Apartment vacation rentals in East Cleveland

An outdoor space features a hot tub surrounded by a stone patio. A wooden table with chairs is shaded by a green umbrella. String lights hang above, adding a touch of brightness to the area. A wall of exposed brick provides a rustic backdrop.

4.98 out of 5 average rating, 124 reviews

Cle Rocks-Little Italy! W Massage chair/Hot tub #2

Fall in love with this charming, newly updated 2-bedroom, 1-bath upper unit triplex apartment situated just minutes from downtown and University Circle. Complete with a well-equipped kitchen, Smart TV, laptop workspace, and modern furnishings, this vacation rental delivers all the essentials so you can spend more time relaxing and exploring. Nearby Case Western University, UH Hospital, University Circle, Cleveland Museum of Art, Cleveland Clinic, Severance Hall, Botanical Garden, and much more!!

A living area features a comfortable sofa and two accent chairs. A rustic wooden coffee table is placed at the center, surrounded by simple decor such as woven baskets and potted plants. Exposed brick walls add texture to the cozy space, illuminated by recessed lighting.

4.98 out of 5 average rating, 105 reviews

Little Italy 3, close to Cleveland Clinic, CWRU

Enjoy a uniquely styled experience at this boho-chic apartment in the heart of Little Italy. Exposed brick walls, hardwood floors, and wooden furnishings combine to give this apartment a boho-chic aesthetic. Enjoy dinner in the cozy kitchen and watch TV while relaxing on the comfortable sofa. One flight of stairs is leading up to the second floor (17 steps)The unit is on a quiet side street in walking distance to the heart of Little Italy (restaurants,cafes, shops).Free parking on premises(1car)

4.95 out of 5 average rating, 708 reviews

Apartment in Tremont

Tremont bistro apartment suite with skyline views

Beautiful skyline views and full service amenities! This 2nd level suite is directly above popular independent bistro Fat Cats. Located on the Towpath Trail connecting downtown through the Cuyahoga River Valley for off-road hiking and biking. Explore the historic Tremont neighborhood and enjoy Lincoln Park. We'd love to cook seasonal farm fresh meals for you, or serve a drink from our craft bar. Open for LUNCH, DINNER, Saturday BRUNCH (closed Sunday). Chef/Owner Ricardo Sandoval is your host!

4.96 out of 5 average rating, 340 reviews

A spacious living area features a large area rug with intricate patterns, complemented by a comfortable armchair and a wooden coffee table. A television is positioned on a stand, and natural light filters through a window adorned with blinds. Warm wood trim enhances the space.

Apartment in Cleveland

Cozy Vintage Asiatown Upstairs Apartment

Charming vintage upstairs apartment on the edge of downtown CLE in Asiatown. The house is set back off the street behind 2 bungalows, so it is very quiet. Just a few blocks from I 90 E & W. No more than 2 miles from Rocket Mortgage, Playhouse Square, CSU, Progressive Field, Cleveland Browns Stadium, Great Lakes Science Center, Rock and Roll HOF & House of Blues. Walking distance to Agora & Temple Live(Masonic Temple). Close to CLE Clinic main campus & University Circle. Great local restaurants.

4.91 out of 5 average rating, 134 reviews

Little Italy Two Bedroom w/ Private Drive & Patio

Stay in the heart of Cleveland's historic Little Italy, one of the city's most vibrant and walkable neighborhoods. Restaurants, cafés, bakeries, galleries, and local markets are just steps away. Whether you're visiting Cleveland Clinic, University Hospitals, Case Western Reserve University, or exploring University Circle and Downtown Cleveland, you'll enjoy a stylish first-floor apartment with two private parking spaces, a fully equipped kitchen, a private patio, and room for up to six guests.

4.92 out of 5 average rating, 129 reviews

The living area features a spacious layout with an orange sectional sofa, a circular coffee table, and a light-colored area rug. Natural light filters through large windows, illuminating the space. A 59" smart TV is positioned across from the seating area, providing a comfortable environment for relaxation.

