House vacation rentals in Simpsonville

Find and book unique houses on Airbnb

Top-rated house rentals in Simpsonville

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Superhost
A cozy living area features a leather couch adorned with pink cushions, positioned near a decorative glass coffee table. Sunlight filters through the windows, illuminating a flat-screen television above a white mantel. A small side table and a bookshelf add functional charm to the space.
Home in Greenville
4.82 out of 5 average rating, 169 reviews

Fenced in Yard, 2 Queen Beds, Downtown!

Hard to beat this amazing value! Nestled on a quiet street 5 minutes from downtown, this 2bed/1bath property is perfect for your visit to Greenville. Each bedroom has a queen bed and plenty of closet space with hangers. Out back, there's a spacious deck to relax on, and the property has a fenced in yard which would be ideal for your curious furry friend. This property is minutes from hospitals & interstate 85. Ideal for work travelers, or simply curious visitors. There's a driveway for parking.

Top guest favorite
A serene bedroom is highlighted by a four-poster bed adorned with decorative pillows and a soft blanket draped at the foot. Natural light filters through the sheer curtains on the left, while a gold-toned coffee table sits in front of the bed, providing a modern touch.
Home in West End
4.91 out of 5 average rating, 149 reviews

Best Nest Loft 3 Beds-1Block fr Main/Walk Downtown

Enjoy quaint GVL downtown spots. Walk the illuminated Main St. Trolley, bike, walk to eateries-breweries-shops-Falls/bridge-trails-theaters/venues & fun. Singles, couples-co-workers-friends-art/music lovers +. Entire 2nd floor. Newly renovated spacious historic loft- 9' ceiling-wood floors-lg glass shower. Relax on private balcony,cook in large kitchen, fast wifi/desk & record player.1300 sq ft.3 beds & luxe bath. SMART TV.Less busy area 1/2 block fr Main St.Sleeps 4.AGES 12+ per safety info

Superhost
A comfortable living room features a grey sofa with accent pillows, a wooden coffee table, and a side table with a lamp. A mid-century modern chair adds a pop of color. Natural light streams through multiple windows, enhancing the welcoming atmosphere.
Home in Greenville
4.88 out of 5 average rating, 104 reviews

2BR Home with Game Room, Near Downtown & Nature

Welcome to Margaret's Place, your home-away-from-home located conveniently next to Downtown GVL (3 mi) Traveler's Rest (5 mi) & Cherrydale Shopping Center (0.8 mi)- full of your favorite clothing shops & grocery stores. With 2 bedrooms, 1 bathroom, a well-stocked kitchen, dining room, and a huge backyard for your pets, we are the perfect jump off point for exploring Greenville! Whether you're looking for the city life or a drive into the mountains, we've got you covered at Margaret's Place!

Top guest favorite
An open-concept living area features a modern kitchen with stainless steel appliances and a spacious island, complemented by a dining table. A cozy living room is equipped with a soft sectional sofa facing a mounted television and warm electric fireplace. Natural light enhances the inviting atmosphere.
Home in Greenville
4.98 out of 5 average rating, 128 reviews

Greenville GEM Luxurious Retreat in Prime Location

Beautifully renovated 3 beds, 2 baths haven! This gem is a tranquil & stylish retreat, blending modern & cozy charm. Spacious bedrooms, each with plush bedding and storage. Two Bathrooms with soaking tub and a spacious walk-in shower. Cozy living room with a fireplace, TV, and comfy seating.  Fully equipped kitchen, Wi-Fi, Private deck and gazebo, fenced yard. Close to the city's best attractions, dining, and entertainment options. This is the perfect home base for your Greenville adventures.

Top guest favorite
The front of the house is showcased with a white exterior and a welcoming porch. Two rocking chairs are positioned on the porch, surrounded by planters displaying seasonal flowers. A well-maintained pathway leads to the entrance, framed by decorative brick steps and a railing.
Home in Greenville
4.97 out of 5 average rating, 238 reviews

Spectacular home 1 mile from Main St Greenville!

Enjoy your stay in this charming up to date house 1 mile from Main St Greenville! Take a walk through the Historic Pinckney district on your way to Greenville’s museums, restaurants, theaters, and stunning Reedy River Falls Park. Easy access to the Swamp Rabbit biking and walking trail, and just 4 blocks from the upcoming Unity Park. House is located on quiet residential street with private driveway. Relax on rocking chairs on front porch or around a portable fire pit in large backyard.

Guest favorite
A welcoming entryway is showcased, featuring a texture-rich armchair positioned beside a wooden side table. A decorative lamp illuminates the space, while an ornate mirror reflects natural light. The wooden front door adds character, and hardwood flooring enhances the overall warmth.
Home in Greenville
4.85 out of 5 average rating, 112 reviews

Sadie’s Place (monthly discounts)

This petite home is cozy & clean with 2 bedrooms: 1 queen and 2 twin beds, 1 bathroom, a kitchen and living room. It is just off Lauren’s road (a main thoroughfare) behind some local businesses and very close to grocery stores, restaurants, & 10 minutes to downtown. Free WIFI. Web enabled Sony smart TV (log into all your favorite streaming providers or sling from your own device), kitchen basics, Keurig, washer, dryer, iron & ironing board, and restaurants within walking distance.

Superhost
A contemporary living area features a comfortable gray sofa with accent pillows, positioned beside a coffee table. A flat-screen TV is mounted on a shiplap wall above an electric fireplace. Natural light floods the space through window coverings, illuminating the stylish decor.
Home in Simpsonville
4.96 out of 5 average rating, 131 reviews

Modern Farmhouse in Downtown Simpsonville, SC

Newly renovated two-bedroom home located in downtown Simpsonville, within easy walking distance of an excellent variety of restaurants, shops and places of interest. A spacious private balcony, leading off from the main bedroom suite overlooks a peaceful backyard... a great place to relax outdoors! The kitchen is fully equipped for preparing great meals. Our home is thoroughly and professionally cleaned & sanitized. ***Please note there is a train that runs midday and late at night.

Top guest favorite
A bright living room features two leather sofas positioned around a cozy area rug. Large windows provide ample natural light, with a mounted TV above a wooden mantel. Decorative wall frames add character to the space, complemented by a soft throw draped over one of the sofas.
Home in Simpsonville
4.95 out of 5 average rating, 153 reviews

Simpsonville Southern Comfort

Welcome to Simpsonville Southern Comfort! Our home offers a comfortable, completely remodeled space with all of the amenities of home to make your stay enjoyable. This home is in a GREAT location just a 5-minute drive from the conveniences of the Five Forks area, and a short 7-minute drive to the enjoyment of The Square in Downtown Simpsonville. Our home is also a quick 20-minute drive from GSP International Airport, and 20 minutes from Downtown Greenville. Enjoy your stay!

Top guest favorite
A calming bedroom features a spacious bed with crisp white linens and decorative pillows. A ceiling fan enhances airflow, while a large TV is mounted on the wall. A potted plant adds a touch of greenery, and soft light is provided by bedside lamps.
Home in Greenville
4.99 out of 5 average rating, 144 reviews

Family & Pet Friendly Home - Sleeps 8

Our home is absolutely perfect for entertaining, work and relaxation. Enjoy fast wifi and free coffee. Connect over a meal at our spacious dining table. Families will love the large, fenced-in backyard, toys and board games in our huge rec room, complete with ping pong table! Quiet and easy connections to Greenville & Simpsonville. Only 5 mins from Discovery Island Waterpark. Community park and playground accessible with lots of space to roam with family or pets.

Top guest favorite
The treehouse structure features a distinctive A-frame design with large glass paneling allowing for abundant natural light. Surrounded by trees, an outdoor deck with seating complements the lush woodland setting. The rooftop deck above adds to the unique architectural appeal.
Home in Greenville
4.99 out of 5 average rating, 235 reviews

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Top guest favorite
A spacious living room showcases a stunning mural of the Blue Ridge mountains. Comfortable seating includes a Pottery Barn sofa and two lounge chairs. A hammock chair adds relaxation options, while a large TV provides entertainment. Bright curtains frame the window, enhancing the room's light.
Home in Greenville
5 out of 5 average rating, 147 reviews

Comfy Pelham Rd Gem | 1 Story | Kid & Dog Friendly

Comfortable and colorful accommodations await you at the Blue Diamond BNB! This charming 1400 sq ft home is loaded with fun and fashionable amenities to ensure you have a memorable stay. Fully stocked and ready to welcome families, couples, business or leisure travelers, as well as extended stays with pet dogs. Situated in a quiet Eastside community, you're minutes from I-85 & 385 and centrally located between Greenville, Greer, Taylors, and Simpsonville.

Top guest favorite
A welcoming living area is displayed, featuring a comfortable sofa and a matching armchair. A wooden coffee table sits in the center, surrounded by a decorative area rug. A flat-screen TV is positioned on a wooden console against the wall, and natural light filters in through nearby windows.
Home in Simpsonville
4.96 out of 5 average rating, 181 reviews

Water Oak Retreat / Comfy king bed, big back yard!

-Private deck with grill and eating area - Fully stocked kitchen with tea, coffee and snacks -Safe and quiet neighborhood -1 mile from all of downtown Simpsonville's shops and restaurants -1 mile to huge park with playground, tennis, basketball, and farmers market -Short 20 minute drive to downtown Greenville -Perfect for families and those traveling for work

Popular amenities for Simpsonville house rentals

When is the best time to visit Simpsonville?

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Avg. priceﺩ.ﺇ474ﺩ.ﺇ459ﺩ.ﺇ448ﺩ.ﺇ444ﺩ.ﺇ466ﺩ.ﺇ466ﺩ.ﺇ437ﺩ.ﺇ470ﺩ.ﺇ455ﺩ.ﺇ466ﺩ.ﺇ444ﺩ.ﺇ488
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Quick stats about house rentals in Simpsonville

  • Total vacation rentals

    Explore 70 vacation rentals in Simpsonville

  • Nightly prices starting at

    Simpsonville vacation rentals start at ﺩ.ﺇ110 per night before taxes and fees

  • Verified guest reviews

    Over 2,180 verified reviews to help you choose

  • Family-friendly vacation rentals

    40 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    40 properties have a dedicated workspace

  • Wi-Fi availability

    70 of Simpsonville vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Simpsonville rentals

  • 4.8 Average rating

    Simpsonville stays are highly rated by guests—averaging 4.8 out of 5!