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Guesthouse vacation rentals in Mesa

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Mesa

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious California King bed is centered in the room, adorned with a white quilt. Two pillows rest against the headboard. Natural light filters through a window with blinds, illuminating the inviting sleeping area.
Guesthouse in Gilbert
4.94 out of 5 average rating, 482 reviews

Spacious Casita, Quiet, Peaceful Home - No Stairs!

Cozy Casita in a beautiful, quiet neighborhood. California King bed sleeps two comfortably. 50 inch TV has cable, Netflix, DVD player with assortment of movies. Keurig coffee pot, fridge and microwave. Dining table inside. Outdoor seating opens to peaceful, scenic backyard. Parking available in the driveway. Park to the left of 2 car garage. Our Casita is a modest room that we have done our best to make comfortable for travelers who want an alternative to an impersonal hotel. No pets allowed.

Top guest favorite
Guesthouse in Mesa
4.97 out of 5 average rating, 197 reviews

Entire Suite: Private and Cozy Clark House Casita

Trade the sterile hotel vibe and feel right at home by staying at our quaint and unique historic casita. Catch up on your favorite shows in the living room with our 65 inch HD smart TV, or watch a movie while cozied up on our comfy queen size bed using the second tv in the bedroom. Our space has a kitchenette to prepare meals, and a full size bathroom. You may also relax in the shaded patio surrounded by mature trees and lush greenery. No smoking or vaping inside or outside of the property.

Guest favorite
A light and airy living area features a contemporary white leather sofa, complemented by a wooden coffee table. Natural light fills the space through two windows adorned with light curtains. A dining table with elegant chairs is visible in the background, surrounded by decorative plants.
Guesthouse in Red Mountain Ranch
4.92 out of 5 average rating, 139 reviews

Luxury Modern Executive Retreat

Northeast Mesa location close to Tonto National Forest, the Salt River and Saguaro lake. 5 minutes from Boeing, Nammo Talley or MD Helicopter. 25 minutes from downtown Phoenix or Scottsdale. Nestled at the base of the Goldfield mountains. Contemporary open floor plan with modern design. Private entrance and single parking spot in front of the main house. Fast WiFi. Roku and cable TV. Beautiful, quiet neighborhood close to city amenities as well as biking and hiking trails. TPT# 21558238

Guest favorite
An open living space showcases a comfortable gray sofa adorned with decorative cushions. A dining table is positioned nearby, with stylish chairs surrounding it. The kitchen features wooden cabinetry, a modern refrigerator, and decorative wall tiles, complemented by soft lighting from elegant chandeliers.
Guesthouse in Chandler
4.91 out of 5 average rating, 138 reviews

Historic Firehouse Downtown Chandler Large shower

Welcome to the historic Firehouse, where you're a quick 5-minute stroll away from bustling Downtown Chandlers top-notch restaurants and bars. You're staying in a historic building that has been magically transformed into a cozy Airbnb retreat. Step Inside the Firehouse Garden with 2 stylish bedrooms that are ready to whisk you away into dreamland, 1 amazing bathroom. With enough space to accommodate up to 6 guests. This is the perfect spot for a getaway with your favorite people.

Top guest favorite
Guesthouse in Mesa
4.96 out of 5 average rating, 151 reviews

Hacienda one bedroom with great pool

Heated pool, 8 seat hot tub, outdoor fireplace, and lots of patios to relax. The outdoor kitchen has a pizza oven, bbq, hot water sink, gas stove and oven, smoker and is a perfect place to enjoy. This place is close to restaurants, hiking, lakes and evening fun. Lots of trees: orange, grapefruit, key limes, lemons, pomegranate, figs, dates, grapes and there is a juicer for morning fresh juices. Safe, quiet, and has many hummingbirds and two giant (50 & 80 pound) tortoises.

Top guest favorite
A bright and airy studio space features a comfortable bed with crisp white bedding and a cozy sitting area with a plush sofa. Natural light fills the room through the window, and a small bedside table with a lamp adds a touch of warmth.
Guesthouse in Mesa
4.98 out of 5 average rating, 287 reviews

Private, Convenient Studio Apartment

Discover the perfect blend of location and comfort in our newly renovated studio apartment. Nestled centrally between Mesa, Scottsdale, and Tempe, you're at the heart of abundant dining choices, shopping convenience, and grocery store accessibility. Just 15 minutes from Sky Harbor and a swift 30 minutes from Mesa Gateway, your travels are a breeze. Enjoy total privacy with your exclusive entrance, ensuring a tranquil, personal escape in the midst of the city's best offerings.

Top guest favorite
A spacious bedroom is highlighted by natural light from a door leading outside. The room features a queen size bed covered with a blue striped comforter, flanked by two bedside tables with lamps. Framed artwork adorns the walls, adding character to the space.
Guesthouse in Mesa
4.95 out of 5 average rating, 303 reviews

Cozy, Private Mid-Century Casita

Enjoy your stay in the Valley of the Sun at this 350 sq. ft. stand-alone private casita with full bathroom & kitchenette. The bedroom features incredible natural light, but also the ability to block it out if you wish. Rest easy on the comfortable queen size bed and catch up on your favorite shows on the HD smart TV. WiFi is available, & for business travelers there is a laptop desk. On-site covered parking. Please no pets. This is a no-smoking property (tobacco, weed, vape).

Superhost
A bright living area is presented with a comfortable sectional sofa and accent chairs in various shades of grey and teal. A television is positioned on a stylish media console, while a decorative area rug adds color beneath a coffee table. Natural light filters through the window.
Guesthouse in Mesa
4.93 out of 5 average rating, 192 reviews

Detached Guesthouse | Driveway Park | Full Kitchen

Enjoy our newly remodeled and professionally designed 1 bed, 1 bath private guesthouse. The stylish and cozy suite includes a full kitchen with brand new appliances, a work space, living room, and bedroom with a closet and ensuite bathroom. It is located just 15 mins away from major destinations, such as ASU, Sky Harbor International Airport, and fun attractions. We offer free parking on the property, in addition to wi-fi, Roku TV and toiletries. We would love to host you!

Top guest favorite
A well-lit outdoor living space features a modern fire pit surrounded by an inviting seating area. String lights above provide a warm ambiance. The view includes glass doors leading into a cozy indoor area, framed by lush greenery and large trees.
Guesthouse in Maple Ash
4.99 out of 5 average rating, 123 reviews

ASU & Gammage | Private, Yard, Misters

The Studio at Maple Ash is your private retreat in Tempe’s iconic Maple Ash Neighborhood. Thoughtfully designed for ASU visitors, Gammage cast and crew, remote workers, and extended stays. This detached studio offers rare privacy just steps from campus, downtown, and the light rail. Unwind in your private fully enclosed 2,500 sq. ft. yard. Walk to ASU, Gammage Theatre, Mill Ave, and Tempe Beach Park or reach Sky Harbor in just 10 minutes.

Guest favorite
The spacious living and kitchen area features wooden cabinetry and modern appliances. A comfortable striped sofa faces a television on a stand. A dining table with chairs is set near a window, which allows natural light to fill the room.
Guesthouse in Mesa
4.95 out of 5 average rating, 296 reviews

Sanitized Spacious Desert Getaway

Newly built guest house in Northeast Mesa. Spacious Living and Kitchen area. 10 foot ceilings. Quite Neighborhood. Right around the corner from Usery Park, Hiking, biking and equestrian trails. Down the road form the Superstition Mountains. 25 minute drive to Saguaro or Canyon Lake. 15 minutes to the Salt River. Quick and easy assess to the Loop 202. Just minutes away from the Superstition Springs Mall.

Top guest favorite
A well-lit bedroom features a king size bed adorned with a floral blue and white duvet. Natural light streams in through plantation shutters. A minimalist armchair and lamp complement the space, while a simple rug adds warmth underfoot.
Guesthouse in Mesa
4.96 out of 5 average rating, 563 reviews

Mesa Casita with King Bed

Casita with a king size bed and kitchenette located in a quiet Mesa neighborhood. The room is a dedicated Airbnb space in a separate building from the main house with it’s own entrance, private bath, and kitchenette perfect for a quick breakfast or a bite to eat. We are minutes from local freeways. A 15 min drive to Scottsdale, Tempe, Chandler, and Gilbert.

Top guest favorite
A welcoming guest house is presented with a blend of white siding and natural stone accents, framed by lush greenery. A pathway leads to the entrance, flanked by well-maintained gardens. An American flag is displayed, contributing to the property’s inviting exterior.
Guesthouse in Mesa
4.94 out of 5 average rating, 173 reviews

The White Barn @ Freedom Farms

Kick off your boots and relax in this calm, stylish, private guest house on Freedom Farms! Explore the natural swimming pond on the property, venture out to the Sonoran desert for a nature hike, tube down the salt river or mountain bike in Usery! You'll find our location close to the city but not in the city.

Popular amenities for Mesa guesthouse rentals

When is the best time to visit Mesa?

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Avg. priceﺩ.ﺇ371ﺩ.ﺇ419ﺩ.ﺇ437ﺩ.ﺇ353ﺩ.ﺇ323ﺩ.ﺇ305ﺩ.ﺇ283ﺩ.ﺇ275ﺩ.ﺇ305ﺩ.ﺇ331ﺩ.ﺇ364ﺩ.ﺇ367
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Quick stats about guesthouse rentals in Mesa

  • Total vacation rentals

    Explore 150 vacation rentals in Mesa

  • Nightly prices starting at

    Mesa vacation rentals start at ﺩ.ﺇ147 per night before taxes and fees

  • Verified guest reviews

    Over 12,420 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Vacation rentals with a pool

    40 properties feature pools

  • Rentals with dedicated workspaces

    70 properties have a dedicated workspace

  • Wi-Fi availability

    150 of Mesa vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Mesa rentals

  • 4.9 Average rating

    Mesa stays are highly rated by guests—averaging 4.9 out of 5!

  • Nearby attractions

    Mesa's top spots, include Sloan Park, Golfland Sunsplash, and Hohokam Stadium

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