Some info has been automatically translated. Show original language

Vacation rentals in Santiago

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.71 out of 5 average rating, 52 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Home in Santiago
5 out of 5 average rating, 3 reviews

Casa Valle de Barbarena

Excelente ubicación cerca del centro a tan solo 2 kilómetros un lugar tranquilo. Cerca del mall Casa de dos cuartos y dos camas Doble un sofá cama Espacio de Lavandería o depósito de almacenamiento Nice location near the city 2 km Away from the center of Santiago close to the mall It has 2 rooms each with a doble bed and a sofa bed in the living room Laundry room with nice space to bring in your bike or any thing that you will like to store inside the house.

Home in Santiago
4.83 out of 5 average rating, 24 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Home in El Espino de Santa Rosa
4.63 out of 5 average rating, 8 reviews

Cozy Home El Espino | Pool and Family Atmosphere

Take the whole family to this fantastic place with spaces to rest and enjoy. Cozy Home in El Espino is inside a private residential complex with a security booth: safe, quiet and family atmosphere, surrounded by nature. Enjoy the social area with a terrace and a 3-level pool. A few meters from the Interamericana. The house has 3 bedrooms (2 with A/C) and 2 bathrooms; one with hot water. Fully equipped kitchen. Rate for 4 (max. $15/person extra) 6) Pets for a fee.

Guest favorite
Home in Canto del Llano
4.89 out of 5 average rating, 35 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Guest favorite
Apartment in Santiago
4.91 out of 5 average rating, 11 reviews

Comfortable and safe apartment in downtown Santiago

Family apartment in downtown Santiago — comfortable, safe and fully equipped Enjoy a prime location in the heart of Santiago de Veraguas, a short walk from the cathedral, municipal park, and main avenue. Everything you need is within walking distance: supermarkets, pharmacies, banks, shops, restaurants and transportation. Ideal for families, professionals, business travelers, or people visiting the city for paperwork or events.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Apartment in Santiago
5 out of 5 average rating, 5 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A cozy corner of the apartment features a deep-colored sofa paired with a wooden table and two modern chairs. Natural light enters through two windows adorned with light curtains, while a small plant adds a touch of greenery to the space.
Condo in Veraguas Province
4.56 out of 5 average rating, 45 reviews

Departamento 3E - BEST place in town.

Departamento accesible en el centro de Santiago, ubicado a 300m de la terminal de Transporte y a poca distancia de supermercados y negocios. Con buena distribución del espacio, frescos e iluminados y con todos los servicios básicos. Los apartamentos brindan un balance armonioso en medio del va y ven característico del centro, perfecto para estadías de amigos, profesionales, parejas y familia.

A small dining area is featured with a round table and two folding chairs. Large windows offer views of lush greenery outside, while sheer white curtains partially filter natural light.
Apartment in Santiago
4.75 out of 5 average rating, 12 reviews

d'rosas apartments 3PB

Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from the city center, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

Guest favorite
A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.82 out of 5 average rating, 22 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

A vibrant bougainvillea tree is seen in full bloom, displaying clusters of bright pink flowers against a clear blue sky. Below, two metal chairs are positioned on a paved area, surrounded by greenery, inviting relaxation in the outdoor space.
Cottage in El Cristo
4.83 out of 5 average rating, 23 reviews

Doña Z. a place to relax

Rustic house with a zinc roof, blinds, a large living room and kitchen, plus a charcoal kitchen outside, a large patio with trees, and areas for outdoor recreation, and ample space for camping

Guest favorite
A two-story cabin is surrounded by greenery, featuring a light blue exterior. A staircase leads to the upper level, with several windows allowing natural light inside. A black dog sits on a grass-covered area nearby, contributing to the serene outdoor setting.
Cabin in La Mesa District
5 out of 5 average rating, 5 reviews

Adulam Cabin

Relax in this unique and quiet cabin getaway. The place is known for a refreshing breeze that is present every day.

Popular amenities for Santiago vacation rentals

Frequently Asked Questions

  • Are there family-friendly vacation rentals in Santiago?

    Santiago has more than 20 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • How much does it cost to stay in house rentals in Santiago?

    Experience the best of Santiago with our house rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Santiago?

    Four-legged friends are welcome in Santiago. Choose from more than 30 vacation rentals for guests traveling with pets.

  • Are there vacation rentals with a dedicated workspace in Santiago?

    Yes! Work meets play with ease at over 20 vacation rentals in Santiago featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do house rentals in Santiago have air conditioning?

    Absolutely! We offer over 20 house rentals with air conditioning in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santiago have a kitchen?

    Absolutely! We offer over 20 house rentals with a kitchen in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santiago have wifi?

    Absolutely! We offer over 20 house rentals with wifi in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santiago have free parking?

    Absolutely! We offer over 20 house rentals with free parking in Santiago. Enjoy a tailored experience with all the comforts you desire.

Quick stats about vacation rentals in Santiago

  • Total vacation rentals

    Explore 60 vacation rentals in Santiago

  • Nightly prices starting at

    Santiago vacation rentals start at ﺩ.ﺇ37 per night before taxes and fees

  • Verified guest reviews

    Over 600 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    40 of Santiago vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santiago rentals

  • 4.7 Average rating

    Santiago stays receive an average rating of 4.7 out of 5 from guests

  1. Airbnb
  2. Panama
  3. Veraguas Province
  4. Santiago
  5. Santiago