Apartment vacation rentals in East Cleveland

Little Italy 3, close to Cleveland Clinic, CWRU

Enjoy a uniquely styled experience at this boho-chic apartment in the heart of Little Italy. Exposed brick walls, hardwood floors, and wooden furnishings combine to give this apartment a boho-chic aesthetic. Enjoy dinner in the cozy kitchen and watch TV while relaxing on the comfortable sofa. One flight of stairs is leading up to the second floor (17 steps)The unit is on a quiet side street in walking distance to the heart of Little Italy (restaurants,cafes, shops).Free parking on premises(1car)

Tremont bistro apartment suite with skyline views

Beautiful skyline views and full service amenities! This 2nd level suite is directly above popular independent bistro Fat Cats. Located on the Towpath Trail connecting downtown through the Cuyahoga River Valley for off-road hiking and biking. Explore the historic Tremont neighborhood and enjoy Lincoln Park. We'd love to cook seasonal farm fresh meals for you, or serve a drink from our craft bar. Open for LUNCH, DINNER, Saturday BRUNCH (closed Sunday). Chef/Owner Ricardo Sandoval is your host!

Little Italy Two Bedroom w/ Private Drive & Patio

Stay in the heart of Cleveland's historic Little Italy, one of the city's most vibrant and walkable neighborhoods. Restaurants, cafés, bakeries, galleries, and local markets are just steps away. Whether you're visiting Cleveland Clinic, University Hospitals, Case Western Reserve University, or exploring University Circle and Downtown Cleveland, you'll enjoy a stylish first-floor apartment with two private parking spaces, a fully equipped kitchen, a private patio, and room for up to six guests.

Rock 'n' Roll Retreat ~15min to DT~8min Cle Clinic

Unwind in this newly renovated 2BR 1Bath Rock n' Roll retreat in a friendly & vibrant Larchmere neighborhood just 15 mins from the Rock 'n' Roll HOF. This 2nd floor apartment offers a relaxing getaway near restaurants, shops, attractions, landmarks, and major hospitals and employers, making it ideal for your stay in the Cleveland area. ✔ 2 Comfy Bedrooms w/ Queen-Size Beds ✔ Central Air and Heat ✔ Fully Equipped Kitchen ✔ Smart TV ✔ High-Speed Wi-Fi ✔ Washer/Dryer ✔ Parking See more below!

Private 2 Level Apartment with Hot Tub in Tremont

Welcome to this remodeled, charming 1 bed 1 bath in the heart of Tremont. This special place is just a minutes walk from all the bars, restaurants, cafes, parks, and vintage stores. Enjoy two floors of living space and a spacious deck on the second floor that is perfect for relaxing with your favorite drink or entertaining friends!! The unit has a private entrance with an open kitchen, LR, BR with a closet and a small workspace; WD. With a private brand new hot tub with plenty of space for 4!

Walkable Little Italy Gem w/ King Bed | Near CWRU

Stay in Cleveland’s Little Italy area in a clean 2BR apartment with a king bedroom, queen bedroom, full kitchen, Wi-Fi, and Roku TV. Walk to neighborhood restaurants, bakeries, and coffee shops, with easy access to Case Western Reserve, Cleveland Institute of Music, Cleveland Clinic, University Hospitals, and University Circle. Ideal for up to 4 guests visiting for school, medical appointments, work, or a Cleveland getaway. ⚠️ See full description for temporary construction April - June 2026

Cle Suites 1BR/1BA | 5 min Walk to Cle Clinic #7

Fully furnished luxury apartment that has been completely renovated combining old-time 19th century charm with modern amenities. Just move in with your suitcase! Within walking distance to the Cleveland Clinic Campus (5 min walk from main hospital). It’s also near University Hospitals, CWRU, Great University Circle, Downtown Cleveland, and Little Italy. This location is perfect for those receiving medical treatments and their families, doctors on rotation, travel nurses, and interns.

Rare Cleveland Apt: Little Italy! W/Sauna&Hot tub!

Fall in love with this charming, newly updated 1-bedroom, 1-bath lower unit triplex apartment situated in the heart of Little Italy, walking distance from University Circle, UH Hospital, Cleveland Museum of Art, Botanical Garden, Public Transportation and much more. Apartment is complete with a well-equipped kitchen, Smart TV, laptop workspace, and modern furnishings, this vacation/business rental delivers all the essentials so you can spend more time relaxing and exploring.

Cozy Condo l Minutes from Cleveland Clinic

Our apartment is ideally located near Cleveland Clinic, making it perfect for medical professionals, patients, and families. You’ll also be minutes from the Health Education Campus, Case Western Reserve University, University Hospitals, and the museums of University Circle. Enjoy a short drive to the charming Little Italy neighborhood, filled with authentic Italian restaurants, cafés, and bakeries, while downtown Cleveland is just 5 miles away for dining and entertainment.

2BR in Little Italy, 5 min walk to Case & UH

Enjoy a stylish experience at this centrally-located place in the heart of Little Italy. Newly renovated with a minimalist design. You are just down the street from restaurants, bakeries and bars. The RTA redline is also a two minute walk away, which takes you straight downtown as well as to the airport. Also within walking distance of Cleveland Clinic and University Circle. The apartment is located on the first floor. There is no private parking at the property.

Sleeps 3 | Cleveland Clinic + University Circle

Chic Studio in Prime Location — Steps from Cleveland’s Best Experience the city right at your doorstep. This modern open-concept studio is ideally located near University Circle, Cleveland Clinic, top museums, Little Italy, and just minutes from Downtown Cleveland, major stadiums, and popular attractions. Features Cozy sleeping area Fully equipped kitchen Clean, modern bathroom High-speed Wi-Fi In-unit washer and dryer Free private parking included

The Maproom Room | 10 Mins to Cleveland Clinic, UH

🗺️ Map-themed studio • Sleeps 2 ✨ Fully renovated • Clean + modern ☕ Kitchenette • Coffee maker • Microwave & Instapot 📺 Smart Roku TV + streaming apps 🚗 Off-street parking for midsize cars (1 spot) 📍 10 min to Cleveland Clinic + University Circle Modern comfort meets world travel charm in this map-inspired studio apartment — thoughtfully designed and ideally located near Cleveland’s best cultural attractions.