
Guesthouse vacation rentals in Mesa
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Mesa
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mesa guesthouse rentals
Family-friendly guest house rentals

Architectural Dream Guest House
Great especially if you have transport great kitchen and patio wonderful design.... all the uber drivers were in awe of the architecture. good fir morning run just great

Centrally Located Renovated Guest House
Shaayna’s place was super clean which is something 100% important! Clean bathroom and tub/shower! Clean appliances! It’s located in a very peaceful area! Check in is pretty easy and WiFi is great! You’ll love it here!

Two Bedroom, clean guest house in Gilbert
The house was just as pictured and exactly what we needed. It was clean, convenient and quiet! It made our graduation visit so easy. I'm not sure the AZ heat will get any easier on us, but we would definitely be happy to stay here again.

The Cozy Container with pool & gym
Easy to follow instructions! Nice spot to lay your head!

Boutique Hotel Style Guest House
We were driving through Phoenix and this was absolutely the best we could have asked for. Phil and Peggy’s casita was exactly what we needed—clean, well-equipped, comfortable bed, and cute outdoor space for our pup. This was one of the highest-quality airbnbs I’ve ever stayed in. Highly recommended

Cozy Guest Home away from Home
The home was very clean and comfortable. Had no problems at all finding the place. Area was very quiet and private also. Would absolutely stay again if needed!

1BR Guest House with Private Yard
We had a great stay! Quiet and loved the separate yard for our pup. Would highly recommend

Unique urban habitat near ASU/downtown Tempe
Great stay in Tempe. The bathroom was amazing—super clean and modern—and the natural lighting throughout the place made it feel bright and welcoming. AC was a little on the noisy side, but nothing that kept me from getting good sleep.
Guest house rentals with a patio

McDowell Suite
As advertised, well equipped, clean and comfortable. I would stay again.

Private Guest House in Phoenix Arts District
Nice and clean great location it felt very luxurious bed was firm and great on my back

Sunshine Studio! Phx/Scottsdale border!
Perfectly adequate little studio in Phoenix. If you plan on spending most of your days out and about it’s perfect. But if you like to stay in your rental and just enjoy the location I would drop a little more cash and get somewhere with more yard space and a pool.

Hidden Oasis at South Mountain!
Such a great little place, a nice retreat from the world with beautiful surroundings. Also close enough to everything to be perfect for business in and around the city.

Private yard - Short walk to Mill - Historic House
To whomever reads this…please don’t second guess this location! BOOK IT! Pictures don’t even do this place justice. He reallyyyy put his all into this cute & cozy space. I truly did not want to leave. I traveled solo & it was the perfect size. It’s even super romantic for couples in my opinion. Also, I took a shower outside…LIITTT! One of the best experiences. I felt so safe staying here. Super comfortable. It was so clean & organized. He has everything you’ll need there, especially in the kitchen! I didn’t utilize it cause I was on the run most of my trip but you name it, he had it! He was an amazing host. He communicated with me, very respectful, very nice, fast response time, he even checked in on me to make sure I was comfortable & I appreciate that sooo much! Greg! Arizona hasn’t seen the last of me, when…yes…WHEN I come back…I will be staying with you again!! Thank you for making my birthday trip one to remember! (I also took some great selfies in this room)

Spacious Midtown guesthouse with full privacy
Eric was friendly and helpful. The place was great. Just what I expected and just what I wanted. Thank you!

Zen Modern Casita w/ Private Pool + King Bed
Another great stay at Ann's casita!! Ann is an amazing host, her casita is wonderful! Highly recommended!

Your favorite PHX guesthouse!
Bradley’s place was perfect! I really appreciated the thoughtful touches like the real plants, coffee station, and bathroom toiletries. It was peaceful, comfortable, and felt just like home. The private entrance with an enclosed gate was an added bonus and made the space feel extra safe. I will definitely stay here again when I return to Phoenix. I highly recommend!!!
Guest house rentals with a washer and dryer

Adorable Willo Cottage in Historic Central Phoenix
So cute, clean, and in a peaceful nice neighborhood. Lynne was so friendly and went above and beyond to make us feel welcome!

Gilbert Guesthouse: Centrally Located Cozy Studio
This is our third time staying here, and we love it! One of the best stays in Gilbert!

Private studio! Central to popular locations.
This is a great place. Mike and Paige’s casita is decorated with many nice touches, it is super clean and comfortable with everything one needs.

Casita Hideaway at South Mountain
This place was really great and I highly recommend it to anyone. Place was clean and very well stocked with what needed. Instructions for check-in were simple and easy to follow. The best part is the location!! I enjoyed it as it was close to several restaurants, Target & Walmart, South Mountain Preserve and downtown Phoenix. I would definitely stay again!

