Pet-friendly vacation rentals in Cape Girardeau County

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Top-rated pet-friendly home rentals in Cape Girardeau County

Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.

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Top guest favorite

A spacious living area features large windows allowing natural light to fill the space. A comfortable grey sofa is paired with a unique coffee table, while stylish dining chairs surround a white table. The kitchen area includes modern appliances and cabinetry.

Apartment in Cape Girardeau

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

WalkabilityOutdoor spacesAir conditioning

4.95 out of 5 average rating, 320 reviews

Guest favorite

The spacious living area features a comfortable couch and a coffee table, while a set of three barstools accompanies a sleek dining table. Natural light streams through multiple windows, highlighting the wood flooring and modern kitchen appliances in the background.

Tiny home in Jackson

The Cottage, Rusted Route Farms

You won’t forget your time in this romantic, memorable place. The Cottage at Rusted Route Farms is a 1 bedroom beautiful suite on an old 10 acre farm history galore. A picturesque pond is settled next to The Market our onsite Restaurant that will be serving food and drinks to be ready on your arrival or for a certain time that you choose. The over 125 year old barn has been renovated to keep the history alive and is located here on site. This retreat is located right outside Cape Girardeau.

Outdoor spacesPetsCheckout

4.95 out of 5 average rating, 78 reviews

Guest favorite

A serene view of the Mississippi River is presented, highlighting the tranquil water and the pavilion that juts into the river. Lush green grass borders the water, and trees line the distant shore, creating a natural landscape under a clear sky.

Apartment in Scott City

RiverSide Barn Suite on the Mississippi River.

The barn suite is a beautiful 2 bedroom apartment overlooking the Mississippi River and housed in a unique barn with its own separate entrance. The deck views are spectacular and takes sitting and relaxing to a new level. Our wine place “The RiverHouse “ is within walking distance with the best worldwide wines and menu in the area. www.theriverhousewineplace.com We are 12 minutes from Cape Girardeau and serviced by Lyft & Car-Go. You May contact us by text or call and available at any time.

WalkabilityPetsSleep quality

4.96 out of 5 average rating, 53 reviews

Top guest favorite

A modern farmhouse is depicted at sunset, featuring a welcoming entrance with a covered porch. A stone pathway leads to the front door, bordered by a grassy lawn that extends to fields and trees in the background.

Barn in Cape Girardeau

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

WalkabilityOutdoor spacesComfort

4.94 out of 5 average rating, 281 reviews

Guest favorite

Home in Cape Girardeau

College town Charm: Minutes from Downtown Cape

EXCELLENT LOCATION near downtown riverfront Cape! Enjoy live music, local dining/coffee, shopping, casino, and seasonal steamboat rides downtown. Less than 5 min. from Southeast Missouri State University & Southeast Hospital. Centrally located near wedding venues: Rusted Route, Deerfield, Watersedge, Sweet Pecan, and Country Club. 2 blocks from scenic Capaha Park. Home to Capaha baseball. This huge park includes play structures, basketball court, disc golf & fishing pond.

WalkabilityLocationValue

4.92 out of 5 average rating, 183 reviews

The entrance features a welcoming front porch with a white bench and colorful flower pots. A vibrant arrangement of yellow daffodils blooms along the walkway, enhancing the inviting appearance of the home. The exterior is characterized by a combination of white brick and gray siding.

Apartment in Cape Girardeau

Visit the "Gone Girl" neighborhood

Living rm/bedrm, full kitchen, ADA bath, and walk in closet. Fully equipped with dishes,linens, refig, micro,stove, keurig, dishwasher and welcome home snacks. Double Murphy bed, queen hide a bed couch convert the living room to bedroom. Space is good for up to 3 adults, 2 adults and 2 children or a single guest. We accept well mannered dogs up to 50 pounds. We do not accept CATS. Like cats but they cause additional clean up. See pets section for dog guest guidelines.

