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Guesthouse vacation rentals in Santa Cruz de la Sierra

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Top-rated guesthouse rentals in Santa Cruz de la Sierra

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Private room in Santa Cruz de la Sierra

Mirador del Cielo - Boutique Apart Hotel 2

Sky Apartment is ideal for travelers looking for a comfortable, elegant place with all the amenities to make the most of their stay. Just 15 minutes from Viru Viru International Airport and with easy access to the city's main areas. Relax in the pool on the top floor, enjoy the jacuzzi, dry sauna, and steam room, or prepare a delicious barbecue with friends and family We look forward to having you join us for a one-of-a-kind experience in Santa Cruz de la Sierra!

A multi-story building is showcased, featuring a distinctive red facade with decorative archways. Balconies extend from the upper floors, providing outdoor space. The ground level houses various storefronts, while utility poles and street signs are visible, indicating a lively urban environment.
Guesthouse in Santa Cruz de la Sierra
4.42 out of 5 average rating, 12 reviews

Cozy family home in Santa Cruz de la Sierra

Family house of 320 square meters, on the second floor, with all the utensils and home clothes, wonderful views from its 30 meters of terrace. Ideal for families who want to have a quiet stay of any duration in the City of Santa Cruz de la Sierra. Very well connected with several bus lines that take you to the entire city and surroundings and very close to the Santuario de Cotoca. Nearby has all kinds of services, breakfasts, meals, markets, shops, etc.

A cozy living space is presented with a comfortable sectional sofa featuring decorative cushions. A coffee table sits in front, with a sleek television mounted on a modern cabinet. Natural light enters through large windows, and a potted plant adds a touch of greenery.
Guesthouse in Santa Cruz de la Sierra

Horizontal duplex in backyard of house with pool

Enjoy a horizontal duplex (complete) in the backyard of my house. With its own entrance to the duplex, it shares entrance to the property. Located in a safe and quiet area easily accessible, close to shops, markets, supermarkets, pharmacy, public transportation (blocks from the main avenues), by car 10 min. from the center, 5 min. from the Fexpo, 30 to 40 min. from the airport, 1 block walk from the society of engineers SIB, clinic Montalvo and Urbari.

Guest favorite
Private room in Centro
5 out of 5 average rating, 6 reviews

Room in the center, two minutes away from everything!

Experience staying in the heart of Santa Cruz, just 3 blocks from the main square. Our bright and cozy room awaits you in a safe and lively area: museums, cafes, bars, shops, and historical spots are just a few steps away. Ideal for those looking for comfort, style and an unbeatable location. With WiFi, details designed for your rest and attention that will make you feel at home.

A spacious common area features comfortable seating arrangements with a mix of sofas and chairs. A central table is set with placemats, while a ceiling fan and air conditioning unit contribute to a comfortable environment. Light filters through large windows, enhancing the welcoming feel.
Guesthouse in Santa Cruz de la Sierra

Spacious house with a patio and parking

Guest house, with a large patio and grill (churrasquera), in a very quiet area. Air conditioning in all environments, thermotanque (hot water), spacious living room. Suite with private bathroom. Common bathroom, sofa bed and spacious sofa on the ground floor. (Can sleep comfortably up to 4 people) Address: km 8, Barrio 14 de Agosto, Calle 3 Between double guard and 17 ½ and 5 ½

Guesthouse in Centro

Complete centric apartment with garden and pool

Complete centric apartment with an enormous garden and pool. Private apartment with fully staffed kitchen, private bathroom and a bedroom with a queensized bed. You'll also have access to the big garden and the pool to relax and refresh yourself. By choosing our accommodation, you’re also supporting Ñañope, a local NGO dedicated to empowering household workers in Santa Cruz.

A well-equipped kitchen features wooden cabinets and a countertop with colorful tiles. A small refrigerator and an oven are included, alongside a wooden dining table with four chairs, creating a functional space for meal preparation and dining.
Guesthouse in Santa Cruz de la Sierra
5 out of 5 average rating, 56 reviews

Lodge surrounded by nature in the city

We renewed our lodge for more comfort for our guests: Imagine a little house surrounded by trees and plants, easy to go and not far away from city center. We´re living on half a hectar and your new place for working o relaxing is inside this paradise. You´re completely independent from us, with all you need for taking a rest or work, including the swimming pool.

Private room in Centro
4.5 out of 5 average rating, 4 reviews

Double or Full Room in Downtown

New and elegant building located just 2 blocks from the main square, surrounded by shopping malls, restaurants, cafes, jewelry, perfumerias, perfumerias, it is located a couple of blocks from the house of culture, the cathedral, museums, 1 block, banks, 7 street market and various shops and locals.

Guest favorite
A cozy bedroom features a spacious bed dressed in neutral linens, accompanied by decorative cushions. Two wooden chairs are positioned beside a round table near a window with light curtains. A wooden nightstand stands beside the bed, contributing to the room's welcoming atmosphere.
Guesthouse in Centro
4.88 out of 5 average rating, 112 reviews

Private Apartment In Downtown

Welcome to our cozy guest house in one of the most beautiful and safe areas of the center! Just 6 blocks from Plaza 24 de Septiembre, our historic neighborhood offers you a unique experience.

Guesthouse in Santa Cruz de la Sierra

Casa Portal Holístico # 1

Enjoy this mystical space of tranquility and harmony where your nights will be restored and revitalizing with the energy of the Holistic Portal

Private room in Santa Cruz de la Sierra
New place to stay

department to share TamisaIII

Disfruta de la sencillez de este alojamiento tranquilo y céntrico.

Private room in Santa Cruz de la Sierra
New place to stay

Apartment-style room

Disconnect from your concerns in this spacious and serene space.

Popular amenities for Santa Cruz de la Sierra guesthouse rentals

Quick stats about guesthouse rentals in Santa Cruz de la Sierra

  • Total vacation rentals

    Explore 50 vacation rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra vacation rentals start at ﺩ.ﺇ37 per night before taxes and fees

  • Verified guest reviews

    Over 350 verified reviews to help you choose

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    50 of Santa Cruz de la Sierra vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santa Cruz de la Sierra rentals

Destinations to explore