Beautiful Private Guest House in Arcadia
Enjoyed the stay! Will book when given the chance again. Host is very nice and friendly.

Private and Quiet - 1 bdrm/1 bath Casita
Nice neighborhood, quiet/private casita - perfect for my work trip!

CASA OSCURA | private, modern spanish casita
I have stayed at Donna’s listing more than a few times- it’s one of my favorite places to stay! Great location, value, amenities and extremely comfortable and organized. I can’t wait to stay again!

Artist Studio Turned Colorful Casita in the Heart of Tempe
Really enjoyed my stay here! Some things were not entirely perfect — there was only one roll of TP, Ben was a little late with the check-in code, and the wifi was a little spotty — but the place itself was amazing; The sheets were clean and soft, the pillows were stuffed with soft, warm down, the wood furniture was beautiful and inviting, and there were coloring books that helped distract me from the pain of recovering from surgery. Whenever a train wasn’t passing through, the place was idyllic, and when there was one, the vibes ranged from soothing to ear-splitting (given, this was because I left the side door open & screened in at night). The neighborhood is beautiful, and there’s a park just down the way. I can’t recommend this place enough to someone looking for a peaceful, beautiful stay in Tempe.
Quick stats about guesthouse rentals in Mesa
Total rentals
140 properties
Nightly prices starting at
ﺩ.ﺇ110 before taxes and fees
Total number of reviews
11K reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
30 properties allow pets
Rentals with a pool
50 properties have a pool
Destinations to explore
- Tucson Vacation rentals
- Verde River Vacation rentals
- Tempe Vacation rentals
- Glendale Vacation rentals
- Palm Springs Vacation rentals
- Southern California Vacation rentals
- Henderson Vacation rentals
- Las Vegas Strip Vacation rentals
- Las Vegas Vacation rentals
- Phoenix Vacation rentals
- Scottsdale Vacation rentals
- Salt River Vacation rentals
- Pet-friendly rentals Mesa
- Rentals with a fireplace Mesa
- House rentals Mesa
- Rentals with an accessible height toilet Mesa
- Rentals with lake access Mesa
- Rentals with a home theater Mesa
- Kid-friendly rentals Mesa
- Rentals with breakfast Mesa
- Rentals with an EV charger Mesa
- Rentals with beach access Mesa
- Rentals with a hot tub Mesa
- Rentals with a patio Mesa
- Smoking-friendly rentals Mesa
- Family-friendly rentals Mesa
- Rentals with a kayak Mesa
- Private suite rentals Mesa
- Hotel rentals Mesa
- Rentals with a sauna Mesa
- Serviced apartment rentals Mesa
- Rentals with pools Mesa
- Tiny house rentals Mesa
- Resort rentals Mesa
- Townhouse rentals Mesa
- Villa rentals Mesa
- Rentals with outdoor seating Mesa
- Cottage rentals Mesa
- Apartment rentals Mesa
- Fitness-friendly rentals Mesa
- Condo rentals Mesa
- Rentals with a fire pit Mesa
- Rentals with a washer and dryer Mesa
- Waterfront rentals Mesa
- Guesthouse rentals Maricopa County
- Guesthouse rentals Arizona
- Guesthouse rentals United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Lake Pleasant Regional Park
- Phoenix Convention Center
- Chase Field
- Arizona Grand Spa
- Salt River Tubing
- Grand Canyon University Championship Golf Course
- Arizona Grand Golf Course
- Tempe Beach Park
- Salt River Fields at Talking Stick
- Hurricane Harbor Phoenix
- Sloan Park
- Camelback Ranch
- WestWorld of Scottsdale
- Peoria Sports Complex
- Oasis Water Park
- Grayhawk Golf Club
- Lost Dutchman State Park
- Papago Park
- Wildlife World Zoo, Aquarium & Safari Park
- Superstition Springs Golf Club
- Royal Palms Golf Course
- Trilogy Golf Club at Power Ranch
- Papago Golf Course
- Seville Golf & Country Club
- Things to do Mesa
- Things to do Maricopa County
- Nature and outdoors Maricopa County
- Things to do Arizona
- Sightseeing Arizona
- Wellness Arizona
- Entertainment Arizona
- Art and culture Arizona
- Nature and outdoors Arizona
- Tours Arizona
- Sports activities Arizona
- Things to do United States
- Sports activities United States
- Entertainment United States
- Food and drink United States
- Tours United States
- Wellness United States
- Sightseeing United States
- Art and culture United States
- Nature and outdoors United States