Guesthouse vacation rentals in Durham

A cozy guest room features a spacious bed with crisp linens, a small dining table with two chairs, and a comfortable couch. Natural light fills the space through multiple windows, creating a bright atmosphere on warm wooden flooring.

4.96 out of 5 average rating, 238 reviews

Quiet, Clean, Scent-Free Guesthouse Near Duke!

New-construction (2022) spotlessly clean farmhouse-style guesthouse is 3 mins to Duke, 15 mins to UNC and 25 mins to Raleigh. Perfect for an RTP work trip or weekend alumni or family/student visit. Explore Durham (8 min drive to downtown Durham, DPAC, American Tobacco, etc.) or anywhere in the Triangle from this South Durham location in the charming Tuscaloosa-Lakewood neighborhood. Walking distance to a supermarket, Cocoa Cinnamon coffee shop and restaurants serving breakfast, lunch and dinner.

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A modern kitchen features vibrant turquoise cabinetry paired with neutral countertops. Stainless steel appliances, including a refrigerator and stove, are present. A small table with two bar stools occupies one corner, while a window allows natural light to fill the space.

4.96 out of 5 average rating, 395 reviews

Modern Cottage With a Vintage Twist Near Downtown

Come stay at our modern vintage guesthouse in Historic Trinity Park. Our cottage has all modern appliances with vintage fixtures. Our cottage is a cozy, lived-in retreat with rustic charm. This 380 square foot cottage is located in a very lively and safe neighborhood just minutes from downtown Durham. Walk one mile on the Ellerbe creek trail to downtown! Walk 1.5 mile to 9th street restaurants and shops 1 mile to Central Park and farmers market <1 mile to bars and restaurants on geer street

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Guesthouse in Hillsborough

A cozy cabin nestled in a wooded area features a wooden deck with vibrant chairs and a dining table. The exterior has large windows that allow natural light to fill the interior, surrounded by lush greenery that enhances the tranquil setting.

4.97 out of 5 average rating, 231 reviews

CFCB cabin retreat minutes from Duke, NCCU, & UNC

Cozy, wheelchair-accessible, recently renovated cabin with unique decor and a sitting porch, located in a beautiful, mature, piedmont forest that abounds with wildlife and has hiking trails along New Hope Creek. Ideal for a quiet retreat but only 8 minutes from UNC Hospital, Hillsborough Campus and within 15 to 25 minutes from Duke University, University of North Carolina at Chapel Hill, North Carolina Central University and historic downtown Hillsborough. Guests of all walks of life welcome.

FamilyValueQuiet

A sparkling blue swimming pool is surrounded by a spacious deck, featuring several lounge chairs for relaxation. A wooden fence provides privacy, while lush trees line the background under a clear sky.

4.99 out of 5 average rating, 144 reviews

Gordon Guesthouse Studio Suite w/ hot tub & pool!

Book now & enjoy the pool, balcony & luxurious hot tub. Open 24hrs, exclusively for guest use. We welcome you to our little piece of paradise, in the country, not far from downtown Durham & Raleigh close to RDU. We offer a well-appointed studio, meticulously cleaned, w/ queen Tempurpedic mattress, premium linens, fireplace, full kitchen, washer/dryer, 2 smart TV's & high speed wifi. *Please Note* Max Occupancy 2 (including kids) We are unable to accommodate animals. Owner allergic :-(

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A light-filled living area features a spacious sectional sofa adorned with decorative pillows. A glass coffee table sits atop a patterned area rug, while several windows allow for natural light to enhance the bright, neutral décor.

4.99 out of 5 average rating, 182 reviews

Urban homesteading in Carrboro

Chickens, garden, bee hive, pottery studio, woodworking shop, full kitchen, fabulous bathroom, private screen porch - a hidden oasis in the center of Carrboro. Our guest house is tucked behind our house on a bus line to UNC, walking distance to The Cat’s Cradle, the farmer’s market, and downtown. You will be welcomed by our two Cattle Dogs, and maybe some of our five cats (none allowed in the guest house). The house sleeps four in two cozy queen-sized bedrooms. Access to a Tesla charger.

LocationValueHiking

The exterior of a two-story orange-clad cabin is shown, featuring a green door and multiple windows. A wooden deck with railing is visible, framed by trees and low shrubbery. The natural surroundings contribute to a tranquil setting.

