House vacation rentals in Lake City

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Top-rated house rentals in Lake City

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Superhost
The charming facade of Kuker Cottage is framed by lush greenery and trees, featuring a covered porch with colorful seating. Large windows are positioned symmetrically, and the brick columns add character to the entrance, inviting guests to relax in a tranquil outdoor space.
Home in Florence
4.87 out of 5 average rating, 540 reviews

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Guest favorite
A spacious outdoor area features a sleek in-ground pool surrounded by modern lounge chairs. The chalet showcases a screened porch and an inviting deck with steps leading up to the entry. Lush greenery and a serene landscape create a peaceful environment.
Home in Manning
4.91 out of 5 average rating, 116 reviews

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach

Bring the whole family to this gorgeous lakefront chalet with tons of guest amenities in a quiet neighborhood on Wyboo Creek. Sleeps 2 families comfortably w/ 4 large BR, 2 bathrooms, a game room, a fully equipped kitchen, living area, & screened porch. Enjoy the in ground pool w/ tanning ledge, hot tub, built-in fire pit, outdoor grilling & dining area, private sandy beach, & pier on open water. Launch your boat at the public ramp at the end of the street (.2 miles) & dock at the private pier.

Top guest favorite
A comfortable living area features a dark gray sofa complemented by two accent pillows. A coffee table is positioned in front of the seating, and two standing lamps provide soft lighting. A simple wall art above the sofa adds a touch of elegance to the space.
Home in Florence
4.98 out of 5 average rating, 113 reviews

Renovated 2 BR/2 B Townhouse Cozy & Clean

Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood with 2 queen beds and 1 sofa bed in the living room. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

Guest favorite
Home in Kingstree
4.94 out of 5 average rating, 123 reviews

magical 1840s farm house getaway

Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Guest favorite
A covered porch features two Adirondack chairs, one painted blue and the other orange, positioned beside a small side table. A view of greenery is visible through a nearby window, contributing to a relaxed outdoor seating area.
Home in Georgetown
4.97 out of 5 average rating, 178 reviews

Carolina Wren Cottage: New, Relaxing, Dog-Friendly

Charming dog friendly cottage located minutes away from historic Georgetown only about an hour from Charleston. Whether you want to sit on the large porch and enjoy listening to the birds sing or watch them fly back and forth through the beautiful trees. Maybe have an adventure walking along the Harbor walk do a little shopping and enjoy the great selection of restaurants. If that wasn't enough there are several beautiful beaches to enjoy. You won't be disappointed. For pets see policies.

Top guest favorite
The exterior of a two-story house is nestled among tall trees, showcasing a deck with steps leading to the ground. Screened-in porches on both levels provide ample outdoor space and views of the surrounding greenery.
Home in Georgetown
4.99 out of 5 average rating, 168 reviews

Black River Refuge on the Water

The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Guest favorite
A bright living area features a light-colored sectional sofa arranged around a circular coffee table. Natural light enters through the windows, enhancing the warm ambiance. A simple desk with a chair is positioned nearby, complementing the overall spaciousness of the room.
Home in Florence
4.92 out of 5 average rating, 102 reviews

Charming Home in Florence, SC

Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

Top guest favorite
A stand-alone apartment building is shown, featuring a low brick exterior and a gabled roof. There are several windows framed with white shutters, allowing natural light to enter. The well-maintained lawn is bordered by neatly trimmed bushes, complementing the overall tidy appearance.
Home in Lake City
4.93 out of 5 average rating, 266 reviews

Home Away From Home Apt 3 - A Hidden Gem

Stand Alone (not a part of the main house) 1 Bed-Room Apt. with Full furnished Kitchen, Full Bath, Private Entrance, private bedroom with door, Private Parking. Living Room- Dining Combo. Fully Furnished. High-Speed WI-Fi, 2 ROKU TVs, 1 in BR & 1 in LR, 1/2 way from New York to Miami, Hablamos Espanol, Fresh Brewed In-Room Coffee. Easy 1-mile walk on Main St. to uptown. 23 miles from I-95, 60 miles to Myrtle Beach, 23 miles to Florence, 1&1/2 hours to Charleston and Columbia.

Guest favorite
The kitchen features modern appliances, including a stainless steel refrigerator and an electric stove. Natural light fills the space through multiple windows. A wooden dining table is visible, accompanied by a set of chairs. A doorway leads to the outside.
Home in Hartsville
4.84 out of 5 average rating, 135 reviews

Quaint 2BR home w access to Black Creek & downtown

Our freshly renovated home sits in a family-oriented neighborhood only a mile from downtown Hartsville and Kalmia Gardens and includes access to Black Creek. This 600 sf home features 2 bedrooms, 1 bath, a full kitchen, washer and dryer and an open living area. Digital antenna reception for smart-tv and high speed wi-fi internet. Small dogs will be considered for stays on a case-by-case basis. Pet stays require prior approval from the hosts and will involve additional fees.

Superhost
A charming bungalow exterior is displayed, featuring a light-colored wooden facade with dark shuttered windows. A small porch with a railing is visible at the front, surrounded by neatly trimmed landscaping and a grassy area leading to the street.
Home in Darlington
4.82 out of 5 average rating, 135 reviews

Located 100 feet from The Darlington Raceway!

This cute little bungalow is located across the street from The Darlington Raceway. Just a few steps puts you at the door of the famous Joe Weatherly Stock Car Museum. We are also within walking distance to Manheim Auto Auction. The Raceway Grill, a favorite of Dale Earnhardt, is located across the street ! If you are here during the week, South of Pearl, Darlington's finest eating establishment, is located in uptown Darlington. WE DO NOT HAVE A STOVE OR WASHER/DRYER

Top guest favorite
A cozy living area features floral-patterned sofas, a wooden coffee table, and a rocking chair. Natural light filters through sheer curtains, highlighting decorative accents like a lamp and wall art. A ceiling fan provides comfort in this welcoming space.
Home in Sumter
4.98 out of 5 average rating, 123 reviews

Quiet Country Living w/private lot

Welcome to Quiet Country Living! Experience all that Sumter has to offer with this renovated home that has everything you will need for your stay. Located in a country neighborhood only 8.9 miles from downtown, local shops, Swan Lake Iris Gardens, and other parks and attractions. Also 19.4 miles to Shaw Air Force Base. Business friendly, military friendly, family friendly. Home available for temporary duty (TDY) . This location is perfect for any and all travelers.

Top guest favorite
A charming blue house is situated in a friendly neighborhood, featuring a welcoming front porch with hanging plants and an American flag. The home is flanked by two adjacent houses, surrounded by greenery and well-maintained lawns, contributing to a pleasant street view.
Home in Georgetown
4.97 out of 5 average rating, 136 reviews

Pepe's Place

This charmer is located in the historical district of Georgetown, SC. This home has been updated and should be the perfect place for your stay when visiting. This home is a comfortable and inviting place to spend your time when not exploring the waterfront, great restaurants, or whatever is bringing you to this beautiful historical city. You can also enjoy our closest beach located in Pawley's Island or even take a day trip to Charleston.

Popular amenities for Lake City house rentals

Quick stats about house rentals in Lake City

  • Nightly prices starting at

    Lake City vacation rentals start at ﺩ.ﺇ110 per night before taxes and fees

  • Verified guest reviews

    Over 930 verified reviews to help you choose

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Lake City rentals

  • 4.9 Average rating

    Lake City stays are highly rated by guests—averaging 4.9 out of 5!