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House vacation rentals in Guadalupe

Find and book unique houses on Airbnb

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Popular amenities for Guadalupe house rentals

House rentals with a pool

Guest favorite
Home in Solvang
4.94 out of 5 average rating, 132 reviews

Hidden Views

JayRating, 5 stars1 month ago
David greeted us upon arrival and, after that, we had privacy in the two-story guest house...which is the size of many homes! The mattresses were so comfortable that my wife wants to know where to get one. The views are lovely, plenty of space for the 4 of us and 3 bathrooms! We thoroughly enjoyed our stay and hope to return again...
Guest favorite
Home in Lompoc
4.95 out of 5 average rating, 183 reviews

Pool & view in Sta Rita Hills Wine Country, Lompoc

AvivRating, 5 stars1 month ago
Stayed here for a few nights and the house is really wonderful! Had everything we needed and a personal touch.
Guest favorite
Home in San Luis Obispo
5 out of 5 average rating, 78 reviews

San Luis Obispo House With Pool And Hot Tub

KathleenRating, 5 stars1 week ago
Our stay at this beautiful Airbnb was truly enchanting. The home itself is warm and inviting, with every comfort thoughtfully provided—the kitchen is remarkably well stocked, and every room is prepared with care and intention, making it feel like a true home away from home. The outdoor space, however, is what made this visit unforgettable. The yard is a haven—anchored by a spectacular eucalyptus tree that feels almost sacred in its quiet majesty. The gentle rustling of its leaves, paired with the joyful flutter of countless birds that visit the property, created a serene soundtrack to our days. The view of the rolling green hills from the house is simply breathtaking—a perfect backdrop for morning coffee or golden hour conversations. Our children were in heaven with the pool, spa, and thoughtfully curated collection of sports equipment—there was always something fun and active for them to enjoy. Meanwhile, we found ourselves deeply relaxed, soaking in the natural beauty and peacefuln
Superhost
Home in Nipomo
4.8 out of 5 average rating, 383 reviews

Getaway at the Highlands+Heated Pool+Hot Tub

JillianRating, 5 stars1 month ago
We had a great time, perfect space for our group (13 people). Plus, we super appreciated the baby amenities they had available. The crib, changing table and high chair made my husband and I’s life a lot easier. They communicated well when we had to call with a time-sensitive question & answered on the AirBNB messenger in a timely matter.
Guest favorite
Home in Solvang
4.92 out of 5 average rating, 237 reviews

FairView Lavender Estate

SteveRating, 5 stars3 days ago
Everything was perfect! Treated my wife and her girlfriends for a weekend stay for her 40th birthday and they came back with stellar reviews. Hilary was communicative and helpful throughout the booking, check-in, and stay. Highly recommend to anyone wanting a unique and special stay up in Solvang
Top guest favorite
Home in Santa Ynez
5 out of 5 average rating, 52 reviews

Beautiful ranch style Santa ynez home

JonathanRating, 5 stars1 week ago
Second time staying at Todd’s place and can’t wait to go back. It’s super spacious and very clean. Has everything you need and so comfortable. The backyard is great! I can’t recommend this place enough. Todd is amazing.
Guest favorite
Home in Los Alamos
5 out of 5 average rating, 13 reviews

Heated pool & family friendly!

LynnRating, 5 stars2 weeks ago
This home was amazing for our multigenerational family stay. It was wonderful for children, with tons of toys, plastic cups and plates, the swing, and of course the pool (with a safety fence!). The house was equipped with everything we needed and we could easily use instacart for groceries when we didn’t want to go to the grocery store. The yard was beautiful and the location was so close to all of the wonderful restaurants in Los Alamos. Jayla and her team were extremely communicative and helpful, responding quickly whenever we needed anything (which we didn’t really need at all!). We highly recommend this home and hope to stay here again!

Weekly house rentals

Top guest favorite
Home in Grover Beach
4.87 out of 5 average rating, 174 reviews

Cute Grover Beach cottage STR-0068

MaryRating, 5 stars3 weeks ago
Such a great location! Molly and Justin super responsive and super nice this is such a great little vacation home. They have games so close to the beach pretty backyard all around it’s an amazing place we will be back in June!
Guest favorite
Home in Arroyo Grande
4.91 out of 5 average rating, 125 reviews

Beautiful Country Home

RamiroRating, 5 stars3 weeks ago
Laurie is an amazing host that was readily available when I had questions and left us lovely notes and instructions when we arrived. The home is beautiful and great for a week or weekend getaway with family or friends. My family loved the place and there were no complaints. We would definitely select this location again and we recommend it to anyone who wishes a lovely stay.
Superhost
Home in Oceano
4.77 out of 5 average rating, 297 reviews

Seaside! Steps to sand & minutes to dunes!

BriannaRating, 5 stars1 month ago
This house is great for a vacation with the family. Very spacious, and just a short walk to the beach!
Guest favorite
Home in Nipomo
4.88 out of 5 average rating, 156 reviews

Working Ranch~Golf, Beach,Wine/No smoking/Pet free

KateRating, 5 stars2 months ago
First, the place is great. It is spacious, the bedrooms are large, and the view is fantastic. Being dog lovers, the highlight for us was Styx the ranch dog who kept us company all weekend. The house was clean and well stocked. The furniture is dated but comfortable. The master bathroom has a heater that made my shower very nice!
Superhost
Home in San Luis Obispo
4.89 out of 5 average rating, 275 reviews

Boutique Bungalow, San Luis Obispo

JaneRating, 5 stars1 week ago
Great location, close to Cal Poly. Looks like the photos, good amount of space and nice outdoor areas. Laundry was a bonus. Very clear instructions and hosts are responsive, when needed. Would highly recommend!
Guest favorite
Home in Arroyo Grande
4.88 out of 5 average rating, 555 reviews

