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Guesthouse vacation rentals in Mount Pleasant

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Mount Pleasant guesthouse rentals

Family-friendly guest house rentals

Guest favorite
An open living space is seen with a brown leather sectional sofa adorned with colorful throw pillows. A wooden coffee table sits in front of the sofa on a blue area rug. The kitchen features white cabinetry and modern appliances, with natural light filtering through a nearby window.
Guesthouse in James Island
4.91 out of 5 average rating, 704 reviews

Island Oasis—Near Downtown

JuliaRating, 5 stars2 weeks ago
Enjoyed our stay with our dog. Would love to stay again! The distance to folly beach and downtown charleston was ideal.
Top guest favorite
A cozy living area is visible, featuring a soft beige couch and a wooden coffee table. A clear vase holds dried flowers, adding a touch of nature. In the background, modern kitchen elements, including a coffee maker and green tile backsplash, can be seen.
Guesthouse in West Ashley
4.93 out of 5 average rating, 760 reviews

Charleston's Coolest Neighborhood

ShannonRating, 5 stars5 days ago
Clean and comfortable! Shower had lots of power and ac worked great! Located in a cute area with lots of unique shopping and food options within minutes. Plus it’s a short drive to downtown Charleston which has many more options.
Top guest favorite
Two classic cars are parked in front of a detached garage, showcasing a vintage white convertible and a sleek gray vehicle. The garage features two closed doors, framed by light green siding and surrounded by trees, adding to the serene environment.
Guesthouse in Summerville
4.88 out of 5 average rating, 796 reviews

New Loft in Historic Summerville

AmyRating, 5 stars3 days ago
We loved our stay at Jacquelynn's! We had to travel with our two older, yet anxious, dogs for a wedding and it turned out to be the perfect place for us. The loft is detached from the home, making it much more private to go to and from. The place was spotless with cute decor. Even though it is a smaller space, she has everything you need to make your stay comfortable. Lots of towels and blankets as well as silverware, coffee pot, and mugs. I was pleasantly surprised at how the bathroom was actually quite spacious for the small space. The most important and best part for us was the peace and quiet. We typically have to worry about outside noise as our dogs will bark at any and every noise they hear. But the loft is nestled in such a quiet and quaint neighborhood, making it perfect for anyone with anxiety ridden dogs. I highly recommend Jacquelynn's loft!
Guest favorite
A studio apartment is shown, featuring a king bed with decorative pillows and a comfortable couch. A wooden dining table and chairs are visible, alongside a chest of drawers. Natural light enters through two windows, creating a bright and inviting space.
Guesthouse in Mount Pleasant
4.94 out of 5 average rating, 251 reviews

Green Garden Studio @greengardenstudio2017

ShawnRating, 5 stars2 weeks ago
My wife and I stayed here for a long weekend during my families wedding. Place was just what we were looking for. Would definitely stay here again if we visit Charleston again! Host was very responsive and even let me borrow their personal iron. 5 stars!!
Top guest favorite
The living area features comfortable leather seating, a wooden coffee table, and a television on a wooden console. Natural light enters through large windows, and a subtle rug adds warmth to the hardwood floor. A separate entry door leads outside.
Guesthouse in Charleston
4.99 out of 5 average rating, 293 reviews

Spacious Daniel Island Apartment

NelleRating, 5 stars2 days ago
We had a wonderful stay at David’s. The space was exactly what we were looking for - clean, quiet, and comfortable. Daniel Island is beautiful, and downtown Charleston and Mount Pleasant are both very accessible by car/Uber. David was very communicative and a great host - we would love to stay here again!
Guest favorite
A lush backyard features a wooden pergola draped with greenery, providing a shaded seating area. The well-maintained garden includes a variety of plants and flowers, enhancing the natural surroundings. The grass is neatly trimmed, offering a spacious area for relaxation.
Guesthouse in James Island
4.91 out of 5 average rating, 362 reviews

Mother in Law in James Island Riverland Terrace

BradRating, 5 stars5 days ago
Very gracious hosts and cute guest apartment convenient to Charleston. Property is beautifully landscaped and is very private and quiet. We enjoyed our stay.
Superhost
A charming yellow cottage is framed by lush greenery, with a cozy seating area featuring bright blue chairs. A colorful hammock hangs nearby, creating an inviting space for relaxation. Sliding glass doors lead into the cottage, promoting a cheerful and welcoming atmosphere.
Guesthouse in James Island
4.84 out of 5 average rating, 118 reviews

Romantic Beach Style Cottage close to everything!

NatalieRating, 5 stars2 days ago
Clean & conscious hosts! Mindful of needs that may crop up, lovely home & family. Flexible! Perfect oasis away from the bustle of Charleston.
Top guest favorite
The entryway showcases an open door revealing a private deck with two outdoor chairs, framed by lush greenery. A modern kitchen area with dark cabinetry is visible, while a welcoming rug lies at the entrance.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 133 reviews

5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!

