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House vacation rentals in Guadalupe

Find and book unique houses on Airbnb

Top-rated house rentals in Guadalupe

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
Home in Lompoc
4.95 out of 5 average rating, 327 reviews

1879 Victorian in Central Coast Wine Country

Lovely private 1879 Victorian built by Lompoc founder W.W. Broughton - with fully stocked kitchen, living room/ dining room, laundry room, full bathroom, back yard (lawn mowed Tuesdays, watering/ gardening is done generally in the mornings, cable TV, internet, set in spacious, beautifully manicured Victorian Gardens. Reservation includes two bedrooms with queen beds. Note: Entrance stairs may be difficult for those with limitations. No pets. Two triplexes with six renters are also on property.

Superhost
Home in Oceano
4.92 out of 5 average rating, 610 reviews

Don't Worry, Be Happy: Ocean, Pismo, SLO, Avila

A complete upstairs beach house with STUNNING views, a kitchen, living room, relaxing bedrooms, smart TVs, backyard, BBQ, Bikes & Game Room- Unlimited Vehicle Pass 2 Dunes - 1 mile to beach - 3/4 mile to Enormous kids park - Restaurants within walking distance - Netflix - Boll & Branch bedding - 6+ minute drive to Pismo, Grover Beach, & Arroyo Grande - Near Avila beach, Shell beach & San Luis Obispo - 20 min drive Cayucos & Morro Bay. Visit our website DropMyPin. c om for amenities & pictures.

Top guest favorite
Home in San Luis Obispo
4.99 out of 5 average rating, 119 reviews

Hilltop Horizon: Centrally Located+Panoramic Views

Newly built,secluded 600 sq ft 1 bedroom home with panoramic views of all of San Luis Obispo. Home is centrally located at 7min from both downtown &/or wineries, 3 miles to Cal Poly- but is completely quiet with no traffic on our multi acre property. This home shares the driveway and parking with our family’s main house, but the home has been designed for the two sets of 8ft glass sliders to have unobstructed views while maintaining complete privacy. We are 15 minutes to Avila and Pismo Beach.

Guest favorite
Home in Nipomo
4.97 out of 5 average rating, 103 reviews

Gateway to SLO County with Pickleball & Game Room

Family fun awaits at this 4500 sq feet home base to explore everything that San Luis County has to offer. Originally a log home, the home has been tastefully updated throughout the years and has a spacious open layout. There are 4 bedrooms, 3 bathrooms, a theater room, a game room and covered patio. There's something for everyone in the backyard with sports court, fire pit and bocce ball. Walk 2 minutes to 140 acre Nipomo Regional Park with new skate park & tennis and basketball courts.

Guest favorite
Home in Santa Maria
4.76 out of 5 average rating, 136 reviews

*Casa Paloma* with sauna & jacuzzi

Whether traveling for work or pleasure, Casa Paloma will welcome you with her spaciousness and modern eclectic décor. Please enjoy our sauna, hot tub, workspace, and close proximity to Old Town Orcutt. Local restaurants & wine tasting a .5 mile walk away! 1 Cal King, 3 queens & 1 twin bed. Tesla charger Safe neighborhood Dogs welcome, large fenced yard Bikes upon request RO drinking water 805 BBQ Workspace & printer Refurbished, modern home Hotel linens Wine tasting Water softener

Superhost
Home in Oceano
4.96 out of 5 average rating, 156 reviews

Casa Del Mar

Enjoy a little getaway in this cottage by the beach. It’s cozy and simple with all the features of comfort. Walking to the beach is a just a short stroll down a windy little road filled with cool beach vibes. Cross a little wooden bridge and walk down a block or two and you are right in front of the Oceano dunes. Plan a bonfire and make s’mores on the beach. Or better yet, stay at the little cottage, grab a bottle of wine and enjoy a fire pit right outside your bedroom door.

Guest favorite
Home in Orcutt
4.95 out of 5 average rating, 195 reviews

Luxe Hideaway: BBQ, Patio, Wineries, 20 min Beach

Kick back & relax in this calm, modern space. Enjoy the privacy of your own home with contactless check-in, high speed internet, comfortable beds, pull-out memory foam sofa sleeper for added guests, full kitchen just waiting for your culinary desires, and a patio with dining set for 6 Santa Maria is located near many wineries, hiking/mountain biking trails and we're only 20 minutes to the beach. Enjoy being centrally located while you explore the beautiful central coast.

Top guest favorite
Home in Nipomo
4.97 out of 5 average rating, 104 reviews

Pleasant hills, king suite, EV Charger

Come relax and enjoy our peaceful home and outdoor spaces. We are located halfway between Los Angeles and San Francisco. Here you can experience the beautiful Central Coast including wineries, Beaches, Cal Poly and golf courses. We are located in a quiet neighborhood adjacent to an organic blackberry farm. Easy access to the 101 Freeway, where you can easily visit Santa Barbara or Paso Robles wine regions. Our home is FULLY Air Conditioned for your comfort.

Superhost
Home in Arroyo Grande
4.93 out of 5 average rating, 225 reviews

Mid-century home in the heart of Arroyo Grande.

Welcome to the Eman House! I can't wait to host you at the 1950's mid century in Arroyo Grande, CA. Enjoy the beautiful remodeled kitchen, private backyard and patio, and two cozy bedrooms while soaking up the best of the central coast. Just a 10 minute walk to the historic Arroyo Grande village, a 5 minute drive to the beaches of Grover, and tucked away in one of Arroyo Grande's most peaceful cul-de-sacs.

Guest favorite
Home in Arroyo Grande
4.89 out of 5 average rating, 601 reviews

( Sanitized!) Country home w/ backyard tiki hut

As 13-time Superhosts we welcome you! This adorable home is perfect for couples or families. Enjoy the relaxation of country living; yet just 15 mins from the beaches. We have included everything we could think of for you to have a stress-free and fun vacation; the softest of beds & linens, a fully-stocked kitchen, games, fire-pit , satellite tv/smart tv and beach gear.

Guest favorite
Home in San Luis Obispo
4.95 out of 5 average rating, 121 reviews

Sanctuary on Sunset Ridge ~ Panoramic Ocean Views

Enjoy extraordinary VIEWS, PEACE, and PRIVACY just 15 minutes from downtown and beaches. Within 10-15 minutes: Hiking, Biking, SUP, Kayaking, Surfing, Wine Tasting, Great Restaurants, etc., etc. We are good-dog friendly. 3-night minimum stay. We have 2 ensuite King bedrooms - the 2nd has a loft with a double bed. Check us out on Insta: @sanctuaryonsunsetridge

Superhost
Home in San Luis Obispo
4.8 out of 5 average rating, 954 reviews

Spacious Slo Studio: AirBnB Dream

Solo or couple travelers this place is for you and what Air BNB was originally all about. Unique, friendly space that has taken on energy from all the travelers. Check in 3pm. Peep reviews, take it from patrons! BUSINESS LICENSE #: Zero Zero Zero One Six One Zero Eight Two Zero One Nine

Popular amenities for Guadalupe house rentals