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Vacation rentals in Santiago

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Top-rated vacation rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness, and more.

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A wide pathway is framed by lush greenery and palm trees, leading towards a red-roofed structure in the background. Sunlight filters through the leaves, casting gentle shadows on the ground. The serene environment highlights the natural beauty of the countryside surrounding the property.

Home in Playa El Agallito

5 out of 5 average rating, 10 reviews

El Refugio: Nature Escape in Chitre

KarlaRating, 5 stars1 month ago

The place is very comfortably and feels safe and cozy. The little details on the house decor and the Rosquitas where a very nice surprise! This house is perfect for large families with easy access and good location 15 minutes away from Chitre downtown.

A spacious lounge area features large glass windows that frame lush greenery outside. Two wooden chairs are positioned on a wooden deck beside a tranquil pool, allowing for relaxation while surrounded by nature. Neutral tones are complemented by natural wood elements throughout the space.

Earthen home in El Cope, Penonome

4.92 out of 5 average rating, 174 reviews

Beautiful Eco House in Panama

ReneeRating, 5 stars2 weeks ago

We had an amazing time at Priscilla’s home. The house itself is absolutely stunning and the views breathtaking. Definitely would recommend this home to anyone looking to relax and unwind in nature. We enjoyed exploring the trails and swimming in the river on the property. The caretaker Miguel was very friendly, made sure to clean the pool every day and prepared a bonfire for us one evening. Our Host also helped us arrange chef services for my boyfriend’s birthday and she made it super easy. We loved the chef and meal he prepared. Overall, fantastic home and we would definitely return!

A covered patio area is shown, featuring wooden furnishings, including a large table. Lush greenery surrounds the space, with various plants and trees providing a natural backdrop. The sunlight casts gentle shadows on the surface, creating a serene outdoor atmosphere.

4.88 out of 5 average rating, 58 reviews

Country House Like in the City / La Casita

GuillermoRating, 5 stars2 days ago

An unbeatable experience! This beautiful house in Chitré is the perfect place to rest and disconnect. The tranquility, privacy and security of the environment are exceptional. Every night we enjoyed sitting in the doorway, talking under a clear sky and in absolute silence, something that feels increasingly rare to find. The attention of the hosts was impeccable: always attentive, friendly and willing to make sure everything was perfect. It felt like being at home. We hope to be back soon!

A tranquil pool with clear turquoise water reflects the surrounding greenery. Lush palm trees frame the view, with distant mountains visible under a bright blue sky. The setting offers a serene atmosphere, inviting relaxation amidst nature.

Villa in Santa Fe

4.97 out of 5 average rating, 35 reviews

Mountain Vista Villa - The Juniper

AnaluzRating, 5 stars1 week ago

The place is a bit far, but it's very beautiful and super peaceful. Communication with Joshua was great, and Juana was very kind and helpful. The space is small but cozy and has everything you need for a relaxing family getaway. Would definitely recommend!

Top guest favorite

A bamboo tiki bar is featured under a thatched roof, showcasing a large wooden counter with colorful cups. A decorative stone basin is positioned in front, accompanied by a unique water fountain made from polished metal, creating a relaxing atmosphere.

Townhouse in Santa Catalina

4.9 out of 5 average rating, 51 reviews

Lago Bay House - Option to Fly - Tour Coiba

MartinRating, 5 stars1 month ago

My stay at Lake Bay was perfect from start to finish. The location is excellent, the place was spotlessly clean and well-equipped with everything you need for a comfortable stay. Brett was very kind and attentive, always available to answer any questions and give recommendations. The photos reflect exactly what the space offers, and it even exceeded my expectations. I would definitely stay here again in the future. Totally recommended!

A contemporary villa nestled among vibrant greenery features large panoramic windows on the left side, offering views of the surrounding landscape. The building is complemented by a spacious outdoor area with stone pathways and natural vegetation, enhancing the connection with the environment.

Farm stay in Santa Fe

4.9 out of 5 average rating, 286 reviews

Santa Fe villa with a espectacular view

walkyria Rating, 5 stars2 weeks ago

I already want to come back and for more days. The blitz experience gue wonderful. It is a beautiful place, quiet, very natural and easy to access. Adventures don't end at Finca Villa del Sol. I'm happy and excited about going back. Marcela, the host, was always very friendly and attentive, pleasant and happy. Thank you Marcela and family blessings!

Vacation rentals for every style

Get the amount of space that is right for you

Hotels

Stylish accommodations and amenities

Unique stays

Spaces that are more than just a place to sleep

Homes

Comfortable places with all the essentials

Popular amenities for Santiago vacation rentals

Free parking on premises

Air conditioning

Other great vacation rentals in Santiago

4.73 out of 5 average rating, 30 reviews

Beautiful House in Chitre with Pool

GabrielaRating, 5 stars3 days ago

Excellent stay! The house is the same as in the photos, very spacious and comfortable. We really enjoyed it.

An arched entryway framed by a stone wall leads into a spacious outdoor seating area. The flooring features terracotta tiles, and lush greenery is visible through the opening, inviting a sense of connection with the natural surroundings.

