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Vacation rentals in Santa María

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Top-rated vacation rentals in Santa María

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 113 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Superhost
A single-story house is nestled beneath a large tree, featuring a tiled roof and a covered parking area. Surrounding greenery includes bushes and ornamental plants, enhancing the natural setting. The house is positioned to provide a sense of privacy and tranquility.
Home in Chitre
4.86 out of 5 average rating, 63 reviews

Country House Like in the City / La Casita

Casa fresca, con árboles y naturaleza. Áreas amplias para descansar. Ubicación céntrica, cerca de malls, restaurantes, estación de buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Ahora, Chitré, tiene un problema con el agua: no está potable; tenemos 50% de lo habitual, a veces estamos sin agua por algunas horas. Por favor, consulten antes de reserar.

Superhost
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.85 out of 5 average rating, 26 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Top guest favorite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonome
4.98 out of 5 average rating, 121 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite
The exterior of the house features a charming design with a red-roofed upper level and a welcoming terrace. A small pool is visible in the foreground, surrounded by lush greenery and natural rock formations. Cloudy skies create a serene atmosphere, enhancing the tranquil setting.
Home in El Nancito
4.94 out of 5 average rating, 33 reviews

Mountain Retreat: Peaceful & Private Escape

Escape to tranquility in our beautiful rural retreat near Laguna de San Carlos, Panama. Nestled on a private hectare of lush land, this cozy two-bedroom, two-bath house boasts an open terrace with breathtaking views of the San Carlos mountains. Whether basking in summer sun or enveloped in clouds during the rainy season, you’ll find peace and beauty here. Just a 30-minute drive to Coronado and the stunning beaches of Panama Oeste, it’s the perfect sanctuary for your getaway.

Guest favorite
Home in Canto del Llano
4.89 out of 5 average rating, 18 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Top guest favorite
An aerial view captures a scenic community surrounded by lush greenery and waterways. Residential buildings with terracotta rooftops are positioned near a serene lake and well-maintained gardens. The coastline is visible in the distance, providing a sense of tranquility to the landscape.
Condo in El Chirú
4.98 out of 5 average rating, 144 reviews

Laguna, Buenaventura

A spacious and quiet place in Buenaventura with capacity for (9) people, where you can enjoy a barbecue on its large terrace and its beautiful lake view. At 190 square meters, this beautiful apartment has: - Three spacious bedrooms. - 3 full bathrooms - Full Kitchen - A living room. -Dining Room - Terrace with barbecue grill, fan, chairs and outdoor armchairs. - A laundry area. - Two (2) parking spaces. - Area for bicycles or motorcycles.

Guest favorite
Cabin in El Valle de Antón
4.87 out of 5 average rating, 141 reviews

5 min from Valle I Incredible View Cabin 2

This cabin is modern and full of Nature. The cabin is 5 minutes before you get to Valle de Antón, it has a single space where the beds, kitchen and breakfast are. Outside there is a terrace with a nice view to enjoy. It has a TV, coffee maker and electric stove without an oven. The last 3 minutes of the road there is a stone street, but a Picanto passes smoothly. Up to two small dogs are allowed. Check in 3:00 p.m. and Check-out 12 md.

Top guest favorite
A bright dining area features a round wooden table surrounded by six turquoise chairs. Large windows allow natural light to fill the space, showcasing a cozy atmosphere. A wooden dresser and potted plants add touches of comfort. Arched openings lead to other rooms.
Home in El Valle de Antón
4.95 out of 5 average rating, 173 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Top guest favorite
A compact dining area features a foldable table surrounded by two upholstered chairs in a bold shade of purple. Natural light filters through a nearby window, illuminating the well-organized kitchenette, where shelves contain various glassware and utensils.
Camper/RV in El Valle de Antón
4.99 out of 5 average rating, 247 reviews

Armadillo Shelter & Garden Valle de Anton

It is a unique and special accommodation that we have designed for you to experience the Anton Valley in a more conscious and natural way. It's a remodeled RV or trailer, to make it cozy>functional and comfortable>tiny house style. The space has a small and complete kitchen, hot water, Wi-Fi, coffee and tea. It is surrounded by a nice garden. With a separate entrance and an area to park the car. Ideal for 1-2 people.

Guest favorite
A cozy sleeping area features a spacious bed with neutral bedding. Soft lighting is provided by bedside lamps, and a ceiling fixture adds warmth. Two framed art pieces adorn the walls, offering a subtle contrast to the light decor.
Tiny home in Penonome
4.84 out of 5 average rating, 63 reviews

Fenced and Pet-Friendly Cottage in Penonomé

Cozy private cottage, fully fenced — perfect for relaxing, remote work, or traveling with your pet. Enjoy the garden surrounded by greenery, rest in the covered hammocks, or do some birdwatching. Equipped kitchen, air conditioning, high-speed WiFi, and secure on-site parking. Just minutes from the Interamerican Highway, with easy access to cafés, shops, and more. Ideal for a peaceful getaway or productive stay.

Guest favorite
Farm stay in Santa Fe
4.9 out of 5 average rating, 310 reviews

Sun Cabin at Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Popular amenities for Santa María vacation rentals

  1. Airbnb
  2. Panama
  3. Herrera
  4. Santa María