( Sanitized!) Country home w/ backyard tiki hut

LloydRating, 5 stars2 weeks ago
It’s a lovely place to stay and gave us the opportunity to both head north and visit Cambria and Morro Bay, as well as to head out to Lopez Lake and Oso Flaco to enjoy birding and nature. There are a number of really wonderful places to eat all along the central coast. We highly recommend Giuseppe‘s in Pismo Beach and Bob’s Well Bread in Los Alamos.
Superhost
Home in Lompoc
4.82 out of 5 average rating, 113 reviews

Wine Country Bungalow 2Bd/1Ba

IpsitaRating, 5 stars4 months ago
We had a short but beautiful stay at Matt and Linda's place on our way to Pinnacles National Park :)
Superhost
Home in Grover Beach
4.88 out of 5 average rating, 247 reviews

Beach Home-walk to the Beach STR0116

IreneRating, 5 stars3 weeks ago
We had a wonderful stay! The place was super comfortable, clean, and spacious. Michael and Eleanor were great hosts as well, super kind and responsive.

Private house rentals

Superhost
Home in San Luis Obispo
4.92 out of 5 average rating, 153 reviews

STENNER CREEK RANCH

CarolinaRating, 5 stars2 days ago
Charles place was beautiful and in a very scenic location. We saw cows grazing on the hillside, turkeys walking along the road, and even saw a baby deer wandering nearby. There were lots of amenities and clear instructions on everything from getting to the place to using the fireplace. One thing I would have liked to be warned about was the bumpy road to get to the house, it can be pretty scary especially whilst driving at night. But other than that our stay was perfect. I would stay here again.
Top guest favorite
Home in San Luis Obispo
4.98 out of 5 average rating, 40 reviews

Upscale. Pet Friendly. Great Location! 2-6 guests

CheriRating, 5 stars1 day ago
This is a beautiful home. It’s pet friendly which is a huge plus. On a nice quiet street but within minutes of historic downtown San Luis Obispo We loved this home and location and would definitely stay again. Cindy is a fantastic host
Superhost
Home in Arroyo Grande
4.84 out of 5 average rating, 43 reviews

Creative & Colorful Home. Large! Near Pismo! SLO!

AeishaRating, 5 stars1 month ago
Beautiful home, when writing this review one of the questions were was this home accurately described and matched the pictures I will say the pictures did NOT due this home justice. I mean this home was beautiful and colorful rooms were way bigger than the pictures. The outside was very peaceful. Everyone in my group immediately said it was such a beautiful home. The hosts were welcoming and very informational… they were not overwhelming like other hosts they truly allowed us to be free in the home.
Superhost
Home in Avila Beach
4.74 out of 5 average rating, 23 reviews

Casa Alina: 3 bedroom home steps from beach and go

RebeccaRating, 5 stars5 months ago
Fantastic place and great location! Super clean, well decorated and comfortable. Big patio with everything you need- furniture, fire and the smell of sea air. Towels were well stocked in the bathrooms plus beach towels in the laundry room were available. Coffee pods and creamer were left by the host which was very thoughtful. We had a great time and everyone raved how nice of a place this was; clean, comfortable, and tastefully decorated. I would definitely stay here again!
Guest favorite
Home in Santa Ynez
4.91 out of 5 average rating, 114 reviews

The perfect retreat - walk to downtown Santa Ynez!

DaraRating, 5 stars2 weeks ago
James was incredibly kind and helpful before and during our stay. The home was super spacious, a close walk to town, and we were even able to make s’mores one evening, which the kids thoroughly enjoyed. We enjoyed our stay tremendously and would be delighted to return in the future!
Top guest favorite
Home in Santa Ynez
4.98 out of 5 average rating, 212 reviews

"Willow" Farmstyle Home in Santa Ynez Township

GillianRating, 5 stars2 days ago
My friends and I booked Chrystine's place for a girls weekend and we all agree we want to visit SYV and stay with Chrystine again. She was the perfect host! The location was lovely on a quiet cul de sac, but also walkable to the main street in town. The property was perfect for us, with comfortable bedrooms, a great living room for hanging out, and a top notch coffee station (which is always VERY important). Don't hesitate to book with Chrystine, you'll love the place!
Guest favorite
Home in Los Alamos
4.93 out of 5 average rating, 100 reviews

Heritage House | Los Alamos | Downtown | Eco-friendly

KatieRating, 5 stars1 month ago
Our stay with Jen was amazing! A girlfriend and I decided to do an impromptu overnight staycation in Los Alamos and we couldn’t be happier with the Heritage House. My bestie is a photographer and loved how every square inch was insta-worthy and photoshoot ready. I think my favorite part of the house is the clawfoot tubs - I’m a sucker for a good bathtub and will plans stays around one. The house itself is adorable and has been remodeled with a ton of charm and character, the attention to detail stood out from the second we stepped in the door. Everything was spotless and the beds were super comfy. It is walking distance to all the best local spots, we popped over to Bob’s for breakfast. Overall we couldn’t be happier with the stay and will definitely be back!
Top guest favorite
Home in Santa Maria
4.94 out of 5 average rating, 354 reviews

Beautiful Home, Central Coast

DougRating, 5 stars1 month ago
Ricardo's house was outstanding and was incredibly well furnished and felt like home! The home was perfect for our family gathering and offered a respite from our travels from across the country. Ricardo is a wonderful host and we truly felt at home. This home is a treasure and we will come again!! much aloha.....

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