4.88 out of 5 average rating, 258 reviews

Lovely Studio with King Sized Tempur-Pedic

Experience the beauty of Duke Forest in your back yard! Cozy and quiet in the trees, yet 2 miles from Duke University. King sized tempur-pedic for an amazing nights sleep. Our wonderful studio apartment boasts a well-equipped kitchenette, a Roku device to access your streaming apps’ accounts. A beautiful, private deck with panoramic views of Duke Forest. Walk right onto Sheperd's Trail, curated by Duke University, from the back yard. 2 miles to Duke Hospital. 3 miles to downtown Durham.

ValueFamilyLaundry

A covered outdoor sitting area is presented, featuring two blue chairs and a small table, surrounded by potted plants. The entrance to the studio cottage is marked by an orange door and is accessed by a short wooden staircase.

4.99 out of 5 average rating, 515 reviews

Cute Downtown Carrboro Studio Cottage

Private studio cottage in downtown Carrboro neighborhood with sidewalks, bike lanes, a block from the free bus. Coffee shop across the street, walking distance to Carrboro and UNC campus. Separate from the main house with its own entrance, outdoor sitting area, small but well-equipped+stocked, clean, efficient, perfectly located. WiFi, 40" TV-Roku, full bathroom, free parking, small kitchenette, queen bed, futon for additional sleeping accommodations, small work station, walk-in closet.

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An outdoor barrel sauna is nestled amidst lush greenery, constructed of natural wood with a curved design. A large glass door provides entry, while a wooden platform with a bucket sits outside, inviting relaxation in a serene environment.

5.0 out of 5 average rating, 101 reviews

Cozy Sauna Retreat - Woodland Guesthouse

Private and peaceful guest house tucked away in the woods just outside of Carrboro - Relax in an outdoor barrel sauna + enjoy the stars by the fire pit - Sleep in a King Bed or a Queen Pull-out couch in the living room for extra guests - Cook in a full kitchen and enjoy your meals inside or dine al fresco with the fire pit - Stay active with the dedicated workout area Minutes from the best restaurants & breweries 13 minutes to UNC Chapel Hill 23 minutes to Duke University

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4.94 out of 5 average rating, 454 reviews

Raleigh Oasis Close to it All

The pool is OPEN and ready for the 2026 season! Don't forget to pack a swimsuit. An owner-occupied private residence with a large private saltwater pool and guesthouse above the detached garage. Enjoy the sights and sounds of a stocked koi pond or observe nature from the private balcony. Minutes from Rex Hospital, Crabtree Mall, Art Museum and PNC arena. The location cannot be beat! Feel far from the city while close to all the things Raleigh/Durham have to offer.

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Guesthouse in Downtown Raleigh

An open living space features a light-colored sofa positioned near a flat-screen TV. A small dining table with seating for three is adjacent to a well-equipped kitchenette. Shelving above the counter displays dinnerware and decorative items, while a rug adds warmth to the hardwood floor.

4.98 out of 5 average rating, 142 reviews

Charming Cottage House in Historic Raleigh

Charming guest cottage in Raleigh's Historic Glenwood Brooklyn district. Walking distance to quaint Five Points and trendy Glenwood South, or a 5-minute Uber ride from downtown Raleigh, Red Hat Amphitheater, and NC State University. One bedroom with queen bed, bath, kitchen, and pull-out sofa. There is plenty of natural light and perfect space for a weekend getaway. Features: Streaming services, wifi, keyless entry, custom closet, microwave, Keurig, and fridge.

LocationFamilySolo travel

Guesthouse in Downtown Durham

A light-filled living area is showcased with large windows that offer views of greenery. A modern sofa adorned with colorful throw pillows is complemented by a round coffee table on a patterned area rug. The kitchen, featuring turquoise cabinetry, is visible in the background.

4.93 out of 5 average rating, 150 reviews

Duplex filled with natural light

A stylish, modern, and beautiful alley guesthouse that is located just 2 blocks from Duke's East Campus and 4 blocks from downtown Durham. The apartment is located in the historic Trinity Park Neighborhood in Durham. The apartment has a top of the line finish, hardwood floors, appliances, and furniture. The loft area is equipped with a standing desk and monitor and 2 Yoga matts, and it is ideal for working professionals visiting the area. Built: 2023

ValueLocationAir conditioning

4.93 out of 5 average rating, 434 reviews

A spiral staircase is seen in the corner of a sunlit room with high, sloped ceilings. The staircase features a wooden handrail and black steps, leading to a loft area. Artwork is displayed on the walls, enhancing the space's character.

