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Guesthouse vacation rentals in Santa Cruz

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Top-rated guesthouse rentals in Santa Cruz

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite
A cozy space features a spacious bed adorned with decorative towels, complemented by patterned curtains and wall accents. A dining table with chairs is positioned near the open kitchen, which includes a stove and sink. Natural light filters in through a window, enhancing the inviting atmosphere.
Guesthouse in Samaipata
5 out of 5 average rating, 6 reviews

La Casita, Finca La Vispera

La Casita, is a perfect place to spend a couple of days with your partner, it is located inside Finca "La Vispera", we have a Parque Nativo, Café Jardín, Herbolario, great view. You’ll love my place because of the location, the people, the neighborhood, the outdoors space, and the ambiance. My place is good for couples, solo adventurers, families (with kids), big groups, and furry friends (pets). You also will enjoy our vegetable Garden. You can collect the vegetables and enjoy a great meal.

A multi-story building is showcased, featuring a distinctive red facade with decorative archways. Balconies extend from the upper floors, providing outdoor space. The ground level houses various storefronts, while utility poles and street signs are visible, indicating a lively urban environment.
Guesthouse in Santa Cruz de la Sierra
4.31 out of 5 average rating, 13 reviews

Cozy family home in Santa Cruz de la Sierra

Family house of 320 square meters, on the second floor, with all the household goods and linen, wonderful views from its 30-meter terrace. Ideal for families who want to have a quiet stay of any duration in the City of Santa Cruz de la Sierra. Very well connected with several bus lines that lead to the entire city and surroundings and very close to the Cotoca Sanctuary. Nearby you will find all kinds of services, breakfasts, meals, markets, shops, etc.

A spacious common area features comfortable seating arrangements with a mix of sofas and chairs. A central table is set with placemats, while a ceiling fan and air conditioning unit contribute to a comfortable environment. Light filters through large windows, enhancing the welcoming feel.
Guesthouse in Santa Cruz de la Sierra

Spacious house with a patio and parking

Guest house, with large patio and grill (churrasquera), in a very quiet area. Air conditioning in all rooms, water heater (hot water), Wi-Fi, spacious living room. Suite with private bathroom. Shared bathroom, sofa bed and large sofa on the ground floor. (Up to 4 people can sleep comfortably) Address: km 8, Barrio 14 de Agosto, Calle 3 Between double track la guardia and radial 17 and a half

Superhost
Private room in Santa Cruz de la Sierra
4.89 out of 5 average rating, 9 reviews

Room in the center, two minutes from everything!

Experience staying in the heart of Santa Cruz, just 3 blocks from the main square. Our bright and cozy room awaits you in a safe and lively area: museums, cafes, bars, shops and historical corners are within walking distance. Ideal for those seeking comfort, style, and an unbeatable location. With WiFi, details designed for your rest and attention that will make you feel at home.

Superhost
Guesthouse in Santa Cruz de la Sierra

Complete centric apartment with garden and pool

Complete centric apartment with an enormous garden and pool. Private apartment with fully staffed kitchen, private bathroom and a bedroom with a queensized bed. You'll also have access to the big garden and the pool to relax and refresh yourself. By choosing our accommodation, you’re also supporting Ñañope, a local NGO dedicated to empowering household workers in Santa Cruz.

A well-equipped kitchen features wooden cabinets and a countertop with colorful tiles. A small refrigerator and an oven are included, alongside a wooden dining table with four chairs, creating a functional space for meal preparation and dining.
Guesthouse in Santa Cruz de la Sierra
5 out of 5 average rating, 56 reviews

Lodge surrounded by nature in the city

We renewed our lodge for more comfort for our guests: Imagine a little house surrounded by trees and plants, easy to go and not far away from city center. We´re living on half a hectar and your new place for working o relaxing is inside this paradise. You´re completely independent from us, with all you need for taking a rest or work, including the swimming pool.

A simple sleeping area features a spacious bed with white linens and bright red curtains framing a nearby window. An open shelf housing no items stands against one wall. A doorway leads to a bathroom visible in the reflection of a mirrored door.
Guesthouse in Ichilo
4.5 out of 5 average rating, 16 reviews

Window to Amboro Park

Enjoy a partial view of the Amboro mountains, with birdsong in the morning and the sounds of the small forest at night. Sometimes nocturnal monkeys or early-rising agoutis may appear. Though only 4 blocks from the main square, the place is quiet, away from traffic noise. With advance confirmation, tours to the north side of Amboro National Park can be arranged.

Guesthouse in Samaipata
New place to stay

Furnished studio with large patio

Quiet and independent studio in Samaipata, ideal for couples or small families. It has a kitchen, private bathroom and a large patio perfect for pets and to park your vehicle comfortably. A cozy and practical space to rest and enjoy the village.

Guest favorite
A cozy bedroom features a spacious bed dressed in neutral linens, accompanied by decorative cushions. Two wooden chairs are positioned beside a round table near a window with light curtains. A wooden nightstand stands beside the bed, contributing to the room's welcoming atmosphere.
Guesthouse in Santa Cruz de la Sierra
4.88 out of 5 average rating, 113 reviews

Private Apartment In Downtown

Welcome to our cozy guest house in one of the most beautiful and safe areas of the center! Just 6 blocks from Plaza 24 de Septiembre, our historic neighborhood offers you a unique experience.

Guesthouse in Santa Cruz de la Sierra

Holistic Portal House # 1

Enjoy this mystical space of tranquility and harmony where your nights will be restored and revitalized with the energy of the Holistic Portal

Superhost
Private room in Santa Cruz de la Sierra
4.75 out of 5 average rating, 4 reviews

El Peregrino 7 Inn

Enjoy the simplicity of this quiet and centrally-located accommodation.

A cozy sleeping area is furnished with a spacious bed adorned with patterned pillows, complemented by a seating area made of wooden pallets. Textured gray walls provide a simple backdrop, while a small table offers additional surface space. Natural light illuminates the room from the doorway.
Guesthouse in Santa Cruz de la Sierra

Separate room with private bathroom

Relax in this independent accommodation where tranquility is breathed.

Popular amenities for Santa Cruz guesthouse rentals