Guesthouse vacation rentals in Durham

A cozy guest room features a spacious bed with crisp linens, a small dining table with two chairs, and a comfortable couch. Natural light fills the space through multiple windows, creating a bright atmosphere on warm wooden flooring.

4.96 out of 5 average rating, 239 reviews

Quiet, Clean, Scent-Free Guesthouse Near Duke!

New-construction (2022) spotlessly clean farmhouse-style guesthouse is 3 mins to Duke, 15 mins to UNC and 25 mins to Raleigh. Perfect for an RTP work trip or weekend alumni or family/student visit. Explore Durham (8 min drive to downtown Durham, DPAC, American Tobacco, etc.) or anywhere in the Triangle from this South Durham location in the charming Tuscaloosa-Lakewood neighborhood. Walking distance to a supermarket, Cocoa Cinnamon coffee shop and restaurants serving breakfast, lunch and dinner.

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A modern kitchen features vibrant turquoise cabinetry paired with neutral countertops. Stainless steel appliances, including a refrigerator and stove, are present. A small table with two bar stools occupies one corner, while a window allows natural light to fill the space.

4.96 out of 5 average rating, 396 reviews

Modern Cottage With a Vintage Twist Near Downtown

Come stay at our modern vintage guesthouse in Historic Trinity Park. Our cottage has all modern appliances with vintage fixtures. Our cottage is a cozy, lived-in retreat with rustic charm. This 380 square foot cottage is located in a very lively and safe neighborhood just minutes from downtown Durham. Walk one mile on the Ellerbe creek trail to downtown! Walk 1.5 mile to 9th street restaurants and shops 1 mile to Central Park and farmers market <1 mile to bars and restaurants on geer street

ValueFamilyAir conditioning

The exterior view of the studio guest house is presented, showcasing a soft blue facade and a warm wooden door. Sunlight filters through nearby trees, casting playful shadows on the wall. A wooden fence outlines the property, enhancing the sense of privacy.

4.97 out of 5 average rating, 189 reviews

Little House Old North Durham

Welcome to our little house in Old North Durham. The 380 square foot studio guest house (open concept) sits behind our Bungalow in a centrally located historic neighborhood.; a 15-20 minute walk to Durham's vibrant Central Park District and a little further to downtown. Close by restaurants, music, movies and shows. Sleeps 2 comfortably on queen bed, and 2 additional on convertible couch from IKEA. Living area joins kitchen and is open to bedroom (see photos). Vaulted ceilings create openness.

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Guesthouse in Hillsborough

A cozy cabin nestled in a wooded area features a wooden deck with vibrant chairs and a dining table. The exterior has large windows that allow natural light to fill the interior, surrounded by lush greenery that enhances the tranquil setting.

4.97 out of 5 average rating, 231 reviews

CFCB cabin retreat minutes from Duke, NCCU, & UNC

Cozy, wheelchair-accessible, recently renovated cabin with unique decor and a sitting porch, located in a beautiful, mature, piedmont forest that abounds with wildlife and has hiking trails along New Hope Creek. Ideal for a quiet retreat but only 8 minutes from UNC Hospital, Hillsborough Campus and within 15 to 25 minutes from Duke University, University of North Carolina at Chapel Hill, North Carolina Central University and historic downtown Hillsborough. Guests of all walks of life welcome.

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4.99 out of 5 average rating, 202 reviews

Relaxing Saltwater Pool Oasis and Modern Retreat

Come relax in our centrally located modern escape. This garage top apartment is drenched in natural light & includes all the extras. The open floor plan living, dining, and kitchen is perfect for couples, friends, and business travelers looking for upscale accommodations. Our salt water lounge pool is open to guests June-Oct. NEW traditional sauna is open year-round. Walk to the beautiful Five Points Neighborhood. 10 mins by car to downtown or NC State campus, and 20 mins to RDU airport

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A sparkling blue swimming pool is surrounded by a spacious deck, featuring several lounge chairs for relaxation. A wooden fence provides privacy, while lush trees line the background under a clear sky.

4.99 out of 5 average rating, 145 reviews

Gordon Guesthouse Studio Suite w/ hot tub & pool!

Book now & enjoy the pool, balcony & luxurious hot tub. Open 24hrs, exclusively for guest use. We welcome you to our little piece of paradise, in the country, not far from downtown Durham & Raleigh close to RDU. We offer a well-appointed studio, meticulously cleaned, w/ queen Tempurpedic mattress, premium linens, fireplace, full kitchen, washer/dryer, 2 smart TV's & high speed wifi. *Please Note* Max Occupancy 2 (including kids) We are unable to accommodate animals. Owner allergic :-(

ValueFamilyAccess

The exterior of a two-story orange-clad cabin is shown, featuring a green door and multiple windows. A wooden deck with railing is visible, framed by trees and low shrubbery. The natural surroundings contribute to a tranquil setting.

4.88 out of 5 average rating, 258 reviews

Lovely Studio with King Sized Tempur-Pedic

Experience the beauty of Duke Forest in your back yard! Cozy and quiet in the trees, yet 2 miles from Duke University. King sized tempur-pedic for an amazing nights sleep. Our wonderful studio apartment boasts a well-equipped kitchenette, a Roku device to access your streaming apps’ accounts. A beautiful, private deck with panoramic views of Duke Forest. Walk right onto Sheperd's Trail, curated by Duke University, from the back yard. 2 miles to Duke Hospital. 3 miles to downtown Durham.

ValueLocationTV

A cozy living area features a combination of leather sofas and armchairs arranged around a glass coffee table. Natural light enters through two large windows adorned with sheer curtains. A wooden door leads outside, and warm lighting is provided by table lamps on either side.

4.91 out of 5 average rating, 202 reviews

Marley's Cottage

A cozy three room cottage in a quiet neighborhood in North Raleigh with access to Raleigh's Greenway Park system. Easy access to Interstate 540 and 440. We are within 20 minutes of most areas in Raleigh. The cottage has three rooms. 1. A combination living room/bedroom with a queen size bed. 2. A combination kitchenette/bedroom with a double bed. This is semi private with a curtain to pull separating the sleeping area from the kitchen area. 3. A full bathroom that has a bathtub.

ValueLocationGetting around

An outdoor barrel sauna is nestled amidst lush greenery, constructed of natural wood with a curved design. A large glass door provides entry, while a wooden platform with a bucket sits outside, inviting relaxation in a serene environment.

5.0 out of 5 average rating, 102 reviews

Cozy Sauna Retreat - Woodland Guesthouse

Private and peaceful guest house tucked away in the woods just outside of Carrboro - Relax in an outdoor barrel sauna + enjoy the stars by the fire pit - Sleep in a King Bed or a Queen Pull-out couch in the living room for extra guests - Cook in a full kitchen and enjoy your meals inside or dine al fresco with the fire pit - Stay active with the dedicated workout area Minutes from the best restaurants & breweries 13 minutes to UNC Chapel Hill 23 minutes to Duke University

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4.95 out of 5 average rating, 456 reviews

Raleigh Oasis Close to it All

The pool is OPEN and ready for the 2026 season! Don't forget to pack a swimsuit. An owner-occupied private residence with a large private saltwater pool and guesthouse above the detached garage. Enjoy the sights and sounds of a stocked koi pond or observe nature from the private balcony. Minutes from Rex Hospital, Crabtree Mall, Art Museum and PNC arena. The location cannot be beat! Feel far from the city while close to all the things Raleigh/Durham have to offer.

ValueFamilyHiking

Guesthouse in Downtown Raleigh

An open living space features a light-colored sofa positioned near a flat-screen TV. A small dining table with seating for three is adjacent to a well-equipped kitchenette. Shelving above the counter displays dinnerware and decorative items, while a rug adds warmth to the hardwood floor.

4.98 out of 5 average rating, 143 reviews

Charming Cottage House in Historic Raleigh

Charming guest cottage in Raleigh's Historic Glenwood Brooklyn district. Walking distance to quaint Five Points and trendy Glenwood South, or a 5-minute Uber ride from downtown Raleigh, Red Hat Amphitheater, and NC State University. One bedroom with queen bed, bath, kitchen, and pull-out sofa. There is plenty of natural light and perfect space for a weekend getaway. Features: Streaming services, wifi, keyless entry, custom closet, microwave, Keurig, and fridge.

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Guesthouse in Downtown Durham

A light-filled living area is showcased with large windows that offer views of greenery. A modern sofa adorned with colorful throw pillows is complemented by a round coffee table on a patterned area rug. The kitchen, featuring turquoise cabinetry, is visible in the background.

4.93 out of 5 average rating, 150 reviews

Duplex filled with natural light

A stylish, modern, and beautiful alley guesthouse that is located just 2 blocks from Duke's East Campus and 4 blocks from downtown Durham. The apartment is located in the historic Trinity Park Neighborhood in Durham. The apartment has a top of the line finish, hardwood floors, appliances, and furniture. The loft area is equipped with a standing desk and monitor and 2 Yoga matts, and it is ideal for working professionals visiting the area. Built: 2023

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Popular amenities for Durham guesthouse rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Family-friendly guest house rentals

A covered outdoor sitting area is presented, featuring two blue chairs and a small table, surrounded by potted plants. The entrance to the studio cottage is marked by an orange door and is accessed by a short wooden staircase.

4.99 out of 5 average rating, 516 reviews

Cute Downtown Carrboro Studio Cottage

LocationFamilyLong stay

A sunroom is presented with a welcome sign, surrounded by large windows allowing natural light. A patterned black and white rug covers the floor. A small table holds decorative items, while two cozy chairs are positioned nearby, creating an inviting space.

4.91 out of 5 average rating, 116 reviews

Adorable studio 10 min from downtown, Duke & UNC

ValueFamilyLong stay

A softly lit guest suite features a spacious bed with an upholstered headboard, complemented by warm curtains framing two windows. Two chairs and a small stool are arranged on a decorative rug, creating a cozy seating area beside a small dining table.

4.98 out of 5 average rating, 318 reviews

Charming/Quiet Guest Suite with King Size Bed

ValueLocationBreakfast

A compact studio features a spacious bed covered in a neutral quilt. A cozy armchair is positioned beside the bed, and a small kitchenette is visible with contemporary cabinetry. Soft lighting creates a comfortable setting, with framed artwork displayed on the walls.

4.94 out of 5 average rating, 146 reviews

Studio on Tobacco Road

LocationValueSleep quality

An open-concept living space features warm wooden cabinetry and a kitchenette equipped with a refrigerator, microwave, and toaster oven. A cozy seating area includes a sofa and a coffee table, while a partition separates the sleeping area, showcasing a queen bed with soft linens.

4.92 out of 5 average rating, 702 reviews

Separate In-Law Suite in Carrboro

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The exterior of the studio apartment is shown, featuring a wooden deck with a railing. A stack of firewood is arranged nearby. The entrance is marked by glass doors, while greenery surrounds the space, creating a natural setting.

4.96 out of 5 average rating, 414 reviews

Cozy Secluded Accessible West Wing

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An airy studio space features a king-size bed, surrounded by large windows allowing natural light. A kitchenette area with a sink is present, alongside a dining table set for two. Ceiling fans provide airflow, and a decorative rug adds warmth to the wood-paneled flooring.

4.86 out of 5 average rating, 142 reviews

Eclectic Forest View Efficiency in Chapel Hill

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A spacious sleeping area is highlighted by a large bed flanked by minimalist wooden cabinets. A blue throw blanket is draped over the bed, and a nature-inspired artwork adorns the wall above. Natural light filters through a nearby window dressed with a light shade.

4.94 out of 5 average rating, 457 reviews

BEST Tiny House in Raleigh - Walk to Restaurants!

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Guest house rentals with a patio

4.97 out of 5 average rating, 102 reviews

Private Carriage House in Quiet Neighborhood

ValueLocationSolo travel

The kitchen features a clean, bright layout with a large island at the center. Modern appliances, including a refrigerator and stove, are present. Three suspended pendant lights illuminate the workspace, while natural light filters through multiple windows. Kitchenware is neatly arranged on the counter.

4.97 out of 5 average rating, 217 reviews

Neighborhood Loft

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The front entrance features a bright red door surrounded by light-colored siding and manicured shrubs on either side. A welcoming path of brick leads to the entrance, providing access to the home nestled among leafy trees.

5.0 out of 5 average rating, 126 reviews

Carolina Cottage

LocationFamilyParking

A well-maintained guest house is situated above a garage, featuring a light blue exterior. White railings encircle the upper patio, where two lounge chairs are positioned. A set of wooden steps leads up to a pair of glass doors, creating an inviting entrance.

4.95 out of 5 average rating, 118 reviews

The Nest: Private Downtown Guest House

LocationValueSleep quality

An open living space features modern finishes with light wood flooring. A compact kitchen area displays quartz countertops and white cabinetry, accompanied by two bar stools. A large television is mounted on the wall, with a cozy seating area located nearby.

4.98 out of 5 average rating, 257 reviews

•Private Urban Oasis• Luxury Cal King bed

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Guesthouse in Holly Springs

The exterior of the carriage house is shown, featuring a brick façade and a covered entrance. Lush greenery from surrounding trees provides a natural backdrop. A spacious driveway extends to the side, with flower beds adding a touch of color.

4.98 out of 5 average rating, 164 reviews

"Wit's End" welcomes you! 2BR comfy guest house

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The exterior of a historic home showcases Victorian architectural details with vibrant yellow siding and spacious porches framed by green railings. Potted plants and outdoor seating invite relaxation. Warm light is visible through the windows, creating a welcoming ambiance as dusk approaches.

4.91 out of 5 average rating, 117 reviews

Historic Oakwood Home - Private Apartment

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Guesthouse in North Hills

A bright and modern dining area features a round table surrounded by four stylish chairs. Natural light enters through a window adorned with light drapes, highlighting the neutral wall tones. A decorative wall piece and a hat rack add character to the inviting space.

5.0 out of 5 average rating, 111 reviews

Stylish Sanctuary with Private Garden & Parking

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Guest house rentals with a washer and dryer

A light-filled living area features a spacious sectional sofa adorned with decorative pillows. A glass coffee table sits atop a patterned area rug, while several windows allow for natural light to enhance the bright, neutral décor.

4.99 out of 5 average rating, 184 reviews

Urban homesteading in Carrboro

ValueFamilyAir conditioning

4.99 out of 5 average rating, 201 reviews

The exterior of the Tilly Guest House features a charming white facade with a sloped roof and a front porch. Colorful autumn leaves blanket the ground, complemented by shrubs and a small bench positioned nearby. A path leads to the entrance, enhancing the welcoming appearance.

Guesthouse in Apex

Tilly Guest House - Downtown Apex

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An open kitchen and living area with natural light features light wood cabinets and modern appliances. A round dining table with blue and white chairs sits centrally. A cozy sofa is positioned nearby, with a glimpse of the bedroom visible in the background.

4.95 out of 5 average rating, 145 reviews

The Rose Garden Retreat - NC State/Cameron Village

ValueLocationWalkability

5.0 out of 5 average rating, 175 reviews

A welcoming living area is highlighted by natural light streaming through two windows with blue curtains. A comfortable white sofa faces a mounted television, while a cozy brown chair is positioned nearby. A wooden coffee table and a fireplace contribute to the inviting ambiance.

Guesthouse in Cary

Guest House on the Cary Downtown Park!

LocationFamilyLaundry

4.93 out of 5 average rating, 198 reviews

2nd Floor Poolside Apartment • Raleigh, NC

ValueFamilyView

The exterior view of the apartment showcases a two-story structure with a wooden façade and large porch. A small pathway leads to the entrance, flanked by a grassy area and stone landscaping. Two outdoor chairs and a table are positioned on the porch, inviting leisurely moments.

4.9 out of 5 average rating, 166 reviews

Soul Retreat in the Heart of Carrboro

ValueFamilyCheck-in

A cozy guest cottage is nestled amidst trees, featuring a white exterior and a welcoming front entrance. Two blue chairs are positioned outside, inviting relaxation in the garden space, which is surrounded by greenery and a wooden fence.

4.85 out of 5 average rating, 476 reviews

Guest cottage close to downtown Carrboro

ValueFamilyShared spaces