Guesthouse vacation rentals in St. Lucie County

4.85 out of 5 average rating, 46 reviews

The Hideaway Suite Hot Tub Projector & Pool Table

Guests have private entrance into a beautiful boho-style guest suite room fitted with a king-size bed and bathroom with shower. Relax in your very own private spacious sheltered lanai with a hot tub, ambient lighting, 120-inch projector, pool table, piano, lounge area, and yoga space, mini kitchenette, fridge freezer, private outdoor patio with grill and dining area this is a perfect little place for unwinding. Hideaway attached to rear main house. Private entrance. (No access to main house)

4.84 out of 5 average rating, 19 reviews

Suite Coastal Retreat / 1 Bedroom Guest House

Welcome to your private guest house in Port St. Lucie, FL. This 1-bedroom, 1-bathroom guest house sleeps up to 4 guests and offers everything you need for a relaxing stay on Florida’s Treasure Coast. The home features a separate bedroom, private bathroom, and a pull-out sofa in the living room. Enjoy a fully equipped kitchen great for short or extended stays. This guest house is close to shopping, popular activities, and just a 20-minute drive to beaches, fishing spots, and waterfront dining.

A well-maintained pathway leads through landscaped greenery, framed by tall hedges and decorative plants. A welcome mat is positioned at the entrance, inviting guests into the private guest house. The blue sky and soft clouds create a serene backdrop for the setting.

4.96 out of 5 average rating, 141 reviews

Private•Stylish guesthouse•Laundry inside•King bed

Feel at home in our totally private apartment, in a quiet neighborhood with all you need for a relaxing stay. Relax in the comfort of a spacious King bed and a cozy queen sofa bed providing ample space for additional guests. Newly added washer and dryer inside the unit for a quick wash. With its own private entrance, and safe and free parking you'll enjoy the freedom to come and go as you please. Stay connected with free high-speed WiFi, and smart tvs on the bedroom and the living room.

Guesthouse in Hutchinson Island

4.91 out of 5 average rating, 194 reviews

Private Detached Guesthouse Oasis

North Hutchinson Island locale a two minute walk to private beach/Indian River Lagoon/fishing dock. Preserve, and, park surroundings, great hiking trails, and, awesome fishing spots. Guest house, with bedroom, living room, and bathroom, includes an alcove with small fridge, Keurig, toaster oven, and microwave. -Never a cleaning fee -No pre check-out chores -This is a private property -Two night weekend minimum -10% discount off nightly rate 3 nights or more (paid in cash upon arrival)

A fenced saltwater pool is framed by a screened enclosure, featuring a decorative statue at the center of the pool deck. Lush greenery and flowering plants are visible in the background, contributing to a serene outdoor environment.

4.85 out of 5 average rating, 162 reviews

Private guest house with heated pool.

This property is located in Southbend Lakes neighborhood in the beautiful Port St Lucie, Florida. This is one of the nicest neighborhoods in the area. Tropical themed guest house with 55 inch roku tv and queen size bed. Private bathroom and access to semi private Heated salt water pool. Owners and kids may use pool as well on occasion. Take time to enjoy the sound of nature all around you. The backyard overlooks the canal and has a variety of plants, flowers , and trees.

4.88 out of 5 average rating, 43 reviews

Cozy Private Studio

Take it easy at this unique and peaceful studio in Port St. Lucie, FL. Conveniently located just one minute from the Turnpike and eight minutes from I-95, you’ll be close to Tradition Square, beautiful beaches, golf courses, as well as great shopping and dining options. Please note that this is a shared property with another unit. But the only shared space is the main hallway. Guests have total privacy in this well equipped space. Please reach out if you have any questions.

A bright, open backyard features a circular pool with clear blue water, surrounded by a concrete deck. Two lounge chairs sit next to the pool, and an umbrella provides shade. The lush green lawn complements the bright sky with scattered clouds.

4.85 out of 5 average rating, 251 reviews

Serene Guesthouse | Saltwater Pool & Private Entry

Our recently remodeled guest-room with queen bed and full bath is detached from the main house offers our guest the sweet serenity of a home away from home. The in-ground pool just feet from the sliding glass doors and private entrance on the side of the house. We are just 10 mins. away from Jensen beach and Hutchinson Island, the mall, Publix, Walmart ect.. The area is full of restaurants, to navigate to I-95 is only a 20 min. drive, West Palm is about 30-45 mins!

Guesthouse in Fort Pierce

An aerial view captures the spacious grounds of Nova Beach Cottage, surrounded by lush greenery and palm trees. The property is located steps from the beach, with a clear view of the ocean in the background. The layout of the buildings and pathways is evident.

4.97 out of 5 average rating, 223 reviews

Extraordinary location, private, beach path, cozy

Location, privacy, ocean. Due to health concerns, pool seen from aerial shots not available Nov-May because owners will be in residence in the main house. Welcome to Nova Beach Cottage, the guest house on the oceanfront estate of famous sculptor, Mihai Popa, a.k.a. “Nova”. Located on the south tip of North Hutchinson Island directly next to the Fort Pierce Inlet State Park. Garden and beach path a few steps from the cottage. Screened patio from bedroom.

Guesthouse in Fort Pierce

5 out of 5 average rating, 96 reviews

Sunny Boho Oasis – Moon House

One of the most beloved homes on Airbnb, fall in LOVE with Casita Luna! * Stand alone Casita Luna is designer decorated, a perfect base to explore Treasure Coast & beaches! * Enjoy your organic coffee or get work done in the window alcove * Sink into comfortable queen bed with luxurious linens, enjoy fully stocked kitchenette & a spacious bath * Watch Prime & Netflix, play games, browse through books * Convenience for long stays * Lovely private patio

Guesthouse in Fort Pierce

A lush garden area features green grass, surrounded by tropical foliage and flowers. A covered patio offers a cozy seating space with soft lighting, creating an inviting atmosphere in the evening. Lanterns add a touch of warmth to the serene outdoor setting.

4.95 out of 5 average rating, 274 reviews

Cozy Island Efficiency • Walk to Beach

Welcome to our cozy efficiency on South Hutchinson Island, Florida! Our one bedroom is perfect for singles or couples, with a queen Murphy bed and private ground-level entrance. an induction cooktop, convection oven, full-size refrigerator, Smart TV, and a full bathroom. Located in a friendly neighborhood, we're close to beaches, jetties, restaurants, and historic downtown. Come stay with us and enjoy all that the Treasure Coast has to offer!

The exterior of a well-maintained home is displayed, featuring a neatly landscaped lawn with lush green grass and decorative plants. A paved driveway leads to a dark garage door. The white facade is accented by a gray metal roof and surrounded by a tidy white fence.

4.89 out of 5 average rating, 438 reviews

Port St Lucie - Peaceful home away from home.

Defined as a dwelling attached to my private home with its own private entrance, containing all the essentials of a home. Lovely, safe, quiet, family neighborhood, decorated with blackout drapes. Host only 1 person or 1 couple max at a time. Freshly renovated with private patio, independent with full kitchen. Mini fridge, coffee maker, microwave, Iron, hair dryer available. 42” LCD tv/premium channels, WiFi, streaming.

A bright sleeping area features a spacious bed dressed in white linens, complemented by decorative pillows. A textured throw is laid across the foot of the bed. Two folding chairs are positioned at the foot, with a woven storage unit and wall art enhancing the cozy ambiance.