Vacation rentals in Santee River

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Top-rated vacation rentals in Santee River

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Home in Summerton

4.86 out of 5 average rating, 153 reviews

Cozy Lake Living

Cozy home on Taw Caw Creek area of Lake Marion with two bedrooms with double beds and a front room with a king bed that overlooks the water. Full kitchen with electric range, microwave, Keurig and regular coffee maker, toaster, refrigerator, dishes, silverware, pots and pans. Living room has a loveseat, couch, WiFi, Roku TV and DVD player. Bathroom has a walk-in shower, no tub. Pets and Parties are NOT allowed. No smoking or vaping inside. Washer and dryer are located under the main living area.

Jul 10 – 17

ﺩ.ﺇ482 per night
Guest favorite

Tiny home in Charleston

4.93 out of 5 average rating, 301 reviews

The Backpacker

Our "Backpacker" is a cute and cozy 96 sq.ft. of tiny house nirvana. Situated on a small tidal slough, it provides a beautiful natural setting for reflection and appreciation of that which is good in life. For those looking for luxury, the Backpacker is not for you (you may encounter bugs and it's really hot in summer). However, the Backpacker has a pretty cool vibe, and is extremely convenient to historic Charleston and Funky Folly Beach. The Backpacker is for backpackers and nature lovers.

ﺩ.ﺇ184 per night
Guest favorite

Cottage in Sumter

4.96 out of 5 average rating, 363 reviews

Restful Lakeside Getaway Cottage -Dogs allowed.

This pond-side cottage is a peaceful place to relax and unwind. Sit on the enclosed porch and watch the water or enjoy the front porch swing where you can listen to the birds and frogs. We are 12 min. from downtown Sumter and 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens and Poinsett State Park. It is only 2 hours to Myrtle Beach and Charleston, SC & 3 hrs to the mtns. While it is conveniently located, this cottage offers a quiet place to put your feet up and rest.

Sep 13 – 20

ﺩ.ﺇ419 per night

Popular amenities for Santee River vacation rentals

Other great vacation rentals in Santee River

Guest favorite

Home in Andrews

4.92 out of 5 average rating, 12 reviews

La’ Avenue

May 21 – 28

ﺩ.ﺇ437 per night
Guest favorite

Home in Moncks Corner

4.94 out of 5 average rating, 36 reviews

Cozy Little Nook

Aug 26 – Sep 2

ﺩ.ﺇ393 per night
Superhost

Home in Bonneau

4.81 out of 5 average rating, 26 reviews

Coastal Cottage at the Lake

Jul 11 – 18

ﺩ.ﺇ538 per night
Guest favorite

Apartment in Moncks Corner

4.94 out of 5 average rating, 47 reviews

Jay’s Upstairs Suite

Jan 20 – 27

ﺩ.ﺇ241 per night
Guest favorite

Home in Moncks Corner

5.0 out of 5 average rating, 98 reviews

Your home away from home in Pinopolis

Sep 5 – 12

ﺩ.ﺇ575 per night
Guest favorite

Guest suite in Moncks Corner

4.94 out of 5 average rating, 47 reviews

Peaceful Pimlico Paradise by the River

Nov 17 – 24

ﺩ.ﺇ394 per night
Guest favorite

Home in Manning

4.94 out of 5 average rating, 17 reviews

Cozy Church Branch Cabin

Aug 5 – 12

ﺩ.ﺇ412 per night
Guest favorite

Home in Moncks Corner

5.0 out of 5 average rating, 16 reviews

The Brown Trailer

Aug 12 – 19

ﺩ.ﺇ389 per night
Guest favorite

Cottage in Hemingway

4.98 out of 5 average rating, 63 reviews

Country Cottage at Black Mingo Plantation

Aug 9 – 16

ﺩ.ﺇ442 per night
Superhost

Tiny home in Cross

5.0 out of 5 average rating, 10 reviews

Tiny Cabin W/ Lake Moultrie View

Aug 21 – 28

ﺩ.ﺇ341 per night
Superhost

Home in Bonneau

4.8 out of 5 average rating, 10 reviews

Hideaway on Lake front for 7 guests

Jun 13 – 20

ﺩ.ﺇ637 per night
Guest favorite

Home in Moncks Corner

4.88 out of 5 average rating, 26 reviews

Bright, airy 2-bedroom home, fenced in back yard

Aug 18 – 25

ﺩ.ﺇ492 per night

Destinations to explore