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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Condo in Chame

4.96 out of 5 average rating, 135 reviews

Exclusive Beachfront apartment 1Hour from Pma City

ESPECTACULAR apartamento de lujo FULL EQUIPADO con 3 recamaras (todas con vista directa al mar), 2 baños completos y medio baño de visita; cuarto y baño de servicio. Finos acabados, cocina 100% de acero inoxidable y aires acondicionados en todo el apartamento de alta eficiencia. Condominio con concepto "Hotel Style Living"; Restaurante y Bar para las noches (de Jueves a Domingo), snack bar en el area de la piscina y un Tiki Bar en la playa, ademas de cancha de Volleyball , Tenis, basketball.

May 16 – 23

ﺩ.ﺇ555 per night
Guest favorite

Apartment in Playa Coronado

4.9 out of 5 average rating, 30 reviews

Luxury Suite 1121 w/Swim up Pool, Free 18 H Golf

Take it easy at this unique & tranquil getaway. Welcome to Coronado Luxury Club. Bright & breezy newly renovated, semi-private Swim Up Suite with garden terrace. Unlimited Free 18 hole Golf & tennis/pickleball included. Other Hotel amenities to be enjoyed, several pools, restaurants, bars, spa, Beach Club, even room service! Located only 80 km from Panama City on the Pacific riviera. Area highlights: boat tours, surfing, Kite Boarding, fishing, shopping & fine dining. Something for everyone!

May 22 – 29

ﺩ.ﺇ405 per night
Guest favorite

Home in Costa Esmeralda

4.96 out of 5 average rating, 101 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sand! Come relax with the whole family at this piece of paradise. Majestic Sand is located in a private beach community in Costa Esmeralda, San Carlos District, Panama. It is located a few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, Santa Clara and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool with multiple hammocks with views of amazing palm trees.

Aug 27 – Sep 3

ﺩ.ﺇ585 per night

Popular amenities for Santa Cruz vacation rentals

Other great vacation rentals in Santa Cruz

Guest favorite

Home in Provincia de Panamá Oeste

4.94 out of 5 average rating, 16 reviews

Villa Brisas de Lajas - Chame

Jun 25 – Jul 2

ﺩ.ﺇ263 per night
Guest favorite

Apartment in Nueva Gorgona

4.96 out of 5 average rating, 70 reviews

Amazing view! Beachfront @Nueva Gorgona Bahia

Jul 20 – 27

ﺩ.ﺇ440 per night
Guest favorite

Home in Nueva Gorgona

5.0 out of 5 average rating, 10 reviews

Stylish & Beachfront in Gorgona

May 14 – 21

ﺩ.ﺇ413 per night
Guest favorite

Cottage in Altos del Maria

4.93 out of 5 average rating, 92 reviews

Cabin with Spectacular Mountain View

Jun 17 – 24

ﺩ.ﺇ1,190 per night
Superhost

Apartment in Playa Coronado

4.87 out of 5 average rating, 23 reviews

Home with perfect ocean views

Oct 11 – 18

ﺩ.ﺇ424 per night
Superhost

Home in Las Lajas

5.0 out of 5 average rating, 3 reviews

Beachfront Condo in Prestigious Coronado, Panama

Jun 30 – Jul 7

ﺩ.ﺇ337 per night
Guest favorite

Condo in Nueva Gorgona

4.91 out of 5 average rating, 80 reviews

Fantastic Beach condo with pool & mountain views.

Jun 5 – 12

ﺩ.ﺇ273 per night
Guest favorite

Apartment in Nueva Gorgona

4.92 out of 5 average rating, 63 reviews

Beachfront Condo at Serena Beach -Riviera Pacifica

Jul 8 – 15

ﺩ.ﺇ287 per night
Guest favorite

Condo in gorgona

4.94 out of 5 average rating, 47 reviews

Zen-sorial Condo beach - Ph Royal Palm

Nov 27 – Dec 4

ﺩ.ﺇ328 per night
Guest favorite

Villa in Panama

4.86 out of 5 average rating, 51 reviews

Beachfront Breeze (C3-PBA) Villa apt, 2 bed 2 bath

Apr 13 – 20

ﺩ.ﺇ390 per night
Superhost

Vacation home in Nueva Gorgona

4.81 out of 5 average rating, 79 reviews

Cozy apartment on Gorgon beach

Jun 9 – 16

ﺩ.ﺇ225 per night
Guest favorite

Apartment in Nueva Gorgona

4.85 out of 5 average rating, 26 reviews

Condo with beautiful mountain and beach views

Sep 10 – 17

ﺩ.ﺇ280 per night

Destinations to explore

  1. Airbnb
  2. Panama
  3. Santa Cruz