House vacation rentals in Durham

The charming brick exterior features a curved roofline and large windows, surrounded by well-maintained greenery. A concrete walkway leads to the black front door, flanked by shrubs and trees, creating an inviting entrance.

4.88 out of 5 average rating, 121 reviews

Spacious Newly Renovated Home in great location

This beautiful home is located in popular Watts-Hillandale neighborhood. Close to Duke's East Campus, Ninth/Broad Street area, downtown and Duke Hospital. Enjoy the fully renovated home with TWO master suites with en suite bathrooms. Plenty of space to relax. Fully equipped kitchen with refrigerator, dishwasher, gas range/oven. Excellent AT&T fiberoptic Wifi and desk area, perfect for working remotely. Driveway and on-street parking available. Screened in back porch and covered front porch.

A modern duplex with a welcoming front porch is showcased. The porch features wooden railings and potted plants on either side. A clear pathway leads to the entrance. The structure is set against a backdrop of trees and an expansive yard.

4.94 out of 5 average rating, 187 reviews

Luxe Modern Retreat *Entire Duplex/ Both Units!*

This stylish modern retreat is sure to become your new favorite getaway. You’ll enjoy access to the ENTIRE DUPLEX (both units!), perfect for traveling with friends, family, or colleagues. Each of the 2 units boasts its own beautiful living room and kitchen, plus 2 bedrooms & 1 bathroom per side. Gather together on the inviting front porch, or enjoy dinner alfresco on the sunny back patio. Ideally situated just 1 mile from the heart of Durham, you’ll enjoy all the best the Bull City has to offer!

A spacious living area features a sleek gas fireplace on one side, with modern artwork displayed on the walls. Comfortable seating includes a large gray sofa and green accent chairs, accompanied by a round coffee table. Natural light floods in through large windows.

4.96 out of 5 average rating, 114 reviews

Modernist Masterpiece: 'Simply the Best'

Welcome to Hazel Modernist 6 - designed and built by Alicia Hylton-Daniel, with her "sister," Modernist 5, next door. Centrally located downtown, this gorgeous escape is truly livable. Fully equipped chefs kitchen opens into the large living & dining space, with Frame TV and fireplace. 3BR & private back deck offer plenty of space together or alone. Each home by Alicia is infused with creative and new design concepts. This glamorous home celebrates the essence of Tina Turner, Simply the Best.

An open living area is presented, featuring a cozy gray sofa paired with a wooden coffee table. Large windows allow natural light to fill the space, complemented by soft curtains. A stylish light fixture hangs above the dining area, which includes a modern round table and black chairs.

4.89 out of 5 average rating, 101 reviews

HistoricallyHip on Hale/Walkable, 3 min to Duke

Historic & Hip this Renovated 1930s bungalow in Old West Durham is extremely walkable!Enjoy a stylish experience at this centrally-located home with 3 king bedrooms, 2 large baths, open kitchen/Living and dining room! Rocking chair front porch and firepit w/fenced in yard! Amazing safe neighborhood walkable to shops, bars & restaurants! By Duke Hospital, NC school of Math & Science, VA hospital, Duke East campus & downtown! Enjoy all new amenities for entertaining and enjoying family & friends!

A spacious living area is highlighted by a vibrant orange couch adorned with decorative pillows. Large windows fill the space with natural light, complemented by green plants that bring a touch of nature indoors. The open layout leads to a modern kitchen in the background.

4.98 out of 5 average rating, 288 reviews

Artist-Designed Cabin Near Duke & Downtown

Relax and recharge in a modern, artist-designed passive solar home tucked into the woods just minutes from downtown Durham and Duke University. This cabin-style retreat blends nature, comfort, and convenience — ideal for weekend getaways, visiting Duke, or extended stays. Inside you’ll find original artwork, abundant natural light, and a professionally equipped kitchen. Outside, enjoy birdsong and mature trees while staying close to Durham’s restaurants, coffee shops, breweries, and shopping.

5.0 out of 5 average rating, 104 reviews

Idyllic historic home—walk to Duke & 9th Street!

Get comfortable, have a drink & enjoy the porch! This renovated home away from home is in popular Old West Durham neighborhood! Duke East campus is a leisurely 15 minute walk or 2 minute drive. You’ll be one block from 9th Street, so great food and shopping are just around the corner. We’re centrally located to anything that brings you to the area: 2 miles to Duke Hospital, DPAC, Downtown Durham, and the Museum of Life and Science, 12 miles to Chapel Hill, and 27 miles to Downtown Raleigh.

A screened porch is illuminated by soft string lights, casting a warm glow against the exterior of the house. The porch features wooden furniture, and a well-maintained lawn is visible in the foreground. A tall tree provides shade beside the porch.

