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House vacation rentals in Santee

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Top-rated house rentals in Santee

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
The interior of the studio showcases a spacious layout, featuring a king size bed adorned with yellow and white pillows. A dark gray sofa complements the decor, facing a coffee table with a plant. Large glass doors provide a view of the garden and outdoor seating.
Home in La Mesa
4.9 out of 5 average rating, 277 reviews

2 Bed Hidden Oasis | Garden, Laundry, Parking

Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Guest favorite
Home in Ramona
4.97 out of 5 average rating, 311 reviews

Wine Country Retreat - Tranquility Hottub/Views

Our famed Wine Country Retreat is back online! (LTR for the last year) Take the back roads scenic drive 50mins up the hill from San Diego and enjoy some much needed quiet and comfy tranquility. Right in the heart of San Diego Wine Country, it’s a rather well appointed place situated on 10 private acres that overlooks expansive green space. With few neighbors in any direction, you can either sleep with the windows open and wake early to roosters crowing, or close the windows and sleep til Noon!

Guest favorite
A contemporary casita is set against a vibrant sunset, showcasing large windows that reflect the warm colors of the sky. The entrance features a clear path leading to a well-lit doorway, surrounded by natural landscaping and scenic hillside views.
Home in Lakeside
4.94 out of 5 average rating, 114 reviews

SD Casita Sleeps 6 - Morey from Prieto Surf Ranch

The Morey de Prieto Surf Ranch is truly awesome! Reserve your stay in this 2 Bed/1 Bath 650 sq. ft. casita for six. Home includes a kitchen with many amenities including a GE electric cooktop, refrigerator, microwave and air fryer, rice cooker, Kitchenaid mixer, mixer for drinks, sink with prep trays, Moen faucet fixtures, gorgeous shower, Krups coffee maker, 50" smart TV equipped with WiFi and NetFlix, mountain views, workspace and a sofabed. How about a large deck with fire pit and BBQ?

Guest favorite
A spacious living area features a large leather sectional sofa positioned around a circular wooden coffee table. A wall-mounted TV is visible above a decorative fireplace, while natural light streams through a large window adorned with sheer curtains. A dining area is seen in the background.
Home in La Mesa
4.87 out of 5 average rating, 107 reviews

Sunny & Spacious 3BR Retreat w/ Parking & A/C

Centrally located in La Mesa is this newly refurbished home ideal for business or pleasure with all of life’s little luxuries waiting for you to enjoy. The home features open concept living with a gourmet kitchen, a chic dining space, 3 beautiful bedrooms, 2 modern bathrooms and an expansive yard with an outdoor lounge. Walk 10 mins to Grossman Center with a Target, restaurants, cafes, a cinema & Walmart or drive to the heart of San Diego and all its attractions just 20 mins from your door.

Guest favorite
The kitchen area features modern black cabinetry and stainless steel appliances, including a microwave and compact refrigerator. A smart TV is mounted on the wall, complementing the wooden counter workspace equipped with essential cooking utensils. A dining table with two chairs is positioned nearby.
Home in La Mesa
4.85 out of 5 average rating, 244 reviews

Newer "Manor Studio"

Centrally located in San Diego County this newer studio style unit has a private entrance, private patio area and street parking. Furnished with a queen size bed, love seat, full bathroom and kitchen area. One large drawer to accommodate personal items, and a wall rack to hang clothing. There is a smart TV with WiFi streaming capabilities and lots of USB plugs to charge your devices. On street parking in front of unit (no parking in driveway). No Pets allowed. No Hair Dying allowed.

Top guest favorite
A view into a modern living space reveals a sleek kitchen with bar seating and a spacious dining area. Natural light floods the room through large glass doors, showcasing lush greenery outside. A cozy area is completed with a colorful rug beneath and a inviting seating arrangement.
Home in La Mesa
4.94 out of 5 average rating, 234 reviews

Cottage in the Garden! New! Modern!

COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Guest favorite
A welcoming living area features a spacious beige sectional sofa adorned with patterned throw pillows. Natural light filters through a large window, complemented by soft, flowing curtains. A dark ottoman with decorative details adds a contrasting element to the cozy space.
Home in La Mesa
4.97 out of 5 average rating, 118 reviews

Zen Retreat: 3-Bedroom Oasis near La Mesa Village

Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

Top guest favorite
A colorful studio space features turquoise walls and a ceiling fan. A comfortable sofa with decorative pillows is paired with a coffee table. A bed with a floral-patterned comforter sits against a window, while a TV and white refrigerator complete the modern setup.
Home in La Mesa
4.98 out of 5 average rating, 304 reviews

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental!   Our studio is newly remodeled with luxury ammenities.  We proudly cater to the cannabis community and non-users alike.   Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest.  This ensures that every guest checks into a clean, fresh-smelling place that feels like home.   Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Guest favorite
A spacious living area features a large sectional sofa adorned with decorative cushions. A flat-screen TV is mounted on the wall opposite a minimalist entertainment unit. Natural light filters in through a window covered by white blinds, enhancing the subtle color palette of the decor.
Home in Cherokee Point
4.94 out of 5 average rating, 142 reviews

Cozy Modern house

Quiet one bedroom house located behind the main house. Completely separate and private structure with 720 square feet of newly renovated space. There is fully loaded kitchen has ample space for cooking , the backyard has plenty of room for enjoyment and 3 full parking spacing in the alley access gated driveway. The bedroom has a memory foam queen mattress and sleeps 2, the new couch can sleep another and a queen air mattress in the closet. There is also a full bed folding couch

Top guest favorite
Home in Rolando
5 out of 5 average rating, 108 reviews

Peaceful Casita | Firepit • Near SDSU

Welcome to our cozy home, perfect for couples visiting the area. It's also a great spot for SDSU parents visiting their kids. Conveniently close to the campus but far enough to enjoy some peace and quiet. If you enjoy this listing, click the heart icon ❤ in the top-right corner to bookmark it for easy access! Minutes from key attractions: ★ 6 min to SDSU/Viejas Arena ★ 14 min to Balboa Park ★ 17 min to Downtown SD (Gaslamp) ★ 19 min to San Diego Zoo ★ 21 min to the Airport

Guest favorite
Home in La Mesa
4.93 out of 5 average rating, 134 reviews

Palm Cottage, San Diego

Palm Cottage sits in the heart of La Mesa Village, San Diego. Enjoy the charm of a historic home with a fully remodeled and stylish interior featuring both Dutch & French doors letting in plenty of sunshine. A large private yard w/ covered outdoor living area creates the ultimate indoor/outdoor lifestyle. You're steps from the local grocery store, village shopping, coffee shops, restaurants, bars and the trolley. You could not ask for a better location!

Guest favorite
A modern living space features a brown leather sofa paired with a stylish round coffee table made of natural wood. Light streams through sheer window coverings, illuminating the open layout that connects the living area with a sleek kitchen and dining space.
Home in City Heights
4.89 out of 5 average rating, 104 reviews

4169 beautiful retreat-New & Close to All!

Kick back and relax in this calm, stylish space. Our newly renovated property will feel like home away from home and located right in the heart of San Diego you will be minutes away from all our beloved city has to offer. Spend a day downtown exploring or catch a game at Petco Park, make a visit to Sea World or the famous San Diego Zoo and Safari Park. With the endless amounts of restaurants and entertainment to choose from you will never be bored!

Popular amenities for Santee house rentals

When is the best time to visit Santee?

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Avg. priceﺩ.ﺇ496ﺩ.ﺇ455ﺩ.ﺇ367ﺩ.ﺇ558ﺩ.ﺇ588ﺩ.ﺇ470ﺩ.ﺇ804ﺩ.ﺇ705ﺩ.ﺇ639ﺩ.ﺇ422ﺩ.ﺇ837ﺩ.ﺇ808
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Quick stats about house rentals in Santee

  • Total vacation rentals

    Explore 50 vacation rentals in Santee

  • Nightly prices starting at

    Santee vacation rentals start at ﺩ.ﺇ110 per night before taxes and fees

  • Verified guest reviews

    Over 1,240 verified reviews to help you choose

  • Family-friendly vacation rentals

    30 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Vacation rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    50 of Santee vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santee rentals

  • 4.9 Average rating

    Santee stays are highly rated by guests—averaging 4.9 out of 5!

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