Pet-friendly vacation rentals in Lake City

Find and book unique pet-friendly homes on Airbnb

Top-rated pet-friendly home rentals in Lake City

Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.

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Guest favorite

A spacious living area features a light-colored sofa and loveseat adorned with decorative pillows. In the center, a wooden coffee table displays a magazine. A flat-screen TV is mounted on a media console, while a ceiling fan provides comfort in the well-lit space.

Condo in Pawleys Island

4.93 out of 5 average rating, 104 reviews

Surf and Turf Getaway!

Newly renovated in August 2019, 2 BR, 2 Bath ground floor unit at True Blue Resort. Master has king bed, 2nd bedroom has twins and there is also a pull out sofa bed. The hall bath has a walk in shower. TVs in every room with digital cable and free WiFi. Fully stocked kitchen. Screen porch with seating and pool within walking distance. 5 minutes to beach. All linens provided. Small pets welcome with additional $50 cleaning fee. No rvs ,trailers, boats or motorcycles are allowed on resort

Top guest favorite

The cottage is surrounded by greenery, showcasing a welcoming front porch with white railings. Two planters are placed at the entrance, and a swing is visible on the side. The entrance is accessible from a paved pathway leading to the door.

Cottage in Sumter

4.97 out of 5 average rating, 451 reviews

Restful Lakeside Getaway Cottage -Dogs allowed

This pond-side cottage is a peaceful place to relax and unwind. Sit on the enclosed porch and watch the water or enjoy the front porch swing where you can listen to the birds and frogs. We are 12 min. from downtown Sumter and 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens and Poinsett State Park. It is only 2 hours to Myrtle Beach and Charleston, SC & 3 hrs to the mtns. While it is conveniently located, this cottage offers a quiet place to put your feet up and rest.

Guest favorite

A charming single-story brick home is shown with a welcoming entrance featuring a circular window and black door. The front yard is landscaped with grass and bushes, while large trees provide shade in the background. A concrete pathway leads to the front steps.

Home in Sumter

4.88 out of 5 average rating, 178 reviews

Bungalow on Bobs

This charming 3 bedroom, 2 bathroom brick home features an updated kitchen with granite countertops and stainless steel appliances. The great backyard space is fully-fenced, with a large deck, charcoal grill, and fire pit. The spacious master bedroom has a private bathroom and a large walk-in closet. The master bedroom and living room both have Smart TVs. Log in to your own streaming accounts, or enjoy the complimentary Hulu account. The split floor plan allows for easy separation of guests.

Guest favorite

Home in Pawleys Island

4.89 out of 5 average rating, 117 reviews

Pawleys Sea Life - Prvt Pool Hot Tub 5 BRs Dogs OK

Whole house 5 bedrooms (3 on 1st floor) - Captains Quarters, Octopus Outlook, Seahorse Sanctuary, Hollywood Room, & Sea Turtle Cove. Private heated pool, screened porch, hot tub, & sauna. Dogs allowed - a $35 per dog, per visit pet fee will be billed separately. In the woods between the ocean & the ICWW. It is more like a camping vacation than a high end beach resort. Expect lots of leaves, bugs, frogs, lizards & spiders. Owners closets, garage, & office not included. POOL OPEN 2025

Guest favorite

A covered porch features two Adirondack chairs, one painted blue and the other orange, positioned beside a small side table. A view of greenery is visible through a nearby window, contributing to a relaxed outdoor seating area.

Home in Georgetown

4.98 out of 5 average rating, 165 reviews

Carolina Wren Cottage: New, Relaxing, Dog-Friendly

Charming dog friendly cottage located minutes away from historic Georgetown only about an hour from Charleston. Whether you want to sit on the large porch and enjoy listening to the birds sing or watch them fly back and forth through the beautiful trees. Maybe have an adventure walking along the Harbor walk do a little shopping and enjoy the great selection of restaurants. If that wasn't enough there are several beautiful beaches to enjoy. You won't be disappointed. For pets see policies.

Top guest favorite

A bright living area features a cozy seating arrangement with two plush armchairs and a sectional sofa. A modern coffee table sits in the center, while a large wall-mounted television is positioned above an elegant fireplace. Natural light filters through large windows adorned with light curtains.

Home in Rembert

4.97 out of 5 average rating, 187 reviews

New Home! Only 15 min to Shaw/Sumter. Dog friendly

Built in March 2022 single story home is full of amenities. High speed internet Upgraded cable 15 min to Shaw AFB Conveniently located between Sumter & Camden Premium mattresses Hotel like stay Backyard w/deck Iron/ironing board Vanity table 55 and 65 inch tv's Home office bedroom combo/printer, desk/ monitor and futon (can sleep 2 kids or 1 adult). Laundry room New appliances Kitchen is full of amenities Outdoor lighting Pet friendly! Dog toys, treats, indoor kennel Fenced in dog run

Top guest favorite

A cozy sleeping area features a spacious bed with soft gray bedding and decorative pillows in orange. A mural depicting a window with greenery enhances the warm yellow walls. Two nightstands hold bedside lamps, while a welcoming door leads outside, adorned with flowing curtains.

Place to stay in Effingham

4.97 out of 5 average rating, 131 reviews

Gated and Private Catholic Hermitage house

Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.

Top guest favorite

The exterior of a quaint cottage features white siding, green shutters, and a covered porch. An American flag is displayed, and two chairs sit on the porch. A gravel driveway leads to the home, surrounded by shade trees in a peaceful setting.

Cottage in Timmonsville

4.97 out of 5 average rating, 936 reviews

*Cottage Near Florence and I-95* 3 Bedrooms

Located just 5 mins from I-95 (exit 153) and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, please). We offer king bed in master, 3 wall-mounted TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. Absolutely no smoking ON OUR PROPERTY ($200 extra fee). Come stay with us. 🙂

Top guest favorite

The cozy interior features rustic wooden beams and a blend of warm tones. A spacious bed is positioned against a wall with a peacock artwork. A kitchenette area is visible, alongside a small dining table and a television, providing a comfortable, multifunctional living space.

Farm stay in Timmonsville

4.95 out of 5 average rating, 622 reviews

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

Top guest favorite

A charming single-story home is surrounded by a wooden fence, offering privacy and security. The property features a spacious front yard with well-maintained grass and tall trees providing shade. The deck at the front invites outdoor relaxation, while the driveway leads to an attached garage.

Home in Santee

4.97 out of 5 average rating, 115 reviews

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Guest favorite

A bright and airy room features a spacious queen bed with soft linens, complemented by a cozy sofa seating area. Two ceiling fans provide circulation, while large windows allow natural light to fill the space. A tasteful area rug adds warmth to the tiled floor.

Guesthouse in Florence

4.93 out of 5 average rating, 823 reviews

The Cottage by the Pool: Close to Interstates

New floors and paint in January of 2023. Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.

Guest favorite

A two-story condo building is depicted, featuring a light brown exterior with white railings and steps leading to the upper level. Lush greenery, including flowering shrubs, surrounds the entrance. Clear skies above add to the inviting appearance of the property.

Condo in Pawleys Island

4.91 out of 5 average rating, 140 reviews

Pawleys Island Retreat!

Welcome to our beautiful place in Pawleys Island, SC. Located on a terrific golf course just minutes from the beach and awesome shopping and restaurants. Main pool, hot tub and 2 tennis/pickleball courts are open year round. Satellite pools are seasonal. Beach chairs and cooler are provided, along with a season pass to Huntington Beach State Park. 1/2hr from Myrtle Beach, 10 minutes from historic Georgetown, and 90 minutes from Charlestown. Come and enjoy.