
House vacation rentals in Lake City
Find and book unique houses on Airbnb
Top-rated house rentals in Lake City
Guests agree: these houses are highly rated for location, cleanliness, and more.

Kuker Cottage Downtown Florence-Near I95 & I20
Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach
Bring the whole family to this gorgeous lakefront chalet with tons of guest amenities in a quiet neighborhood on Wyboo Creek. Sleeps 2 families comfortably w/ 4 large BR, 2 bathrooms, a game room, a fully equipped kitchen, living area, & screened porch. Enjoy the in ground pool w/ tanning ledge, hot tub, built-in fire pit, outdoor grilling & dining area, private sandy beach, & pier on open water. Launch your boat at the public ramp at the end of the street (.2 miles) & dock at the private pier.

Renovated 2 BR/2 B Townhouse Cozy & Clean
Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood with 2 queen beds and 1 sofa bed in the living room. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

magical 1840s farm house getaway
Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Manchester Place
Hartsville is a Charming Town with plenty of family activities, shops, and dining. Home is located in the quiet Fox Hollow subdivision which is just outside the city limits but still close to downtown. Robinson Nuclear Plant 10 min. Sonoco 7 min. Coker University 7 min. Downtown Hartsville 7 min. Carolina Pines Hospital 9 min. McLeod Hospital Florence 42 min. Byerly Park 9 min. Hartsville Center Theater 6 min. Governor's School for Science and Mathematics 9 min. Darlington Raceway 22 min.

Carolina Wren Cottage: New, Relaxing, Dog-Friendly
Charming dog friendly cottage located minutes away from historic Georgetown only about an hour from Charleston. Whether you want to sit on the large porch and enjoy listening to the birds sing or watch them fly back and forth through the beautiful trees. Maybe have an adventure walking along the Harbor walk do a little shopping and enjoy the great selection of restaurants. If that wasn't enough there are several beautiful beaches to enjoy. You won't be disappointed. For pets see policies.

Black River Refuge on the Water
The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Charming Home in Florence, SC
Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

Quiet Country Living w/private lot
Welcome to Quiet Country Living! Experience all that Sumter has to offer with this renovated home that has everything you will need for your stay. Located in a country neighborhood only 8.9 miles from downtown, local shops, Swan Lake Iris Gardens, and other parks and attractions. Also 19.4 miles to Shaw Air Force Base. Business friendly, military friendly, family friendly. Home available for temporary duty (TDY) . This location is perfect for any and all travelers.

Historic Charm near Downtown | Clean and Quiet
Experience southern hospitality in this historic charmer perfect for professionals. •Quaint, quiet downtown neighborhood walkable to restaurants •Fast wifi, laundry room, large fenced backyard w/ fire pit, off-street parking •Fully loaded kitchen, 2 Roku TV's, queen sleeper sofa, relaxing front porch •3 min to FMU Performing Arts Center, 5 min to McLeod Hospital, 10 min to FMU & MUSC Medical Center. • Perfect for short or long stays!

Highway Oasis and Myrtle Beach
Welcome to this charming new house ideally situated close to both a major highway i 95 and i20 and the serene Myrtle beach, offering the perfect blend of convenience . Nestled in a great neighborhood, this residence boasts easy access to shopping center, ensuring that all your daily needs are just moments away. Very close to Florence Civic Center, 15 minutes to Buc-ee's Myrtle beach in 1 hr of a drive and shopping amenities.

Browns Bed and Breakfast, a peaceful country home
A spacious and peaceful, home away from home. Browns Bed and Breakfast, on over 2-acres of land, is in a quiet country setting and is surrounded by family. This entire 4-bedroom, 3-bathroom home is available for bookings, or you can choose the option to just book a room or two. We are also conveniently located and close to many popular South Carolina destinations and attraction. A continental Breakfast is served daily.
Popular amenities for Lake City house rentals
House rentals with a pool

Eagle Point Poolside Escape

Low Country Lux

Eagle Point Retreat W/Pool

Wyboo Retreat at Lake Marion W/Pool

Quiet Retreat:Secluded & Idyllic

Paradise Palms (one-of-a-kind Oasis)

Heated Indoor Pool on Lake Marion with Dock

Race Weekend Getaway
Weekly house rentals

The Cottage

Cozy 3-Bedroom Retreat Florence

Newly Remodeled 2 bed house

Private Country Escape

Suits Me

Lake Marion Cottage

SANTEE LAKE MARION GOAT ISLAND AREA NEWLY UPDATED

Relaxing Lake Marion Home, near 3 boat landings
Private house rentals

Spacious 3 bd Home with Office, GameRoom & Balcony

The Mayesville - Sumter-Florence Family Getaway

A Lake Slice of Heaven

Almost Heaven on Lake Marion, SC

The River House

Cozy 3 Bedroom Home! Located NEAR MUSC-Florence

Beautiful place in the wild

Cozy Church Branch Cabin
Destinations to explore
- Norfolk Vacation rentals
- Western North Carolina Vacation rentals
- Atlanta Vacation rentals
- Myrtle Beach Vacation rentals
- Charleston Vacation rentals
- Outer Banks Vacation rentals
- Gatlinburg Vacation rentals
- Charlotte Vacation rentals
- Hilton Head Island Vacation rentals
- Savannah Vacation rentals
- Jacksonville Vacation rentals
- Cape Fear River Vacation rentals
- Myrtle Beach Boardwalk
- Lakewood Camping Resort
- Myrtle Beach State Park
- Huntington Beach State Park
- Garden City Beach
- Caledonia Golf & Fish Club
- Murrells Inlet Marsh Walk
- Brookgreen Gardens
- Oceanside Village
- Atalaya Castle
- Wild Water & Wheels
- Medieval Times Dinner & Tournament
- Tupelo Bay Golf Center
- Conway Riverwalk
- Fun Warehouse
- Savannah's Playground





