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Vacation rentals in Santa María

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa María

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.79 out of 5 average rating, 29 reviews

Casa de Campo en Olá, ríos, cascadas, Los Picachos

Finca La Terapia hace honor a su nombre, se encuentra entre las montañas del pintoresco pueblo de Olá de Penonomé, en la cual podrás desconectarte del ajetreado día a día de la ciudad. Cuenta con 42 Hectáreas privadas para explorar la naturaleza. El distrito de Olá, se caracteriza por tener lo mas hermosos paisajes Naturales entre los que podemos mencionar, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, entre otros a muy poco minutos de la Finca.

Guest favorite
Tiny home in El Higo
4.95 out of 5 average rating, 58 reviews

Private Pool Oasis in a Tiny Boutique Villa

Eden Ubedi: Your own, small private sanctuary Valle Antón is a 40 minute drive. We are not in Valle Antón Enjoy 150m² of exclusive space featuring a private plunge pool, garden, spa bath, and cinema screen It is one single space: loft-style Discover a destination beyond the usual tourist spots. Try Panama by staying close to real local communities near the highway Our boutique villa for 2 people ensures privacy with No shops or restaurants nearby, beaches and dining are a 5–10 minute drive

Guest favorite
Apartment in San Carlos
5 out of 5 average rating, 18 reviews

Casamar | Amplia terraza y jardín vista al mar

Apartamento en primera planta, amplia terraza y jardín privado con vista al mar, diseñado con múltiples espacios para relajarse y compartir. Cada recámara cuenta con su propia terraza, además de varios ambientes exteriores en el jardín. Desde la propiedad se accede directamente a una de las piscinas del complejo y se encuentra a pocos pasos del mar y del club de playa, ideal para disfrutar al máximo la experiencia en Casamar. Complejo con waterpark, piscinas y club de playa con acceso al mar.

Guest favorite
A private pool is surrounded by a smooth concrete deck, with gentle steps leading into the water. The adjacent open-air area features large glass doors that highlight the indoor living space, while the softly lit evening sky adds a serene ambiance.
Home in El Higo
4.97 out of 5 average rating, 33 reviews

CasAna

Fantástico lugar con espacios abiertos, luz natural y aire puro, 2 habitaciones con baño interno, terraza para recibir el amanecer y el atardecer, piscina privada que hace sentir que vuelas, mientras puedes compartir con amigos y familiares en un área grupal proporcionada por un espacioso deck, disfrutar de tus asados en la terraza y cocina equipada con todo lo que necesitas Ubicada a 10 mtos de Playa La Ermita y 12 mtos de la entrada del Valle, y a un salto del Restaurante Los Camisones.

Guest favorite
A thatched-roof ranch overlooks a swimming pool area, surrounded by vibrant flowering plants. The ranch provides shaded seating, while a hot tub is positioned next to the pool, enhancing the outdoor space's relaxation opportunities.
Villa in Rio Grande
4.94 out of 5 average rating, 84 reviews

Cheerful 3 bedroom countryside Villa with pool.

Forget your worries in this spacious and serene space. This 2 hectares villa includes an 185 square meters house, with 3 air conditioned bedrooms. In addition it includes a swimming pool and 40 square meter ranch. Bedrooms have in total 9 beds, accomodating 12 people. There are 3. 5 bathrooms, internet and hot water. Total perimeter of land is fenced, including an electric gate at the entrance. The price includes the presence of an employee who will support you during your stay.

Guest favorite
Home in San Carlos
5 out of 5 average rating, 15 reviews

Casa privada + Playa a 400mt + Jacuzzi + BBQ / 10p

Casa privada en Playa Corona para hasta 10 personas, a solo 400 metros de la playa. Ideal para cumpleaños, escapadas familiares o reuniones con amigos. Disfruta de un jacuzzi grande, espacioso con hidromasaje y burbujas, área de BBQ y bohío amplio para compartir al aire libre. Propiedad cerrada que brinda privacidad y seguridad durante tu estadía. A 5 minutos caminando de la playa y cerca del río. Un espacio cómodo y perfecto para crear momentos inolvidables en grupo.

Guest favorite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.94 out of 5 average rating, 48 reviews

Private Beach Studio · Sunset & Nature Views

Designed for comfort, functionality, and a welcoming atmosphere: • Comfortable bed for a truly restful sleep • Air conditioning • Wi-Fi • Kitchen • 2 Bathrooms • Parking Perfect for short stays or longer breaks. Wake up at your leisure, enjoy a relaxing coffee, stroll to the beach, or simply unwind in this space. This place is ideal for: • Romantic getaways • Personal retreats • “Work from the beach” • Escaping the hustle and bustle of the city

Guest favorite
Home in Canto del Llano
4.91 out of 5 average rating, 55 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Guest favorite
Home in Chitre
5 out of 5 average rating, 11 reviews

Casa Blu Central Chitre| Sleeps 6| Private Parking

Stay in a newly renovated private home in the center of Chitré with free gated parking, a large backyard, fast Wi-Fi, and space for the whole family. Walk to restaurants, supermarkets and the cathedral while enjoying the comfort of an entire home to yourselves. It combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home.

Top guest favorite
A modern beachfront building rises against a bright blue sky, with large windows reflecting the surroundings. Thatched-roof cabanas are visible on the sandy beach, bordered by lush greenery. The structure stands in a tranquil setting, inviting relaxation and enjoying ocean views.
Loft in Rio Hato
4.97 out of 5 average rating, 73 reviews

Beachfront Loft in Farallón

Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!

Guest favorite
Farm stay in Santa Fe
4.9 out of 5 average rating, 324 reviews

Cabaña del Sol en Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favorite
Cottage in Santa Fe
4.9 out of 5 average rating, 20 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Popular amenities for Santa María vacation rentals

  1. Airbnb
  2. Panama
  3. Herrera
  4. Santa María