Vacation rentals in Santa María District

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Top-rated vacation rentals in Santa María District

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Guest favorite

Cabin in Torio

4.97 out of 5 average rating, 152 reviews

Cozy open space, unique jungle views, river access

Casa Corotu is located in Torio Hills a 10 minute's walk to the beach with a a trail to access Torio river. Fiber Optic WiFi and two work spaces. The property surrounded by big trees that keep the house cool, which also provide shelter for birds and wildlife. The house is NOT childproof, minimal railing system. It's a great house to live the experience of #toriolife and all it has to offer. It is also an opportunity to experience the jungle in an open-style home with a mesmerizing treetop view.

Top guest favorite

An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.

Home in Costa Esmeralda

4.98 out of 5 average rating, 160 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise. Majestic Sands is located in a private beach community in Costa Esmeralda, San Carlos District, Panama. It is located a few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, Santa Clara and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.

Guest favorite

Cabin in Chicá

4.93 out of 5 average rating, 225 reviews

Horizonte Cabin by Casa Amaya

Take it easy at this unique and tranquil getaway at Cabaña Horizonte. Casa Amaya is a complex of 6 cabins located in Chicá de Chame, a cool climate between 18 and 24 degrees, where you can connect with nature and relax with your partner, friends or family. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya We have an electric generator in case of power outages.

Top guest favorite

A glass of red Merlot stands on a wooden table alongside an unopened bottle. The background features lush greenery, with soft natural light filtering through trees, creating a relaxed atmosphere. A hint of a hammock can be seen, suggesting a tranquil setting.

Tiny home in Cocle

4.93 out of 5 average rating, 122 reviews

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains

Hermosa cabaña de dos habitaciones y dos baños , den panorámico ubicada a unos 50 minutos de Penonome, Provincia de Cocle, en el Area del Parque Nacional Omar Torrijos Herrera , temperaturas entre 22 y 25 grados C a orillas del turístico Chorro de las Yayas en la comunidad de Barrigon del Cope, distrito de La Pintada. Agradable ambiente rodeado de árboles frutales y hermosas cascadas. Ideal para disfrutar de la naturaleza y relajarse. Cuenta con internet satelital de rápida velocidad .

Guest favorite

The modern house is set against a backdrop of rolling mountains, illuminated by the soft glow of evening light. A spacious entrance is visible, with large sliding doors opening to inviting communal areas. Lush greenery surrounds the property, enhancing its natural appeal.

Earthen home in El Cope, Penonome

4.92 out of 5 average rating, 177 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Guest favorite

Apartment in Los Canelos

4.89 out of 5 average rating, 36 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Top guest favorite

Large glass doors frame a view of lush greenery, connecting the interior to the outdoors. Warm lights illuminate the space, while a hammock hangs above, adding a relaxing touch. The entrance features a wooden door, providing a welcoming contrast to the surrounding nature.

Cabin in Penonome

4.97 out of 5 average rating, 103 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite

Two marshmallows are roasted over an open flame, held on sticks by hands. The fire crackles atop a wooden log, surrounded by dark green grass. The night setting adds to the cozy atmosphere created by the glowing flames.

Dome in Altos del Maria

4.91 out of 5 average rating, 58 reviews

Los Domos Panama, Domo Fuego, Glamping en Altura.

Immerse yourself in a natural oasis where the connection to nature becomes palpable. Surrounded by trees and coffee plantations, our space offers a unique experience for those looking to reconnect with nature. From the singing of the birds to the pure air that is breathed, every moment here is an invitation to harmony. We have a private river of totally cool spring water and immerse yourself in the evening experience with our hot outdoor jacuzzi.

Guest favorite

An inviting infinity pool is positioned on a spacious patio, overlooking a sweeping mountain view. Two lounge chairs are arranged on the deck, facing the water, while lush greenery and colorful blooms enhance the serene environment surrounding the pool area.

Cottage in Altos del Maria

4.94 out of 5 average rating, 147 reviews

Mountain Cottage with Great View and Heated Pool

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a heated pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

Guest favorite

A softly illuminated garden path is lined with stepping stones, leading through lush vegetation. A decorative lantern casts a warm glow, complemented by string lights in the background, creating a serene atmosphere in the evening.

Tiny home in Penonome

4.89 out of 5 average rating, 35 reviews

Cumbrera Deal

Enjoy the best of both worlds in this cozy and charming tiny home. Surrounded by nature, you can relax in the garden, rest in the hammocks, or admire the trees. You are also just minutes away from the highway, where you can find coffee shops, shopping malls, and everything you need. Whether you are looking for a peaceful getaway or a convenient base, this is the perfect place for you in Penonomé, Coclé.

Top guest favorite

A spacious living area features a cozy seating arrangement with plush cushions and a low wooden coffee table. A large hammock hangs nearby, and natural light filters through the windows, illuminating the handcrafted wooden beams and spiral staircase leading to the loft.

Earthen home in playa el arenal pedasi

4.97 out of 5 average rating, 149 reviews

Earth House Pedasi Experience

Welcome to the Earth House. This space is destined to give you the experience of spending your vacations in a Eco House with all the amenities and facilities of a ¨Regular Home¨. Why Eco? This house is made with 95% adobe and with natural materials from the surroundings like rock and wood. Everything is handmade for this unique space. It is a wonderful experience to share with family and friends.

Superhost

A dining area is presented with a wooden table set with plates and utensils. Large, framed windows allow natural light to fill the space, revealing views of the surrounding greenery. The rustic ambiance is enhanced by wooden accents and woven elements along the windows.

Farm stay in Santa Fe

4.9 out of 5 average rating, 290 reviews

Santa Fe villa with a espectacular view

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.