Guesthouse vacation rentals in Johns Island
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Johns Island
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Johns Island guesthouse rentals
Family-friendly guest house rentals
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
Sep 4 – 11
Guesthouse in Charleston
4.91 out of 5 average rating, 648 reviewsIsland Oasis—Near Downtown
Oct 21 – 28
Guesthouse in Summerville
4.98 out of 5 average rating, 643 reviews★Delightful guest house near historic plantations★
Apr 16 – 23
Guesthouse in Charleston
4.99 out of 5 average rating, 263 reviewsSpacious Daniel Island Apartment
Feb 14 – 21
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 220 reviewsGreen Garden Studio @greengardenstudio2017
Oct 15 – 22
Guesthouse in Ridgeville
4.82 out of 5 average rating, 213 reviewsPond House Bungalow at Natural Gathering Grounds
Nov 9 – 16
Guesthouse in Charleston
4.93 out of 5 average rating, 316 reviewsCozy Island Cottage
Feb 4 – 11
Guesthouse in North Charleston
5.0 out of 5 average rating, 110 reviewsThe Park Circle Clerestory Studio Guest House
Jun 20 – 27
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 122 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Apr 6 – 13
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Mar 10 – 17
Guesthouse in Johns Island
5.0 out of 5 average rating, 53 reviewsDriftwood Cottage
Oct 8 – 15
Guesthouse in Charleston
4.85 out of 5 average rating, 26 reviewsAdorable Studio Apartment with Patio
Aug 2 – 9
Guesthouse in Charleston
5.0 out of 5 average rating, 12 reviewsLowcountry Guesthouse
Jul 15 – 22
Guesthouse in Charleston
5.0 out of 5 average rating, 23 reviews1/1 sleeps 3 ADU Modern+Amazing!
Jul 9 – 16
Guesthouse in Charleston
5.0 out of 5 average rating, 74 reviewsLuxury Loft (2 miles from Folly Beach)
Dec 8 – 15
Guesthouse in Charleston
5.0 out of 5 average rating, 13 reviewsGas Light Carriage House James Island
Jul 16 – 23
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Mar 4 – 11
Guesthouse in Charleston
4.99 out of 5 average rating, 141 reviewsLarge Guesthouse with Private Dock & Marsh Views
Jan 26 – Feb 2
Guesthouse in Charleston
4.98 out of 5 average rating, 106 reviewsCharleston Casita near Folly Beach *Dog Friendly*
Dec 1 – 8
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 222 reviewsCozy Apartment in Mount Pleasant
Apr 23 – 30
Guesthouse in Charleston
5.0 out of 5 average rating, 143 reviewsThe Guesthouse at Old Orchard
Sep 10 – 17
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 436 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Nov 2 – 9
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 248 reviewsUpscale Couple's Escape | Beach & Downtown CHS
Jul 5 – 12
Guesthouse in Summerville
4.97 out of 5 average rating, 216 reviewsTiny Oak Cottage in Historic Downtown Summerville
Sep 8 – 15
Quick stats about guesthouse rentals in Johns Island
Total rentals
40 properties
Wifi availability
40 properties include access to wifi
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Pet-friendly rentals
10 properties allow pets
Total number of reviews
5.7K reviews
Nightly prices starting at
ﺩ.ﺇ147 before taxes and fees
Destinations to explore
- Savannah Vacation rentals
- Hilton Head Island Vacation rentals
- Kiawah Island Vacation rentals
- Tybee Island Vacation rentals
- Folly Beach Vacation rentals
- Surfside Beach Vacation rentals
- Mount Pleasant Vacation rentals
- Hilton Head Vacation rentals
- Atlanta Vacation rentals
- Orlando Vacation rentals
- Charleston Vacation rentals
- Myrtle Beach Vacation rentals
- Guesthouse rentals United States
- House rentals United States
- House rentals Myrtle Beach
- House rentals Charleston
- Guesthouse rentals Charleston
- House rentals Savannah
- Guesthouse rentals Savannah
- House rentals South Carolina
- Guesthouse rentals South Carolina
- Rentals with a hot tub Johns Island
- Townhouse rentals Johns Island
- Pet-friendly rentals Johns Island
- Rentals with breakfast Johns Island
- Waterfront rentals Johns Island
- Rentals with a washer and dryer Johns Island
- Rentals with pools Johns Island
- Apartment rentals Johns Island
- Kid-friendly rentals Johns Island
- Rentals with a fireplace Johns Island
- Rentals with a patio Johns Island
- Family-friendly rentals Johns Island
- Fitness-friendly rentals Johns Island
- Rentals with lake access Johns Island
- Monthly Rentals Johns Island
- Private suite rentals Johns Island
- Rentals with a fire pit Johns Island
- Rentals with beach access Johns Island
- Rentals with outdoor seating Johns Island
- Rentals with a kayak Johns Island
- House rentals Johns Island
- House rentals Charleston County
- Guesthouse rentals Charleston County
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom