Guesthouse vacation rentals in Mesa

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Mesa

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Mesa

4.99 out of 5 average rating, 165 reviews

Hideaway- Pool, Hot tub, Bikes, Near Hiking, Lakes

Midcentury guest house situated on the base of a mountain. 1.6 acre property near the Superstition Mountains. Pool, Hot tub, Mountain bikes or Beach Cruisers. 850 sq. ft. 1 bedroom, 1 bath, full kitchen, desk area - work space with great WI FI, washer, dryer, wood burning stove. Tastefully decorated with local artwork. Great location for hiking and biking. Our home is situated on the slope of a mountain and guest house is down below. Private with carport and covered patio with Barbeque Grill.

Jul 7 – 14

ﺩ.ﺇ436 per night

Guest favorite

Guesthouse in Mesa

4.92 out of 5 average rating, 370 reviews

The Oasis Hideout

Welcome to our delightful, hidden oasis in the Valley of the Sun! •A 10-minute walk from the light rail station for convenient access to the downtowns of Phoenix/Tempe/Mesa, Sky Harbor Airport, ASU, and Mill Ave •Kingsdown luxury mattress with adjustable base •Fast 1-Gbps WiFi & Chromecast TV for use with your streaming accounts •Refreshing 9' deep diving pool •Enjoy some R&R lounging in the hammock, sipping drinks, or watching the dusk fade around the firepit .Due to allergies, no pets,please

Aug 13 – 20

ﺩ.ﺇ367 per night

Guest favorite

Guesthouse in Gilbert

4.93 out of 5 average rating, 224 reviews

Private Cozy Cottage in Gilbert. Close to it all!

Recently updated- the Cozy Cottage is perfect for your AZ stay and has everything needed to make your trip as comfortable as possible. Ideal for couples and young families. Safe for solo travelers. The neighborhood is upscale and a great location. Walk to the Gilbert Riparian a nature lovers paradise just 1/4 mile away. Shopping, restaurants, nightlife are 10 minutes away. 20 mins to Phx, Scottsdale or desert hiking. We are here to answer any questions or help with any issues 24/7.

May 12 – 19

ﺩ.ﺇ377 per night

Guest favorite

Guesthouse in Gilbert

4.99 out of 5 average rating, 222 reviews

TnT Family Farm Guest House

Private guest house on a nonsmoking property with galley kitchen, full bath and walk in closet. Fully furnished and equipped, located on site at TnT Family Farm, a gated hobby farm. Well behaved dogs and declawed cats welcome. Due to space, only two animals are permitted - see house rules before instant booking. Easy Interstate 60 & Loop 202 access. Close to Gateway Banner Hospital, AT Stil University, ASU Polytech, Mesa Gateway & Sky Harbor International Airports.

Jun 19 – 26

ﺩ.ﺇ365 per night

Guest favorite

Guesthouse in Mesa

4.94 out of 5 average rating, 127 reviews

Private Entry Detached Guesthouse w/ Free Parking!

Enjoy our newly remodeled and professionally designed 1 bed, 1 bath private guesthouse. The stylish and cozy suite includes a full kitchen with brand new appliances, a work space, living room, and bedroom with a closet and ensuite bathroom. It is located just 15 mins away from major destinations, such as ASU, Sky Harbor International Airport, and fun attractions. We offer free parking on the property, in addition to wi-fi, Roku TV and toiletries. We would love to host you!

Jun 13 – 20

ﺩ.ﺇ444 per night

Guest favorite

Guesthouse in Mesa

4.98 out of 5 average rating, 122 reviews

Entire Suite:Private and Cozy Clark House Casita

Enjoy your stay at our unique 350 sq ft casita! It is partially attached to the main house, but has its own entryway for total privacy. The space has a full bathroom and a kitchenette. Rest easy on the comfortable queen size bed while catching up on your favorite Netflix series on the HD smart tv, or relax in the shaded patio surrounded by mature trees. You will have access to a covered parking space in the carport. No smoking or vaping on or inside the property.

Jul 17 – 24

ﺩ.ﺇ298 per night

Guest favorite

Guesthouse in Tempe

5.0 out of 5 average rating, 163 reviews

Guest house built in 2022 with everything you need

Keep it simple at this peaceful downtown Tempe guest house. Enjoy 10% off for stays of a week or more. It's walking distance to Mill Avenue shops and restaurants, and ASU. Park off street and access through your own entrance. The kitchen has a two hob induction stovetop and a microwave convection oven combo if you want to eat in. A private patio with a gas grill is also available for your use. There is a dishwasher and washer dryer for all the comforts of home.

Apr 7 – 14

ﺩ.ﺇ383 per night

Guest favorite

Guesthouse in Mesa

4.97 out of 5 average rating, 425 reviews

Mesa Casita with King Bed

Casita with a king size bed and kitchenette located in a quiet Mesa neighbored. The room is a dedicated Airbnb space in a separate building from the main house with it’s own entrance, private bath, and kitchenette perfect for a quick breakfast or a bite to eat. We are located minutes from the freeway and a 15 minute drive to Scottsdale, Tempe, Chandler, and Gilbert. Within minutes of some of the many hiking trails around the valley.

Jul 14 – 21

ﺩ.ﺇ369 per night

Guest favorite

Guesthouse in Chandler

4.94 out of 5 average rating, 187 reviews

Stylish Studio

Private guest house tucked away from the hustle and bustle. New AC unit! Enjoy the clean and bright space with a full kitchen, comfortable bed, and comfy couch. Enjoy a cool drink on your private porch. Minutes away from the airport (12 min), shopping (5min), Tempe Town lake (10 min), Scottsdale (10 min) and much more. You have full access to the pool and yard. There is no pool fence, so please use caution with small children.

Jul 27 – Aug 3

ﺩ.ﺇ343 per night

Guest favorite

Guesthouse in Mesa

4.93 out of 5 average rating, 198 reviews

Cozy, Private Mid-Century Casita

Enjoy your stay in the Valley of the Sun at this 350 sq. ft. stand-alone private casita with full bathroom & kitchenette. The bedroom features incredible natural light, but also the ability to block it out if you wish. Rest easy on the comfortable queen size bed and catch up on your favorite Netflix series on the HD smart TV. WiFi is available, & for business travelers there is a laptop desk. Please, no children or animals.

Jun 7 – 14

ﺩ.ﺇ233 per night

Guest favorite

Guesthouse in Mesa

4.97 out of 5 average rating, 207 reviews

Sanitized Spacious Desert Getaway

Newly built guest house in Northeast Mesa. Spacious Living and Kitchen area. 10 foot ceilings. Quite Neighborhood. Right around the corner from Usery Park, Hiking, biking and equestrian trails. Down the road form the Superstition Mountains. 25 minute drive to Saguaro or Canyon Lake. 15 minutes to the Salt River. Quick and easy assess to the Loop 202. Just minutes away from the Superstition Springs Mall.

Sep 7 – 14

ﺩ.ﺇ293 per night

Guest favorite

Guesthouse in Mesa

4.9 out of 5 average rating, 182 reviews

Orchard Cottage, Heated Pool and Hot Tub

Beautiful private self contained suite with a large heated pool and hot tub. Very private and far away from other living areas. Great fast internet, AC is new and works great (important in Arizona) and the bathroom shower is amazing. Lots of beautiful sitting spaces, sun or shade, relax at the pool or just hang out and read on the large hammocks.

Aug 5 – 12

ﺩ.ﺇ382 per night