4.97 out of 5 average rating, 147 reviews

Near Duke, Southpoint, UNC

Discover the perfect retreat in South Durham, NC! Our tranquil Airbnb offers an idyllic escape with a prime central location that guarantees a memorable stay. Start your morning on the inviting screen porch, where you can relish a cup of coffee and take in the view of the flower garden before headed out to enjoy some of the Triangle's finest attractions. Convenience is at your fingertips, as our Airbnb is just minutes away from RTP, RDU airport, Downtown Durham, DUKE, UNC, and the DPAC.

The kitchen area features white cabinetry and a wooden countertop. A modern fridge is positioned next to the entrance door, leading to a cozy living area with a brown sofa and a bright red chair. A colorful wall art piece adds a touch of decoration.

4.91 out of 5 average rating, 244 reviews

Clean Quiet Medical&Work Stay, Fenced Yard, Pets

Welcome to a spotlessly clean, quiet, and comfortable home in downtown Durham, thoughtfully set up for medical stays, longer work visits, and guests traveling with pets. Many guests choose this home while visiting Duke University Hospital, the VA Hospital, or Duke University, and appreciate having a calm place that feels easy to live in during what can be stressful or busy times. This is not a party house —it’s a peaceful, practical space designed to help you rest, reset, and settle in.

A spacious living area features large glass walls allowing natural light and views of surrounding trees. A unique wood coffee table is centered on a light rug. Two comfortable sofas provide seating, paired with a modern lamp and elegant decor.

4.96 out of 5 average rating, 207 reviews

Luxurious Modernist Tree House

Stunning, private, and truly one-of-a-kind—this unique home is perfect for a vacation, staycation, special occasion, or simply celebrating everyday life. Designed by renowned modernist architect Frank Harmon. The 2,128-square-foot residence sits on 1.3 acres and was crafted with meticulous attention to detail. Inside, you’ll feel nestled among the treetops while remaining conveniently close to restaurants, shopping, downtown Raleigh, WakeMed, UNC, Duke, and Research Triangle Park.

4.98 out of 5 average rating, 105 reviews

Duke Forest Zen Treehouse - pool table, decks

Enjoy a unique japanese-inspired custom home just 2 miles from Duke. Ascend through the gated entrance up the winding driveway to your own Zen treehouse retreat perched on the edge of the forest. large custom kitchen with a gas range, striking stonework and fireplaces. Outside there is a built-in grill, dining area, and firepit. The downstairs rec room is perfect for families featuring a pool table, movie watching area, and huge enclosed exrerior porch

A charming white house is surrounded by tall trees, featuring a sloped roof and black shutters on the windows. Two blue Adirondack chairs are placed on the front patio, inviting relaxation, while a wooden staircase leads up to the entrance.

4.81 out of 5 average rating, 197 reviews

Cheerful cottage w/ 1st floor BR near UNC and Duke

Lovely retreat in an amazing location, one of Durham's best neighborhoods, only six miles to UNC, six miles to Duke and 12 miles to RDU airport. Three bedrooms and two full baths, with an amazing back yard and miles of walking paths through the safe wooded neighborhood, complete with playgrounds, playing fields, and restaurants and shops at both ends of the neighborhood. Very convenient to RTP, I-40 and Southpoint Mall.

4.85 out of 5 average rating, 233 reviews

5BR Durham Retreat | Movie Nights, Games & Gazebo

Welcome to your 5BR Durham retreat near Duke & DPAC! ✨ Perfect for families, friends & groups. 🎬 Private outdoor movie nights under the stars 🌳 Gazebo & outdoor lounge for relaxing 🎮 Game room for all ages 🛏️ 5BR | 9 beds | Sleeps 14 🍳 Fully equipped kitchen 📍 Near Duke, DPAC, Downtown Durham, dining & attractions Gather, relax, play, and make unforgettable memories in your private Durham getaway!

Popular amenities for Durham house rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

House rentals with free parking

5.0 out of 5 average rating, 137 reviews

Luxe 5* Home 4 Mins Duke/DPAC, King Beds, Fire Pit

A newly built two-story home features a blue exterior with white trim, showcasing a covered porch with rocking chairs. Well-maintained landscaping surrounds the entrance, providing an inviting approach. Nearby greenery and a tree enhance the tranquil setting.

4.96 out of 5 average rating, 107 reviews

New Build |Trinity Park | 5 Min to Duke & Hospital

A dining area features a large reclaimed wood table surrounded by white chairs. A floral wallpaper adorns the walls, showcasing vibrant colors. A round, white paper pendant light hangs overhead, while a shelf displays dishes and greenery. Fresh flowers rest on the table, adding a touch of nature.

4.92 out of 5 average rating, 143 reviews

3BR Durham Haven: Perfect for Visiting Duke & DTWN

4.99 out of 5 average rating, 69 reviews

Boho Bungalow Retreat Minutes from Downtown

5.0 out of 5 average rating, 19 reviews

NEW 4BR Speakeasy Near Duke + Theatre | Sleeps 12

4.96 out of 5 average rating, 74 reviews

Modern Durham Retreat | Near Duke & Downtown

A second-story patio features comfortable seating arranged around a fire pit, creating a cozy outdoor space. Soft evening light illuminates the area, with a modern home visible in the background. The deck is surrounded by a railing, enhancing the sense of privacy.

