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Pet-friendly vacation rentals in Cape Girardeau

Find and book unique pet-friendly homes on Airbnb

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Popular amenities for Cape Girardeau pet-friendly home rentals

Pet-friendly home rentals with a pool

Guest favorite
Camper/RV in De Soto
4.92 out of 5 average rating, 37 reviews

Glamping W/Hotub, pool, & lake

StevenRating, 5 stars1 month ago
We really enjoyed staying in this travel trailer. We wanted to see what it was like, and this was a good first experience for us!
Home in Carbondale
4.52 out of 5 average rating, 84 reviews

Peaceful Custom Carbondale Home w/ Pool, Near SIU!

HilaryRating, 5 stars6 months ago
Loved staying at this location. So close to restaurants and shops and outdoor adventures. Very quiet. Amazing views of stars. Plenty of sleeping spaces. Very responsive and helpful host!
Top guest favorite
Camper/RV in De Soto
4.96 out of 5 average rating, 28 reviews

Camp in quiet w/ Spa Lake Pool

EmilieRating, 5 stars1 week ago
This place is absolutely perfect! Our family cannot wait to go back! We will definitely book with Kevin and Mary again. Thanks again for sharing your perfect little getaway with us! Memories were made! 🤗
Guest favorite
Camper/RV in De Soto
5 out of 5 average rating, 19 reviews

Wooded, Private Lake, Pool & Spa

NateRating, 5 stars2 weeks ago
We chose to take this trip for our daughters birthday weekend a perfect setting to get away and have the option to camp, fish, swim and able to relax around a peaceful fire while eating smores. The camper had everything we needed very nice and spacious. The beds were very comfy. The area was nice and quiet. We caught fish from the dock. The family was welcoming to the pool area. And cant forget the friendly Pugley. He was for sure a bonus he loves to play fetch.
Cabin in Perryville

Black Bear Cabin K03A

MichaelRating, 5 stars1 month ago
It was very clean when we arrived and we really enjoyed our stay! The dogs loved it and it was very peaceful! we will be back!
Superhost
Home in Carbondale
4.73 out of 5 average rating, 138 reviews

Brick Estate with pool in Quiet Neighborhood

MattRating, 5 stars5 days ago
Dave’s place was perfect for our family. There were 5 of us and we had plenty of room. It’s an older home, but has been kept up very well, and is very charming. The neighborhood is beautiful and we loved taking walks every day with our kids. Dave was very communicative and responded immediately if we ever had a question. Thank you Dave, we hope to be back soon!
Cabin in Perryville

Rustic Bass Cabin

Cabin in Perryville

Coyote Cabin F09

Pet-friendly home rentals with a hot tub

Top guest favorite
Home in Carbondale
4.98 out of 5 average rating, 65 reviews

Hot Tub Overlooking Sunset Ridge | Sleeps 6

AndrewRating, 5 stars1 month ago
Great location, quiet, great view. Communication and instructions were clear and concise. Easy to work with.
Guest favorite
Cabin in Carbondale
5 out of 5 average rating, 6 reviews

Hot Tub Cabin- In the Heart of Shawnee Wine Trail

DanRating, 5 stars1 week ago
Very quiet and peaceful place to stay. I recommend to any couple who likes to hike and have a private place stay.
Top guest favorite
Cabin in Carbondale
5 out of 5 average rating, 73 reviews

Ideal Couple's Wooded Retreat near Giant City Park

BrandonRating, 5 stars1 week ago
The place was amazing. It was the perfect mini getaway we needed. We felt like we were in a home away from home.
Guest favorite
Cabin in Dongola
4.95 out of 5 average rating, 40 reviews

HotTub! FirePit, Private Pond, GameRoom! Slps12+

PatriciaRating, 5 stars5 days ago
Amazing get away to spend time with our grown kids and their families. Lots to do with the game room, fire pit, kayaks, fishing, etc… this location is pet friendly and had a very large fenced in porch with the dogs loved. We took walks on the winding country roads and met minimal cars. But those that did drive by met us with a wave and a smile. One car stopped to admire our pets and welcome us to the area and said how thankful they were to have guests in the area. We will definitely make this an annual stay.
Superhost
Home in Saint Mary
4.73 out of 5 average rating, 26 reviews

Ste. Genevieve Co. House w/ HOT TUB!

JohnRating, 5 stars1 month ago
What a great experience. Charming home away from home, opportune for making it our own, accommodated our family, while we each had our individual space. It’s clear that this family ranch was well preserved and host many positive memories. A coveted sprawling ranch cabin in the woods. ❤️
Guest favorite
Cabin in Anna
4.88 out of 5 average rating, 152 reviews

Contemporary Glamping with Native American Appeal!

SamuelRating, 5 stars5 days ago
Beautiful cabin with all the comforts of home. Owner was responsive, friendly and helpful. The town and surrounding area are gorgeous if you want to explore, and there are great restaurants everywhere. Would 100% stay here again.
Superhost
Cabin in Makanda
New place to stay

Wistful Cabin - Hot Tub, Loft

RachaelRating, 5 stars6 days ago
We stayed this little gemstone by happenstance and can not say enough great things about it! Approaching this sweet little cabin in the woods down a little gravel path with string lights to light the way feels like you’ve stepped into a fairytale story! Cozy and secluded, complete with a hot tub, grill, and fire pit. Just what the doctor ordered for a relaxing reset. Bonus: Lirkey trailhead is just a hop, skip, and jump down the road for some peaceful hiking. We have been to S. IL many times and Wistful Cabin is the best place we have stayed so far! Jess is very responsive and the whole process was very turnkey…did I mention the fresh honey? 5 STARS
Guest favorite
Home in Cobden
4.96 out of 5 average rating, 72 reviews

Wine trail cozy cabin! Hot Tub!

JayRating, 5 stars1 month ago
Really cozy! I got a nice staycation with a lot of peace and serenity

Pet-friendly house rentals

Top guest favorite
Home in Makanda
5 out of 5 average rating, 25 reviews

Twisted Sister's Retreat

ChristyRating, 5 stars2 weeks ago
We were in town for a girls get away with some hiking and Twisted Sister was perfect! Such a beautiful setting and so close to the places we wanted to go. It was super easy to get in, very clean, and had everything we needed to cook for ourselves as we prefer to do. We also enjoyed strawberries from Flamm Orchard, and great hikes at nearby Little Grand Canyon and Cove Hollow, plus of course Giant City State Park. Candace was an excellent hostess. She lives next door but gave us complete privacy. And when I had questions or wanted recommendations she was super responsive. It made us feel safe and cared for. It is so nice that she shares her beautiful property with guests in this way. We will be back!
Top guest favorite
Home in Murphysboro
5 out of 5 average rating, 31 reviews

Sleeps 16! 7 Bedrooms! 8 Bathrooms! 8 Beds!

LauraRating, 5 stars6 days ago
We had a group of 15 and this home was absolutely perfect for our stay! There’s a ton of gathering space, especially in the living room where the large couch and footrest easily accommodated everyone. The multiple dining areas upstairs also made mealtimes easy and comfortable. The kitchen was incredibly well-stocked — we cooked every meal for all 15 of us without any issues. Having the extra fridge downstairs was a huge plus for storing all our food and drinks. The outdoor area is truly picturesque. We loved lounging on the deck, soaking in the peaceful surroundings, and listening to the local wildlife. All of the bedrooms were spacious, and it was a huge bonus that everyone upstairs had their own bathroom. The home had everything we needed and more — highly recommend for large groups!
Guest favorite
Home in Makanda
4.89 out of 5 average rating, 62 reviews

Cedar Lake Retreat

DonaldRating, 5 stars1 week ago
I went to SIUC many many years ago and never visited Giant City. We came down to visit the campus and Giant City and Theresa’s place allowed us to bring our pet and was a great location. It was clean and nicely decorated at a good price.
Guest favorite
Home in Carbondale
5 out of 5 average rating, 18 reviews

Owls Nest

KevinRating, 5 stars1 day ago
Great place to bring our large family together and explore so much of the area: SIU, Giant City, Makanda art, the Wine Trail, and so many nature hikes. At night, quiet cabin with a fire pit in both front and back yards. Brought our dog with and appreciated the fenced in back yard.
Guest favorite
Home in Cape Girardeau
4.96 out of 5 average rating, 24 reviews

Located near downtown and casino

HeatherRating, 5 stars2 weeks ago
Great house, great location. Quiet neighborhood. Beds were comfortable. Plenty of room for my son to play. He loved playing in the basement.
Guest favorite
Home in Pomona
4.85 out of 5 average rating, 13 reviews

Shawnee Forest Vacation Lodge

JulesRating, 5 stars6 days ago
Kevin’s place was PERFECT!! Super cozy & CLEAN! Our family loved the peaceful, secluded location. Kevin quickly responded any time I had a question and gave us several good recommendations. Our pups felt right at home too. We look forward to staying here again!
Superhost
Home in Cape Girardeau
4.82 out of 5 average rating, 11 reviews

Cottage Near Casino

MelissaRating, 5 stars3 months ago
Had a great stay. Was there for work and it was a quick drive to everywhere in town. Quiet and peaceful just what was needed for my off hours.
Guest favorite
Home in Altenburg
4.88 out of 5 average rating, 33 reviews

Historic House in the heart of Altenburg

GeoffRating, 5 stars5 months ago
If you are looking for a nice old house in a neat little town this is it. We had our family visit us from the area and it was a perfect place to host from. The kitchen was well stocked and made cooking a breeze. Also the host was very responsive to any questions we had about the house and the area. We will definitely stay here again if we will be in the area!

Quick stats about vacation rentals that are pet-friendly in Cape Girardeau

  • Total rentals

    40 properties

  • Nightly prices starting at

    ﺩ.ﺇ147 before taxes and fees

  • Total number of reviews

    3.3K reviews

  • Family-friendly rentals

    20 properties are a good fit for families

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

  • Wifi availability

    40 properties include access to wifi

Destinations to explore

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  2. United States
  3. Missouri
  4. Cape Girardeau County
  5. Cape Girardeau
  6. Pet-friendly rentals