Guesthouse in Apex

Country place close to all Triangle locations

Beautiful setting on 8 acres near Jordan Lake and the American Tobacco Trail - 30 minutes or less to RDU, RTP, Raleigh, Durham and Chapel Hill. Full use of a private 2 bdr guesthouse with a spiral staircase leading to a loft bedroom. Downstairs, soaring 20 foot ceilings and huge windows look out on our horse pastures. Ideal for fishing stays - less than 10 minutes from Jordan Lake, and plenty of parking. Level 2 EV charging available.

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Popular amenities for Durham guesthouse rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Family-friendly guest house rentals

The exterior of the studio apartment is shown, featuring a wooden deck with a railing. A stack of firewood is arranged nearby. The entrance is marked by glass doors, while greenery surrounds the space, creating a natural setting.

4.96 out of 5 average rating, 414 reviews

Cozy Secluded Accessible West Wing

LocationFamilyQuiet

A compact studio features a spacious bed covered in a neutral quilt. A cozy armchair is positioned beside the bed, and a small kitchenette is visible with contemporary cabinetry. Soft lighting creates a comfortable setting, with framed artwork displayed on the walls.

4.94 out of 5 average rating, 146 reviews

Studio on Tobacco Road

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A softly lit guest suite features a spacious bed with an upholstered headboard, complemented by warm curtains framing two windows. Two chairs and a small stool are arranged on a decorative rug, creating a cozy seating area beside a small dining table.

4.98 out of 5 average rating, 315 reviews

Stylish /Quiet Guest Suite with King Size Bed

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A spacious sleeping area is highlighted by a large bed flanked by minimalist wooden cabinets. A blue throw blanket is draped over the bed, and a nature-inspired artwork adorns the wall above. Natural light filters through a nearby window dressed with a light shade.

4.94 out of 5 average rating, 456 reviews

BEST Tiny House in Raleigh - Walk to Restaurants!

ValueFamilyWalkability

An airy studio space features a king-size bed, surrounded by large windows allowing natural light. A kitchenette area with a sink is present, alongside a dining table set for two. Ceiling fans provide airflow, and a decorative rug adds warmth to the wood-paneled flooring.

4.86 out of 5 average rating, 142 reviews

Eclectic Forest View Efficiency in Chapel Hill

LocationFamilyLong stay

An open-concept living space features warm wooden cabinetry and a kitchenette equipped with a refrigerator, microwave, and toaster oven. A cozy seating area includes a sofa and a coffee table, while a partition separates the sleeping area, showcasing a queen bed with soft linens.

4.92 out of 5 average rating, 702 reviews

Separate In-Law Suite in Carrboro

LocationFamilyHospitality

Guesthouse in Downtown Raleigh

A bright sleeping area features a spacious bed with soft bedding and decorative pillows. Light green walls complement the wooden flooring. A door leads to the bathroom, while a closet and air conditioning unit are visible, contributing to the room's functionality.

4.99 out of 5 average rating, 170 reviews

Downtown Carriage House Oasis

ValueFamilyNearby

The living area features a bright, airy ambiance highlighted by large windows. A sectional sofa is placed next to a wooden dining table, set for two. A decorative light fixture hangs from the ceiling, complementing the neutral color palette of the room.

4.9 out of 5 average rating, 143 reviews

Grandma's place

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Guest house rentals with a patio

A cozy living area features a combination of leather sofas and armchairs arranged around a glass coffee table. Natural light enters through two large windows adorned with sheer curtains. A wooden door leads outside, and warm lighting is provided by table lamps on either side.

4.91 out of 5 average rating, 202 reviews

Marley's Cottage

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The front entrance features a bright red door surrounded by light-colored siding and manicured shrubs on either side. A welcoming path of brick leads to the entrance, providing access to the home nestled among leafy trees.