4.99 out of 5 average rating, 82 reviews

Sleeps 4: Ocean-Blue Rooftop mins from Downtown

4.93 out of 5 average rating, 29 reviews

Pristine Stay Near Duke | No Carpet + Parking

House rentals with a pool

The front of the home features a charming exterior with blue shutters and a welcoming entrance. Lush purple flowers bloom vibrantly in the landscaped yard, complemented by green shrubs and a small tree. A driveway is visible, leading to the side of the house.

4.79 out of 5 average rating, 131 reviews

Spacious 3bd Lake & pool near Duke UNC Southpoint

A private pool surrounded by lush greenery showcases clear blue water under bright natural light. A wooden deck with seating is visible nearby, complementing the tranquil outdoor setting. The area features tall trees providing shade, enhancing the inviting atmosphere for relaxation and gatherings.

4.89 out of 5 average rating, 149 reviews

Designer home close to RDU and downtown, sleeps 12

4.98 out of 5 average rating, 117 reviews

A cozy living area is presented, featuring a dark gray sectional and armchair adorned with yellow throw pillows. A wooden coffee table sits at the center, accompanied by lamps providing soft illumination. Artwork depicting daisies is displayed on the wall above the seating.

Home in Chapel Hill

Cozy 2-bed, 2.5 bath near UNC

4.92 out of 5 average rating, 147 reviews

The exterior of the home features a two-story layout with white siding and a striking red front door. Lush greenery surrounds the entrance, and a concrete path leads to the porch. Tall trees provide a natural and shaded ambiance in the front yard.

Home in Cary

Serene Landing Place near Downtown Cary

4.79 out of 5 average rating, 159 reviews

The charming exterior of the cottage is shown, featuring a well-maintained lawn and landscaped flower beds. A concrete walkway leads to the front door, framed by lush greenery and trees in the background.

Home in Chapel Hill

UNC Cottage- near Univ/Hospital, YMCA, Franklin St

A woven basket holding two glasses and a floral arrangement rests on the poolside. The clear blue water of the pool reflects sunlight, surrounded by a spacious grassy area and shaded seating options under a gazebo in the background.

4.86 out of 5 average rating, 118 reviews

The Aqua Haven l4B2.5Bl Pool&Spacious yard near DT

A two-story brick house features a symmetrical façade with large arched windows and a center door. A well-maintained lawn surrounds the home, and a concrete driveway leads to a two-car garage. The roofing is sloped, with a mix of shingles and decorative elements.

5.0 out of 5 average rating, 58 reviews

4 Beds & More - Plus Playground & Pool Access

4.94 out of 5 average rating, 34 reviews

7 The Pinnacle - A Ranch Villa w/Hot Tub Spa

House rentals with a hot tub

4.95 out of 5 average rating, 158 reviews

A hot tub bubbles invitingly in the foreground, while a rustic house with warm lighting is visible in the background. Strings of lights illuminate the outdoor area, and lush trees frame the serene setting, creating a tranquil ambiance.

Home in Youngsville

Modern Woodland Retreat

A screened porch is furnished with comfortable seating, including a woven couch adorned with decorative pillows. A stylish fire pit is centered on a vibrant area rug featuring floral patterns. Lush greenery is visible outside, complementing the tranquil atmosphere.

5.0 out of 5 average rating, 117 reviews

Ebenezer Home w/ LAND + HOT TUB!

4.85 out of 5 average rating, 186 reviews

Private Hot Tub • Fire Pit • BBQ • Games

4.96 out of 5 average rating, 110 reviews

A view from a covered porch descends onto a stone pathway leading to a fenced inground pool. Surrounding foliage provides a natural backdrop, while lounge chairs are arranged along the edge of the pool. Colorful landscaping enhances the outdoor setting.

Home in Garner

Fence house w/private pool, hot tub,fire pit.

4.88 out of 5 average rating, 187 reviews

A cozy outdoor space features a hot tub illuminated by soft blue lights, creating a tranquil atmosphere. A woven chair sits nearby, accompanied by a potted plant. Intertwined string lights add warmth to the evening setting, enhancing the inviting appeal of the deck.

Home in Wake Forest

Welcome To The Jungle! Private Hot Tub!

4.99 out of 5 average rating, 185 reviews

The kitchen area features dark wooden cabinetry complemented by a granite countertop. Stainless steel appliances, including a refrigerator, microwave, and oven, are visible. A toaster oven and utensils in a knife block are neatly arranged, highlighting a functional and modern cooking space.

Home in North Hills

Shop, Dine, Explore, & Relax at North Hills Main

A private backyard features a hot tub surrounded by a wooden wall, providing a secluded area for relaxation. Nearby, a playground structure with a slide and swings stands on a grassy lawn, complemented by a fire pit area for cozy gatherings.

4.87 out of 5 average rating, 104 reviews

Hot Tub/ Playground/ Fire Pit/ Backyard Retreat