Cottage in La Pintada

4.67 out of 5 average rating, 3 reviews

Enchanting Riverfront Villa in a Secluded Oasis

BradRating, 5 stars1 week ago

This is truly a country gem secluded behind a nursery and surrounded by nature. Well manicured grounds and a creek at the rear of the property with a cool little tree lined trail. We played outside and enjoyed the outdoor terrace with hammocks and plenty of outdoor seating. If your looking for a few days to unwind this is a must visit

A spacious outdoor area features tiled flooring and multiple ceiling fans to enhance airflow. Several wrought-iron tables and chairs provide seating, while a swing and grill enhance the space's functionality. Large screens surround the area, offering a glimpse of the lush greenery outside.

Home in Chupampa

5 out of 5 average rating, 4 reviews

Cozy house in Chupampa via Ocú

KarimaRating, 5 stars1 month ago

This is my second time and it was also a super experience. Ariadna's house is fully recommended.

An open living area is presented, featuring a dining table set for six and a comfortable seating arrangement with green chairs. A doorway leads to another room, while natural light filters in through large windows, highlighting the space's neat arrangement.

4.5 out of 5 average rating, 14 reviews

Brisas de los Guayacanes, house 253

DemetraRating, 5 stars19 months ago

Hercilia was a great host! The house is a good place to have a getaway weekend with friends, as we did. Close to the terminal bus station and easy to find! What we appreciated the most was her proactive response and prompt service when we needed help with the air conditioning. She was available to help us by sending a technician, so we really felt she was putting a great effort into making our stay comfortable! ¡Gracias Hercilia!

A modern house with a light exterior is shown, featuring a porch with two black chairs and a small table. A neat pathway leads to the entrance, flanked by landscaped greenery. Large windows allow ample natural light into the space, enhancing the inviting facade.

4.8 out of 5 average rating, 5 reviews

Santa Clara

PaulRating, 5 stars1 week ago

A very cozy place, everything is well organized and Victor is a great guy, always attentive to what you need. We will always keep it in mind for when we travel again

A serene pool area features a spacious swimming pool alongside a relaxing hot tub, both surrounded by lush greenery. Sun loungers are positioned for comfort. The setting is sunny, with a clear sky and distant trees enhancing the tranquil atmosphere.

Bungalow in Panamá

4.98 out of 5 average rating, 44 reviews

The Breeze House

JavierRating, 5 stars19 months ago

On behalf of my family and my own, I want to thank you for allowing me to stay in your beautiful home. Everything is very beautiful, quiet, reserved, the lovely breeze, everything is very beautiful, and tidy. It doesn't cause you to leave there. Thank you again for staying. And I would always do it again. I recommend to people looking for family union, peace , working on the laptop, tranquility, and healthy La Casa de la Brisa is ideal. They will fall in love as we have my beloved family.

A spacious ranch area is shaded by a thatched roof, featuring wooden tables and benches. The view includes a sparkling swimming pool and landscaped greenery, with a relaxing hammock in the background. The flooring is marked with stone tiles, creating a cozy gathering space.

Villa in Rio Grande

4.93 out of 5 average rating, 71 reviews

Cheerful 3 bedroom countryside Villa with pool.

KeilaRating, 5 stars1 month ago

We loved this place, super quiet, spacious, fresh breeze, Mr. Marcos very attentive at all times, helpful, the house had everything we needed for our stay, and if we needed something Mr. Marcos I'll guide us to find it. WE'LL BE BACK.

The exterior showcases a charming single-story house with a welcoming porch. Greenery in decorative pots complements the manicured lawn, and string lights are draped for evening ambiance. The roof features terracotta tiles, and large windows allow natural light to fill the interior.

Home in Monagrillo

5 out of 5 average rating, 4 reviews

Wonderful Residence in Chitré

AlvaroRating, 5 stars1 week ago

Good location, good host, everything tidy and very clean

Quick stats about vacation rentals in Santiago

Total rentals
60 properties
Nightly prices starting at
ﺩ.ﺇ37 before taxes and fees
Total number of reviews
460 reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
30 properties allow pets
Rentals with dedicated workspaces
20 properties have a dedicated workspace

Frequently Asked Questions

Are there vacation rentals with a dedicated workspace in Santiago?
Yes! Work meets play with ease at over 20 vacation rentals in Santiago featuring dedicated workspaces. Stay connected and productive in your home away from home.
Do apartment rentals in Santiago have air conditioning?
Absolutely! We offer over 10 apartment rentals with air conditioning in Santiago. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly vacation rentals in Santiago?
Santiago has more than 10 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.
What are the most popular amenities for House Rentals in Santiago?
Enhance your stay in our House Rentals with the most popular amenities: over 10 homes with wifi, over 20 homes with air conditioning, over 20 homes with a kitchen, over 20 homes with free parking, and more. Indulge in the ultimate retreat, tailored to your preferences.
Do apartment rentals in Santiago have wifi?
Absolutely! We offer over 10 apartment rentals with wifi in Santiago. Enjoy a tailored experience with all the comforts you desire.
Are there pet-friendly vacation rentals in Santiago?
Four-legged friends are welcome in Santiago. Choose from more than 30 vacation rentals for guests traveling with pets.
How much does it cost to stay in house rentals in Santiago?
Experience the best of Santiago with our house rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Do house rentals in Santiago have a kitchen?
Absolutely! We offer over 20 house rentals with a kitchen in Santiago. Enjoy a tailored experience with all the comforts you desire.

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