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Vacation rentals in Santiago

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Top-rated vacation rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness, and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.71 out of 5 average rating, 52 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

A spacious living area features large windows that provide panoramic views of the surrounding mountains and forest. Comfortable seating is arranged around a coffee table, and a television is mounted on the wall. A staircase leads to the upper level.
Cabin in Chepo
4.5 out of 5 average rating, 6 reviews

Cabin at El Montuoso Reserve.

Escape into serenity with your loved ones or enjoy a romantic retreat for two at Arrues Mountain Retreat, nestled in the picturesque Chepo Las Minas region of Panama, specifically in the heart of La Reserva Forestal El Montuoso. Here, tranquility is not just a promise but an immersive experience. Surrounded by the pristine beauty of Montuoso's nature, the climate is temperate, creating the perfect backdrop for a peaceful getaway with an awe-inspiring panorama of the majestic mountains.

Home in Santiago
New place to stay

Casa Valle de Barbarena

Excelente ubicación cerca del centro a tan solo 2 kilómetros un lugar tranquilo. Cerca del mall Casa de dos cuartos y dos camas Doble un sofá cama Espacio de Lavandería o depósito de almacenamiento Nice location near the city 2 km Away from the center of Santiago close to the mall It has 2 rooms each with a doble bed and a sofa bed in the living room Laundry room with nice space to bring in your bike or any thing that you will like to store inside the house.

Superhost
Home in Santiago
4.83 out of 5 average rating, 24 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Home in El Espino de Santa Rosa
New place to stay

Cozy Home El Espino | Pool and Family Atmosphere

Take the whole family to this fantastic place with spaces to rest and enjoy. Cozy Home in El Espino is inside a private residential complex with a security booth: safe, quiet and family atmosphere, surrounded by nature. Enjoy the social area with a terrace and a 3-level pool. A few meters from the Interamericana. The house has 3 bedrooms (2 with A/C) and 2 bathrooms; one with hot water. Fully equipped kitchen. Rate for 4 (max. $15/person extra) 6) Pets for a fee.

Guest favorite
Home in Canto del Llano
4.88 out of 5 average rating, 32 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Guest favorite
Apartment in Santiago
4.9 out of 5 average rating, 10 reviews

Comfortable and safe apartment in downtown Santiago

Family apartment in downtown Santiago — comfortable, safe and fully equipped Enjoy a prime location in the heart of Santiago de Veraguas, a short walk from the cathedral, municipal park, and main avenue. Everything you need is within walking distance: supermarkets, pharmacies, banks, shops, restaurants and transportation. Ideal for families, professionals, business travelers, or people visiting the city for paperwork or events.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Apartment in Santiago
5 out of 5 average rating, 5 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A cozy corner of the apartment features a deep-colored sofa paired with a wooden table and two modern chairs. Natural light enters through two windows adorned with light curtains, while a small plant adds a touch of greenery to the space.
Condo in Veraguas Province
4.55 out of 5 average rating, 44 reviews

Departamento 3E - BEST place in town.

Departamento accesible en el centro de Santiago, ubicado a 300m de la terminal de Transporte y a poca distancia de supermercados y negocios. Con buena distribución del espacio, frescos e iluminados y con todos los servicios básicos. Los apartamentos brindan un balance armonioso en medio del va y ven característico del centro, perfecto para estadías de amigos, profesionales, parejas y familia.

A welcoming living area features a comfortable leather sofa and a small dining table with two chairs. Natural light fills the space from sliding glass doors that open to a balcony, enhancing the connection with the outdoors. A kitchenette and a red refrigerator are visible in the corner.
Apartment in Santiago
4.65 out of 5 average rating, 17 reviews

d'rosas apartments 5PA

Enjoy the simplicity of this quiet and central accommodation. Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

Place to stay in Las Minas
4.6 out of 5 average rating, 5 reviews

Exclusive cabin with Jacuzzi and unforgettable landscape

Escape to the tranquility of the Montuoso in Chepo de Las Minas and enjoy a unique experience in our private cabin. Perfect for a romantic getaway or a family vacation, this accommodation offers privacy, comfort and a breathtaking view of the mountains. Designed to give unforgettable moments, our cabin combines rustic charm with modern details.

Guest favorite
A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.82 out of 5 average rating, 22 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

Popular amenities for Santiago vacation rentals

  1. Airbnb
  2. Panama
  3. Veraguas Province
  4. Santiago