Vacation rentals in East Cleveland

New Cleveland Apt: Little Italy! Massage&Hot tub!

Fall in love with this charming, newly updated 1-bedroom, 1-bath lower unit triplex apartment situated just minutes from downtown and University Circle. Complete with a well-equipped kitchen, Smart TV, laptop workspace, and modern furnishings, this vacation rental delivers all the essentials so you can spend more time relaxing and exploring. Nearby Case Western University, UH Hospital, University Circle, Cleveland Museum of Art, Cleveland Clinic, Severance Hall, Botanical Garden, and much more!!

Location · Family · Heating

In the heart of Little Italy! Free Parking! 3BR-UP

Enjoy your stay at this centrally located - upper unit- in a two-family home in Little Italy. Apartment is complete with a well-equipped kitchen. The living room includes comfortable seating for 6, a smart TV, 3 poufs & coffee table - so that ALL may rest their feet from a long day, modern furnishings and a washer/dryer/linen closet. Each bedroom includes USB plugs in the lamps, alarm clocks with sound machines, blackout curtains, ceiling fans, Smart TVs, "ultra-quiet" ACs, desk, chair & mirror.

Family · Location · Amenities

The Worlds Cozy Nest

Rest and relax in this calm, stylish space. Sitting right in the heart of one of Cleveland’s most prestigious, safe suburbs, University Heights. This cozy home is Less than 15 minutes from Cleveland clinic and University hospitals main campus. Walking distance from plenty of shops and restaurants and less than 10 minutes from Legacy Village and Beachwood Mall, two of Clevelands premier, upscale shopping areas. This house has been newly renovated and comes equipped with all essentials plus more!

Location · Family · Getting around

Stay at Supreme!

Enjoy a comfortable and convenient stay in the heart of Beachwood. Located just minutes from Cleveland Clinic and University Hospitals, beautiful parks and nature trails, and top shopping and dining at Pinecrest and Eton Malls, our home is perfectly situated for both short and extended stays. The house is minutes from local synagogues and kosher restaurants. A spacious, fully renovated home, with a modern touch. It’s an ideal place to relax and feel at home—no matter the reason for your visit.

Location · Value · Quiet

Historic Little Italy Garden Apartment

Stylish garden apartment. This retreat blends modern comfort with the vibrant cultural charm of Historic Little Italy. Steps away from shops, restaurants, and lively bars. Wade Oval Park is a nearby cultual hub, home to The Art & Natural History Museums and Botanical Gardens. Easy access to Case Western Reserve, Cleveland Clinic and University Hospital. Walk to the beautiful Lakeview Cemetary or take transit downtown to 4th street. Perfect for short or long stays. Book for a memorable time.

Value · Family · Bathroom

Mid-Century Modern Retreat in Little Italy

Nestled in the vibrant yet peaceful and safe Little Italy neighborhood of Cleveland, this newly remodeled Mid-Century Modern style 2bed/1bath Lower unit is within walking distance to the best Cleveland has to offer. Enjoy a stroll to Case Western Reserve University, University Circle, the Cleveland Museum of Art, Cleveland Botanical Garden, and more. Discover local shops, bakeries, and renowned restaurants that give Little Italy its charm. The RTA redline station is a five minute walk.

Location · Family · Indoor spaces

Cle Suites 1BR/1BA | 5 min Walk to Cle Clinic #7

Fully furnished luxury apartment that has been completely renovated combining old-time 19th century charm with modern amenities. Just move in with your suitcase! Within walking distance to the Cleveland Clinic Campus (5 min walk from main hospital). It’s also near University Hospitals, CWRU, Great University Circle, Downtown Cleveland, and Little Italy. This location is perfect for those receiving medical treatments and their families, doctors on rotation, travel nurses, and interns.

Location · Value · Comfort

Little Italy|Pet Friendly|1BR

Enjoy a stylish experience at this centrally-located place in the heart of Little Italy. Newly renovated with a minimalist design. You are just down the street from restaurants, bakeries and bars. The RTA redline is also a two minute walk away, which takes you straight downtown as well as to the airport. Also within walking distance of Cleveland Clinic and University Circle. The apartment is located on the second floor with stairs. There is no private parking at the property.

Family · Location · Hospitality

Cozy Condo l Minutes from Cleveland Clinic

Our apartment is ideally located near Cleveland Clinic, making it perfect for medical professionals, patients, and families. You’ll also be minutes from the Health Education Campus, Case Western Reserve University, University Hospitals, and the museums of University Circle. Enjoy a short drive to the charming Little Italy neighborhood, filled with authentic Italian restaurants, cafés, and bakeries, while downtown Cleveland is just 5 miles away for dining and entertainment.

Location · Value · Laundry

Clinic & CWRU 2BR | Balcony + Parking, 24/7 GYM

Live in the heart of Little Italy, steps from University Circle, UH, and CWRU, with Cleveland Clinic just minutes away. This professionally designed 2BR 1BA suite has: ✓ Sleeps up to 6 ✓ Includes secure gated parking ✓ A gym ✓ An in-unit washer/dryer, ✓ and resort-style community amenities Whether you’re visiting for work, medical travel, or a city getaway, this centrally located space offers comfort, convenience, and a refined place to recharge.

Location · Family · Pool

Purple Haus - Game room w/ pool table, poker table

Welcome to the Purple Haus, the "pur"fect short-term rental for your vacation, staycation, or baecation. Enjoy staying in a creative, comfy, modern, yet fun, and playful space. The Purple haus is a "purple" (colored) themed Air bnb filled with multiple photo ops throughout the home. Located on the eastside of Cleveland Ohio, 10 minutes from Downtown CLE. Minutes away from I 90 and on the RTA bus line. The Purple Haus is what you have been looking for!

Family · Location · Decor

South Euclid 3BR Cozy Home — Near Clinic

Forget your worries in this spacious and serene space. Nestled in a peaceful and friendly neighborhood, our private house offers a perfect retreat for families, groups, or solo travelers looking to enjoy the best of Cleveland. This spacious home combines comfort, style, and convenience, ensuring a memorable stay. The house is equipped with everything you need for long stays or short vacation, just bring your suitcase .

Family · Location · Walkability