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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 7 reviews

Skyline Luxury • Rooftop, Piscina, Billar & Lounge

Designed for discerning guests seeking an experience superior to a 5-star hotel. Located in Equipetrol, the most exclusive and secure area of Santa Cruz, this elegant apartment on the second-to-last floor offers a double balcony with unique views! Premium amenities such as a sky pool, lounge, pool table, barbecue grills, fully equipped gym, and more! Surrounded by the best restaurants, bars, cafes, theaters, shops and business centers. Ideal for executive trips, luxury getaways or unforgettable stays.

Superhost
A modern outdoor pathway is flanked by sleek buildings and lush greenery. Soft, natural light filters through the space, illuminating the smooth stone finish of the walkway. Curved steps lead up to elevated garden areas, creating a harmonious blend of nature and architecture.
Apartment in Santa Cruz de la Sierra
4.89 out of 5 average rating, 72 reviews

Luxury 18th-Floor Apt | City View, Pools & Netflix

Enjoy a comfortable and stylish stay in this modern 18th-floor apartment with panoramic city views in Santa Cruz. Ideal for families, business travelers, and groups, the apartment offers space, privacy, fast Wi-Fi, and resort-style amenities, all within a secure high-rise building. For security purposes, there is a Ring doorbell camera located outside the apartment entrance, facing the exterior hallway. There are no cameras inside the apartment. there is security on duty 24x7 4th bed inflatable

Guest favorite
A modern living room features a blue sofa adorned with decorative cushions. A large TV is mounted on a sleek white unit, complemented by a decorative mirror and a stylish round coffee table. Elegant lighting fixtures and patterned wallpaper enhance the inviting ambiance.
Apartment in Santa Cruz de la Sierra
4.96 out of 5 average rating, 26 reviews

Luxurious apartment in the best area of the complex. 1 Bedroom and Parking

Relax in this quiet and elegant space in the best area of Santa Cruz, a place where you can get to know the charms of the city, such as gastronomy, nightlife, bars, business center, cafe, supermarkets, mall ventura, mazano 40, Green Tower, everything close. Enjoy the smart apartment with ALEXA technology, with voice command to turn lights and air on and off. You will be delighted with its social areas with a unique view of the city, where you and your family will not want to leave.

Guest favorite
Apartment in Santa Cruz de la Sierra
4.93 out of 5 average rating, 14 reviews

Sophisticated 2 Bedroom Absolute Luxury

Experience absolute luxury and superior sophistication. This exclusive 2-bedroom apartment redefines the concept of comfort in Equipetrol, the most prestigious area of SCZ. Each space has been carefully designed with elegant furnishings and a refined aesthetic that conveys distinction in every detail. Exclusive social areas: 🏊 Pool 💪 GYM 🎯 Playroom 🌇 Viewpoint with panoramic view Ideal for those looking for elegance and a superior experience in the best area of the city.

Guest favorite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Apartment in Santa Cruz de la Sierra
4.92 out of 5 average rating, 79 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Top guest favorite
A well-appointed living space features a modern kitchen with wooden cabinetry and stainless steel appliances, including a refrigerator. A cozy seating area with a light gray sofa is arranged beside a spacious bed, while natural light filters through large windows.
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 64 reviews

Smart Studio in Equipetrol

Welcome to this great Smart Apartment in the best residential and business area of Equipetrol. You're half a block from Av. San Martin and a short walk from restaurants, shops, bars, and more. The apartment is fully furnished with everything you need for a comfortable stay, including a fully equipped kitchen, air conditioning, Wi-Fi, and a large flat-screen TV. It has a swimming pool, barbecue, co-work rooms and washing machines on the terrace and common areas

Top guest favorite
A spacious bed is positioned against a large window, offering a view of the cityscape. Soft pillows and a neatly arranged blanket enhance the comfort of the sleeping area. A small rug lies on the floor, complementing the modern decor.
Apartment in Santa Cruz de la Sierra
4.89 out of 5 average rating, 151 reviews

Cómodo/moderno monoambiente hermosa vista 300Mbps

Bienvenidos a la zona más activa de Santa Cruz! El precio ya incluye todas las comisiones no pagarás nada adicional en la app. El apartamento es un monoambiente totalmente equipado, moderno y cómodo. Cuenta con una cama de 2 plazas y un sofá cama además del baño privado, lavadora/secadora, cocina y todos los electrodomésticos necesarios. Internet Wi-Fi, tv cable y NETFLIX. Cerca de supermercados, los mejores restaurantes de la ciudad y malls.

Top guest favorite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 135 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Guest favorite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 9 reviews

Aurora: Eco-Sustainable and Bohemian Apartment

Let yourself be captivated by a space that combines sustainability, comfort and a prime location. This exclusive apartment was designed to offer you an experience of rest and style, in a self-sustaining building with an innovative design. Ideal for those looking to disconnect and be at peace without moving away from the best of the city. Every detail has been carefully chosen to make you feel at home from the moment you arrive.

Top guest favorite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 31 reviews

Equipetrol, Fantastic 2 Bedroom Apartment

Enjoy luxury and comfort with your family in the best area of Santa Cruz, Equipetrol! Welcome to the exclusive ARA Tower, where modern design merges with functionality in this stylish 2 bedroom apartment fully equipped, for your comfort. We also offer: infinity pool, lounge, rooftop barbecue and 24/7 security. You'll be steps away from the best restaurants, cafes, and nightlife. Book now and have an unforgettable experience!

Guest favorite
Apartment in Santa Cruz de la Sierra
4.92 out of 5 average rating, 26 reviews

POX: Green Tower 16th floor | Luxury and elegance - 2H

Live the POX experience! We present our largest apartment in the iconic Green Tower, the most exclusive and luxurious building in Santa Cruz. A fully equipped apartment for you to live a unique experience with your family or friends. Be dazzled by the best view of the city, 24/7 service and close to banks, restaurants, shopping malls, everything you need meters away. We'll make sure you have a great stay, welcome to POX!

Guest favorite
Apartment in Santa Cruz de la Sierra
4.94 out of 5 average rating, 17 reviews

The best view of Santa Cruz

From this apartment in the best area of Santa Cruz (Equipetrol Norte, in the business center) you will have the best apartment with a pleasant climate. It is located on the 16th floor, unsurpassed views and sunsets. The whole group will enjoy easy access to supermarkets, restaurants, pharmacies, banks, transportation, paddle courts, etc. The Ventura mall is steps away from the apartment.

Popular amenities for Santa Cruz vacation rentals