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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A modern single-story house is displayed with a large front porch and a carport. The exterior features a mix of light and dark materials, with a neatly landscaped yard and a white picket fence. Clear blue skies and scattered clouds complete the setting.
Home in Chame

Casa de Veraneo

Lleva a toda la familia a este fantástico lugar con muchas zonas para divertirse. Cerca a todas las amenidades de Coronado, a pocos minutos de playas, laguna de San Carlos y a tan solo una hora y media de la ciudad. El PH cuenta con piscina del PH y una privada, en una zona tranquila y espaciosa. Encontraras 4 supermercados, farmacias, hospital privado (urgencias). Cerca a actividades campestres, playas, montañas, lago. Tiene en un gazebo con todas las comodidades. El lugar es seguro y completo.

ValueLocationIndoor spaces

4.94 out of 5 average rating, 67 reviews
Top guest favorite
Home in Playa Costa Esmeralda

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

FamilyLocationDecor

4.98 out of 5 average rating, 222 reviews
Guest favorite
Home in Las Lajas

Paradishaus in Natur in Playa Coronado mit Pool

Genieße entspannte Tage mit der ganzen Familie oder Deiner Freunden in dieser friedlichen Unterkunft mit viel Natur! Der Strand ist in 5 Minuten zu Fuß entfernt. Viele verschiedene Geschäfte sind mit einem Auto in 8 Minuten zu erreichen. Zwei kleine Läden sind auch in 5 Minuten zu Fuß erreichbar. Für alles ist im Haus gesorgt: Klimaanlagen in jedem Zimmer, großer 75" TV, Waschmaschine, Trockner, Föhn, Handtücher.... alles was Du brauchst. Der Pool sorgt für Erfrischung – ein Ort zum Wohlfühlen!

FamilyLocationHospitality

4.94 out of 5 average rating, 35 reviews
Top guest favorite
A swimming pool is positioned in the foreground, surrounded by lounge chairs and shaded by umbrellas. The house features a terracotta roof and a hammock hangs near the entrance, with lush greenery and a twilight sky providing a serene backdrop.
Home in Playa Coronado

The Dream of Playa Coronado

Whether traveling to Playa Coronado to relax, spend time with family, flee the cold weather or scout your retirement destination, this house is perfectly located in the heart of Playa Coronado and features an airy, tropical ambience, a pool with loungers to soak up the sun, two bohios with dining/lounging areas, hammocks to sway your day away and a BBQ to cook fresh fish bought at the local fish market. The house has a water well so no problems with access to water during the Dry Season.

LocationValueBeach

5.0 out of 5 average rating, 43 reviews
Guest favorite
Home in Bejuco

Casa de Campo con Piscina / Villas del Maria

Relájate en este espacio tranquilo y elegante. Este alojamiento es perfecto para grupos de personas, viajes en familia o una puerta de entrada romántica. Ubicado en Sora, a 5 minutos de la Interamericana, a 15 minutos de supermercados y lugares para comer en Coronado. Villas del María es un lugar seguro y relajante para pasar el tiempo en familia. Disfruta de un acogedor lugar silencioso con todo lo necesario para la estancia. A ti y a tu familia les encantará este lugar!

FamilyLocationAir conditioning

4.86 out of 5 average rating, 22 reviews
Guest favorite
Home in Nueva Gorgona

Playa Malibu Beach House.

Wake up to the sound of the waves at this beautiful oceanfront home in Playa Malibu, where the beach is literally your backyard. Step outside and enjoy direct beach access, morning walks on the sand, and unforgettable sunsets over the water. The home features a private pool, BBQ area, and an outdoor dining space perfect for shared meals and long, laid-back evenings. Inside, the house offers a cozy, comfortable, and relaxed vibe, with all the essentials for a stress-free stay.

FamilyLocationComfort

4.95 out of 5 average rating, 44 reviews
Superhost
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del María

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

ValueLocationCheckout

4.82 out of 5 average rating, 337 reviews
Superhost
Home in Altos del María

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

LocationValueGrill

4.76 out of 5 average rating, 170 reviews
Guest favorite
Home in Las Lajas

Luxury Beachfront Home • Private Pool • Coronado

Welcome to your private beachfront retreat in Coronado, one of Panama's premier Pacific Coast communities. This beautiful home combines contemporary design with relaxed coastal living. Enjoy a private pool, tropical gardens, spacious indoor and outdoor areas, a fully equipped kitchen, Wi-Fi, ocean views and direct access to a wide, beautiful beach. Perfect for families and groups seeking privacy, comfort and a true beachfront experience.

FamilyLocationBeach

4.89 out of 5 average rating, 18 reviews
Top guest favorite
Home in Nueva Gorgona

Spectacular Beachfront House

Beautiful house with private beach access right on the property. Relax on the hammocks and be surrounded by nature, with the best ocean view. Only 10 minutes drive from Coronado with all its amenities. There are two wonderful caretakers on the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

LocationFamilyGrill

5.0 out of 5 average rating, 41 reviews
Guest favorite
A pool area is visible with a clear blue pool surrounded by a concrete patio. Two lounge chairs are positioned beside the pool, and greenery from surrounding plants enhances the outdoor space. The area is framed by a shaded overhang, providing a comfortable retreat.
Home in Bejuco Chame

Casa de Campo- familiar Bejuco-Chame

Este lugar único tiene su propio estilo. Apropiado para celebrar cumpleaños, proyectos, trabajar, escribir y estar totalmente en tranquilidad .Leer un buen libro, darse una buena terapia de piscina y compartir grandes momentos y eventos en familia o pareja .Además de poder estar en un área de vivencias cultural.

FamilyValueQuiet

4.88 out of 5 average rating, 50 reviews
Superhost
An outdoor area features modern seating arranged around a central fire pit, surrounded by gravel and stone pathways. Elevated swings are positioned for relaxation, with a backdrop of expansive mountain views. Natural light filters through a structured canopy, enhancing the spacious feel.
Cabin in Chame

Paseo por Las Nubes

Relájate en esta escapada unica y tranquila a solo una hora y media de la ciudad. Cada rincón de este lugar mágico fue meticulosamente diseñado para brindar el escape perfecto a las parejas que buscan intimidad, serenidad y momentos inolvidables juntos.

FamilyLocationNearby

4.84 out of 5 average rating, 159 reviews

Popular amenities for Santa Cruz vacation rentals