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House vacation rentals in St. Lucie County

Find and book unique houses on Airbnb

Top-rated house rentals in St. Lucie County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
A glistening pool surrounded by lush tropical landscaping creates a private oasis. The clear blue water reflects the sky and palm trees, while lounge chairs sit beside the pool on a tiled patio. A peaceful ambiance invites relaxation in a serene outdoor setting.
Home in Jensen Beach
4.86 out of 5 average rating, 21 reviews

Private Tropical Getaway! 2/2 Home with Pool!

Cute as a button and neat as a pin, this great home has been totally remodeled. Two bedroom, two bath home comes complete down to sheets and linens, dishes and cook wear, sunshine and tropical breezes. Your stay will be comfortable as you relax for a weekend or a season. Relax with our indoor tiki bar and new furniture with 4 flat screen TV's, including a new 50' HD televison in living room, and wi-fi access for your laptop or cell phones. A/C Garage has an air hockey table, futon beds and TV.

Guest favorite
A serene outdoor space features a saltwater pool surrounded by lush landscaping. A prominent Bismarck palm stands nearby, casting gentle shadows. Comfortable seating is positioned on the screened-in patio, creating inviting spots for relaxation under the bright sky.
Home in Port St. Lucie
4.93 out of 5 average rating, 105 reviews

3/2 w Heated Salt Pool Getaway on Calusa

This is your instant "home away from home". The property is located just minutes from the beach! However the brand new salt water pool makes it easy to forget the beach is so close. There is outdoor seating in the sunshine, and also located in the screened in patio area, new privacy wood fenced back yard making it perfect for enjoying the outdoors . The landscaping is also amazing, with a beautiful 30 FT Bismarck palm outside. If you are a regular vacationer this will be your new vacation spot.

Guest favorite
Home in Port St. Lucie
4.98 out of 5 average rating, 195 reviews

Riverfront Port St Lucie home with private dock.

Beautiful 3 bedroom 2 bath river front home with private dock. deep water access to the ocean bring your boat. One block away from river front park with boat ramp and nature reserve, 10 min from Oxbow reserve. 20 min from the beach. Close to Met's spring training First Data Field , all shopping is close by. Boat trailer parking available, Beautifully landscaped yard with Palm trees, Tropical themed interior design. Sleeps 6 comfortably with 2 extra air mattress and bedding for extra guests.

Guest favorite
The exterior of the cottage showcases a brick façade complemented by lush green ferns. A gently sloping roof is visible, alongside a front door framed by windows that allow natural light into the interior. Surrounding trees add to the serene environment.
Home in Port St. Lucie
4.97 out of 5 average rating, 33 reviews

Welcome to the Cottage: A Home Away from Home

Experience a restful stay in a quiet, established, and central area. Soak up the Florida sun with a quick trip to our local boardwalk and beaches. Proximal for golfing, on the world-renowned PGA golf course; fishing, and experiencing the beauty of Florida. Are you a baseball fan? Stay with us in spring, to see the Mets train. Perfect for families, business executives, and guests looking for a central location with shopping and local dining out options within walking and driving distance!

Top guest favorite
Home in Fort Pierce
4.88 out of 5 average rating, 114 reviews

Castle Santa Clara

You’re sure to have a memorable getaway to FL when you stay at this recently renovated home, where there’s enough room for a family or group of close friends in the 1,350 sq feet of well-appointed living space. All the amenities you need to feel as relaxed as possible are here, a fully equipped kitchen; wireless internet access, in-unit laundry machines, central air conditioning, large patio, gas grill, private in-ground heated pool , fenced yard, three flat-screen Smart TV, and much more!

Guest favorite
An airy living room displays tall ceilings and large windows, allowing natural light to fill the space. A comfortable sectional sofa is positioned around a low table, with a view of the patio and surrounding greenery visible through the glass doors.
Home in Port St. Lucie
4.97 out of 5 average rating, 107 reviews

Relaxing Beautiful 5BR w/ heated pool and Spa

Enjoy a relaxing stay at a beautiful home in sunny southern Florida. A short drive to beaches, shopping and many nature parks. Take a drive for manatee sightings, Mets baseball, visit the local brewery or stay in and enjoy the heated pool and relax in the spa. Smart TVs in every bedroom, office and family room. Fast wifi for remote work. Beverage station, pool table and exercise equipment. Pool and SPA area with grill and fire pit. Walking distance to convenience stores and restaurants.

