Vacation rentals in DeSoto County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in DeSoto County

Guests agree: these stays are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Guest favorite
A white picket fence frames the entrance to a wooded area as the sun sets, casting shades of pink and orange across the sky. Leafless trees stand along the winding path that leads deeper into the serene surroundings.
Guesthouse in Hernando
4.92 out of 5 average rating, 144 reviews

DeerRun:Hidden Gem with Woods,Wildlife,and Gardens

We have 2 airbnbs at Deer Run that are close to Memphis,TN, I-55, restaurants and dining, great views. The spacious, 750+ sq ft cottage on 10 acres is good for retiree, couple, solo and business travelers alike. We look forward to sharing our property in this semi-secluded setting. Come relax in the comfy 12 inch deep foam mattress with super soft sheets. Enjoy the splendor of the woods, wildlife and gardens. We are far enough off the road that you will not see the street. Wheelchair accessible.

Top guest favorite
The exterior of a one-story home is displayed, featuring a combination of brick and stone. A large arched window adds character to the entryway. The paved driveway leads to a two-car garage, while well-maintained shrubs frame the front of the house.
Home in Hernando
5 out of 5 average rating, 16 reviews

Forked Creek Retreat

Spacious 3 bed/2 bath, is located in the heart of Hernando. Only 2 mins to the beautiful downtown square, restaurants, shopping and only 5 minutes to the Interstate . Covered Patio. Open floor plan, large living room . Kitchen is fully stocked. Living Room/couch, recliner, 50" smart tv, wifi/Internet. Kitchen/Dining room seats 12. Master bedroom, queen bed, large on-suite, jetted tub, shower, large closet, toilet room, Bedroom 1/queen bed Bedroom 2/queen bed, 2nd bathroom/tub/shower combo.

Superhost
The lake house is nestled among lush greenery, featuring large windows that provide views of the surroundings. Warm lights illuminate the exterior, creating a welcoming ambiance. A wooden deck leads to the entrance, surrounded by trees and natural landscaping.
Home in Hernando
4.87 out of 5 average rating, 246 reviews

Hernando Hideaway (Entire Lakehouse)

Enjoy our 2000 sq ft lake house in a private peaceful community with panoramic views of the lake. We are a licensed BNB with DeSoto County and the State of Mississippi until the year 2035. (Lic # 20110070) You will have the entire lake house to yourself and we provide coffee and pastries for breakfast. We are 15 minutes from Tunica Expo, 5 minutes to Tunica National Golf Course, 10 Minutes to the casinos; 38 minutes to Beale St, Bass Pro Shop, Peabody Hotel, Graceland and The Lorraine Hotel.

Guest favorite
A charming two-story Colonial home is displayed, featuring a wraparound porch with black railings. The exterior is painted in light hues, complemented by dark shutters. Lush greenery surrounds the property, offering a welcoming atmosphere, with sunlight filtering through the trees in the background.
Home in Hernando
4.97 out of 5 average rating, 34 reviews

Four Bedroom Home - King Bed - Full Kitchen

Beautiful Colonial home perfect for up to 8 guests. Complete with four bedrooms, two and a half baths, master bedroom has its own private bathroom, a two-car garage, full kitchen, appliances, washer and dryer, wi-fi, TV, and security system -- all to yourself. Very quiet and peaceful – centered on the historic Hernando Square. Relax and spend your day with free access to the nearby Hernando Golf & Racquet Club as part of your stay with dinning, swimming pool, golf and tennis available.

Guest favorite
The exterior of the cottage is framed with natural wood and features a screened porch, allowing for views of the surrounding forest. A wooden staircase leads to the entrance, and a stone pathway guides visitors through the lush, green landscape.
Cottage in Coldwater
4.94 out of 5 average rating, 180 reviews

Wynnewood - Odell Cottage

Country get-away! Only 30 Minutes from Downtown Memphis, TN, yet out in the country on a 62 acre estate. Nature trails through the property allow for beautiful, peaceful strolls. We have fishing (in season). **** This cottage is set back in the woods and there is not a TV in this unit but there is Wifi. We have created a serene and unplugged experience. We have the "Wynnewood Elizabeth Cottage" and the "Wynnewood Jettie Jewel cottage" on our property that are listed separately.

Top guest favorite
The kitchen features wooden cabinetry and a large countertop with seating for two. Appliances include a black refrigerator and stove set against a backdrop of wood paneling. Soft lighting from overhead fixtures highlights the warm tones of the space.
Farm stay in Olive Branch
4.96 out of 5 average rating, 398 reviews

Horse Farm Hideaway

Industrial farmhouse style meets southern charm on an idyllic horse boarding family farm safely outside of Memphis. Perfect location both for sightseeing in Memphis or bypassing the city entirely. Take a walk among the horses to decompress. Full kitchen and a large bathroom. No exterior windows. Guests sleep well in our quiet and private space. Due to safety concerns, no children under 12. Locals or those without prior positive reviews will be rejected. Our property is smoke free.

Top guest favorite
A clear view of the detached guesthouse is showcased, featuring a covered porch with rocking chairs. The well-maintained pool reflects sunlight, with surrounding concrete patio enhancing the outdoor space. A clock and decorative elements adorn the porch, adding a welcoming touch.
Guesthouse in Hernando
4.99 out of 5 average rating, 247 reviews

Guesthouse 1 bed, beautiful views NO cleaning fees

Adorable 1 bedroom quite hide-a-way, but still have the convenience of being located close to everything. There are beautiful views from the front covered porch. NO PARTIES! Located about 20 minutes from Memphis and Tunica Casino Strip. Enjoy local attractions: Hernando Town Square, Snowden Grove, Shopping, Graceland, Memphis Botanic Gardens, Museums and Beale Street. This area and home is made for family life, not for the party style, come and enjoy your tranquil stay with us.

Guest favorite
A versatile living space features a large wall-mounted television opposite a desk with an adjustable lamp. A classic arcade machine adds a playful touch. Natural light enters through two windows, complemented by decorative mirrors and a potted plant in the corner.
Home in Southaven
5 out of 5 average rating, 35 reviews

Your Stay at The Top of Mississippi

*Stylish Renovated Townhome in Southaven, MS* - Features 2 bedrooms, each with its own vanity. Primary bedroom with king bed, the second bedroom features two full-size beds. - Free wifi, fully equipped kitchen, washer and dryer. - Situated just 12 minutes from Memphis Airport, 20 minutes from downtown Memphis, and only minutes from local restaurants and parks. Plus, it’s only 5 minutes from the local hospital, making it a great choice for medical professionals or visitors. -No smoking

Guest favorite
The front of a two-story brick house features a gabled roof and a white garage door. A well-maintained driveway leads to the entrance, bordered by green grass and trees in the background. A clear blue sky provides a bright backdrop.
Home in Southaven
4.87 out of 5 average rating, 52 reviews

Family Getaway Home

Bring the family to enjoy. We offer lots of room for you to enjoy during your stay. 4 bedrooms with one of them having a full size air hockey table. Home offers a covered patio to sit and enjoy as well. Home is located in a nice quiet cove in the heart of DeSoto County. This home is convenient to lots of great restaurants and things to do. Downtown Memphis is a short 25 minute drive as well , home of the Memphis Tigers. Come , relax , and enjoy . Note - This is a nonsmoking home 😊

Top guest favorite
A guesthouse is nestled among green trees and lush grass, with a pathway leading to a bright red door. Two small chairs are positioned in front of the entrance, inviting guests to relax in the outdoor space.
Guesthouse in Hernando
4.99 out of 5 average rating, 137 reviews

Cozy 2 Bedroom Guesthouse in a Relaxing Setting

Our two bedroom, two bath guesthouse is the perfect get-a-way from it all, yet close enough to everything you're looking to do: 3 minutes to the historic Hernando Town Square, 10 minutes to the MS River Delta and Historic Hwy 61, 12 minutes to Tanger Outlets & Landers Center in Southaven, 20 minutes to Snowden Grove Ballfields & Amphitheatre in Southaven, 23 minutes to Tunica Casino Strip, 25 minutes to Midtown/Downtown Memphis, 1 hour to Oxford, MS and 1 hour to Clarksdale, MS.

Superhost
The image features a decorative ceramic 'HOME' sign, displayed prominently on a dark wooden surface. The letters exhibit a textured pattern, enhancing their visual appeal against a soft green background.
Townhouse in Southaven
4.75 out of 5 average rating, 198 reviews

The Tanger 1 Townhome

Hello Wonderful Guest This property is in a HOA Neighborhood and is geared more towards families and those visiting for work. If you are looking for a place that is quiet and you want to cozy up and hide out while visiting the near by cities this is also a place for you. Late traffic, parties, and gathering are prohibited in the neighborhood.LONG TERM BOOKINGS ASK ABOUT DISCOUNT !!!!!!!!!! ARE WELCOME! YOU WILL LOVE YOUR STAY HERE

Top guest favorite
Home in Olive Branch
5 out of 5 average rating, 16 reviews

Suburban Comfort - 7 minutes from Silo Square!

Kick back and relax in this calm, cozy space! This beautiful home is located in between Southaven, MS and Olive Branch, MS. Conveniently located near the Silo Square, South Point Grocery Store, Bank Plus Amphitheatre, Landers Center, Snowden Grove Park, Target, Tanger Outlets, local restaurants, grocery shopping, parks, hospital, schools, and many more! A perfect place to stay for vacation, work, visiting family, etc.

Popular amenities for DeSoto County vacation rentals