Guesthouse vacation rentals in Durham County

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Top-rated guesthouse rentals in Durham County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Durham

5.0 out of 5 average rating, 19 reviews

“Meelie Doll”~ Private - Cozy Stdio Apt abv garage

Cute Private Studio apt, nestled in the trees, including major amenities along with prkg on premises. Relax after a long day out on the patio with a cup of tea. Read a bk in the wicker chairs and listen to the birds sing near by. Close to RTP and all Major Co.'s in the pk. Close to all Major Trigle Colleges, Univ.'s & Hospitals including Duke, UNC, NC State, all within 15-20 mins away. 10 mins from RDU Airport, Shopping & Restaurants. You will Love it!! If longer stay is needed pls message me.

Oct 15 – 22

ﺩ.ﺇ361 per night

Guest favorite

Guesthouse in Durham

4.94 out of 5 average rating, 52 reviews

Studio on Tobacco Road

Whether you're coming to work or play, the newly completed Studio on Tobacco Road is a perfectly positioned launch pad to experience Durham & Chapel Hill. Just 6 miles to enjoy Downtown Durham's renowned breweries & culinary scene, experience its creative arts culture & explore its rich history. Minutes from your home court -4 miles to Duke Univ. and 5 miles to UNC. All from a newly constructed & beautifully designed studio on a quiet, nature-rich landscape less than a mile from Duke Forest.

Nov 22 – 29

ﺩ.ﺇ395 per night

Guest favorite

Guesthouse in Durham

4.94 out of 5 average rating, 247 reviews

Modern Cottage With a Vintage Twist Near Downtown

Come stay at our modern vintage guesthouse in Historic Trinity Park. Our cottage has all modern appliances with vintage fixtures. This 380 square foot cottage is located in a very lively and safe neighborhood just minutes from downtown Durham. Walk one mile on the Ellerbe creek trail to downtown and enjoy all the great entertainment Durham has to offer. Walk 1.5 mile to 9th street restaurants and shops 1 mile to Central Park and farmers market <1 mile to bars and restaurants on geer street

Jun 27 – Jul 4

ﺩ.ﺇ445 per night

Guest favorite

Guesthouse in Durham

5.0 out of 5 average rating, 355 reviews

Light-filled Guesthouse Near Duke

Best of both worlds--a new garage apartment in a charming, peaceful Durham neighborhood. Twenty minutes to RDU Airport, five minutes to Duke's East Campus and ten minutes to West Campus, we are an easy walk to a range of locally-owned restaurants. Lovely, light-filled apartment has a bedroom, full kitchen and living area, bathroom, private entrance, and patio with seating. Occasionally, we may have first-floor space available at extra cost. Well-behaved pets welcome. See below for fees.

Jun 19 – 26

ﺩ.ﺇ428 per night

Guest favorite

Guesthouse in Durham

4.95 out of 5 average rating, 118 reviews

Spotless Scent & Mold-Free Guesthouse Near Duke!

New-construction (2022) spotlessly clean farmhouse-style guesthouse is 3 mins to Duke, 15 mins to UNC and 25 mins to Raleigh. Perfect for an RTP work trip or weekend alumni or family/student visit. Explore Durham (8 min drive to downtown Durham, DPAC, American Tobacco, etc.) or anywhere in the Triangle from this South Durham location in the charming Tuscaloosa-Lakewood neighborhood. Walking distance to Cocoa Cinnamon coffee shop and restaurants serving breakfast, lunch and dinner.

Jul 22 – 29

ﺩ.ﺇ388 per night

Guest favorite

Guesthouse in Durham

5.0 out of 5 average rating, 49 reviews

Delightfully Durham: Guesthouse with Kitchen!

Enjoy a peaceful stay only 3 miles from the heart of downtown Durham! Whether you're in town for work or to explore the area, this sunny and private guesthouse is a great place to get to know this gem of a city. 3 minutes from: - The Museum of Life & Science - The Ellerbee Creek Trailhead (paved w/ bike access to downtown) - Duke Regional Hospital 10 minutes from: - Duke University - Downtown Durham - Local Shopping & Dining (9th St., Foster St., Brightleaf District)

Jun 19 – 26

ﺩ.ﺇ564 per night

Guest favorite

Guesthouse in Durham

4.85 out of 5 average rating, 150 reviews

Lovely Studio with King Sized Trmpur-Pedic

Experience the beauty of Duke Forest in your back yard! Cozy and quiet in the trees, yet 2 miles from Duke University. King sized tempur-pedic for an amazing nights sleep. Our wonderful studio apartment boasts a well-equipped kitchenette, Roku with Hulu, Netflix included. A beautiful, private deck with panoramic views of Duke Forest. Walk right onto Sheperd's Trail, curated by Duke University, from the back yard. 2 miles to Duke Hospital. 3 miles to downtown Durham.

Jul 7 – 14

ﺩ.ﺇ402 per night

Guest favorite

Guesthouse in Durham

4.96 out of 5 average rating, 801 reviews

Tiny House in the Trees

You'll sleep in a loft nestled in the trees, and wake up to the songs of the morning birds. Super comfy and whimsical, the tiny house has everything you'll need in 120 TINY square feet of charm, right in our backyard in case you need anything at all. The space can accommodate a max of two guests. * This cozy spot is for folks who like it simple, small, rustic and sweet. * * Intentionally, there are no window coverings except for on the kitchen window.*

May 28 – Jun 4

ﺩ.ﺇ359 per night

Guest favorite

Guesthouse in Rougemont

4.91 out of 5 average rating, 192 reviews

Cozy Cottage on a Hilltop

Private cottage for people & pets (please indicate what kind of pets you are bringing). The cottage offers beautiful views of the countryside overlooking the pastures. There is a private seating area by the side of the cottage where you can enjoy amazing sunrises with a cup of coffee or cocktails in the evening. My 2 acres of property offer privacy and quiet atmosphere to enjoy a peaceful retreat. Please let me know the ETA the day of the arrival.

Jun 26 – Jul 3

ﺩ.ﺇ295 per night

Guest favorite

Guesthouse in Durham

5.0 out of 5 average rating, 159 reviews

Chic Poolside Hideaway Near Duke & UNC

Tucked away in the back of our 1927 property sits The Sidekick, a thoughtfully restored carriage house surrounded by peaceful woods & grand homes. Part cowboy clubhouse, part restful retreat, The Sidekick is a conveniently-located getaway for couples, solo travelers, or small groups. Take a dip in the saline pool, lounge in the mature garden, or just rest your sleepy head on luxurious linens in your sweet lil' loft bedroom.

Sep 9 – 14

ﺩ.ﺇ1,169 per night

Guest favorite

Guesthouse in Durham

4.98 out of 5 average rating, 60 reviews

Cozy Urban Cottage (with chickens!)

Enjoy one of Durham's most beautiful and charming neighborhoods at this unique and tranquil getaway! The cottage a short drive from Downtown Durham, Duke University and Hospital, and the American Tobacco Campus. Walking distance to several coffee shops, parks, Museum of Life and Science, and Ellerbee Creek trail. A lovely little spot to rest and relax after a fun day exploring the area.

ﺩ.ﺇ325 per night

Superhost

Guesthouse in Durham

4.93 out of 5 average rating, 89 reviews

Adorable + private guesthouse close to downtown

Kick up your feet in our adorable and very comfortable guesthouse close to downtown Durham and Northgate Park. Walking distance to green ways, grocery stores, restaurants and the Museum of Life and Science – and a short, easy drive to everything in and around downtown Durham. This well-appointed spot has everything you need for a quick weekend away or a two-week stay.

Jun 10 – 17

ﺩ.ﺇ431 per night