Guesthouse vacation rentals in Mount Pleasant

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Top-rated guesthouse rentals in Mount Pleasant

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
The exterior of the garage apartment is presented with a light grey facade. A gabled roof enhances the structure's height. The garage door features three sections with paned windows at the top, while surrounding greenery and a simple front pathway contribute to a welcoming atmosphere.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 270 reviews

Cozy Apartment in Mount Pleasant

Our place is a cozy and bright garage apartment. It has one bedroom, living room with sleeper sofa, a full bath with tub and fully equipped kitchen. We hope this provides that home away from home feel in a relaxed, yet inviting setting. It is close to dining, the beach and a ten minute ride across the bridge to Charleston. You’ll love our place because of the coziness and the location. Our place is good for couples, solo adventurers, and business travelers. STRPermit# ST250045 SCBUSLIC#20132490

Top guest favorite
A charming guest house exterior is shown, featuring a porch with comfortable seating arrangements. Large windows allow natural light to illuminate the space. Vibrant green grass covers the ground, accented by a small hammock and lush surrounding foliage, creating a relaxing outdoor setting.
Guesthouse in Park Circle
5 out of 5 average rating, 178 reviews

5 Star Private Guest House • Heart of Park Circle

Escape to this peaceful, light-filled guest house in Park Circle, one of Charlestons most vibrant neighborhoods. Relax on the private patio or in one of the hammocks, refresh in the dual shower, and rest easy on a plush Nectar bed. Enjoy fast WiFi, off-street parking, and brand-new bikes to explore restaurants, breweries, and festivals at Riverfront Park or Firefly Distillery. Consistently rated top 1% and 5% of Airbnb’s, caring local hosts, constantly upgraded for your perfect Lowcountry stay!

Top guest favorite
A spacious bedroom features a wooden bed frame adorned with a floral-patterned comforter. Two bedside tables with lamps are positioned on either side of the bed. Bright light filters in through a window, complemented by soft neutral walls and warm wood flooring.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 153 reviews

5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!

The Treehouse is a private, cozy, modern retreat in the hippest area of Mt. Pleasant - right between downtown & the beaches for easy access to both. Located less than 5 mi. from Sullivan's Island, less than 2 mi. from the Cooper River Bridge (to downtown Charleston), and just a short walk from Shem Creek, you won't find a better place to stay in the Holy City. *Minimum age required to rent: 21 years old. Children welcome with adult accompaniment.*STR PERMIT #: ST250220 SC BUS. LIC #: 20135380

Top guest favorite
A bright and airy living area features a light blue sofa, accompanied by a small table and chair set. The fully equipped kitchen is visible in the background, showcasing modern appliances. Natural light floods the space through the windows, enhancing the inviting atmosphere.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 117 reviews

Coastal Charm: Village Hideaway

Charming two- bedroom, one bathroom cottage tucked away in a quiet neighborhood located close to both nature and local attractions. Our cottage was a thoughtfully designed space with attention to detail in every corner. We offer a fully equipped kitchen with modern appliances and a breakfast bar. PLEASE note, as a reminder to house rules: no smoking, vaping, e-cigarettes, or pets allowed in or outside of property. Owner has severe allergies. Thank you. STR Permit #: 250271 BL#: 20127320

Top guest favorite
A bright living area features a white sofa adorned with blue and white decorative pillows, alongside a leather recliner. Two woven tables sit in front of the couch on a textured rug. A flat-screen TV and kitchen are visible in the background.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 313 reviews

Upscale Couple's Escape | Beach & Downtown CHS

Perfect getaway for anyone looking to relax and enjoy the beautiful Charleston beaches. We maintain the highest standards for luxury - including curated interior design touches to make you forget reality and enjoy some much needed R&R time. The Pump House is the ideal place to escape to and enjoy the outdoors, local restaurants, breweries, parks, and, of course, beaches! Our reviews speak for themselves - Always 5 stars and many return guests! Permit #ST250099 | Business License #20122954

Top guest favorite
The exterior of the bungalow features a white-painted facade and a welcoming entrance, framed by lush landscaping with flowering shrubs. Two windows provide natural light, accompanied by a small porch covered by an awning. Nearby trees contribute to the serene atmosphere.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 560 reviews

Old Mt. Pleasant/Shem Creek close to Sullivans/DT

This 1 bed/1 bathroom bungalow sits among the Old Mt. Pleasant neighborhood off Coleman Blvd, which is only 3 mi. to Sullivans Island Beach, <1 mi. to Shem Creek! A quick ride will land you in bustling downtown Charleston. Close to the stunning Pitt St Bridge to watch the sunset. Walk popular Coleman Blvd which boasts restaurants, shops, boutiques and fitness venues alike, only 1 block away. 3 grocery stores <1 mi. Quiet, clean, and quaint! STR Permit #ST260001 MP Bus Lic #20132292

Top guest favorite
A modern two-story guest house is depicted, featuring a combination of white and light brown exteriors. A covered entryway with pergola extends over the front door. A tranquil pool is visible in the foreground, surrounded by landscaped greenery and stone paving.
Guesthouse in Mount Pleasant
4.96 out of 5 average rating, 152 reviews

