
Vacation rentals in Santa María
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Top-rated vacation rentals in Santa María
Guests agree: these stays are highly rated for location, cleanliness, and more.

Pacific View | Jacuzzi, Pool, Views and Alexa
We are a country house for a maximum of 10 people on a fenced 1,000 m² plot at the top of Valle Los Lirios, Las Uvas de San Carlos, which maintains a feeling of seclusion. Located in a neighborhood with 24/7 video surveillance and a security gate. It offers views of the ocean, Valle de Antón, and forests. Relax in the Jacuzzi with hydro-massage and jets or swim in the pool. We have hammocks, a barbecue, a ping pong table, a fire pit and an Alexa voice assistant. There is parking for a maximum of 6 cars.
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CasAna
Fantastic place with open spaces, natural light and fresh air, 2 bedrooms with internal bathroom, terrace to receive the sunrise and sunset, private pool that makes you feel like you are flying, while you can share with friends and family in a group area provided by a spacious deck, enjoy your barbecues on the terrace and kitchen equipped with everything you need Located 10 meters from Playa La Ermita and 12 meters from the entrance to the Valley, and a hop from the Los Camisones Restaurant.
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Country House in Olá, rivers, waterfalls, Los Picachos
Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.
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Private Beach Studio · Sunset & Nature Views
Designed for comfort, functionality, and a welcoming atmosphere: • Comfortable bed for a truly restful sleep • Air conditioning • Wi-Fi • Kitchen • 2 Bathrooms • Parking Perfect for short stays or longer breaks. Wake up at your leisure, enjoy a relaxing coffee, stroll to the beach, or simply unwind in this space. This place is ideal for: • Romantic getaways • Personal retreats • “Work from the beach” • Escaping the hustle and bustle of the city
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Santiago city, home w/ spacious living & office
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.
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Stunning loft in Buenaventura Golf&Beach Resort
Stunning Remodeled Loft in The Buenaventura Golf & Beach Resort, Panama. Nestled within the lush offerings of Buenaventura Beach Resort in Panama, this completely remodeled loft presents a harmonious blend of modern luxury and natural beauty, creating a truly stunning living space. The loft features an open-concept design that maximizes light and airiness. The high ceilings lend an expansive feel, making the space both inviting and luxurious.
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Peaceful Garden Home |3BR| Fast WiFi|Near Penonomé
We want you to feel truly comfortable and at home. A home away from home. If you’re looking to spend quality time with family or friends, “Mi casa es su casa” at Villas de Santa María is the perfect place to relax, disconnect, and escape the noise of crowded cities. Enjoy our private garden and unwind on the terrace with stunning views of Guacamayas Hill, where you’ll experience peaceful surroundings and beautiful sunsets every afternoon.
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Casa Blu Central Chitre| Sleeps 6| Private Parking
Stay in a newly renovated private home in the center of Chitré with free gated parking, a large backyard, fast Wi-Fi, and space for the whole family. Walk to restaurants, supermarkets and the cathedral while enjoying the comfort of an entire home to yourselves. It combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home.
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Beachfront Loft in Farallón
Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!
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Cabaña del Sol en Finca Namuiki by the River
Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.
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k* Casa Matilde | 2BR Santa Fe Retreat by River
Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.
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Colonial House in Parita
Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.
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Popular amenities for Santa María vacation rentals
Other great vacation rentals in Santa María

NinaHouse, spacious and cool house in Chitré.
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Private house + Beach 400 meters away + Jacuzzi + BBQ / 10 people
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Espectacular Apartamento en Santiago
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Vacation Home
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Private Pool Oasis in a Tiny Boutique Villa
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Private Oceanfront Villa | Sleeps 14 |Playa Blanca
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Luxury 4BR Villa + Guesthouse & Pool @Buenaventura
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Casamar | Large terrace and garden overlooking the ocean
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