
Vacation rentals in Santiago
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Santiago
Guests agree: these stays are highly rated for location, cleanliness, and more.

Salamanca Loft
Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Cabin at El Montuoso Reserve.
Escape into serenity with your loved ones or enjoy a romantic retreat for two at Arrues Mountain Retreat, nestled in the picturesque Chepo Las Minas region of Panama, specifically in the heart of La Reserva Forestal El Montuoso. Here, tranquility is not just a promise but an immersive experience. Surrounded by the pristine beauty of Montuoso's nature, the climate is temperate, creating the perfect backdrop for a peaceful getaway with an awe-inspiring panorama of the majestic mountains.

Casa Valle de Barbarena
Excelente ubicación cerca del centro a tan solo 2 kilómetros un lugar tranquilo. Cerca del mall Casa de dos cuartos y dos camas Doble un sofá cama Espacio de Lavandería o depósito de almacenamiento Nice location near the city 2 km Away from the center of Santiago close to the mall It has 2 rooms each with a doble bed and a sofa bed in the living room Laundry room with nice space to bring in your bike or any thing that you will like to store inside the house.

Casa a minutos de Santiago, U Latina, HospChichoF.
Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Cozy Home El Espino | Pool and Family Atmosphere
Take the whole family to this fantastic place with spaces to rest and enjoy. Cozy Home in El Espino is inside a private residential complex with a security booth: safe, quiet and family atmosphere, surrounded by nature. Enjoy the social area with a terrace and a 3-level pool. A few meters from the Interamericana. The house has 3 bedrooms (2 with A/C) and 2 bathrooms; one with hot water. Fully equipped kitchen. Rate for 4 (max. $15/person extra) 6) Pets for a fee.

Peaceful home w/ spacious living & office area
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Comfortable and safe apartment in downtown Santiago
Family apartment in downtown Santiago — comfortable, safe and fully equipped Enjoy a prime location in the heart of Santiago de Veraguas, a short walk from the cathedral, municipal park, and main avenue. Everything you need is within walking distance: supermarkets, pharmacies, banks, shops, restaurants and transportation. Ideal for families, professionals, business travelers, or people visiting the city for paperwork or events.

Studio Hotel Gran David
This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

Departamento 3E - BEST place in town.
Departamento accesible en el centro de Santiago, ubicado a 300m de la terminal de Transporte y a poca distancia de supermercados y negocios. Con buena distribución del espacio, frescos e iluminados y con todos los servicios básicos. Los apartamentos brindan un balance armonioso en medio del va y ven característico del centro, perfecto para estadías de amigos, profesionales, parejas y familia.

d'rosas apartments 5PA
Enjoy the simplicity of this quiet and central accommodation. Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

Exclusive cabin with Jacuzzi and unforgettable landscape
Escape to the tranquility of the Montuoso in Chepo de Las Minas and enjoy a unique experience in our private cabin. Perfect for a romantic getaway or a family vacation, this accommodation offers privacy, comfort and a breathtaking view of the mountains. Designed to give unforgettable moments, our cabin combines rustic charm with modern details.

2 bedroom house in Santiago
centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.
Popular amenities for Santiago vacation rentals
Other great vacation rentals in Santiago

Comfortable rooms in Santiago

2A Apartment

Room in a cottage

d'rosas apartments 6PA

Apartment 4C

Departamento 2E - BEST place in town.

d'rosas apartments 3PB

Apartment 3B - BEST place in Town.




