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Cape Girardeau vacation rentals

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Top-rated vacation rentals in Cape Girardeau

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

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Rental unit in Cape Girardeau

4.98 out of 5 average rating, 393 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Guest suite in Cape Girardeau

4.97 out of 5 average rating, 137 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

Rental unit in Cape Girardeau

4.95 out of 5 average rating, 214 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Rental unit in Cape Girardeau

4.85 out of 5 average rating, 577 reviews

Unique Design | Walk Downtown/River | .5 mile SEMO

At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.

Treehouse in Cape Girardeau

4.99 out of 5 average rating, 106 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Home in Cape Girardeau

4.83 out of 5 average rating, 105 reviews

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Cottage in Cape Girardeau

4.98 out of 5 average rating, 352 reviews

The Candle Cottage in downtown Cape.

All the best that downtown Cape Girardeau has to offer just steps away from your front door! Short distance from Isle Casino and just 2 1/2 blocks from the Mississippi River walk, downtown restaurants, shops and minutes from Southeast Missouri State River Campus. Completely renovated with loads of charm and coziness, high ceilings, comfy bed, fully stocked kitchen, and laundry. My place is ideal for couples, solo adventurers, and business travelers. Owner is licensed real estate agent.

Cottage in Cape Girardeau

4.99 out of 5 average rating, 201 reviews

Historic Cottage Walkable to Downtown Cape

This welcoming 3 bedroom, 2.5 bathroom brick German vernacular cottage on a tree-lined street is just 2 blocks away from the Mighty Mississippi River and historic downtown Cape Girardeau's shops, restaurants, historic sites, river walk, and SEMO's River Campus.This home has been restored with an eye for family gatherings and was built by Joseph Lansman in 1892. The main floor is friendly for mobility-challenged guests with no stairs on the main level when entering from the front door.

Barn in Cape Girardeau

4.96 out of 5 average rating, 160 reviews

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Guesthouse in Cape Girardeau

4.94 out of 5 average rating, 478 reviews

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

Home in Jackson

4.92 out of 5 average rating, 303 reviews

The Rusty Owl-A Charming Victorian Dwelling

The Rusty Owl is a peaceful place with easy access to I-55. House has high speed (300 up and down) wifi. Jackson: Check out Flickerwood Arena, (9 minutes away... for ATV and barrel racing; horse shows and rodeos) Jackson History Center: Free. Open daily. Cape Girardeau downtown: Live music and relaxation at The Library, Casino, VFW and Eagles. 1 private lower level queen bedroom/ two private (1 queen, 1 twin) rooms and one room with a queen bed and a twin bed upstairs.

Treehouse in Makanda

4.97 out of 5 average rating, 261 reviews

Panthers Inn Treehouse

Come nestle amongst the leaves at Panthers Inn Treehouse. This secluded, well equipped, elevated cabin has the perfect combination of natural beauty and artful luxury. Isolated yet conveniently located 2 minutes from Blue Sky and Feather Hill wineries, within 5 minutes of Panthers Den hiking trail and the Shawnee Hills canopy tour and only 10 min from I-57 exit 40. Panthers Inn is the perfect starting and ending point to your Shawnee Hills Wine Country vacation!

Vacation rentals for every style

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Popular amenities for Cape Girardeau vacation rentals

Laptop-friendly workspace

Air conditioning

Stay near Cape Girardeau's top sights

Minglewood Brewery13 locals recommend

Port Cape13 locals recommend

Katy O'Ferrell's Publick House9 locals recommend

Top of the Marq8 locals recommend

Isle of Capri Casino8 locals recommend

Coin-Op Cantina7 locals recommend

Other great vacation rentals in Cape Girardeau

Cabin in Pomona

5 out of 5 average rating, 62 reviews

Modern Cabin at Trillium Ridge

Guesthouse in Cape Girardeau

4.91 out of 5 average rating, 91 reviews

Cozy 1-BR guest house w/free parking on premises

Farm stay in Jackson

4.84 out of 5 average rating, 19 reviews

Beautifully Renovated Farmhouse in Jackson, MO

Cabin in Cobden

5 out of 5 average rating, 76 reviews

Pop’s Country Cabin

Home in Cape Girardeau

4.8 out of 5 average rating, 98 reviews

Herman’s Cozy Corner

Home in Cape Girardeau

5 out of 5 average rating, 16 reviews

Mid-Town Historic Like New Gem

Home in Cape Girardeau

4.92 out of 5 average rating, 60 reviews

Cozy Cottage

Cabin in Cape Girardeau

4.95 out of 5 average rating, 19 reviews

Cape Haven Cabin

Quick stats about vacation rentals in Cape Girardeau

Total rentals
160 properties
Nightly prices starting at
ﺩ.ﺇ73 before taxes and fees
Total number of reviews
9K reviews
Family-friendly rentals
80 properties are a good fit for families
Pet-friendly rentals
50 properties allow pets
Rentals with dedicated workspaces
90 properties have a dedicated workspace

Frequently Asked Questions

Are there vacation rentals with a dedicated workspace in Cape Girardeau?
Yes! Work meets play with ease at over 90 vacation rentals in Cape Girardeau featuring dedicated workspaces. Stay connected and productive in your home away from home.
Are there pet-friendly vacation rentals in Cape Girardeau?
Four-legged friends are welcome in Cape Girardeau. Choose from more than 50 vacation rentals for guests traveling with pets.
Do apartment rentals in Cape Girardeau have wifi?
Absolutely! We offer over 40 apartment rentals with wifi in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.
How much does it cost to stay in apartment rentals in Cape Girardeau?
Experience the best of Cape Girardeau with our apartment rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there family-friendly house rentals in Cape Girardeau?
Cape Girardeau has more than 40 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
Do house rentals in Cape Girardeau have a bbq area?
Absolutely! We offer over 10 house rentals with a bbq area in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.
Do house rentals in Cape Girardeau have air conditioning?
Absolutely! We offer over 70 house rentals with air conditioning in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.
What are the most popular amenities for Apartment Rentals in Cape Girardeau?
Enhance your stay in our Apartment Rentals with the most popular amenities: over 40 homes with air conditioning, over 40 homes with wifi, and more. Indulge in the ultimate retreat, tailored to your preferences.

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