5.0 out of 5 average rating, 125 reviews

Carolina Cottage

LocationValueQuiet

A charming green carriage house is visible perched among trees, showcasing a staircase leading to a private entrance. A wooden deck features a table, two chairs, and a sunshade, surrounded by landscaped greenery, creating a serene outdoor environment.

4.97 out of 5 average rating, 101 reviews

Carriage House Studio in Quiet Neighborhood

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Guesthouse in Holly Springs

The exterior of the carriage house is shown, featuring a brick façade and a covered entrance. Lush greenery from surrounding trees provides a natural backdrop. A spacious driveway extends to the side, with flower beds adding a touch of color.

4.98 out of 5 average rating, 163 reviews

"Wit's End" welcomes you! 2BR comfy guest house

FamilyValueWalkability

A well-maintained guest house is situated above a garage, featuring a light blue exterior. White railings encircle the upper patio, where two lounge chairs are positioned. A set of wooden steps leads up to a pair of glass doors, creating an inviting entrance.

4.95 out of 5 average rating, 118 reviews

The Nest: Private Downtown Guest House

LocationValueParks

The kitchen features a clean, bright layout with a large island at the center. Modern appliances, including a refrigerator and stove, are present. Three suspended pendant lights illuminate the workspace, while natural light filters through multiple windows. Kitchenware is neatly arranged on the counter.

4.97 out of 5 average rating, 217 reviews

Neighborhood Loft

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The exterior of a historic home showcases Victorian architectural details with vibrant yellow siding and spacious porches framed by green railings. Potted plants and outdoor seating invite relaxation. Warm light is visible through the windows, creating a welcoming ambiance as dusk approaches.

4.91 out of 5 average rating, 116 reviews

Historic Oakwood Home - Private Apartment

ValueLocationSolo travel

An open living space features modern finishes with light wood flooring. A compact kitchen area displays quartz countertops and white cabinetry, accompanied by two bar stools. A large television is mounted on the wall, with a cozy seating area located nearby.

4.98 out of 5 average rating, 256 reviews

•Private Urban Oasis• Luxury Cal King bed

LocationFamilyNearby

Guest house rentals with a washer and dryer

4.99 out of 5 average rating, 202 reviews

Relaxing Saltwater Pool Oasis and Modern Retreat

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An open kitchen and living area with natural light features light wood cabinets and modern appliances. A round dining table with blue and white chairs sits centrally. A cozy sofa is positioned nearby, with a glimpse of the bedroom visible in the background.

4.95 out of 5 average rating, 143 reviews

The Rose Garden Retreat - NC State/Cameron Village

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4.93 out of 5 average rating, 197 reviews

2nd Floor Poolside Apartment • Raleigh, NC

ValueFamilyBackyard

5.0 out of 5 average rating, 175 reviews

A welcoming living area is highlighted by natural light streaming through two windows with blue curtains. A comfortable white sofa faces a mounted television, while a cozy brown chair is positioned nearby. A wooden coffee table and a fireplace contribute to the inviting ambiance.

Guesthouse in Cary

Guest House on the Cary Downtown Park!

ValueLocationLayout

4.99 out of 5 average rating, 201 reviews

The exterior of the Tilly Guest House features a charming white facade with a sloped roof and a front porch. Colorful autumn leaves blanket the ground, complemented by shrubs and a small bench positioned nearby. A path leads to the entrance, enhancing the welcoming appearance.

Guesthouse in Apex

Tilly Guest House - Downtown Apex

ValueFamilySolo travel

A cozy guest cottage is nestled amidst trees, featuring a white exterior and a welcoming front entrance. Two blue chairs are positioned outside, inviting relaxation in the garden space, which is surrounded by greenery and a wooden fence.

4.85 out of 5 average rating, 476 reviews

Guest cottage close to downtown Carrboro

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The exterior view of the apartment showcases a two-story structure with a wooden façade and large porch. A small pathway leads to the entrance, flanked by a grassy area and stone landscaping. Two outdoor chairs and a table are positioned on the porch, inviting leisurely moments.

4.9 out of 5 average rating, 166 reviews

Soul Retreat in the Heart of Carrboro

FamilyValueView

A modern, detached garage is visible at the end of a paved driveway, framed by greenery. The garage features a wooden façade and sleek design, complemented by a well-maintained garden area with gravel pathways and low plants. The inviting entrance is marked by wooden steps leading towards the house.