
Hotel vacation rentals in Mission Bay
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Top-rated hotel rentals in Mission Bay
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay hotel rentals
Family-friendly hotel rentals

Stylish San Diego downtown Suite

Ocean Beach - Bed in a 8-Bed Mixed Dorm

Ocean Beach - Bed in 6-Bed Female Dorm

Equipped with the essentials

Pet-friendly Hotel with Free Breakfast and Pool!

Award-winning stay in the Gaslamp District

Greely Gaslamp - Loft w Parking & 3 Beds #302

Ocean Beach - Bed in 6-Bed Mixed Room
Hotel rentals with a pool

Recently reno’d escape near the Gaslamp Quarter

Convenient Base Near San Diego Zoo & Balboa Park

Modern Room with Sunset Views – A La Jolla Delight

Marriott At San Diego - Studio

Iconic Resort in San Diego

Soothing neutrals & killer coastline location

1-Bedroom Hotel Suite - 1 bed

Playful escape near games & concerts at Petco Park
Hotel rentals with a patio

Coronado Beach Resort July 6-13

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Charming 1 bedroom resort steps away from beach

Comic-Con 2026: Spacious King Suite + Sofa Bed

ITH Mission Beach Backpacker Hostel Mixed Dorm
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