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Hotel vacation rentals in Los Santos Province

Find and book unique hotel rentals on Airbnb

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Popular amenities for Los Santos Province hotel rentals

Family-friendly hotel rentals

Guest favorite
Hotel room in Playa Venao
4.76 out of 5 average rating, 25 reviews

Estrella Room - Quiet, budget friendly - queen bed

SofiaRating, 5 stars1 month ago
Best hotel in Venao
Guest favorite
Hotel room in Playa Venao
5 out of 5 average rating, 12 reviews

Brisa - Ocean Views, Calm Vibes, King/Twin beds

KristinaRating, 5 stars2 months ago
El Sitio exceeded our expectations. The staff are warm, helpful, and professional. We arrived late and the staff were wonderful at checking us in and getting us settled. The suite was beyond the pictures. The hotel is right on the beach, perfect for us as we were surfing. The restaurant on site was equally amazing, exceeded expectations, and reasonably priced. The bar and restaurant staff were fantastic. In the late afternoon each day a dj would spin until after sunset. The only thing we wished was that we could have stayed longer. Whether for a relaxing trip, surf and sun, family, romance or a friends trip, we highly recommend visiting Playa Venao and staying with the folks at El Sitio. It is truly a magical place!
Guest favorite
Private room in Playa Venao
4.73 out of 5 average rating, 11 reviews

Arena Room - Family Room, Incredible Ocean Views

MiguelRating, 5 stars6 months ago
I have already gone before and I always get a lot of attention. And the clean rooms, great pool on the beach shore. Good attention. Recommended
Superhost
Hotel room in Playa Venao
4.67 out of 5 average rating, 12 reviews

Playa Room - First floor family space, ocean views

OliverRating, 5 stars1 month ago
Everything was excellent! Fully recommended for beach lovers

Hotel rentals with a pool

Superhost
Hotel room in Playa Venao
5 out of 5 average rating, 7 reviews

Olas Room - Quiet, Second Floor w/ Queen bed

NataliRating, 5 stars2 months ago
My friend and I had the best time! Perfect location, walking distance from all the cute cafes and all employees were lovely :) will definitely be going back 😁
Guest favorite
Hotel room in Playa Venao
5 out of 5 average rating, 8 reviews

Palmas Room - Tranquil Space with King Bed

AmandaRating, 5 stars2 months ago
An incredible oasis and perfect location right on the beach and close to all the fun Venao has to offer. We were lucky to get an upgrade to a premium room for my husband’s birthday. The hosts were very attentive and responsive. Would definitely return.
Superhost
Hotel room in Playa Venao
4.92 out of 5 average rating, 12 reviews

Luna Room - Peaceful and Economical, two twin beds

AdrienRating, 5 stars3 months ago
Great place. I had a terrible ending of being drugged and robbed. Regardless, amazing Airbnb host and a good location.
Guest favorite
Hotel room in Playa Venao
5 out of 5 average rating, 8 reviews

Sol Suite - Large room, King bed, Ocean Views

AndrewRating, 5 stars13 months ago
Amazing stay. Great communication. Great view. The one disruption was there’s light construction happening next door. Overall great stay.
Superhost
Hotel room in Playa Venao
5 out of 5 average rating, 5 reviews

Morro Room - Second Floor, Peaceful location

AbsRating, 5 stars2 months ago
Close to everything. Bed and Sheets were of very high quality. For this room not a super view of the pool & beach but that was expected. Accurate description.
Superhost
The room features a spacious king bed accented with two decorative pillows. Rustic decor is highlighted by a wooden headboard and earthy green walls. A mirror reflects the room's design, while a corner with tall bamboo adds a natural touch. Air conditioning is visible on the wall.
Hotel room in Playa Venao
4.75 out of 5 average rating, 4 reviews

Oria Room - Quiet and Peaceful Space, King bed

AstrixRating, 5 stars27 months ago
Great place to stay, right on the beach with a beautiful pool.
Superhost
Hotel room in Las Tablas Abajo
4.69 out of 5 average rating, 16 reviews

Yellow Room for 4 at Casa Lassini - Oceanfront!

JohnRating, 5 stars1 month ago
Good location right on the water. Kate and Rob were wonderful hosts and helped us get acquainted with the area.
Superhost
A refreshing pool is visible, surrounded by a concrete patio and framed by a palm tree. The ocean reflects a clear blue sky, creating a serene setting. Wooden seating overlooks the water, providing a peaceful area for relaxation.
Hotel room in Las Tablas Abajo
4.87 out of 5 average rating, 15 reviews

Green Room for 3 at Casa Lassini - Oceanfront!

