Vacation rentals in Florence County

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Top-rated vacation rentals in Florence County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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The image shows a view of a bathroom entrance from the hallway. A sleek black countertop is visible on the left, and a light-colored tiled floor leads into the bathroom. The bathroom features a shower with sliding glass doors, a toilet, and neatly arranged white towels.

Apartment in Lake City

4.84 out of 5 average rating, 266 reviews

Home Away from Home Apt. 8 - Family Suite

Located on Main Street in a family home that has been updated to be like brand new. Two private bedrooms, with private entrance, one full bath. Back BR has a full size bed, TV, dressing area and closet . Front BR has queen bed, TV, microwave, full size refrigerate, closet and dining table. Amenities include 2 CABLE & Roku TV's, wifi, front door parking, fresh brewed coffee,CAFE VALE. Up town Lake City is an easy one mile walk along Main Street. Hablamos Español 1/2 way from New York to Miami.

Guest favorite

An outdoor porch presents comfortable seating options with two red chairs and a turquoise sofa, each adorned with decorative pillows. Natural light filters through the windows, and a ceiling fan is visible, promoting a refreshing atmosphere. The flooring is covered with a natural fiber rug.

Home in Florence

4.88 out of 5 average rating, 482 reviews

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Guest favorite

A compact bathroom features a sleek toilet and a modern sink with a stylish black faucet. The walls are adorned with decorative tiles and framed wall art. A plush bathroom rug with a playful message is positioned in front of the toilet, enhancing the space's character.

Apartment in Florence

4.93 out of 5 average rating, 15 reviews

“Cozy Escape | Relax & Recharge”

Discover your perfect getaway in this beautifully furnished 2-bedroom, 1.5-bathroom retreat. Featuring sleek, updated appliances and the convenience of an in-unit washer and dryer, this space blends style and comfort effortlessly. Nestled in a prime, sought-after neighborhood, you’ll enjoy both tranquility and easy access to local hotspots. Conveniently located near Magnolia Mall. A perfect blend of shopping, dining. Book your stay and experience the best of home living with a touch of luxury!

Top guest favorite

An outdoor seating area is presented under a wooden pergola, featuring two wicker chairs adorned with vibrant floral cushions. A small side table rests between the chairs, and a quaint storage shed is visible in the background, surrounded by lush greenery.

Place to stay in Effingham

4.97 out of 5 average rating, 131 reviews

Gated and Private Catholic Hermitage house

Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.

Top guest favorite

A large tree with a thick trunk and abundant green leaves creates shade over a grassy area. Surrounding the tree are several smaller trees, contributing to the serene, open landscape that defines the peaceful outdoor setting.

Cottage in Timmonsville

4.97 out of 5 average rating, 936 reviews

*Cottage Near Florence and I-95* 3 Bedrooms

Located just 5 mins from I-95 (exit 153) and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, please). We offer king bed in master, 3 wall-mounted TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. Absolutely no smoking ON OUR PROPERTY ($200 extra fee). Come stay with us. 🙂

Top guest favorite

A cozy entrance features a covered porch adorned with string lights, illuminating the space at dusk. Two chairs and a small table are positioned near the door, with a decorative planter adding a touch of greenery. The surrounding yard is well-maintained, creating a welcoming atmosphere.

Farm stay in Timmonsville

4.95 out of 5 average rating, 622 reviews

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

Guest favorite

A charming farmhouse is surrounded by expansive green grass under a colorful sunset sky, featuring shades of pink and orange. Two Adirondack chairs are positioned around a firepit, creating an inviting space for relaxation and outdoor gatherings.

Farm stay in Hemingway

4.95 out of 5 average rating, 198 reviews

Quiet farmhouse near the beach

The best memories are made on the farm. Life is just better away from the hustle and bustle of city lights and busy schedules. Come stay in this recently renovated fourth generation 1950s farmhouse on an 80 acre working farm. Unwind on the porch, walk trails, find millions of years old sharks teeth, build a bonfire, pick blackberries, swim in the ponds, collect walnuts, or just relax while you’re here but don’t forget to wish on a dandelion or a shooting star before you leave.

Guest favorite

A welcoming outdoor space features a tranquil pool surrounded by palm trees and vibrant greenery. Picnic tables and comfortable seating areas are visible, providing options for relaxation. The inviting cottage stands in the background, surrounded by a serene, well-maintained setting.

Guesthouse in Florence

4.93 out of 5 average rating, 823 reviews

The Cottage by the Pool: Close to Interstates

New floors and paint in January of 2023. Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.

Top guest favorite

A welcoming entryway features exposed brick walls and original hardwood floors. A large mirror enhances the space, and soft lighting from a lamp creates a warm ambiance. The area transitions into adjacent rooms through an open doorway, contributing to a sense of spaciousness.

Loft in Marion

4.99 out of 5 average rating, 242 reviews

The Loft at 109

located at 109 Arch Street in downtown Marion, South Carolina, is a fully furnished apartment that offers all the amenities of home -and more. Housed in a historic building in the heart of the Pee Dee, The Loft has charming character with exposed brick walls and original hardwood floors. Offered as a nightly rental, your experience begins as you're greeted with gas lanterns and continues inside where you'll find our 1,000 square foot living space

Top guest favorite

The dining area features a round wooden table surrounded by four light-colored chairs. A chandelier hangs from the ceiling, illuminating the space. Elegant curtains frame two windows, and a large mirror reflects the room’s decor, which includes a sideboard and a decorative plant.

Bungalow in Florence

4.99 out of 5 average rating, 89 reviews

Quaint Bungalow in Historic Downtown Florence

You are invited to experience a quiet and relaxing time at Elley’s Bungalow. This home is completely renovated and fully furnished. Surrounded by friendly neighbors extending southern hospitality. Excellent property for nurses, per diem workers, or professionals on a short term assignment in Florence or surrounding areas. Located minutes away from McLeod Regional Medical Center, MUSC Florence, Francis Marion University, and Downtown Florence.

Top guest favorite

Home in Florence County

5 out of 5 average rating, 113 reviews

Highway Oasis and Myrtle Beach

Welcome to this charming new house ideally situated close to both a major highway i 95 and i20 and the serene Myrtle beach, offering the perfect blend of convenience . Nestled in a great neighborhood, this residence boasts easy access to shopping center, ensuring that all your daily needs are just moments away. Very close to Florence Civic Center, 15 minutes to Buc-ee's Myrtle beach in 1 hr of a drive and shopping amenities.

Guest favorite

A private guest house is nestled among trees, featuring a small porch with a table and chairs. Pathways lined with stepping stones lead to the entrance. Surrounding greenery and shrubs create a serene atmosphere that complements the charm of the outdoor space.

Guesthouse in Florence

4.91 out of 5 average rating, 197 reviews

Midtown Retreat - Guest House in heart of Florence

A private, relaxing place to stay right in the middle of town. Conveniently located close to all Florence has to offer, this 1-bedroom guest house is nestled among the trees behind the main house. Located in a beautiful, quiet neighborhood, yet within a few minutes to restaurants, grocery stores, fitness centers, McLeod and MUSC Medical Centers, and more.