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

LOCATION, LOCATION, LOCATION! Welcome to Persimmon Place, a brand new guesthouse in the heart of Old Village in Mt. Pleasant. Historic Old Village is one of Charleston's most beautiful neighborhoods, central to all Charleston has to offer. This 2BR 1 BA is the perfect spot for your Lowcountry visit. -Walk to Shem Creek with bars, restaurants, & water activities -Less than 4 miles(8 min drive)to Sullivan's Island Beach -5 miles(9 min drive)to downtown Charleston ST250213 BL20137971

Top guest favorite
A spacious bedroom features a black metal bed frame adorned with white bedding. Two stylish chairs are positioned beside large windows offering views of the surrounding landscape. A wooden dresser and a woven area rug add elements of comfort and warmth to the room.
Guesthouse in West Ashley
4.99 out of 5 average rating, 219 reviews

Large Guesthouse with Private Dock & Marsh Views

This newly built carriage house is separate from the main house. The cottage is about 1,200 sqft so it very open and spacious and great views of marsh and our tidal creek. We have a separate work area with desk and a massive dinning table if you need more room to work or to gather with friends. Full kitchen, washer and dryer, massive shower, the list goes on. You may not want to leave! Feel free to go sit and have coffee or cocktails on the dock. PERMIT# OP2024-04998

Top guest favorite
A tranquil waterfront view features a dock extending into calm waters, framed by lush greenery and trees. A hammock can be seen suspended from the dock, inviting relaxation. The sunlight glistens on the water's surface, creating a serene atmosphere.
Guesthouse in Daniel Island
4.99 out of 5 average rating, 321 reviews

Spacious Daniel Island Apartment

Fully furnished 1 bedroom (queen bed) apartment on Daniel Island. We are able to bring a single mattress out to the apartment for guests bringing a child, so the apartment can accommodate up to three (two adults and a child). Full kitchen with glass cook top, dish washer, full-sized refrigerator/freezer, toaster oven, etc. Includes linens, dishes and utensils. Washer/dryer en suite. Has Youtube TV, HBO Max, and wifi. 15 mins from airport, downtown Charleston, and beaches.

Top guest favorite
The exterior of the cottage is presented, featuring a red brick facade and a welcoming entrance with two chairs positioned on a stone pathway. Lush greenery surrounds the area, while string lights add a gentle touch of ambiance.
Guesthouse in Charleston
4.98 out of 5 average rating, 253 reviews

Cottage Under the Oaks

A lovely studio centrally located on James Island, The Cottage is about 5 miles to Folly Beach or Downtown. There are a few restaurants within walking distance, and almost everything on the island is within a few miles. *No children under 13 without prior approval.* **We do have a 30-day minimum during some dates. If you need a shorter reservation and your dates aren’t showing as available, message us and we’ll see if we can make it work.** Permit Number: OP2024-05670

Top guest favorite
A newly-built guest cottage is depicted, elevated on pilings and surrounded by lush greenery. Light-colored siding is complemented by green shutters. Steps lead up to a welcoming porch with a railing, providing access to the spacious entry and large windows that invite natural light.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 213 reviews

Stunning Couples Cottage with Creek Dock!

You will fall in love with this stunning, newly-built guest cottage nestled under the canopy of a majestic 400-year-old live oak tree! Providing ultimate comfort, convenience and serenity, this is the perfect place to launch your Charleston adventure – 10 minutes to Shem Creek, & 15 minutes to Sullivan's Island or Downtown Charleston. PLUS, come enjoy our brand new dock on the creek! A picture-perfect spot to relax and enjoy the stunning Lowcountry scenery!

Top guest favorite
A stylish living area features a green velvet sofa paired with a round wooden coffee table. Decorative items are placed atop the table, while a floor lamp provides soft lighting. Large windows allow natural light to illuminate the space, which is accented by framed artwork and a potted plant.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 118 reviews

Old Village Guesthouse walkable, close to beach/DT

Location. Location. Location! It's trite, but it's true. You’ll be minutes from downtown Charleston and the beach at Sullivan’s Island when you stay with us in the historic Old Village of Mount Pleasant. Walk to some of the town’s best restaurants and waterfront bars or seize the moment to relax in our breezy, modern guest house in one of the oldest, most beautiful neighborhoods in the country. STR permit number: ST250100 Business license number: 20122246

Popular amenities for Mount Pleasant guesthouse rentals

When is the best time to visit Mount Pleasant?

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Avg. priceﺩ.ﺇ510ﺩ.ﺇ503ﺩ.ﺇ580ﺩ.ﺇ628ﺩ.ﺇ639ﺩ.ﺇ643ﺩ.ﺇ665ﺩ.ﺇ606ﺩ.ﺇ595ﺩ.ﺇ580ﺩ.ﺇ562ﺩ.ﺇ529
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Quick stats about guesthouse rentals in Mount Pleasant

  • Total vacation rentals

    Explore 50 vacation rentals in Mount Pleasant

  • Nightly prices starting at

    Mount Pleasant vacation rentals start at ﺩ.ﺇ331 per night before taxes and fees

  • Verified guest reviews

    Over 7,080 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    50 of Mount Pleasant vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Mount Pleasant rentals

  • 5 Average rating

    Mount Pleasant stays are highly rated by guests—averaging 5 out of 5!

  • Nearby attractions

    Mount Pleasant's top spots, include Shem Creek Park, Isle of Palms Marina, and Pitt Street Bridge

Destinations to explore