa and a wooden coffee table. Large windows allow natural light to fill the space, complemented by light curtains. A ceiling fan is visible, and a television is mounted on a stand in the corner.

4.81 out of 5 average rating, 107 reviews

Herman's Corner Cottage.

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

The exterior of a charming brick farmhouse is displayed, featuring a symmetrical layout with two dormer windows. A well-maintained lawn surrounds the house, complemented by flower beds. A walkway leads to the welcoming entryway, which opens to a sunroom on the right.

4.96 out of 5 average rating, 138 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

4.95 out of 5 average rating, 60 reviews

A wooden staircase with intricate banisters leads to the upper level, showcasing craftsmanship from 1892. A large stained glass window allows natural light to filter into the space, illuminating the hardwood floor and highlighting the classic architectural details.

Home in Alto Pass

Havisham House - Main House

You will love Havisham House, where 1892 meets modern luxury in a vacation home rental. This newly renovated home sits in the heart of the southern Illinois wine trail, Shawnee National Forest, Giant City & Ferne Clyffe State Parks (great hiking, waterfalls, pottery, etc.), Bald Knob Cross & Tunnel Hill Bike Trail. Opened in 2017 in Alto Pass. A must-stay. The Carriage House (#19380139) at Havisham can also be rented with the Main House - by doing so, you can comfortably sleep 12. See pics.

5 out of 5 average rating, 114 reviews

A charming log cabin is framed by vibrant autumn foliage, with trees and shrubs displaying various shades of orange and green. A circular driveway leads to the entrance, where a welcoming porch provides a space to enjoy the surrounding nature and seasonal changes.

Home in Murphysboro

Embers of Murphysboro

Escape to the beauty of Embers of Murphysboro. The sprawling landscapes and cabin with high end amenities have everything to offer for a weekend getaway or larger gathering. Sucumb to the beauty of nature around you that will awaken your inner senses and relax your mind. Nestled upon a 26 acre property the cabin will astound you with picturesque landscapes and a lodging infused with both character and luxury. Explore local wineries, hiking trails, fishing, boating , dining and more...

A spacious living room is furnished with a large sectional couch, complemented by decorative pillows. A wooden coffee table sits center stage on an area rug. A ceiling fan is visible, and light enters through window treatments, creating a comfortable atmosphere.

4.85 out of 5 average rating, 120 reviews

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

4.69 out of 5 average rating, 26 reviews

A charming exterior view showcases a single-story home surrounded by greenery. The structure features a shaded porch under a dark roof, framed by blooming shrubs and trees. A gravel road runs in front, leading to a private, serene setting.

Home in Alto Pass

Notting Hill Cottage

Welcome! We are new to Airbnb but not to a sister site where we have a couple hundred 5star reviews. We have had our home as a rental for almost 5 years now! It has two bedrooms with one queen and two twin beds. A loft and a futon! A full kitchen. One bathroom with a tub/shower combo. You’ll find yourself relaxing on our large deck that spans the rear of the house. Sit in the hot tub overlooking the fenced-in yard and the woodlands below. Private wooded setting! Dogs welcome with fee.

A comfortable living room is presented with soft, beige seating adorned with red accent pillows. A dark trunk serves as a coffee table, while a lamp gently illuminates the space. The room features multiple windows, enhancing natural light alongside decorative curtains.

4.88 out of 5 average rating, 100 reviews

House Of Clubs- 2 Bed 1.5 Bath

The PERFECT hideway. The House of Clubs offers a quiet setting with a creek that wraps around the enitre property. Two bedrooms, each include a queen size bed. One Full bathroom. Full Laundry room that also offers a private cammode. The stylish living room offers a unique style that higlights Cape Girardeaus rich history. Enjoy your morning coffee in the four seasons room with breathtaking views of this hidden gem . Less than 5 minutes to downtown. Only 2 minutes to Cape Country Club.

4.76 out of 5 average rating, 136 reviews

A charming brick house is presented with a symmetrical façade, featuring dormer windows on the upper level. The entryway is framed by neatly trimmed hedges and steps leading to the front door, flanked by decorative plants. An American flag adds a welcoming touch.

Home in Carbondale

Brick Estate with pool in Quiet Neighborhood

Large fully furnished 4 BR, 3 BTH house in a beautiful, quiet neighborhood in Carbondale. Private pool & large backyard. Very safe & walkable neighborhood. Inspected and licensed by the City of Carbondale. Carbondale Vacation Rental Unit License Number 24-06. Basement with bar, pool table, ping pong. Complete kitchen with all utensils & cookware. Garden patio w/ Weber grill, tables, chairs, beautiful landscaping, etc. ***Pool is open from Memorial Day through Labor Day***

4.99 out of 5 average rating, 121 reviews

An outdoor seating area features a round table surrounded by four chairs, set on a stone patio. Flowering plants line the edge of a grassy space, and a door leads into the house. The clear blue sky and greenery provide a serene backdrop.

Home in Alto Pass

The Farmhouse in Rhine Valley

Newly renovated Farmhouse in Alto Pass situated between Trail of Tears State Forest and just a hike or short drive away from Bald Knob Cross and wilderness. Minutes away from local wineries. Enjoy a peaceful pause from the hustle and bustle in our private little Farmhouse. Perfect for single family or small groups. Nearby venues and activities include: hiking, fishing, public hunting, wineries, restaurants, and many other local venues and events. Hunters are welcome.