House vacation rentals in Cape Girardeau

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Top-rated house rentals in Cape Girardeau

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Top guest favorite

The exterior of a charming one-story house is displayed, featuring a sloped roof with a pointed peak. Two planters with colorful flowers flank the steps leading to the entrance, surrounded by lush greenery and autumn foliage.

Home in Cape Girardeau

5 out of 5 average rating, 12 reviews

Urban Cape Downtown Escape-The Rivertown Nook

Welcome to The Rivertown Nook, your downtown escape into the heart of Cape Girardeau! Centrally located, this stylish one-story retreat is perfect for couples or small families. Walk to local eateries, breweries, coffee shops, and take in Broadway Street’s charm, or take a quick drive to Southeast Missouri State University. The cozy, modern home features a sleek kitchen, spa-like bathroom, and off-street parking. Whether for a weekend or vacation, it's the perfect base to explore Cape Girardeau!

Superhost

The cottage exterior presents a single-story structure with light blue siding and a dark roof. A wooden deck is located at the front, featuring a railing. The yard is grassy, bordered by a privacy fence, with a driveway visible beside the house.

Home in Cape Girardeau

4.84 out of 5 average rating, 122 reviews

Herman's Corner Cottage.

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

Guest favorite

The exterior of a charming brick farmhouse is displayed, featuring a symmetrical layout with two dormer windows. A well-maintained lawn surrounds the house, complemented by flower beds. A walkway leads to the welcoming entryway, which opens to a sunroom on the right.

Home in Cape Girardeau

4.97 out of 5 average rating, 143 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

Guest favorite

A spacious living room is furnished with a large sectional couch, complemented by decorative pillows. A wooden coffee table sits center stage on an area rug. A ceiling fan is visible, and light enters through window treatments, creating a comfortable atmosphere.

Home in Cape Girardeau

4.84 out of 5 average rating, 129 reviews

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Guest favorite

A comfortable living room is presented with soft, beige seating adorned with red accent pillows. A dark trunk serves as a coffee table, while a lamp gently illuminates the space. The room features multiple windows, enhancing natural light alongside decorative curtains.

Home in Cape Girardeau

4.87 out of 5 average rating, 111 reviews

House Of Clubs- 2 Bed 1.5 Bath

The PERFECT hideway. The House of Clubs offers a quiet setting with a creek that wraps around the enitre property. Two bedrooms, each include a queen size bed. One Full bathroom. Full Laundry room that also offers a private cammode. The stylish living room offers a unique style that higlights Cape Girardeaus rich history. Enjoy your morning coffee in the four seasons room with breathtaking views of this hidden gem . Less than 5 minutes to downtown. Only 2 minutes to Cape Country Club.

Top guest favorite

An outdoor seating area features a round table surrounded by four chairs, set on a stone patio. Flowering plants line the edge of a grassy space, and a door leads into the house. The clear blue sky and greenery provide a serene backdrop.

Home in Alto Pass

4.99 out of 5 average rating, 132 reviews

The Farmhouse in Rhine Valley

Newly renovated Farmhouse in Alto Pass situated between Trail of Tears State Forest and just a hike or short drive away from Bald Knob Cross and wilderness. Minutes away from local wineries. Enjoy a peaceful pause from the hustle and bustle in our private little Farmhouse. Perfect for single family or small groups. Nearby venues and activities include: hiking, fishing, public hunting, wineries, restaurants, and many other local venues and events. Hunters are welcome.

Superhost

A cozy living area features a sectional sofa adorned with decorative pillows. A large television sits on a wooden console across from the seating. Soft lighting from two lamps enhances the space, while patterned curtains complement the rich textures of the decorative area rug.

Home in Cape Girardeau

New place to stay

Cozy Artistic Downtown Loft

Charming downtown loft with cozy vintage vibes and artistic touches. Walkable to shops, dining, and nightlife. Perfect for solo travelers, couples, or creatives. Includes a queen bed (upstairs), full bath, and private entrance with parking. Ideal for a weekend escape or longer stay. 🎯 Whether you’re a traveling nurse, remote worker, or just here for a weekend escape—this loft has you covered with charm, comfort, and convenience. Available for extended stays also.

Superhost

A living area features a blend of floral wallpaper and hardwood flooring. A light-colored sofa and an armchair are arranged around a circular coffee table, with a patterned area rug underneath. Natural light enters through window drapes, enhancing the cozy ambiance.

Home in Cape Girardeau

4.83 out of 5 average rating, 12 reviews

Cottage Near Casino

Welcome to your cozy cottage with a delightful retro feel, conveniently located near the Casino, Downtown, and SEMO University. You'll be greeted by the inviting sight of a white fence that surrounds the property, adding a touch of quaint charm to home away from home. This home features 2 bedrooms, 1 full bathroom and the convenience of main floor laundry. This is the perfect haven for traveling nurses or professionals seeking a comfortable and stylish residence.

Top guest favorite

A well-furnished living area features a tufted coffee table centered on a patterned area rug. Two large windows allow natural light to illuminate the space. A comfortable leather armchair and a plush sofa provide ample seating, with a bookshelf displaying decorative items in the background.

Home in Cape Girardeau

5 out of 5 average rating, 31 reviews

Mid-Town Historic Like New Gem

This spacious and unique historic home is completely renovated; like new inside and out. Nice covered deck, overlooking a large back yard. 2 minute drive to SEMO University and the Cape Catfish. Within walking distance to Mercy Hospital, Muy Bueno, The Pickleball Factory, as well as Pacific Rim Market and Walmart Neighborhood Market for groceries. Centrally located within a 5 minute drive of most of Cape Girardeau. Close to downtown dining and entertainment.

Superhost

Home in Cape Girardeau

4.73 out of 5 average rating, 238 reviews

3+ acre:King Bed, Hot Tub, Mini Golf, Pool Table

Home - unique & open, with tall ceilings, multiple decks, and outdoor entertaining areas. 4 Acres of Oasis. 4 miles from Downtown, the space offers both experiences, Natural Beauty & Nightlife. Boasting with personality and comfort. PERFECT for Longer Stays! Guests LOVE • POOL (Summer ONLY end of May beginning June if no issues prices reflect) • Hot Tub • King Bed • Multiple Decks • Putt Putt • Pool Table • Swing Daybed • Plush Beds • Eclectic Decor

Guest favorite

A brightly lit bedroom features two beds with decorative headboards and comfortable bedding. Pillows are arranged neatly on each bed, complemented by window treatments that allow natural light to filter in. The hardwood floor adds a warm touch to the inviting space.

Home in Cape Girardeau

4.79 out of 5 average rating, 112 reviews

Historic Blvd District Home in Cape Girardeau

This beautiful, private home is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. With large bedrooms, spacious living room and separate dining room you will have all the room you need! The kitchen is fully equipped with amenities. This quiet neighborhood setting with a big front porch sitting area where you can enjoy your morning coffee.

Guest favorite

A single-story house with a red roof and brick facade is nestled among tall trees, providing shade. The home is situated on a gentle slope covered with green grass, creating a serene outdoor setting with ample space surrounding it.

Home in Jackson

4.86 out of 5 average rating, 21 reviews

Rural Comfort in Fruitland

Enjoy a peaceful, private, country setting on the back patio with country views and a large yard space, while also having easy access to I-55, Cape Girardeau, and Jackson & multiple restaurants within a few mile radius. This home offers two fully furnished living spaces, two bedrooms, 1.5 bath and a fully equipped kitchen. There is a full laundry room/mud room with full size washer and dryer and use of the garage is negotiable.