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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A modern single-story house is displayed with a large front porch and a carport. The exterior features a mix of light and dark materials, with a neatly landscaped yard and a white picket fence. Clear blue skies and scattered clouds complete the setting.
Home in Chame
4.94 out of 5 average rating, 66 reviews

Casa de Veraneo

Lleva a toda la familia a este fantástico lugar con muchas zonas para divertirse. Cerca a todas las amenidades de Coronado, a pocos minutos de playas, laguna de San Carlos y a tan solo una hora y media de la ciudad. El PH cuenta con piscina del PH y una privada, en una zona tranquila y espaciosa. Encontraras 4 supermercados, farmacias, hospital privado (urgencias). Cerca a actividades campestres, playas, montañas, lago. Tiene en un gazebo con todas las comodidades. El lugar es seguro y completo.

LocationFamilyBackyard

Top guest favorite
Home in Playa Costa Esmeralda
4.98 out of 5 average rating, 222 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

FamilyValueHot tub

Guest favorite
Home in Las Lajas
4.94 out of 5 average rating, 35 reviews

Paradishaus in Natur in Playa Coronado mit Pool

Genieße entspannte Tage mit der ganzen Familie oder Deiner Freunden in dieser friedlichen Unterkunft mit viel Natur! Der Strand ist in 5 Minuten zu Fuß entfernt. Viele verschiedene Geschäfte sind mit einem Auto in 8 Minuten zu erreichen. Zwei kleine Läden sind auch in 5 Minuten zu Fuß erreichbar. Für alles ist im Haus gesorgt: Klimaanlagen in jedem Zimmer, großer 75" TV, Waschmaschine, Trockner, Föhn, Handtücher.... alles was Du brauchst. Der Pool sorgt für Erfrischung – ein Ort zum Wohlfühlen!

LocationFamilyComfort

Guest favorite
An expansive view of a tranquil beach is seen, with soft sandy shores meeting clear turquoise waters. The horizon features a blend of blue sky and distant buildings, while palm trees and shaded cabanas dot the beach area.
Condo in Chame
4.96 out of 5 average rating, 184 reviews

Exclusive Beachfront apartment 1Hour from Pma City

ESPECTACULAR apartamento de lujo FULL EQUIPADO con 3 recamaras (todas con vista directa al mar), 2 baños completos y medio baño de visita; cuarto y baño de servicio. Finos acabados, cocina 100% de acero inoxidable y aires acondicionados en todo el apartamento de alta eficiencia. Condominio con concepto "Hotel Style Living"; Restaurante y Bar para las noches (de Jueves a Domingo), snack bar en el area de la piscina y un Tiki Bar en la playa, ademas de cancha de Volleyball , Tenis, basketball.

ValueFamilyLayout

Top guest favorite
A swimming pool is positioned in the foreground, surrounded by lounge chairs and shaded by umbrellas. The house features a terracotta roof and a hammock hangs near the entrance, with lush greenery and a twilight sky providing a serene backdrop.
Home in Playa Coronado
5.0 out of 5 average rating, 43 reviews

The Dream of Playa Coronado

Whether traveling to Playa Coronado to relax, spend time with family, flee the cold weather or scout your retirement destination, this house is perfectly located in the heart of Playa Coronado and features an airy, tropical ambience, a pool with loungers to soak up the sun, two bohios with dining/lounging areas, hammocks to sway your day away and a BBQ to cook fresh fish bought at the local fish market. The house has a water well so no problems with access to water during the Dry Season.

LocationFamilyComfort

Top guest favorite
The exterior of the cabin is depicted, featuring a stone wall and a metal roof. A manicured grass area surrounds the structure, with pine trees in the background against a bright blue sky, creating a serene environment.
Cabin in Chica
4.94 out of 5 average rating, 319 reviews

Cabaña Horizonte by Casa Amaya

Relájate en esta escapada única y tranquila en Cabaña Horizonte. Casa Amaya es un complejo de 6 cabañas ubicado en Chicá de Chame, clima fresco entre 18 y 24 grados, donde podrás contactarte con la naturaleza y relajarte con tu pareja, amigos o familia. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya Contamos con generador eléctrico en caso de apagón.

FamilyValueIndoor spaces

Guest favorite
Home in Bejuco
4.86 out of 5 average rating, 22 reviews

Casa de Campo con Piscina / Villas del Maria

Relájate en este espacio tranquilo y elegante. Este alojamiento es perfecto para grupos de personas, viajes en familia o una puerta de entrada romántica. Ubicado en Sora, a 5 minutos de la Interamericana, a 15 minutos de supermercados y lugares para comer en Coronado. Villas del María es un lugar seguro y relajante para pasar el tiempo en familia. Disfruta de un acogedor lugar silencioso con todo lo necesario para la estancia. A ti y a tu familia les encantará este lugar!

LocationFamilyBeach

Guest favorite
Home in Nueva Gorgona
4.95 out of 5 average rating, 43 reviews

Playa Malibu Beach House.

Wake up to the sound of the waves at this beautiful oceanfront home in Playa Malibu, where the beach is literally your backyard. Step outside and enjoy direct beach access, morning walks on the sand, and unforgettable sunsets over the water. The home features a private pool, BBQ area, and an outdoor dining space perfect for shared meals and long, laid-back evenings. Inside, the house offers a cozy, comfortable, and relaxed vibe, with all the essentials for a stress-free stay.

LocationFamilyHospitality

Superhost
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del María
4.82 out of 5 average rating, 336 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

LocationFamilyWifi

Guest favorite
Villa in Chame
4.86 out of 5 average rating, 119 reviews

Ocean Waves Villa (C6-1D) 2 bed, 2 bath

This unique place is a fully furnished 2 bed/2 bath plus a sofa bed, second floor villa unit has breathtaking ocean views with direct beach access. The unit has a open concept living, dining & kitchen space (6 guests). Unique villa apartment over looking the picturesque Playa Caracol coast with 1km of ocean front and majestic mountain views. Playa Caracol is located on a the beach of Chame and is a newly developed area with expansion for the property and amenities.

ValueFamilySleep quality

Superhost
Home in Altos del María
4.76 out of 5 average rating, 170 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

FamilyLocationAccess

Top guest favorite
Home in Nueva Gorgona
5.0 out of 5 average rating, 41 reviews

Spectacular Beachfront House

Beautiful house with private beach access right on the property. Relax on the hammocks and be surrounded by nature, with the best ocean view. Only 10 minutes drive from Coronado with all its amenities. There are two wonderful caretakers on the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

FamilyLocationGrill

Popular amenities for Santa Cruz vacation rentals