Vacation rentals in Cape Girardeau County

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

The Candle Cottage in downtown Cape.

All the best that downtown Cape Girardeau has to offer just steps away from your front door! Short distance from Isle Casino and just 2 1/2 blocks from the Mississippi River walk, downtown restaurants, shops and minutes from Southeast Missouri State River Campus. Completely renovated with loads of charm and coziness, high ceilings, comfy bed, fully stocked kitchen, and laundry. My place is ideal for couples, solo adventurers, and business travelers. Owner is licensed real estate agent.

Private two room suite in downtown Cape Girardeau

Spacious two room suite with a queen size bed in one room along with a single bed and a futon sofa in the other room. Private full bathroom. Kid friendly. Refrigerator with drinks available. Separate heating and cooling control. Cathedral ceiling. Located in a good neighborhood. Walking distance to downtown, riverfront, restaurants, and musical venues such as the university River Campus. A wide porch and large goldfish pond are in front. The suite is on the second level of the home.

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.