AndrewRating, 5 stars1 week ago
Amazing treehouse in quiet and beautiful neighborhood, just wow! Short distance to shem creek that has plenty of restaurants, night life, and views. We took the bikes down a few times, only 5-10 minutes. Then you get to come home to peace and quiet. One of the most beautiful neighborhoods we have ever been in. Easy Uber into Charleston. If you want to be close to the action but not right in the middle of it, this is the place for you!

Guest house rentals with a patio

Guest favorite
Guesthouse in Harleston Village
4.95 out of 5 average rating, 38 reviews

Secret Garden Guesthouse

RachelleRating, 5 stars2 days ago
Elizabeth & Jason were wonderful hosts to my husband and myself. The accommodations were pristine and quiet. We thoroughly enjoyed the peacefulness of the backyard/patio area! The location was very centralized to the downtown area. We would highly recommend this home to our family and friends! Don & Rocky
Guest favorite
An outdoor lounge area features a spacious sectional sofa in dark upholstery, surrounding a low wooden coffee table. Potted plants add greenery around the space. A shed with blue siding and double glass doors sits in the background, framed by tall trees and a wooden fence.
Guesthouse in West Ashley
4.94 out of 5 average rating, 236 reviews

Quaint Cottage Studio in Ashley Forest (Avondale), New Zealand

JenniferRating, 5 stars1 week ago
John and his family offer a cozy place to rest after exploring the nearby neighborhoods by foot and the region by car. A comfy bed, a responsive host, a central location and great local recommendations were highlights.
Top guest favorite
Guesthouse in Summerville
4.99 out of 5 average rating, 73 reviews

Hearts & Dreams Peaceful Family Retreat w/ pool

AbigailRating, 5 stars1 week ago
Perfect spot for a family with young kids! Plenty for us to enjoy outdoors in the beautiful South Carolina weather. Hosts were very gracious!
Guest favorite
Guesthouse in West Ashley
5 out of 5 average rating, 5 reviews

Stylish Carriage House+Pool House

KylieRating, 5 stars2 weeks ago
Jessie & Robin were PHENOMENAL hosts. Our stay wasn’t long but it was peaceful, clean and just what we were looking for. The space was exactly as described. They were quick to respond and were proactive at check in and check out. Our time in Charleston was wonderful and the stay only added to that! If we find our way back to Charleston I will be booking with them again.
Guest favorite
A red efficiency building with a covered porch is surrounded by trees. Outdoor seating is arranged on the patio under the roof, complemented by potted plants. A barbecue grill is positioned nearby, providing a cozy area for sharing time outdoors.
Guesthouse in James Island
4.95 out of 5 average rating, 65 reviews

Country in the City, "The Outback"

BaileyRating, 5 stars2 days ago
Staying at the Outback was an absolute pleasure. We enjoyed the pool, Sue’s adorable pup and her kindness. She made us feel right at home and we couldn’t have asked for a better place to rest our heads. Thanks so much Sue!
Top guest favorite
A light-filled living area features a comfortable sectional sofa and a ceiling fan. Two windows provide natural light, while a TV is mounted on the wall. A decorative painting adds color above the sofa, and a woven area rug lies underfoot.
Guesthouse in Johns Island
4.97 out of 5 average rating, 115 reviews

Driftwood Cottage

MeriRating, 5 stars3 days ago
Terry made staying at the Driftwood Cottage easy. Everything was clean and comfortable. Nice placce about 25 minutes outside of Charleston. Perfect place for exploring the area. Terry introduced himself and made sure everything was ok. Then I had complete privacy. Perfect host. Would stay at again.
Guest favorite
A shaded outdoor seating area is furnished with a comfortable couch and chairs, surrounded by tropical plants. A flat-screen TV is mounted on the wall, while a dining table awaits nearby. The entrance door adds a touch of charm to the inviting space.
Guesthouse in Park Circle
4.92 out of 5 average rating, 131 reviews

My Happy Place

BridgetRating, 5 stars2 days ago
We loved our stay at the pool house! It had everything we needed and the location was great. I would highly recommend it!
Top guest favorite
Guesthouse in James Island
4.99 out of 5 average rating, 153 reviews

The James: “Tiny” Home b/w Downtown & Folly

AutumnRating, 5 stars1 week ago
where do I begin? we LOVED this place! it was so clean, the beds were comfortable, and it was in a quiet neighborhood! we met Caitlin + Spencer the first day & they were SO kind! they have gone above and beyond to the attention to detail! they left us a bottle of Prosecco for our celebratory trip, a dog treat for Luna, & the sweetest handwritten letter! everything you might need they had! we are so obsessed with this cute Airbnb & we’ll definitely stay here again next time we stay in Charleston! Luna, our golden girl, also approved! Thanks so much for the beautiful stay Caitlin and Spencer we enjoyed it so much! 🩵🐶🐚🌴

