
Hotel vacation rentals in Los Santos Province
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Los Santos Province
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Los Santos Province hotel rentals
Family-friendly hotel rentals

Estrella Room - Quiet, budget friendly - queen bed
Best hotel in Venao

Brisa - Ocean Views, Calm Vibes, King/Twin beds
El Sitio exceeded our expectations. The staff are warm, helpful, and professional. We arrived late and the staff were wonderful at checking us in and getting us settled. The suite was beyond the pictures. The hotel is right on the beach, perfect for us as we were surfing. The restaurant on site was equally amazing, exceeded expectations, and reasonably priced. The bar and restaurant staff were fantastic. In the late afternoon each day a dj would spin until after sunset. The only thing we wished was that we could have stayed longer. Whether for a relaxing trip, surf and sun, family, romance or a friends trip, we highly recommend visiting Playa Venao and staying with the folks at El Sitio. It is truly a magical place!

Arena Room - Family Room, Incredible Ocean Views
I have already gone before and I always get a lot of attention. And the clean rooms, great pool on the beach shore. Good attention. Recommended

Playa Room - First floor family space, ocean views
Everything was excellent! Fully recommended for beach lovers
Hotel rentals with a pool

Olas Room - Quiet, Second Floor w/ Queen bed
My friend and I had the best time! Perfect location, walking distance from all the cute cafes and all employees were lovely :) will definitely be going back đ

Palmas Room - Tranquil Space with King Bed
An incredible oasis and perfect location right on the beach and close to all the fun Venao has to offer. We were lucky to get an upgrade to a premium room for my husbandâs birthday. The hosts were very attentive and responsive. Would definitely return.

Luna Room - Peaceful and Economical, two twin beds
Great place. I had a terrible ending of being drugged and robbed. Regardless, amazing Airbnb host and a good location.

Sol Suite - Large room, King bed, Ocean Views
Amazing stay. Great communication. Great view. The one disruption was thereâs light construction happening next door. Overall great stay.

Morro Room - Second Floor, Peaceful location
Close to everything. Bed and Sheets were of very high quality. For this room not a super view of the pool & beach but that was expected. Accurate description.

Oria Room - Quiet and Peaceful Space, King bed
Great place to stay, right on the beach with a beautiful pool.

Yellow Room for 4 at Casa Lassini - Oceanfront!
Good location right on the water. Kate and Rob were wonderful hosts and helped us get acquainted with the area.

Green Room for 3 at Casa Lassini - Oceanfront!
Katherine and Rob were wonderful hostsâŠ. Very helpful and nice peopleâŠ. We enjoyed our stay very much
Hotel rentals with a patio

Charming SIMBA Room! Casa Wabi Sabi
This is a great place to stay in Pedasi! There isnât much to do in pedasi - was an extremely quiet town. But this place was attached to a restaurant with great food and live music so it was perfect. Highly recommended!

Hotel Villas Don Pablo / Las Tablas Villa No. 1
Very nice hostel, very friendly owners and very nice food in the restaurant right next door. Unfortunately a little off the beaten path so you need a taxi or car to get into the city or to the beach.

Boutique Inn_The Hill 3_Private Entry_Sea View_16+
My room was decorated with excellent taste (the photos are accurate), very confortable and the bed, huge and relaxingly firm. The view over the garden and the sea from inside as well as from its private terrace are one of its best features. The internet connection is fast, which allowed me to work from there and have conf calls without any problem. The kitchen, gravity center of the Hill, is beautiful and perfectly equipped. The common areas are very well designed - as befits the house - and actually make you want to stay there all day. But there's so much to do in Cambutal. On top of hanging out on its black sand beach set against the tropical greenery, there's good surfing spots, hikes in the jungle, swimming in cascade pools...Stephan had very good advice and helped me organize all these activities. I had such a great time there that I extended my stay and would have stayed more if I could.

Boutique Inn_The Hill 1_Private Entry_Sea View_16+
Staying at The Hill was definitely an experience that was worth it. The views were amazing! Upon arrival, you're greeted by the hosts, Stephan and Thuy. You're offered a welcome drink before being showed your room. During our stay, we had the privilege of choosing between the room we initially booked and another vacant room to choose. We chose the other room as the view from the room we ended up choosing was more than worth it. We spent one night watching the sunset from our balcony. Each of the bedrooms have their own separate theme. The theme of our room was pink, my friend was in love as it's her favorite color. Overall, the stay was welcoming. The view was beautiful, the host were accommodating and the stay was relaxing. Since the location is called the hill, please be aware that it is located on a hill and you will be traveling up dirt roads in order to reach the beauty. There is a path for 4Ă4 and one for 4Ă2.

Boutique Inn_The Hill 4_Private Entry_16+
I can wholeheartedly recommend Stephan and Duyâs place. The house and surroundings are stunning, and the hosts are warm, friendly and helpful. The only backside of our stay was that we needed to work (which is totally feasible thanks to good WiFi, desk etc). We hope to return soon. Thanks again Stephan and Duy đ

Room in Boutique Hostel; Private Bathroom
Really nice appartment in the middle of Pedasi. Alexa was super helpful and also the shared kitchen was nice - there could be a little more utensils like a good knife and also the kitchen stove didnât work but overall it was good. We worked remotely their and we enjoyed the outdoor area next to the kitchen very much. Can only recommend :)

2nd floor room for up to 6 people!
The cabanas, pool/patio area and attention met our expectations, keep them clean and nice; the owners are very friendly and the restaurant offers delicious food for lunch and dinner. We felt right at home, the treatment is very warm and friendly, they support what you always need. The only observation is that El Puerto Beach is not as cute as other beaches in Panama. We really enjoyed it because we know it and we already know what to expect, it is a beach that we have gone to many times and we love it because it is quiet, with a delicious breeze, it is shallow and safe for the boys. This place is perfect for a quiet getaway to be secluded for a few days but is also very close to Las Tablas or Chitre if you want to visit. We loved it!
Destinations to explore
- Smoking-friendly rentals Los Santos Province
- Rentals with outdoor seating Los Santos Province
- Kid-friendly rentals Los Santos Province
- Pet-friendly rentals Los Santos Province
- House rentals Los Santos Province
- Rentals with a fire pit Los Santos Province
- Beachfront rentals Los Santos Province
- Rentals with pools Los Santos Province
- Rentals with beach access Los Santos Province
- Rentals with a patio Los Santos Province
- Rentals with a washer and dryer Los Santos Province
- Waterfront rentals Los Santos Province
- Rentals with an accessible height bed Los Santos Province
- Villa rentals Los Santos Province
- Apartment rentals Los Santos Province
- Condo rentals Los Santos Province
- Hotel rentals Panama
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom