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Vacation rentals in Cape Girardeau

Book unique vacation rentals, houses, and more on Airbnb

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Popular amenities for Cape Girardeau vacation rentals

Stay near Cape Girardeau's top sights

Minglewood Brewery13 locals recommend
Port Cape13 locals recommend
Katy O'Ferrell's Publick House9 locals recommend
Top of the Marq8 locals recommend
Isle of Capri Casino8 locals recommend
Coin-Op Cantina7 locals recommend

Other great vacation rentals in Cape Girardeau

Guest favorite
Cabin in Jackson
4.94 out of 5 average rating, 31 reviews

The Cabin at Timber Creek

KarenRating, 5 stars2 weeks ago
This cabin/lodge was a very unexpected find in a more rural area of southeast Missouri! Ideal location for us to drive to local small towns in surrounding area or head to the city. The cabin had beautiful outdoor scenery and the inside had a charming rustic vibe. We very much enjoyed our visit and found the place to be very clean and welcoming. Highly recommend!
Guest favorite
Place to stay in Murphysboro
4.93 out of 5 average rating, 46 reviews

4Bdrm~EACHw/PRIVATEBathrms!

Shetara LatriceRating, 5 stars4 months ago
I hosted a slumber party for my 10 year old and 9 of her friends, THEY HAD AN ABSOLUTE BALL!! The second night, my husband, mother and 3 children enjoyed a night ourselves, and no one wanted to leave the next morning! Thank you for providing such a comforting atmosphere for my family and I to enjoy!
Top guest favorite
Home in Cobden
5 out of 5 average rating, 42 reviews

South Pass Hideaway

DixieRating, 5 stars2 weeks ago
Absolutely perfect for a girls’ weekend! The space was amazing and had everything we needed for a relaxing getaway. We loved sipping wine, laughing around the table, and soaking in the peaceful vibe. The location was convenient but still felt like a retreat. Highly recommend for a fun, memory-making weekend with your favorite people!
Top guest favorite
Cabin in Makanda
4.98 out of 5 average rating, 117 reviews

Hygge Log Cabin: HotTub & Hiking

AimeeRating, 5 stars1 day ago
We love hiking so we visited the Garden of the Gods, the Little Grand Canyon and the Giant City Nature Trail. This cabin is in a great location for visiting the Shawnee National Forest and perfect place to unwind after a day of hiking. The grill for making dinner was so clean, as well as the hot tub for relaxing. Also a fire pit out back. The kitchen had everything you could need. Shampoo and conditioner were also provided. This is by far the best Airbnb I have visited, HIGHLY RECOMMEND!!! We had a great time :)
Guest favorite
Home in Carbondale
4.96 out of 5 average rating, 224 reviews

Cozy 2 Bedroom Garden Oasis Home

MarissaRating, 5 stars1 day ago
Lia's place was perfect for our weekend getaway. When we arrived it was easy to check in with the keypad. The kitchen was stocked with coffee and tea essentials, and the living room had plenty of throw blankets to use. The "Moon" room was comfy and private, and we had no issues keeping it climate controlled. Overall we had a great stay in Lia's quiet neighborhood. We would definitely stay here again.
Superhost
Home in Makanda
4.83 out of 5 average rating, 171 reviews

Ranch style home in country setting, near SIU-C

JenniferRating, 5 stars1 week ago
Rebecca's place was a warm and cozy. exceeded out expectations. we had to stay for a remeberance ceremony at SIU and Rebecca made us feel welcomed. The location was perfect. Highly recommend
Top guest favorite
Cabin in Carbondale
5 out of 5 average rating, 23 reviews

Cabin on hobby farm.

JenniferRating, 5 stars1 week ago
My son and I very much enjoyed our stay. Both Jill and Danny were very responsive to any of our questions, and we really loved the trail that we were able to access for our private use. The animals were so much fun to be around.
Top guest favorite
Cottage in Burfordville
5 out of 5 average rating, 58 reviews

Entire Cottage Nestled in the Woods

KarenRating, 5 stars4 months ago
My family and I have stayed at Lara's place the last few years, and we absolutely love it! There is no clutter but plenty of seating and lots of space to stretch and move about. The location is private and perfectly close to our family in Jackson. Everything is always clean and inviting. Perfect home away from home!

Quick stats about vacation rentals in Cape Girardeau

  • Total rentals

    150 properties

  • Nightly prices starting at

    ﺩ.ﺇ73 before taxes and fees

  • Total number of reviews

    9.1K reviews

  • Family-friendly rentals

    70 properties are a good fit for families

  • Pet-friendly rentals

    40 properties allow pets

  • Rentals with dedicated workspaces

    80 properties have a dedicated workspace

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Cape Girardeau?

    Yes! Work meets play with ease at over 80 vacation rentals in Cape Girardeau featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there pet-friendly vacation rentals in Cape Girardeau?

    Four-legged friends are welcome in Cape Girardeau. Choose from more than 40 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in apartment rentals in Cape Girardeau?

    Experience the best of Cape Girardeau with our apartment rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Do house rentals in Cape Girardeau have self check-in?

    Absolutely! We offer over 20 house rentals with self check-in in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Cape Girardeau have wifi?

    Absolutely! We offer over 60 house rentals with wifi in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.

  • Are there family-friendly house rentals in Cape Girardeau?

    Cape Girardeau has more than 40 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.

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