Guest house rentals with a washer and dryer

Guest favorite
The tranquil pool area is softly illuminated, showcasing a clear water surface reflecting the evening sky. Surrounding the pool, a well-maintained white fence provides privacy. Lounge chairs are positioned nearby, creating a relaxing outdoor space for guests to enjoy.
Guesthouse in James Island
4.85 out of 5 average rating, 121 reviews

CHS Guest house w/ Pool on Golf Course

KarenRating, 5 stars3 weeks ago
The home was neat & clean, conveniently located, private, and quiet. We had so much fun visiting many parts of Charleston with the guest house as our homebase. The home had everything our small family needed for our stay and more! Alicia was a gracious, respectful, and responsive host. She even brought extra supplies to us in case we needed them! We would welcome the opportunity to be a guest with her again.
Top guest favorite
A detached two-car garage is visible, featuring brown doors and white siding. Above the garage, a cozy guest house is present, capped with a pitched roof and adorned with multiple windows. Lush greenery surrounds the structure, enhancing the outdoor space.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 146 reviews

Groves Carriage House, near Shem Creek

JimiRating, 5 stars1 week ago
Wonderful, responsive hosts. This above garage unit has everything you need. The neighborhood is very accessible to anywhere you want to go. 5 minutes from Shem Creek. 15 minutes to Sullivan’s Island or Isles of Palms. Roughly 10-15 minutes from Downtown Charleston. The hosts were very helpful with any of my simple needs. I would definitely stay here again.
Top guest favorite
A serene waterfront view is presented, featuring calm waters reflecting the soft colors of sunset. Lush green grass and trees frame the scene, while a wooden pier extends into the distance. A gathering area with shelter is visible, adding to the inviting landscape.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 150 reviews

Beach, downtown, Alhambra Hall weddings so close!

ColleenRating, 5 stars2 days ago
Great spot to stay in Mt Pleasant!
Top guest favorite
The exterior of the garage apartment is presented with a light grey facade. A gabled roof enhances the structure's height. The garage door features three sections with paned windows at the top, while surrounding greenery and a simple front pathway contribute to a welcoming atmosphere.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 247 reviews

Cozy Apartment in Mount Pleasant

ElizabethRating, 5 stars3 days ago
We felt right at home from the moment we arrived. The apartment is beautifully appointed, comfortably furnished, and spotlessly clean. The kitchen had everything we needed. We appreciated the comfortable bed and how quiet the neighborhood was, while being so convenient to restaurants, shops, and everything the area has to offer. We also very much enjoyed meeting our hosts, who were so welcoming.
Guest favorite
The cottage's exterior features a welcoming front porch with two chairs flanking the entrance. Wooden double doors are framed by two lanterns, while neat landscaping includes a grassy area and stone pathway leading to the entry.
Guesthouse in Mount Pleasant
4.94 out of 5 average rating, 107 reviews

Private Coastal Cottage-Near Beaches & Charleston!

ZacharyRating, 5 stars8 months ago
Thank you again for hosting us. The place was in a perfect location, and you all were very accommodating. Great storage if bringing a boat down, and Jaime and her husband are very welcoming. Would recommend this place to all
Top guest favorite
A well-lit entrance features a white door with a lantern light above. Two stylish chairs and a small round table sit on a wooden deck, which is bordered by lush greenery that offers privacy and a serene atmosphere.
Guesthouse in James Island
5 out of 5 average rating, 251 reviews

James Island "La Casita" Nestled btw Beach & City

MollyRating, 5 stars3 weeks ago
This apartment was the perfect spot to explore Charleston and the surrounding areas! It was clean and cozy in a cute neighborhood on John's Island! Definitely recommend!!
Top guest favorite
A charming street scene features a collection of historic buildings with warm-colored facades and elegant shutters. Tall trees provide shade, while window boxes with greenery add a touch of vibrancy. A passerby strolls along the sidewalk, embodying the inviting atmosphere of the neighborhood.
Guesthouse in Summerville
4.97 out of 5 average rating, 258 reviews

Summerville’s Tiny Oak Hideaway

BrittanyRating, 5 stars1 week ago
Loved staying in this cute little cottage! Perfect amount of space for myself, a friend, and her newborn! Very peaceful and in walking distance to local coffee shops + more! Justin sent recommendations and the check in was easy. Will be back :)
Top guest favorite
A charming outdoor patio area features two white folding chairs and a small round table, surrounded by vibrant greenery. The entrance is framed by wooden fencing and a decorative fish has been mounted on the wall above the door, adding a unique touch to the space.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 287 reviews

#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!

KathleenRating, 5 stars1 week ago
Paige and Perry were excellent hosts. The apartment is exactly as described and more. Spotlessly cleaned with nice extras like coffee/tea and creamer. Perfect for us and our baby. Paige even set up the pack n play for us as we were arriving late at night. Having baby essentials like that and the high chair was hugely helpful. The location is perfect, easy drive downtown and close to beaches. We can’t want to stay here again!

Quick stats about guesthouse rentals in Mount Pleasant

  • Total rentals

    50 properties

  • Total number of reviews

    6.3K reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wifi availability

    50 properties include access to wifi

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