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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in Costa Esmeralda
4.98 out of 5 average rating, 190 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Top guest favorite
A modern single-story house is displayed with a large front porch and a carport. The exterior features a mix of light and dark materials, with a neatly landscaped yard and a white picket fence. Clear blue skies and scattered clouds complete the setting.
Home in Chame District
5 out of 5 average rating, 32 reviews

Summer House

Take the whole family to this fantastic place with many areas to have fun. Close to all the amenities of Coronado, a few minutes from beaches, San Carlos lagoon and just an hour and a half from the city. The PH has a PH pool and a private one, in a quiet and spacious area. You will find 4 supermarkets, pharmacies, and a private hospital (emergency room). Close to country activities, beaches, mountains, lake. It has a gazebo with all the amenities. The place is safe and complete.

Top guest favorite
The exterior of the house features a charming design with a red-roofed upper level and a welcoming terrace. A small pool is visible in the foreground, surrounded by lush greenery and natural rock formations. Cloudy skies create a serene atmosphere, enhancing the tranquil setting.
Home in El Nancito
4.96 out of 5 average rating, 27 reviews

Mountain Retreat: Peaceful & Private Escape

Escape to tranquility in our beautiful rural retreat near Laguna de San Carlos, Panama. Nestled on a private hectare of lush land, this cozy two-bedroom, two-bath house boasts an open terrace with breathtaking views of the San Carlos mountains. Whether basking in summer sun or enveloped in clouds during the rainy season, you’ll find peace and beauty here. Just a 30-minute drive to Coronado and the stunning beaches of Panama Oeste, it’s the perfect sanctuary for your getaway.

Top guest favorite
A stone paved area features four wooden chairs arranged around a central fire pit, illuminated by soft landscape lighting. In the background, a cabin structure can be seen, bordered by lush greenery and softly lit paths, creating an inviting outdoor space.
Cabin in Provincia de Panamá Oeste
4.89 out of 5 average rating, 270 reviews

Buenavista Cabin by Casa Amaya

Casa Amaya is a cabin complex located one hour from the capital city, in Chicá de Chame, with pleasant temperatures between 18 and 24 degrees, where you can get in touch with nature and relax with your partner, friends or family. Other cabins: https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya We have an electric generator in case of outages.

Guest favorite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guesthouse in Panamá Oeste
4.81 out of 5 average rating, 111 reviews

Mountain cabin with a private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and with spectacular views, here you can breathe pure air and gaze at the stars. ✔️ Great for couples, families or adventurers. Nearby ✔️ trails, rivers and viewpoints. ✔️ Comfortable and equipped spaces for your comfort. - Capacity of 4 people - Possibility of having 1 double bed and 2 singles or 4 single beds - Discount from two nights

Guest favorite
The earth-sheltered studio home is nestled among lush greenery, with large windows offering views of the surrounding nature. The circular design blends with the landscape, demonstrating a harmonious relationship with its natural environment.
Tiny home in Altos del Maria
4.82 out of 5 average rating, 165 reviews

Arcón House

This earth-sheltered studio home offers a unique and romantic escape in the mountain of Altos del Maria. Cozy space surrounded by a lush green environment, ideal for those seeking a peaceful getaway, or an affordable stay to explore the gated community's amenities. This bunker home provides an inviting haven to unwind and disconnect from the hustle of city life.

Top guest favorite
Home in Nueva Gorgona
5 out of 5 average rating, 17 reviews

Spectacular Beachfront House

Beautiful house with private beach access right on the property. Relax on the hammocks and be surrounded by nature, with the best ocean view. Only 10 minutes drive from Coronado with all its amenities. There are two wonderful caretakers on the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

Top guest favorite
A charming two-story house is set in a lush natural environment, surrounded by large trees and vibrant greenery. A gated entrance leads along a curved pathway to the home, which features a sloped roof and outdoor seating areas, inviting relaxation amidst the serene landscape.
Cottage in Panamá
4.92 out of 5 average rating, 106 reviews

Casa Cruz - Altos de Maria - complete house

Cozy house, surrounded by nature, ideal for rest and relaxation, near rivers with beautiful waterfalls, near beaches and ecological hiking trails. Enjoy a mild cool climate. The home offers all the confort that our guests need to feel at home. Gated community with security, must present your identification in the gate for access to the community.

Guest favorite
Cabin in Altos del Maria
4.94 out of 5 average rating, 34 reviews

Blue Sky Lodge; the best view in Altos del María

This newly built luxury mountain cabin offers a modern design, quality finishes, and 180° panoramic views of mountains and sea. It is located in a secure gated community, surrounded by a green garden, with large glass windows that favor connection with nature. The climate is pleasant, with temperatures between 23°C and 28°C. .

Top guest favorite
A spacious bed is dressed in a colorful quilt, complementing an inviting orange pillow. Large glass doors offer a panoramic view of the surrounding mountains and lead to a private outdoor space with a swimming pool.
Tiny home in Panamá
4.98 out of 5 average rating, 215 reviews

Mountain cabin in Altos del María

The cabin in Altos del María is located in the heart of the mountain, with beautiful landscapes, trees, animals, monkeys, birds, just minutes from picnic areas, outdoor games, river, waterfall, trails and viewpoints. Escape into nature! Close to everything, away from the daily grind!

Top guest favorite
A light-filled living area features a comfortable white sofa adorned with colorful pillows. A glass coffee table is centered on the tiled floor, complemented by two chairs. Large sliding glass doors provide a view of the surrounding landscape and allow access to a private balcony.
Condo in Nueva Gorgona
4.94 out of 5 average rating, 251 reviews

Beautiful Beach Apt-PH Royal Palm-Gorgona

FIRST LINE TO THE SEA WITH DIRECT ACCESS TO THE BEACH FROM THE PH POOLS. Comfortable apartment to enjoy alone, as a couple or as a family. Large social areas with 4 swimming pools, jacuzzi, restaurant, gym, sauna and with direct and exclusive access to the beach

Superhost
An outdoor area features modern seating arranged around a central fire pit, surrounded by gravel and stone pathways. Elevated swings are positioned for relaxation, with a backdrop of expansive mountain views. Natural light filters through a structured canopy, enhancing the spacious feel.
Cabin in Chame District
4.85 out of 5 average rating, 128 reviews

Walk through the Clouds

Relax on this unique and quiet getaway just an hour and an half from the city. Every nook of this magical place was meticulously designed to provide perfect escape to couples seeking intimacy, serenity, and unforgettable moments together.

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz