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Vacation rentals in Santa Cruz

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Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
An expansive view of a tranquil beach is seen, with soft sandy shores meeting clear turquoise waters. The horizon features a blend of blue sky and distant buildings, while palm trees and shaded cabanas dot the beach area.
Condo in Chame District
4.96 out of 5 average rating, 165 reviews

Exclusive Beachfront apartment 1Hour from Pma City

ESPECTACULAR apartamento de lujo FULL EQUIPADO con 3 recamaras (todas con vista directa al mar), 2 baños completos y medio baño de visita; cuarto y baño de servicio. Finos acabados, cocina 100% de acero inoxidable y aires acondicionados en todo el apartamento de alta eficiencia. Condominio con concepto "Hotel Style Living"; Restaurante y Bar para las noches (de Jueves a Domingo), snack bar en el area de la piscina y un Tiki Bar en la playa, ademas de cancha de Volleyball , Tenis, basketball.

Top guest favorite
An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.
Home in Costa Esmeralda
4.98 out of 5 average rating, 178 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with solar and battery backup systems.

Top guest favorite
A modern single-story house is displayed with a large front porch and a carport. The exterior features a mix of light and dark materials, with a neatly landscaped yard and a white picket fence. Clear blue skies and scattered clouds complete the setting.
Home in Chame District
5 out of 5 average rating, 21 reviews

Summer House

Take the whole family to this fantastic place with many areas to have fun. Close to all the amenities of Coronado, a few minutes from beaches, San Carlos lagoon and just an hour and a half from the city. The PH has a PH pool and a private one, in a quiet and spacious area. You will find 4 supermarkets, pharmacies, and a private hospital (emergency room). Close to country activities, beaches, mountains, lake. It has a gazebo with all the amenities. The place is safe and complete.

Top guest favorite
The exterior of the house features a charming design with a red-roofed upper level and a welcoming terrace. A small pool is visible in the foreground, surrounded by lush greenery and natural rock formations. Cloudy skies create a serene atmosphere, enhancing the tranquil setting.
Home in El Nancito
4.94 out of 5 average rating, 18 reviews

Mountain Retreat: Peaceful & Private Escape

Escape to tranquility in our beautiful rural retreat near Laguna de San Carlos, Panama. Nestled on a private hectare of lush land, this cozy two-bedroom, two-bath house boasts an open terrace with breathtaking views of the San Carlos mountains. Whether basking in summer sun or enveloped in clouds during the rainy season, you’ll find peace and beauty here. Just a 30-minute drive to Coronado and the stunning beaches of Panama Oeste, it’s the perfect sanctuary for your getaway.

Guest favorite
A stone paved area features four wooden chairs arranged around a central fire pit, illuminated by soft landscape lighting. In the background, a cabin structure can be seen, bordered by lush greenery and softly lit paths, creating an inviting outdoor space.
Cabin in Provincia de Panamá Oeste
4.88 out of 5 average rating, 250 reviews

Buenavista Cabin by Casa Amaya

Casa Amaya is a cabin complex located one hour from the capital city, in Chicá de Chame, with pleasant temperatures between 18 and 24 degrees, where you can get in touch with nature and relax with your partner, friends or family. Other cabins: https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya We have an electric generator in case of outages.

Top guest favorite
Loft in Chame District
5 out of 5 average rating, 14 reviews

Chica Sector 2 Large Lofts, Sea View and Autodromo

🩷 TWO large independent lofts. (2 people per loft) The 2 lofts are completely independent Each unit: WiFi - Air conditioning - Fridge 1 bedroom 🛏️ (orthopedic bed) 1 living room 🛋️ 1 bath 🚿 Parking 24-hour on-site caretaker 👮‍♀️ Private VIP terrace just for YOU Kitchenette & wood-fired pizza oven 🍙 Enjoy amazing views of the valley, sea, Punta Chame Islands and the new AUTODROMO 🏁 25 km from Coronado 28 km from Costa Verde 50 km from Panama

Superhost
An outdoor patio space is presented with wooden chairs and a small table. Lush green grass extends towards the sandy beach, adorned with palm trees and sun loungers under thatched umbrellas, creating a calm coastal view.
Home in Chame
4.8 out of 5 average rating, 75 reviews

P/Caracol Ocean Haven View (C5-PBB) 2 bed, 2 bath

This unique place has a style all its own, steps away from the ocean and fully furnished ground floor unit 2 bed/2 bath apt has an open concept living, dining & kitchen space and an outside pergola area. (4 guests). This is a unique villa apartment over looking the picturesque Playa Caracol coast with ocean front and majestic mountain views and great on-site amenities. 1km of beach to offer you the best beach and surfing experience around.

Guest favorite
An inviting infinity pool is positioned on a spacious patio, overlooking a sweeping mountain view. Two lounge chairs are arranged on the deck, facing the water, while lush greenery and colorful blooms enhance the serene environment surrounding the pool area.
Cottage in Altos del Maria
4.94 out of 5 average rating, 165 reviews

Mountain Cottage with Heated Pool and Amazing View

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a heated infinity pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

Superhost
A large swimming pool is surrounded by tropical palm trees, appearing inviting under a clear blue sky. Lounge chairs are positioned around the pool area, providing ample space for relaxation. A portion of the pool is shallow, leading toward a landscaped section with greenery.
Apartment in San José
4.85 out of 5 average rating, 138 reviews

B31-Tropical beach paradise, 2R/2B condo, w/pool

Disconnect for a few days from the routine. Have fun with your partner or family in our apartment in Punta Barco Viejo, we have everything you need to be comfortable and have fun in one of the most exclusive areas of the area. We have everything nearby for your best convenience, restaurants, banks, supermarkets ... I´ll deliver a personalized 5 stars attention. Oh and of course, the BEACH 5min by car!

Top guest favorite
Home in Nueva Gorgona
5 out of 5 average rating, 16 reviews

Spectacular Beachfront House

Beautiful house with private beach access right on the property. Relax on the hammocks and be surrounded by nature, with the best ocean view. Only 10 minutes drive from Coronado with all its amenities. There are two wonderful caretakers on the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

Guest favorite
The two-story house is illuminated at night, showcasing vibrant exterior colors and a balcony on the upper floor. Large windows are visible, allowing light to spill out. A seating area is set up in the outdoor space, surrounded by plants and decorative string lights.
Home in El Valle de Antón
4.81 out of 5 average rating, 255 reviews

Casa Antares by Esther

Agradable casa de dos pisos con vistas a las montañas. **NO APTO PARA PERSONAS CON POCA MOVILIDAD, FAVOR LEER SECCIÓN DE SEGURIDAD** Dos cuartos privados en la parte superior con balcón en la habitación principal. Baño, sala y cocina en la planta baja. Contamos con bicicletas para que puedan pasear alrededor del Valle de Antón.

Top guest favorite
A spacious living area features large windows that provide a view of the ocean. Comfortable seating options include a sectional sofa and armchairs. A round coffee table sits on a textured rug, while ceiling fans circulate air in the bright, airy space.
Condo in Nueva Gorgona
4.94 out of 5 average rating, 189 reviews

Fabuloso Apto de playa-Ph Royal Palm-Gorgona

FIRST LINE TO THE SEA WITH DIRECT ACCESS TO THE BEACH FROM THE PH POOLS. Fabulous BEACH APARTMENT, Beach Front Unit, comfortable, unique and to relax with the family, it has 4 incredible swimming pools, jacuzzi, sauna, sports courts, board games and access to the beach and restaurant service, coming is not wanting to leave ever

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz