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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A bright bedroom features a spacious bed with light bedding and two decorative pillows. A sleek media unit displays a large flat-screen TV mounted on the wall. Sliding glass doors provide access to an outdoor area, allowing natural light to fill the space.
Apartment in Santa Cruz de la Sierra
4.95 out of 5 average rating, 56 reviews

Very cozy studio

This cozy space features: A queen size bed; high-speed WiFi ideal for work and fun; an equipped kitchen; a very comfortable sofa/bed; a washing machine; air conditioning; a 55" TV; a coworking room; a swimming pool, and a barbecue grill. You will be steps away from the Mall Ventura and close to popular restaurants such as “Pizza Hut” and “Starbucks”. In addition, you will have quick access to supermarkets, squares, gyms, and a variety of shopping centers. *There is an additional cost for using the grill.

Top guest favorite
A modern living area is furnished with a gray sofa and a brown accent chair. A wooden coffee table sits on a textured rug in front of the sofa. Natural light floods in through large windows, illuminating the open layout that connects to an equipped kitchen.
Apartment in Santa Cruz de la Sierra
4.96 out of 5 average rating, 24 reviews

Luxury and comfort in every detail

This apartment combines luxury, style, and comfort in every detail. Designed as a boutique hotel, it offers a unique experience with impeccable finishes, an equipped kitchen, a cozy living room, spacious bedrooms, and a beautiful balcony to relax. Located in the heart of Equipetrol and a short walk from restaurants, shops and attractions. Perfect for business trips or relaxation, this modern and elegant space is ideal for relaxing and enjoying an unforgettable stay. You'll love it! Parking is included!

Top guest favorite
The living area features a comfortable couch positioned near a large window, allowing natural light to fill the space. A flat-screen television is mounted on a wood-paneled wall, and a small round table is visible nearby. The view showcases the city skyline and nearby greenery.
Condo in Santa Cruz de la Sierra
5 out of 5 average rating, 17 reviews

Luxury, comfort, ideal location

Bienvenidos a la mejor ubicación de Santa Cruz! En el corazón del centro empresarial, pero en una calle tranquila. Supermercados y mucho más a la vuelta de la esquina. A pocos pasos encontrarás decenas de restaurantes increíbles: parrillada, comida japonesa, italiana o americana. Comida rápida o cenas elegantes. Manzana 40 está a 10 minutos a pie. Ventura Mall está a solo 5 min en auto. Ya sea para trabajo o diversión, este es el lugar ideal! El edificio cuenta con personal de seguridad 24/7.

Guest favorite
A modern studio design features a spacious bed complemented by a geometric shelving unit. Natural light enters through large windows, illuminating the warm wood accents. A dining area with colorful chairs and a work desk is visible in the background, enhancing the multifunctional layout.
Apartment in Santa Cruz de la Sierra
4.86 out of 5 average rating, 136 reviews

25% off NOW! Don't pay more than you have to.

Preparado para estar en la mejor zona de Santa Cruz? Este Studio es moderno con una vista hermosa de la ciudad, además de tener excelentes zonas de diversión como piscina, mesa de billar e incluso su propio Beer Garden. Si lo que buscas es trabajar cuentas con una zona co-work y sala de reuniones. Si te gustaría conocer el vecindario, hay comercio y varias opciones gastronómicas en los alrededores. Si tienes hijos o tu amigo peludo, cruzando la calle cuentas con un pequeño parque.

Guest favorite
An outdoor pool area is visible, lined with loungers under a bright blue sky. The pool features inviting turquoise tiles and is surrounded by a spacious deck. Two hot tubs are positioned beside the pool, with a view of city buildings in the background.
Condo in Santa Cruz de la Sierra
4.93 out of 5 average rating, 58 reviews

Cozy&Elegant apartment Equipetrol

¡Sumérgete en una experiencia de lujo en el corazón de Equipetrol, la zona más exclusiva de Santa Cruz! Hospédate en un espectacular monoambiente que combina comodidad y el encanto de un resort de alta categoría. Disfruta de la belleza y calidez del lugar, con acceso a las mejores áreas sociales: piscina de ensueño, sauna y jacuzzi para relajarte y desconectarte. Todo está pensado para que vivas momentos inolvidables y disfrutes al máximo tu estancia en esta vibrante ciudad.

