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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A modern living area is furnished with a gray sofa and a brown accent chair. A wooden coffee table sits on a textured rug in front of the sofa. Natural light floods in through large windows, illuminating the open layout that connects to an equipped kitchen.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 55 reviews

Luxury and comfort in every detail

This apartment combines luxury, style, and comfort in every detail. Designed as a boutique hotel, it offers a unique experience with impeccable finishes, an equipped kitchen, a cozy living room, spacious bedrooms, and a beautiful balcony to relax. Located in the heart of Equipetrol and a short walk from restaurants, shops and attractions. Perfect for business trips or relaxation, this modern and elegant space is ideal for relaxing and enjoying an unforgettable stay. You'll love it! Parking is included!

LocationFamilyAir conditioning

Guest favorite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 7 reviews

Ideal luxury with exclusive social spaces

Designed for discerning guests seeking an experience superior to a 5-star hotel. Located in Equipetrol, the most exclusive and secure area of Santa Cruz, this elegant apartment on the second-to-last floor offers a double balcony with unique views! Premium amenities such as a sky pool, lounge, pool table, barbecue grills, fully equipped gym, and more! Surrounded by the best restaurants, bars, cafes, theaters, shops and business centers. Ideal for executive trips, luxury getaways or unforgettable stays.

LocationComfortPool

Superhost
A modern outdoor pathway is flanked by sleek buildings and lush greenery. Soft, natural light filters through the space, illuminating the smooth stone finish of the walkway. Curved steps lead up to elevated garden areas, creating a harmonious blend of nature and architecture.
Apartment in Santa Cruz de la Sierra
4.89 out of 5 average rating, 73 reviews

Luxury 18th-Floor Apt | City View, Pools & Netflix

Enjoy a comfortable and stylish stay in this modern 18th-floor apartment with panoramic city views in Santa Cruz. Ideal for families, business travelers, and groups, the apartment offers space, privacy, fast Wi-Fi, and resort-style amenities, all within a secure high-rise building. For security purposes, there is a Ring doorbell camera located outside the apartment entrance, facing the exterior hallway. There are no cameras inside the apartment. there is security on duty 24x7 4th bed inflatable

LocationValueCleanliness

Top guest favorite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 8 reviews

Beautiful, spacious, and unique apartment in the best area.

Create unforgettable memories in this unique and family home. Exceptional 122 m2 apartment in the heart of Equipetrol. Very quiet place to rest or work, but at the same time close to fun. You'll have an amazing stay! Spacious, modern, furnished and decorated apartment, A/C, Wi-Fi, 65" and 55" 4K Smart TVs, kitchen, 2 bedrooms, 3 bathrooms, private laundry and drying area, ample free parking at the entrance 24 hours a day. Beautiful swimming pool and sauna. Large balcony with a nice city view.

FamilyAmenitiesKitchen

Superhost
Apartment in Santa Cruz de la Sierra
4.67 out of 5 average rating, 15 reviews

Sophisticated 2 Bedroom Absolute Luxury

Experience absolute luxury and superior sophistication. This exclusive 2-bedroom apartment redefines the concept of comfort in Equipetrol, the most prestigious area of SCZ. Each space has been carefully designed with elegant furnishings and a refined aesthetic that conveys distinction in every detail. Exclusive social areas: 🏊 Pool 💪 GYM 🎯 Playroom 🌇 Viewpoint with panoramic view Ideal for those looking for elegance and a superior experience in the best area of the city.

FamilyLocationWifi

Guest favorite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Apartment in Santa Cruz de la Sierra
4.93 out of 5 average rating, 82 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

LocationFamilyView

Top guest favorite
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 82 reviews

Spacious 3-bedroom | heated pool | Macororo

Enjoy a comfortable and elegant stay in this spacious 3-bedroom apartment at Macororo 13/14, on Av. Los Cusis. Great for families, groups and business trips. • Heated pool and social areas • Free private parking • Fast Wi-Fi • Equipped kitchen • Washer & Dryer • Smart TV Within walking distance, you'll find a 24-hour supermarket, Starbucks, restaurants, a mall, and a gym in front of the building. A comfortable, safe space designed for an excellent stay.

FamilyLocationCheckout

Guest favorite
An outdoor terrace features sleek wooden decking, complemented by low seating arrangements and lush greenery. A tranquil water feature runs along one side, reflecting the surrounding cityscape. Modern buildings rise in the background under a clear, blue sky.
Apartment in Santa Cruz de la Sierra
4.97 out of 5 average rating, 58 reviews

Elegant family apartment in Equipetrol

Have fun with the family in this new, central, and stylish accommodation. Beautiful and modern apartment located in the best area of Santa Cruz. Just a few steps away from the city's best restaurants, pharmacies, supermarkets, cafes, nightclubs, and shopping malls. Ideal for families, a group of friends, or two couples. You can have all the comforts of a luxury apartment for a cozy and pleasant stay. The building's common areas are a dream!

LocationFamilyNearby

Guest favorite
A comfortable living area features light-colored furniture, including two sofas and a round wooden table. A large window provides ample natural light and views of the city. A wall-mounted television and a decorative plant add to the inviting ambiance.
Condo in Centro
4.86 out of 5 average rating, 43 reviews

Amazing views in the Cristo area | 12th floor

Amazing views and an unbeatable location is what best defines this beautiful apartment with everything you need to spend the best vacation. Located just 5 minutes from the Equipetrol area and downtown. A few meters away you can find a supermarket, restaurants and cafes such as Starbucks, Burger King, KFC, Flo Backery, Pollos Sacura and you can enjoy a walk along the main avenue Monseñor Rivero. You can use the pool and free parking.

LocationFamilySleep quality

Top guest favorite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 32 reviews

Equipetrol, Fantastic 2 Bedroom Apartment

Enjoy luxury and comfort with your family in the best area of Santa Cruz, Equipetrol! Welcome to the exclusive ARA Tower, where modern design merges with functionality in this stylish 2 bedroom apartment fully equipped, for your comfort. We also offer: infinity pool, lounge, rooftop barbecue and 24/7 security. You'll be steps away from the best restaurants, cafes, and nightlife. Book now and have an unforgettable experience!

LocationFamilyAmenities

Guest favorite
Apartment in Santa Cruz de la Sierra
4.93 out of 5 average rating, 30 reviews

POX: Green Tower 16th floor | Luxury and elegance - 2H

Live the POX experience! We present our largest apartment in the iconic Green Tower, the most exclusive and luxurious building in Santa Cruz. A fully equipped apartment for you to live a unique experience with your family or friends. Be dazzled by the best view of the city, 24/7 service and close to banks, restaurants, shopping malls, everything you need meters away. We'll make sure you have a great stay, welcome to POX!

LocationIndoor spacesCheck-in

Guest favorite
Apartment in Santa Cruz de la Sierra
4.94 out of 5 average rating, 17 reviews

The best view of Santa Cruz

From this apartment in the best area of Santa Cruz (Equipetrol Norte, in the business center) you will have the best apartment with a pleasant climate. It is located on the 16th floor, unsurpassed views and sunsets. The whole group will enjoy easy access to supermarkets, restaurants, pharmacies, banks, transportation, paddle courts, etc. The Ventura mall is steps away from the apartment.

LocationWalkabilityHot tub

Popular amenities for Santa Cruz vacation rentals