Pet-friendly vacation rentals in DeSoto County

Find and book unique pet-friendly homes on Airbnb

Top-rated pet-friendly home rentals in DeSoto County

Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.

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Home in Hernando

4.88 out of 5 average rating, 234 reviews

Hernando Hideaway (Entire Lakehouse)

Enjoy our 2000 sq ft lake house in a private peaceful community with panoramic views of the lake. We are a licensed BNB with DeSoto County and the State of Mississippi until the year 2035. (Lic # 20110070) You will have the entire lake house to yourself and we provide coffee and pastries for breakfast. We are 15 minutes from Tunica Expo, 5 minutes to Tunica National Golf Course, 10 Minutes to the casinos; 38 minutes to Beale St, Bass Pro Shop, Peabody Hotel, Graceland and The Lorraine Hotel.

Top guest favorite

A winding pathway lined with gravel and stones leads to a charming farmhouse, framed by a large tree. The covered porch invites relaxation while greenery surrounds the home, offering a peaceful countryside ambiance.

Home in Lake Cormorant

5 out of 5 average rating, 29 reviews

Modern Farmhouse! Clean, Private, Spacious!

Forget your worries in this spacious and serene space. This renovated farmhouse dates back to the early 1900’s. Boasting large rooms and tall ceilings with abundant common areas and a modern farmhouse vibe with plenty of original character. 4 bedrooms, 3.5 baths, formal living room, den, formal dining, kitchen, laundry room, covered front porch, courtyard with water fountain, back patio overlooks 4 wooded acres with dining and fire pit table. Side patio off the private queen suite. Owner/Agent

Guest favorite

The exterior of a newly constructed brick home features a well-maintained lawn and a concrete driveway leading to a two-car garage. Colorful flower beds line the porch entrance, adding a touch of greenery to the inviting facade. The clear sky enhances the serene atmosphere.

Home in Southaven

4.9 out of 5 average rating, 68 reviews

Newly constructed, “award winning,” cozy home

Recognized by the City of Southaven. The neighborhood is very quiet and safe. The home is 10 minutes from Memphis Airport; 2 minutes from I-55; less than 15 minutes from downtown Memphis, Orpheum Theater, FedEx Forum, Beale Street, Bass Pro Shop, and many other attractions; 2 minutes from North Creek Golf Course; 5 minutes away from restaurants, malls, grocery stores, Walmart, Target, movies theaters, etc. The perfect place to relax after a long eventful day! 6 exterior security cameras.

Guest favorite

A versatile living space features a large wall-mounted television opposite a desk with an adjustable lamp. A classic arcade machine adds a playful touch. Natural light enters through two windows, complemented by decorative mirrors and a potted plant in the corner.

Home in Southaven

5 out of 5 average rating, 22 reviews

Your Stay at The Top of Mississippi

*Stylish Renovated Townhome in Southaven, MS* - Features 2 bedrooms, each with its own vanity. Primary bedroom with king bed, the second bedroom features two full-size beds. - Free wifi, fully equipped kitchen, washer and dryer. - Situated just 12 minutes from Memphis Airport, 20 minutes from downtown Memphis, and only minutes from local restaurants and parks. Plus, it’s only 5 minutes from the local hospital, making it a great choice for medical professionals or visitors. -No smoking

Top guest favorite

A guesthouse is nestled among green trees and lush grass, with a pathway leading to a bright red door. Two small chairs are positioned in front of the entrance, inviting guests to relax in the outdoor space.

Guesthouse in Hernando

4.99 out of 5 average rating, 122 reviews

Cozy 2 Bedroom Guesthouse in a Relaxing Setting

Our two bedroom, two bath guesthouse is the perfect get-a-way from it all, yet close enough to everything you're looking to do: 3 minutes to the historic Hernando Town Square, 10 minutes to the MS River Delta and Historic Hwy 61, 12 minutes to Tanger Outlets & Landers Center in Southaven, 20 minutes to Snowden Grove Ballfields & Amphitheatre in Southaven, 23 minutes to Tunica Casino Strip, 25 minutes to Midtown/Downtown Memphis, 1 hour to Oxford, MS and 1 hour to Clarksdale, MS.

Guest favorite

The home features a charming exterior with light-colored siding and a brick foundation. A manicured front yard is complemented by neatly trimmed shrubs and flower beds. A paved pathway leads to the front door, framed by decorative columns and a gabled roof.

Home in Southaven

5 out of 5 average rating, 9 reviews

Spacious Cottage in Silo Square

Booking requests from September onward will only be approved for long-term stays over 28+ nights*** Kick back and relax in this calm, stylish space! This beautiful new construction home is located in the heart of the Snowden District in Southaven, MS. Conveniently located near the Bank Plus Amphitheatre, Landers Center, Tanger Outlets, local restaurants, grocery shopping, parks, hospital, schools, and many more! A perfect place to stay for vacation, work, visiting family, etc.