Top guest favorite
Green Tower, one of the tallest buildings in Bolivia, showcases modern architecture with its glass facade reflecting the surrounding cityscape. The image captures the building's contemporary design, set against a backdrop of Santa Cruz, featuring both urban and natural elements.
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 27 reviews

Green Tower - 26th Floor Spectacular Views

Enjoy your stay in the highest Airbnb in Santa Cruz, and in the best building in the city. In the facilities you can enjoy a pool, steam sauna, spectacular views from the 26th floor to the beautiful Manzana 40 building, the nature of the ecological cordon and the urubo. A few steps from supermarket, restaurants, mall, business center, banks, spa. The tallest and most beautiful restaurants in Santa Cruz, Cielo Skay Bar and Jardin de Asia, are in the same building.

Guest favorite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Apartment in Santa Cruz de la Sierra
4.92 out of 5 average rating, 39 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Guest favorite
A studio space is presented with a modern aesthetic. A spacious bed is complemented by a sleek couch. The kitchen area features stylish bar stools and dark cabinetry, while a large TV is positioned for easy viewing. Soft lighting enhances the overall ambiance.
Apartment in Santa Cruz de la Sierra
4.92 out of 5 average rating, 96 reviews

Experience luxury and comfort

You'll wake up in a fully-equipped studio that combines home comfort and hotel opulence. You'll enter a sophisticated lifestyle; every detail has been carefully designed to meet high expectations. You'll have all the amenities. Relax? Dive into the pool. Exercise? There's a gym! Work? You can continue your routine in the multiple social areas that offer the perfect setting.Have fun? You can play pool and use the common room. Book and discover this Studio!

Top guest favorite
A modern living area features a comfortable sofa adorned with decorative pillows, alongside a sleek TV unit. Large windows offer panoramic city views, while two round mirrors enhance the brightness of the space. A small chair and indoor plant add a touch of decor.
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 44 reviews

Modern Apt WiFi, AC, Kitchen, Pool, Washer, Parkng

✨ A space designed for your comfort and relaxation. Located in a safe and quiet area, this modern apartment combines style, convenience, and technology to offer you a unique experience. Perfect for business travelers, couples, or small families, this accommodation features high-speed WiFi, air conditioning, and premium entertainment, along with access to a pool, gym, and free parking. 📌 Enjoy an unforgettable stay with all the amenities you deserve!

Top guest favorite
An outdoor terrace features sleek wooden decking, complemented by low seating arrangements and lush greenery. A tranquil water feature runs along one side, reflecting the surrounding cityscape. Modern buildings rise in the background under a clear, blue sky.
Apartment in Santa Cruz de la Sierra
4.97 out of 5 average rating, 39 reviews

Elegante departamento familiar en Equipetrol

Have fun with the family in this new, central, and stylish accommodation. Beautiful and modern apartment located in the best area of Santa Cruz. Just a few steps away from the city's best restaurants, pharmacies, supermarkets, cafes, nightclubs, and shopping malls. Ideal for families, a group of friends, or two couples. You can have all the comforts of a luxury apartment for a cozy and pleasant stay. The building's common areas are a dream!

Guest favorite
A tranquil studio space features a spacious bed dressed with light linens and decorative pillows. A cozy seating area includes a dark grey sofa and a round wooden coffee table. Natural light streams through a large window draped with light curtains, highlighting a wall accentuated with soft textures.
Condo in Santa Cruz de la Sierra
4.88 out of 5 average rating, 229 reviews

Quiet Monoenvironment in Equipetrol

Enjoy the simplicity of this quiet studio in the heart of Equipetrol, where you can be close to restaurants, supermarkets, squares, churches, the business center if you come for work in the same way. In your leisure time, the studio has Wify, TV, Netflix, kitchen, microwave, oven, refrigerator and everything you need to be comfortable inside the building, since in the social areas you can enjoy the pool, churrasqueras, game room and coWork

Guest favorite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Apartment in Santa Cruz de la Sierra
4.97 out of 5 average rating, 112 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Bolivia
  3. Santa Cruz