Apartment in Cleveland

Rock 'n' Roll Retreat ~15min to DT~8min Cle Clinic

Unwind in this newly renovated 2BR 1Bath Rock n' Roll retreat in a friendly & vibrant Larchmere neighborhood just 15 mins from the Rock 'n' Roll HOF. This 2nd floor apartment offers a relaxing getaway near restaurants, shops, attractions, landmarks, and major hospitals and employers, making it ideal for your stay in the Cleveland area. ✔ 2 Comfy Bedrooms w/ Queen-Size Beds ✔ Central Air and Heat ✔ Fully Equipped Kitchen ✔ Smart TV ✔ High-Speed Wi-Fi ✔ Washer/Dryer ✔ Parking See more below!

4.88 out of 5 average rating, 522 reviews

The living area features a neutral-toned sectional sofa, a wooden coffee table, and two dining chairs beside a small dining table. A textured green wall art piece adds a touch of nature, while framed abstract prints enhance the decor.

Apartment in Tremont

Private 2 Level Apartment with Hot Tub in Tremont

Welcome to this remodeled, charming 1 bed 1 bath in the heart of Tremont. This special place is just a minutes walk from all the bars, restaurants, cafes, parks, and vintage stores. Enjoy two floors of living space and a spacious deck on the second floor that is perfect for relaxing with your favorite drink or entertaining friends!! The unit has a private entrance with an open kitchen, LR, BR with a closet and a small workspace; WD. With a private brand new hot tub with plenty of space for 4!

Superhost

The spacious living room features two leather sofas, one adorned with a yellow throw, arranged around a sleek black coffee table. A stone fireplace serves as a focal point, complemented by a wall-mounted TV. Natural light filters in through the large windows.

4.84 out of 5 average rating, 85 reviews

Walkable Little Italy Gem w/ King Bed | Near CWRU

Stay in Cleveland’s Little Italy area in a clean 2BR apartment with a king bedroom, queen bedroom, full kitchen, Wi-Fi, and Roku TV. Walk to neighborhood restaurants, bakeries, and coffee shops, with easy access to Case Western Reserve, Cleveland Institute of Music, Cleveland Clinic, University Hospitals, and University Circle. Ideal for up to 4 guests visiting for school, medical appointments, work, or a Cleveland getaway. ⚠️ See full description for temporary construction April - June 2026

4.94 out of 5 average rating, 66 reviews

The living room features a blue couch, a wooden coffee table, and a green accent chair. Natural light fills the space through multiple windows. A dining area with a table for two is visible, and a modern kitchen is partially seen in the background.

Apartment in Cleveland

Cle Suites 1BR/1BA | 5 min Walk to Cle Clinic #7

Fully furnished luxury apartment that has been completely renovated combining old-time 19th century charm with modern amenities. Just move in with your suitcase! Within walking distance to the Cleveland Clinic Campus (5 min walk from main hospital). It’s also near University Hospitals, CWRU, Great University Circle, Downtown Cleveland, and Little Italy. This location is perfect for those receiving medical treatments and their families, doctors on rotation, travel nurses, and interns.

Superhost

A spacious living area features a modern sofa facing a wall-mounted 4K HDR Smart TV. Light streams through three large windows, illuminating the warm hardwood floor. A round glass coffee table is positioned centrally, enhancing the open feel of the room.

4.68 out of 5 average rating, 44 reviews

Cozy Condo l Minutes from Cleveland Clinic

Our apartment is ideally located near Cleveland Clinic, making it perfect for medical professionals, patients, and families. You’ll also be minutes from the Health Education Campus, Case Western Reserve University, University Hospitals, and the museums of University Circle. Enjoy a short drive to the charming Little Italy neighborhood, filled with authentic Italian restaurants, cafés, and bakeries, while downtown Cleveland is just 5 miles away for dining and entertainment.

A light-filled bedroom features a comfortable bed with a checked comforter and a yellow accent pillow. The space includes a chair and desk, with a cozy sitting area visible through an open door. Bright curtains frame the windows, illuminating the warm wood floor.

4.83 out of 5 average rating, 128 reviews

2BR in Little Italy, 5 min walk to Case & UH

Enjoy a stylish experience at this centrally-located place in the heart of Little Italy. Newly renovated with a minimalist design. You are just down the street from restaurants, bakeries and bars. The RTA redline is also a two minute walk away, which takes you straight downtown as well as to the airport. Also within walking distance of Cleveland Clinic and University Circle. The apartment is located on the first floor. There is no private parking at the property.