ChristineRating, 5 stars2 months ago
Katherine and Rob were wonderful hosts
. Very helpful and nice people
. We enjoyed our stay very much

Hotel rentals with a patio

A woven basket contains lush green leaves, creating a natural accent in the interior space. The plant's vibrant foliage contrasts against the neutral wall, adding a touch of nature to the environment.
Private room in PocrĂ­
4.63 out of 5 average rating, 8 reviews

Charming SIMBA Room! Casa Wabi Sabi

RobynRating, 5 stars22 months ago
This is a great place to stay in Pedasi! There isn’t much to do in pedasi - was an extremely quiet town. But this place was attached to a restaurant with great food and live music so it was perfect. Highly recommended!
Two cottages are set in a natural environment, showcasing a covered patio with a dining table and chairs. Lush greenery surrounds the area, and the exterior features a welcoming entrance with a door and window, highlighting the tranquil landscape beyond.
Private room in Las Tablas
4.75 out of 5 average rating, 8 reviews

Hotel Villas Don Pablo / Las Tablas Villa No. 1

MaraRating, 5 stars17 months ago
Very nice hostel, very friendly owners and very nice food in the restaurant right next door. Unfortunately a little off the beaten path so you need a taxi or car to get into the city or to the beach.
Superhost
Hotel room in Cambutal
4.91 out of 5 average rating, 11 reviews

Boutique Inn_The Hill 3_Private Entry_Sea View_16+

FernandoRating, 5 stars8 months ago
My room was decorated with excellent taste (the photos are accurate), very confortable and the bed, huge and relaxingly firm. The view over the garden and the sea from inside as well as from its private terrace are one of its best features. The internet connection is fast, which allowed me to work from there and have conf calls without any problem. The kitchen, gravity center of the Hill, is beautiful and perfectly equipped. The common areas are very well designed - as befits the house - and actually make you want to stay there all day. But there's so much to do in Cambutal. On top of hanging out on its black sand beach set against the tropical greenery, there's good surfing spots, hikes in the jungle, swimming in cascade pools...Stephan had very good advice and helped me organize all these activities. I had such a great time there that I extended my stay and would have stayed more if I could.
Superhost
Hotel room in Cambutal
5 out of 5 average rating, 11 reviews

Boutique Inn_The Hill 1_Private Entry_Sea View_16+

LashayeRating, 5 stars1 month ago
Staying at The Hill was definitely an experience that was worth it. The views were amazing! Upon arrival, you're greeted by the hosts, Stephan and Thuy. You're offered a welcome drink before being showed your room. During our stay, we had the privilege of choosing between the room we initially booked and another vacant room to choose. We chose the other room as the view from the room we ended up choosing was more than worth it. We spent one night watching the sunset from our balcony. Each of the bedrooms have their own separate theme. The theme of our room was pink, my friend was in love as it's her favorite color. Overall, the stay was welcoming. The view was beautiful, the host were accommodating and the stay was relaxing. Since the location is called the hill, please be aware that it is located on a hill and you will be traveling up dirt roads in order to reach the beauty. There is a path for 4×4 and one for 4×2.
Top guest favorite
Hotel room in Cambutal
5 out of 5 average rating, 10 reviews

Boutique Inn_The Hill 4_Private Entry_16+

MajaRating, 5 stars4 months ago
I can wholeheartedly recommend Stephan and Duy’s place. The house and surroundings are stunning, and the hosts are warm, friendly and helpful. The only backside of our stay was that we needed to work (which is totally feasible thanks to good WiFi, desk etc). We hope to return soon. Thanks again Stephan and Duy 😊
A unique outdoor space is framed by bamboo structures, creating a distinctive and inviting environment. Green foliage and palm trees are visible, enhancing the natural surroundings. The sky is partly cloudy, adding a sense of openness to the area.
Hotel room in Pedasi
4.67 out of 5 average rating, 21 reviews

Room in Boutique Hostel; Private Bathroom

SabrinaRating, 5 stars2 months ago
Really nice appartment in the middle of Pedasi. Alexa was super helpful and also the shared kitchen was nice - there could be a little more utensils like a good knife and also the kitchen stove didn’t work but overall it was good. We worked remotely their and we enjoyed the outdoor area next to the kitchen very much. Can only recommend :)
Two lounge chairs are positioned in front of a swimming pool, illuminated with soft blue lighting. Lush greenery surrounds the area, with hammocks hanging nearby. A thatched structure is visible in the background, suggesting a relaxing atmosphere for guests.
Hotel room in La Enea
4.68 out of 5 average rating, 34 reviews

2nd floor room for up to 6 people!

MarieRating, 5 stars3 months ago
The cabanas, pool/patio area and attention met our expectations, keep them clean and nice; the owners are very friendly and the restaurant offers delicious food for lunch and dinner. We felt right at home, the treatment is very warm and friendly, they support what you always need. The only observation is that El Puerto Beach is not as cute as other beaches in Panama. We really enjoyed it because we know it and we already know what to expect, it is a beach that we have gone to many times and we love it because it is quiet, with a delicious breeze, it is shallow and safe for the boys. This place is perfect for a quiet getaway to be secluded for a few days but is also very close to Las Tablas or Chitre if you want to visit. We loved it!

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