Top guest favorite

A spacious living room features a comfortable sectional sofa with recliners and a coffee table. A 75-inch smart TV is positioned on an entertainment unit. Natural light filters through large windows, complemented by a ceiling fan. A dining area is visible in the background.

Home in Southaven

5 out of 5 average rating, 46 reviews

The Luxury King Villa— in the heart of Southaven

It's a home away from home! Located in the heart of Southaven and nestled in a peaceful neighborhood, this spacious 4-bedroom home offers comfort, relaxation, and easy access to places of attraction; only 5 minutes from Snowden Grove Park, and Silo Square, where you will find all local restaurants, 8 minutes from Landers Center, 15 minutes from downtown Memphis, 10 minutes from Memphis Int’l Airport. This home can accommodate 15 guests and sleep 9 guests comfortably.

Guest favorite

The exterior of the new construction home is showcased, featuring a combination of light green siding and brick detailing. A wooden post supports the overhang by the entrance, while neatly arranged landscaping includes subtle shrubs and grass in the foreground.

Home in Southaven

4.8 out of 5 average rating, 20 reviews

Stylish Cottage in Silo Square near Snowden Grove

This stylish new construction home is a home away from home. It is centrally located in the heart of the Snowden Grove community in Silo Square. This location not only boosts close proximity to Snowden Grove Park (Concert Amphitheater, Baseball, Soccer, Tennis), it is steps away from local shops and restaurants. 10 miles to Memphis Airport, 12 miles to Graceland Mansion. The home offers optional concierge service (i.e. stocked fridge/pantry) at an additional cost.

Top guest favorite

The compact kitchen features wooden walls and open shelving, displaying colorful pots and dishes. A stainless steel refrigerator and countertop appliances are visible, along with a sink and wooden countertop. A mounted artwork of a Longhorn adds character to the space.

Farm stay in Southaven

4.99 out of 5 average rating, 111 reviews

The Longhorn Tiny House: Farm Stay Near Memphis

Escape to The Longhorn House, a cozy tiny house on 38 acres of rolling hills near Memphis, TN. Explore the countryside, fish or canoe on Blue Haze Lake, and enjoy sunsets with grazing miniature Longhorns. Relax at the outdoor seating area, grill out, or watch a movie under the stars at our outdoor theater. Inside, enjoy memory foam bedding, TVs, records, and board games. Just minutes from Memphis and Graceland, this is your perfect escape to nature and comfort.

Top guest favorite

A spacious living area is furnished with multiple seating options, including soft couches and armchairs. Natural light filters through large windows, complementing the neutral tones of the decor. A coffee table centers the room, surrounded by decorative elements and a calming rug.

Home in Byhalia

5 out of 5 average rating, 24 reviews

Elegant Country Retreat

Welcome to Your Perfect Getaway! Experience the best of comfort and convenience in our brand-new 4-bedroom, 3-bathroom Airbnb, located in a serene and family-friendly neighborhood. Whether you're traveling for work or leisure, our home offers the ideal retreat for your stay. Book your stay today and experience the perfect blend of tranquility and convenience. Our home is ready to welcome you for an unforgettable stay!

Guest favorite

The exterior of the house is shown, featuring a modern design with a covered porch and two symmetrical large windows framed in dark accents. A stone chimney rises from one side, while well-maintained grass lines the pathways leading to the entrance.

Home in Hernando

4.93 out of 5 average rating, 14 reviews

Relaxing Row House in Downtown Hernando

Enjoy this relaxing 2-bedroom 2-bathroom house in walking distance to restaurants, bars, and boutiques for shopping. This relaxing home is located in downtown Hernando, Mississippi. With less than a 30 minute drive to Memphis, a 10 minute drive to Southaven, and less than an hour to Oxford, this location offers various day trip opportunities!

Guest favorite

A spacious living room features a large sectional sofa facing a coffee table. Warm light from a nearby lamp complements the hardwood floor, while a ceiling fan adds airflow. An art piece with floral design adorns the wall, and a window offers natural light, revealing a glimpse of the kitchen.

Home in Southaven

4.86 out of 5 average rating, 57 reviews

Cozy 4BR 2BA Southaven Home

Charming 1,900 sq ft 4-bedroom home in Southaven, MS—perfect for families or groups. Blending comfort with Southern charm, it offers a warm, inviting space close to dining, shopping, and local attractions. Whether relaxing or exploring, this home sets the stage for a memorable stay.