Top guest favorite
The modern kitchen island features a large white countertop with a sink, surrounded by stylish pendant lights. An open layout connects the kitchen to a spacious living area with a sectional sofa and a flat-screen TV, creating a bright and inviting space.
Home in Port St. Lucie
4.93 out of 5 average rating, 58 reviews

Relaxing Port St. Lucie Getaway with Lake Access

Relaxing Port St. Lucie Getaway with Lake Access Escape to this spacious 4-bedroom, 3-bath home in beautiful Port St. Lucie, FL, perfect for your next getaway. Featuring 4 luxurious king beds, this property comfortably accommodates families, friends, or groups. Enjoy serene lake access, a fully equipped BBQ area, and plenty of space to relax and unwind. Whether you’re seeking a peaceful retreat or a convenient base to explore the area, this home is ideal for creating lasting memories.

Guest favorite
The exterior of the guest house is framed by lush greenery and landscaped flower beds. A paved walkway leads to a front porch, with a large tree and various plants enhancing the garden's natural appeal. A car is parked in the driveway beside the house.
Home in Port St. Lucie
4.93 out of 5 average rating, 270 reviews

Private Guest House

Guest House with private entrance Bedroom: Queen bed, 42" HDTV WIFI Full bath w/shower Kitchen/Living area: Sofa, table, fridge, stove, sink, micro & toaster oven Close to casual & fine dining, PGA Golf Courses, Mets Stadium, the Turnpike and I-95. Enjoy fun activities like kayaking, nature walks, paddle-boarding, museums, and fabulous beaches. Our guest house is good for couples, individuals, business travelers, weekend golfers. Contact host for additional sleeping arrangements.

Guest favorite
A single-family home is showcased with a well-manicured front yard. The exterior features light-colored siding paired with stone accents. A driveway leads to a two-car garage. Lush green grass and planted shrubs add to the inviting curb appeal under a partly cloudy sky.
Home in Port St. Lucie
4.91 out of 5 average rating, 154 reviews

FreshStay next to Tradition

Welcome to your home away from home! Our 4 bed 2 bath single family Airbnb is the perfect spot for your next getaway. Located right next to Tradition, you'll have easy access to all the shops and restaurants this charming community has to offer. Plus, with the highway just around the corner, you'll be able to explore all the nearby attractions with ease. Inside, you'll find a spotless and comfortable space that's perfect for relaxing after a long day of adventuring.

Top guest favorite
An open living area is furnished with a modern black sofa featuring vibrant orange pillows, complemented by a wooden coffee table. Natural light filters in through the large windows, revealing a spacious kitchen area in the background and a cozy seating area nearby.
Home in Port St. Lucie
4.98 out of 5 average rating, 211 reviews

Relaxing, quiet house yet close to action and fun

Great, all new relaxing getaway house. Just been remodeled and updated, fenced back yard and screened patio. Fast wifi, Four beds and two bathrooms to fit up to 8 guests comfortably, washer and dryer, BBQ grill, KEURIG, VITAMIX, and kitchen tools . Come enjoy the local non-crowded beaches or the laidback nightlife of Stuart or Jensen beach. Tradition is literally blocks away, shopping, dining, golf courses etc. Quick access to 95 and Turnpike.

Top guest favorite
A serene backyard features a circular arrangement of five Adirondack chairs positioned around a fire pit. The area is bordered by lush greenery and decorative stones, creating a peaceful outdoor retreat. Soft grass and stepping stones lead towards the seating area.
Home in Port St. Lucie
4.99 out of 5 average rating, 209 reviews

Fire Pit Oasis Near Jensen Beach w/ Private Patio

Welcome to The Palm — a fire pit oasis near Jensen Beach. Unwind in the private backyard, relax in the screened patio with smart TV and hanging chairs, or cook in the fully stocked modern kitchen. Just minutes from Jensen Beach, Stuart Beach, and historic downtown Stuart, this home is perfect for families, couples, and remote workers. Enjoy fast Wi-Fi, memory-foam beds, and kid-friendly extras like a pack & play and changing station.

Top guest favorite
A screened patio surrounds a heated saltwater pool, featuring a gentle staircase leading into the water. The home's exterior is visible, with large windows allowing natural light to illuminate the space and a palm tree adding a touch of greenery.
Home in Port St. Lucie
5 out of 5 average rating, 28 reviews

By Golf/Beaches ~ Pool ~ Putting Green ~ King Bed

Welcome to the Treasure Coast Getaway. Leave your worries behind as you unwind and enjoy time in this beautiful 4 bedroom, 2 bathroom coastal style home featuring a temperature controlled HEATED saltwater pool and a 4-hole putting green in the backyard to help sharpen your game between tee times. Make memories of a lifetime while exploring Port Saint Lucie's Treasure Coast. Golfing, shopping and beaches are just minutes away.

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