Vacation rentals in San Pedro del Espino

Raices de Domingo Cabin

Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (20-min ride from Pixvae or 1hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available).

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Casa de Campo in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia honors its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes among which we can mention, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the Farm.

Santa Fe villa with a espectacular view

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Apartment 2A

Accessible apartment in the center of Santiago, located 300 meters from the Transportation terminal and walking distance to supermarkets and businesses. With good layout of the space, fresh and bright and with all the basic amenities. The apartments provide a harmonious balance in the middle of the city, perfect for stays of families, friends, professionals, couples.

Serena Lodge & Camping - El Cope

Nestled in the heart of El Cope, Panama, Serena Lodge at Ventorrillo is surrounded by lush greenery, majestic mountains, and pristine rivers. Our secluded location provides a peaceful sanctuary away from the hustle and bustle of city life, offering guests a chance to reconnect with nature and rejuvenate their senses.

d'rosas apartamentos 3PB

Discover the comfort in our cozy home in the heart of Santiago, Veraguas. Just a 5 minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring local culture and resting after a day of adventure. We look forward to seeing you!

La Yeguada - Forest Point Cabin

It takes the whole family to this fantastic place with many areas to have fun, fully equipped cottage with spacious kitchen, living room with access to TV, hammocks, refrigerator, stove, hot water and everything you need to have a good time away from the noise and live with nature.

Cabin with river view

Take it easy at this unique and tranquil getaway. Enjoy the unique experience of nature in your bedroom and living room : -) Comfortable cabin. (glamping). Access to the river. Panoramic view. Very quiet, very zen. Massages and osteopathy upon request.

Cabana Vergara Santa Fe

Kick back and relax on this 2 acre ( 1 hectare) private mountain side property, on the Santa Maria River. Equipped with all the amenities you will need to make your stay a home away from home!

3BD, 2BTHS, furnished house

House with 3 bedrooms, 2 bathrooms, central, furnished, security garage, kitchen, automatic washing machine, A/A, Wi-fi, cable TV, new construction in beautiful residential.