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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A modern living area is furnished with a gray sofa and a brown accent chair. A wooden coffee table sits on a textured rug in front of the sofa. Natural light floods in through large windows, illuminating the open layout that connects to an equipped kitchen.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 49 reviews

Luxury and comfort in every detail

This apartment combines luxury, style, and comfort in every detail. Designed as a boutique hotel, it offers a unique experience with impeccable finishes, an equipped kitchen, a cozy living room, spacious bedrooms, and a beautiful balcony to relax. Located in the heart of Equipetrol and a short walk from restaurants, shops and attractions. Perfect for business trips or relaxation, this modern and elegant space is ideal for relaxing and enjoying an unforgettable stay. You'll love it! Parking is included!

Top guest favorite
Condo in Santa Cruz de la Sierra
5 out of 5 average rating, 31 reviews

Luxury, comfort, ideal location

Bienvenidos a la mejor ubicación de Santa Cruz! En el corazón del centro empresarial, pero en una calle tranquila. Supermercados y mucho más a la vuelta de la esquina. A pocos pasos encontrarás decenas de restaurantes increíbles: parrillada, comida japonesa, italiana o americana. Comida rápida o cenas elegantes. Manzana 40 está a 10 minutos a pie. Ventura Mall está a solo 5 min en auto. Ya sea para trabajo o diversión, este es el lugar ideal! El edificio cuenta con personal de seguridad 24/7.

Guest favorite
A modern living area is displayed, featuring a comfortable sofa and a green accent pouf. A dining table is situated nearby. Floor-to-ceiling windows offer a view of the greenery outside, allowing natural light to fill the space. The kitchen is equipped with sleek appliances.
Apartment in Santa Cruz de la Sierra
4.91 out of 5 average rating, 151 reviews

Studio 518 - Luxury near Everything

Acceso automático, 2 Aires Acondicionados, Lavadora, Cocina, Sofa y TV perfecto para trabajar todo el día con una vista verde de un 8 piso desde el barrio más cotizado de la ciudad, Equipetrol. Si te aburres puedes usar la piscina sin costo, áreas sociales, asado BBQ. Si te aburres más estarás a 2 minutos de Supermercados, Farmacias a cuadras de la principal de Equipetrol con Restaurantes renombrados, a 5 min de la Plaza Central o a 5 min del shopping más grande de Bolivia, Ventura Mall.

Top guest favorite
An expansive rooftop pool is illuminated by soft lighting, reflecting the city skyline at night. Lounge chairs are neatly arranged along the pool's edge, and the sleek wooden deck complements the modern aesthetic of the space.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 152 reviews

Luxurious and modern apartment. Equipetrol Sky Elite

This luxurious studio is located in the Equipetrol neighborhood, Sky Elite Building, one block from the Los Tajibos Hotel; it represents the perfect combination of exclusivity and first-class amenities in the city of Santa Cruz de la Sierra, surrounded by restaurants, shops, cafes, pharmacies and supermarkets. The building offers more than 3,000 square meters of social areas including a modern gym, extensive swimming pool, barbecue, coworking, private movie theater, sauna and whirlpool.

Top guest favorite
An inviting pool area is surrounded by modern buildings, featuring lounge chairs arranged neatly along the water's edge. The pool's surface reflects the colorful lights of the surrounding structures and the evening sky, creating a tranquil atmosphere.
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 51 reviews

Green Tower 26th Floor, Luxury, Panoramic Views

Enjoy your stay in the most spacious, roomy, and tallest Airbnb in Santa Cruz, where everything is close by and in the best building in the city. On the premises, you can enjoy a swimming pool, a steam sauna, and spectacular views from the 26th floor of the beautiful Manzana 40 building and the iconic Pirai River. Steps from supermarket, restaurants, malls, banks, spa, etc. The beautiful and luxurious restaurants Cielo Sky Bar (rooftop), Jardin de Asia and more are in the same building.

Guest favorite
An outdoor terrace is showcased, featuring a dining table surrounded by wooden chairs. A sleek kitchen area with a dark countertop is positioned nearby, while panoramic city views are framed by glass railings. Soft lighting enhances the space as the sunset casts a warm glow.
Apartment in Santa Cruz de la Sierra
4.94 out of 5 average rating, 68 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Top guest favorite
An infinity pool is positioned on a rooftop terrace, featuring clear water that blends with the horizon. Surrounding glass railings provide unobstructed views of the city skyline, showcasing buildings and greenery. A spacious wooden deck complements the tranquil setting.
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 55 reviews

Smart Studio in Equipetrol

Welcome to this great Smart Apartment in the best residential and business area of Equipetrol. You're half a block from Av. San Martin and a short walk from restaurants, shops, bars, and more. The apartment is fully furnished with everything you need for a comfortable stay, including a fully equipped kitchen, air conditioning, Wi-Fi, and a large flat-screen TV. It has a swimming pool, barbecue, co-work rooms and washing machines on the terrace and common areas

Guest favorite
An open-plan layout showcases a well-equipped kitchen to the left with a black countertop and modern appliances. The living area features a cozy bed and a dining table set for two, with natural light streaming through a large window, creating an inviting atmosphere.
Condo in Santa Cruz de la Sierra
4.86 out of 5 average rating, 284 reviews

Quiet Monoenvironment in Equipetrol

Enjoy the simplicity of this quiet studio in the heart of Equipetrol, where you can be close to restaurants, supermarkets, squares, churches, the business center if you come for work in the same way. In your leisure time, the studio has Wify, TV, Netflix, kitchen, microwave, oven, refrigerator and everything you need to be comfortable inside the building, since in the social areas you can enjoy the pool, churrasqueras, game room and coWork

Top guest favorite
A spacious bedroom features a large window offering panoramic views of the cityscape, complemented by warm natural light. A cozy bed is adorned with neutral linens, and a bedside lamp provides soft illumination. Simple wall decor adds a touch of elegance.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 132 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Guest favorite
Apartment in Santa Cruz de la Sierra
4.95 out of 5 average rating, 19 reviews

Luxury 1-bedroom apartment, equipped and close to everything.

Discover a luxury retreat in a quiet residential area. This 1-bedroom apartment offers a contemporary design and spaciousness that is noticeable in every detail: bright spaces, fully equipped kitchen. A place designed for your rest and comfort, with a queen bed, large closets, washing machine, TV in the living room and bedroom. Prime location near malls, restaurants, pharmacies and supermarkets. Enjoy total comfort and privacy.

Superhost
Apartment in Santa Cruz de la Sierra
4.88 out of 5 average rating, 17 reviews

POX: Green Tower 16th floor | Luxury and elegance - 2H

Live the POX experience! We present our largest apartment in the iconic Green Tower, the most exclusive and luxurious building in Santa Cruz. A fully equipped apartment for you to live a unique experience with your family or friends. Be dazzled by the best view of the city, 24/7 service and close to banks, restaurants, shopping malls, everything you need meters away. We'll make sure you have a great stay, welcome to POX!

Top guest favorite
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 31 reviews

Green Tower* 27th Floor Stunning views & Luxury

Truly the highest floor in the building, this modern luxury retreat soars above the city with breathtaking panoramic views. Sleek finishes, stylish decor, and plush comforts create a refined, high-end ambiance. Whether you’re sipping wine at sunset or waking up in the clouds, this stunning high-rise sanctuary delivers an unforgettable, elevated stay.

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Bolivia
  3. Santa Cruz