Apartment vacation rentals in Cape Girardeau

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Family · Location · Parks

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Family · Location · Access

Historical Kage House

The Building is reminiscent of eighteenth-century New Orleans architecture, and was built sometime before 1883. The Kage House is located at 120 Broadway in the historical district and is less than a minutes walk to Main Street and less than a 10 minutes walk to the Isle of Capri Casino. On Main Street you will find many fine shops and restaurants, or just enjoy the scenic area as you walkabout. This is by far one of the best places in Cape. Additional reviews can be read on the VRBO website.

Location · Family · Bathroom

RiverSide Barn Suite on the Mississippi River.

The barn suite is a beautiful 2 bedroom apartment overlooking the Mississippi River and housed in a unique barn with its own separate entrance. The deck views are spectacular and takes sitting and relaxing to a new level. Our wine place “The RiverHouse “ is within walking distance with the best worldwide wines and menu in the area. www.theriverhousewineplace.com We are 12 minutes from Cape Girardeau and serviced by Lyft & Car-Go. You May contact us by text or call and available at any time.

Value · Family · Cleanliness

The Windbreak

This is a spacious apartment, the lower/first level of a 3-level house. It is a peaceful place at the end of a woodsy, country lane, not far from two state parks, five lakes, wine trail, Southern Illinois University and other interesting features of this area. The 1st level apartment is large, sleep six, has a fully equipped kitchen, dining room, 2 bedrooms, living room/bedroom with a pull-out queen bed, a full bath, and a utility room, 2 exterior doors, one to a patio with a fire pit.

Location · Value · Amenities

Apple Creek Loft

Make some memories at this unique and family-friendly place. Enjoy what many remember to be the Old Store in Old Appleton. Have a peaceful experience near the Historic Bridge spanning the Apple Creek waterfall. Enjoy kayaking, fishing, and swimming in the creek right outside your door. This destination has beds to accommodate 6 people. Plus, there is a spacious living room and master bedroom where more guests could sleep if they would like to bring an air mattress/sleeping bag.

Family · Location · Hospitality

Upstairs Apt, directly across the street from SIU!

Welcome to Campus View! Located directly across the street from the beautiful SIU Campus!! Clean, modern, upstairs apartment right in the middle of Historic Downtown Carbondale just off "The Strip" within close walking distance of local restaurants, bars, shops, art galleries, train station and SIU Campus plus the beautiful campus lake. 2 Queen Beds, 1 Bath with walk-in shower, full kitchen, WiFi and free parking. Enjoy a stylish urban experience at this centrally-located place.

Family · Location · Bathroom

Quiet, private duplex Carbondale

Take a break and unwind at this peaceful home away from home. Located in a privately owned duplex community, this fully furnished apartment will meet your needs and give you a place to recharge. Equipped and newly furnished, you will find a clean, well-maintained apartment ready for your stay in Carbondale. Queen size bed in the bedroom, sound machine and fan will ensure that you have good sleep. Front room is set up as an office. If needed we can set up as a second bedroom.

Fresh & Cozy Retreat w/ King Bed · By KeenStays

This fresh apartment offers a unique blend of chic style and cultural charm, nestled in a freshly rehabilitated building in Downtown Cape Girardeau. Enjoy a vibrant stay by being in walking distance to shopping, dining, and downtown entertainment! The apartment features a spacious, light-filled layout with chic finishes and appliances. Enjoy a comfortable & spacious living area. Don't forget to visit the viral mac & cheese bar, Roni's Mac Bar, downstairs!

Family · Location · Hospitality

Downtown 4BR with 2 King Beds! Off-street parking

- Massive two story 2,400 sq ft historic apartment on Broadway - Recently renovated - Downtown location - Free off-street parking - Walking distance to SEMO and River Front - 2 King beds! - 3 Bathrooms - 2 futons and one couch for extra sleepers - Self check-in with smart lock - Full kitchen - Washer/Dryer included - Formal dining area - Second cozy living room upstairs - Room darkening shades in all bedrooms - Note: narrow staircase at entrance

Location · Family · Access

Regal Rustic Retreat

Take it easy at this unique and tranquil getaway. Close to SIU Carbondale and also Murphysboro. We offer a quiet, simple apartment to relax and recharge. Free local over the air television. We have a 43" Roku monitor with broadband connection. The second bedroom is an open loft area, not a separate room. We offer a large storage space for bicycles and mudroom with washer/dryer for cleaning up after a hike or bike race. Full kitchen.

Location · Family · Amenities

Riverwalk 2BR | Easy, Walkable Stay

Enjoy easy, single-level living just steps from the River Campus and Riverwalk. This updated first-floor 2-bedroom home sits on the southeast side of Cape Girardeau — a short 5-minute walk to downtown while still tucked into a quiet residential street. Renovated in 2023, the home blends historic character with practical updates, offering a clean, functional space with no interior stairs.

Location · Family · Walkability