Outdoor spacesWalkabilityParking

4.89 out of 5 average rating, 105 reviews

Top guest favorite

Tiny home in Cape Girardeau

A-Frame @ Inspiration Village on Boulder Creek

Experience tiny living without sacrificing comfort at Inspiration Village tiny home community. The Mermaid A-frame comfortably sleeps 5 with a main-floor queen bedroom, an open-tread loft with a second queen bed, and a living area futon. Enjoy modern conveniences like fast WiFi, a functional kitchenette (mini-fridge, microwave, hotplate), and an individual mini-split AC unit. Spend evenings outside playing life-size yard games or gathering around the shared fire pit.

Outdoor spacesPetsIndoor spaces

4.98 out of 5 average rating, 49 reviews

Superhost

Home in Cape Girardeau

Cottage Near Casino

Welcome to your cozy cottage with a delightful retro feel, conveniently located near the Casino, Downtown, and SEMO University. You'll be greeted by the inviting sight of a white fence that surrounds the property, adding a touch of quaint charm to home away from home. This home features 2 bedrooms, 1 full bathroom and the convenience of main floor laundry. This is the perfect haven for traveling nurses or professionals seeking a comfortable and stylish residence.

WalkabilityPetsHeating

4.89 out of 5 average rating, 18 reviews

Guest favorite

A single-story house with a red roof and brick facade is nestled among tall trees, providing shade. The home is situated on a gentle slope covered with green grass, creating a serene outdoor setting with ample space surrounding it.

Home in Jackson

Rural Comfort in Fruitland

Enjoy a peaceful, private, country setting on the back patio with country views and a large yard space, while also having easy access to I-55, Cape Girardeau, and Jackson & multiple restaurants within a few mile radius. This home offers two fully furnished living spaces, two bedrooms, 1.5 bath and a fully equipped kitchen. There is a full laundry room/mud room with full size washer and dryer and use of the garage is negotiable.

WalkabilityCheck-inGetting around

4.91 out of 5 average rating, 43 reviews

Superhost

The cottage exterior presents a single-story structure with light blue siding and a dark roof. A wooden deck is located at the front, featuring a railing. The yard is grassy, bordered by a privacy fence, with a driveway visible beside the house.

Home in Cape Girardeau

Herman’s Cottage on the Corner

This beautifully remodeled 2 bed/1 bath home offering modern comfort and total convenience. Enjoy central air, stylish furnishings, and high-speed internet. The home features keyless entry, a fully fenced backyard, and a BBQ grill perfect for relaxing evenings. Conveniently located near shopping, dining, and local attractions. Fully furnished and move-in ready, this space is ideal for comfortable, hassle-free living.

PetsOutdoor spacesNearby

4.81 out of 5 average rating, 144 reviews

Superhost

Apartment in Cape Girardeau

Riverwalk 2BR | Easy, Walkable Stay

Enjoy easy, single-level living just steps from the River Campus and Riverwalk. This updated first-floor 2-bedroom home sits on the southeast side of Cape Girardeau — a short 5-minute walk to downtown while still tucked into a quiet residential street. Renovated in 2023, the home blends historic character with practical updates, offering a clean, functional space with no interior stairs.

WalkabilityAccessHospitality

4.88 out of 5 average rating, 8 reviews

An outdoor space features a charming cottage with a light-colored brick facade and dark doors. A shaded area with a patio table and four metal chairs is surrounded by well-maintained grass and trees, providing a serene spot for relaxation.

Guesthouse in Cape Girardeau

The Cottage at Eden

Pet friendly! The Cottage at Eden is a great place to stay for a weekend getaway or staying for a week or more. This one bedroom cottage has a full kitchen. S The Cottage at Eden is location in downtown Cape Girardeau. It is across the street from the Old Red Cabin and Historic Old St. Vincent Church. This unique building was built in 1830.

WalkabilityOutdoor spacesCondition

4.73 out of 5 average rating, 880 reviews